Sonogashira coupling reaction in the synthesis of novel positive allosteric modulators ofα7 nicotinic acetylcholine receptors

A series of 2-arylamino-1,3,5-triazine derivatives(4a–4g),which were designed and synthesized via Sonogashira coupling reaction,were evaluated using two-electrode voltage clamp(TEVC)recordings of humanα7 nAChR expressed in Xenopus ooctyes.Compound 4g as a positive allosteric modulator(PAM)showed better efficacy than lead compound 3(HZZ-A-11)with an EC50 value of 1.23±0.41μM.Further pharmacological evaluation of compound 4g might lead to the developmental potential for therapy of cognitive deficits commonly shared by neuropsychiatric disorders,such as schizophrenia and Alzheimer’s disease.

Cu(I)/Diamine-catalyzed Aryl-alkyne Coupling Reactions

CuI/ethylene diamine/K2CO3/dioxane is shown to be a useful system for the cross coupling reactions of various aryl iodides and bromides with aryl and alkyl alkynes. Compared to the conventional Sonogashira reactions, the new procedure is free of palladium and phosphines.

Synthesis of calix[4]arene derivatives via a Pd-catalyzed Sonogashira reaction and their recognition properties towards phenols

A novel series of calix[4]arene derivatives were synthesized via a Pd-catalyzed Sonogashira coupling reaction from para-substituted iodobenzene and 25,27-dipropargyl-calix[4]arene. Fluorescence studies found that nitro-phenols clearly exhibited quenching effects on 2c. Moreover, we minimized the free energy of the complexes by theoretical calculations. As the result, the πr-π stacking interactions take place between the 4-nitrophenol and calix[4]arene, which may lead to the significant fluorescence quench.

A copper- and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand

An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand.The use of 2 mol%Pd（OAc）_2 in the presence of K_2CO_3 allows the coupling reaction to proceed at mild condition with good to excellent yields.

Synthesis and characterization of dendronized hyperbranched polymers through the “A_3+B_2” approach

Dendronized hyperbranched polymer （DHP） is a new kind of polymer, which combines the advantages of dendrimers and hy- perbranched polymers. In this work, two dendronized hyperbranched polymers, DttPG0 and DHPG1, were successfully pre- pared through the simple ＂A3＋B2＂ type Sonogashira coupling reaction. The nonlinear optical （NLO） effects of DHPG0 and DItPG1, characterized by the d33 values, were 183 and 220 pm V-1 respectively, higher than those of their analogues of den- dronized polymers and dendrimers, thanks to the special topological structure. Also, the obtained polymers displayed excellent solubility, good processability, and high thermal stability.

A facile and efficient synthetic method for 4-phenylethynylphthalic anhydride

A novel approach to the synthesis of 4-phenylethynylphthalic anhydride has been described.The target compound was synthesized by Pd/Cu catalyzed Sonogashira coupling reaction between phenylacetylene and 4-bromophthalic acid which was for the first time employed as start material,followed by dehydration of 4-phenylethynylphthalic acid.Compared with traditional synthetic routes,this method provides several advantages such as readily available raw materials,convenient manipulation and high yield.The products were characterized by IR,~1H NMR,^（13）C NMR,MS and elemental analysis,respectively.