Thirteen new 2 alkylaminoimidazolones (4) were rapidly synthesized by a new solution phase parallel synthetic method, which includes aza Wittig reaction of iminophosphorane (1) with aromatic isocyanate to give carb...Thirteen new 2 alkylaminoimidazolones (4) were rapidly synthesized by a new solution phase parallel synthetic method, which includes aza Wittig reaction of iminophosphorane (1) with aromatic isocyanate to give carbodi imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate.展开更多
Semiconductor nanocrystals(dots,rods,wires,etc.)exhibit a wide range of electrical and optical properties that differ from those of the corresponding bulk materials.These properties depend on both nanocrystal size and...Semiconductor nanocrystals(dots,rods,wires,etc.)exhibit a wide range of electrical and optical properties that differ from those of the corresponding bulk materials.These properties depend on both nanocrystal size and shape.Compared with nanodots,nanorods have an additional degree of freedom,the length or aspect ratio,and reduced symmetry,which leads to anisotropic properties.In this paper,we report the Au nanoparticle-catalyzed colloidal synthesis of monodisperse CdS nanorods.Based on systematic high resolution transmission electron microscopy studies,we propose a growth mechanism for these nanorods.展开更多
A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solu- tion-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and 1-Pro-l-Ph...A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solu- tion-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and 1-Pro-l-Phe-OMe which utilizes diisopropylcarbodiimide （DIPC） as coupling agent and N-methylmorpholine （NMM） as the base. Deprotection of linear tetrapeptide unit followed by its cyclization provided a cyclopeptide, identical in all aspects to the natural molecule. Pharmacological evaluation showed cytotoxic, antifungal and antihelmintic po- tential of synthesized peptide against Dalton＇s Lymphoma Ascites （DLA） and Ehrlich＇s Ascites Carcinoma （EAC） cell lines, pathogenic dermatophytes and earthworms.展开更多
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 10 2 0 0 1)
文摘Thirteen new 2 alkylaminoimidazolones (4) were rapidly synthesized by a new solution phase parallel synthetic method, which includes aza Wittig reaction of iminophosphorane (1) with aromatic isocyanate to give carbodi imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate.
基金This work is supported by NSF-DMR 0547036,NSFCBET 0652042,and UB Integrated Nanostructured Systems Instrument Facilities.
文摘Semiconductor nanocrystals(dots,rods,wires,etc.)exhibit a wide range of electrical and optical properties that differ from those of the corresponding bulk materials.These properties depend on both nanocrystal size and shape.Compared with nanodots,nanorods have an additional degree of freedom,the length or aspect ratio,and reduced symmetry,which leads to anisotropic properties.In this paper,we report the Au nanoparticle-catalyzed colloidal synthesis of monodisperse CdS nanorods.Based on systematic high resolution transmission electron microscopy studies,we propose a growth mechanism for these nanorods.
文摘A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solu- tion-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and 1-Pro-l-Phe-OMe which utilizes diisopropylcarbodiimide （DIPC） as coupling agent and N-methylmorpholine （NMM） as the base. Deprotection of linear tetrapeptide unit followed by its cyclization provided a cyclopeptide, identical in all aspects to the natural molecule. Pharmacological evaluation showed cytotoxic, antifungal and antihelmintic po- tential of synthesized peptide against Dalton＇s Lymphoma Ascites （DLA） and Ehrlich＇s Ascites Carcinoma （EAC） cell lines, pathogenic dermatophytes and earthworms.
