In order to assess the responses of different skin types stimulated by tape stripping,after which two kinds of brand cosmetics of cream and hydrogel,were separately applied to evaluate the individual soothing effect o...In order to assess the responses of different skin types stimulated by tape stripping,after which two kinds of brand cosmetics of cream and hydrogel,were separately applied to evaluate the individual soothing effect of the product on different skin types.A total of 30 volunteers aged 18~65 years were recruited,which were divided into four groups(oily,dry,normal and combined)according to the self-oiling ability of facial and T zones.Four 3 cm×3 cm of skins on inner forearm of each volunteer were chosen and randomly marked as blank,negative control,soothing cream and soothing gel.The blank area was kept untreated,and the remaining areas were tape-stripped by 10 times(Transparent universal 1527C-1,3M China Co.,Ltd.,)to disrupt the skin corneum and induce erythema.Images,erythema index(EI)and transcutaneous water loss rate(TEWL)of the marked skin areas before and 5 min after tape-stripping were taken to assess the distinct responses of different skin type to the taping treatment;Ten minutes after tape-stripping,The soothing products were applied to the test area,the skin images,EI and TEWL at 20 min and 50 min(corresponding to 30 min and 60 min after tape-stripping,respectively)were measured after cosmetics application to compare and evaluate the soothing effects of cream and hydrogel on different skin types.Results showed that different skin displayed diverse reactions to the tape-stripping,and the oily skin was more sensitive with longer duration of erythema than other skin types.After the application of soothing products,both cream and hydrogel could relieve skin erythema,while the soothing effects are dependent both on skin types and the cosmetic base materials:Hydrogel has a better efficacy in alleviating erythema and TEWL of dry skin,while the cream was more effective on normal,oily and combined skin types.The results suggest that the modelling method for soothing evaluation should consider the skin types of the volunteers,and the cosmetics of different base materials might have the target skin types.展开更多
To explore the method of evaluating the soothing effect of human skin damage,a human skin damage model was established using UV light induction.Four test areas were set up,namely blank control area,UV damage preventio...To explore the method of evaluating the soothing effect of human skin damage,a human skin damage model was established using UV light induction.Four test areas were set up,namely blank control area,UV damage prevention and soothing area,immediate soothing area after UV damage and soothing area after UV damage.Five skin parameters,including skin melanin,red pigment value,skin pigmentation value,a*value,and skin redness value,were used to characterize skin pigmentation before and after using the sample Changes in properties such as skin erythema and skin pigment.The results showed that the method showed significant changes in the skin condition of volunteers before and after using the sample,and could achieve a soothing effect,which has certain reference significance.展开更多
Present study is aimed to investigate in vitro biological efficacy of Tambourissa trichophylla leaf extract(TTLE),a plant-derived ingredient in cosmetic,on antioxidant activity and soothing efficacy.The total phenols ...Present study is aimed to investigate in vitro biological efficacy of Tambourissa trichophylla leaf extract(TTLE),a plant-derived ingredient in cosmetic,on antioxidant activity and soothing efficacy.The total phenols content of TTLE was determined by the Folin-Ciocalteu method,antioxidant activity was tested by DPPH free radical scavenging assay,hyaluronidase inhibition activity was performed by using in vitro enzyme inhibitory assays based on spectrophotometric evaluation,and the soothing efficacy of TTLE was performed by the expression of nitric oxide(NO)and interleukin-6(IL-6)produced by LPS-induced RAW264.7 cells.The results shown that the total phenolic content of TTLE was as high as 54%,the DPPH scavenging activity was 81.18%at the concentration of 25μg/mL,the hyaluronidase inhibition activity was 69.04%at the concentration of 5 mg/mL,and the inhibition of NO and IL-6 were 15.70%and 76.57%at 0.05 mg/mL,respectively.TTLE has a high content of total phenols,high antioxidant activity and soothing effects,which indicated that TTLE was a promising ingredient in the development and application of cosmetics.展开更多
p-Hydroxyacetophenone(p-HAP)was used as preservatives in cosmetics recently,their new efficacy was rarely reported.Here,We evaluate the soothing and oil control efficacy of p-HAP in vitro cells,providing a new efficac...p-Hydroxyacetophenone(p-HAP)was used as preservatives in cosmetics recently,their new efficacy was rarely reported.Here,We evaluate the soothing and oil control efficacy of p-HAP in vitro cells,providing a new efficacy basis for its application in cosmetics.The content of nitric oxide(NO),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were determined in LPS-induced RAW264.7 and lipid contents were determined in testosterone-induced SZ95.The results revealed that p-HAP attenuated pro-inflammatory cytokines,such as NO,TNF-αand IL-6(P<0.01).Simultaneously,0.05mg/mL of p-HAP also inhibited the formation of lipid droplets in human sebocytes,with 17.64%of inhibition(P<0.001).These findings may be beneficial in the application of p-HAP as an efficacy ingredient in cosmetics,which may have a soothing and oil control efficacy according to the inhibition of pro-inflammatory cytokines and lipid contents.展开更多
In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed...In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed that the concentration of NO and IL-6 was significantly reduced in LPS-induced RAW264.7 cells when applied to two essences.The inhibition rate of NO-release was 85.87%and 84.57%,while IL-6 was 44.18%and 38.76%,respectively.Furthermore,the spontaneous rotating of zebrafish embryos was significantly decreased to 51.85%and 76.54%in SDS-stimulated zebrafish embryos model.In the 28 days of clinical assessment,the concentration of hydration was significantly increased to 55.56%and 39.61%,while the erythrodesis was significantly decreased to 4.75%and 6.68%.This indicates that the three evaluation methods of soothing efficacy in this research were effective,and can be used in the evaluation of cosmetics.展开更多
The skin is a formidable physical and biological barrier which communicates continuously with the outside of the body. And the stratum corneum, the outermost layer of human epidermis, plays a central role in the inter...The skin is a formidable physical and biological barrier which communicates continuously with the outside of the body. And the stratum corneum, the outermost layer of human epidermis, plays a central role in the interaction between the cutaneous tissue and the external environment. The horny layer, and more generally the whole skin layers, avoid the penetration of harmful exogenous agents, produce molecules named anti-microbial peptides which impact the composition of the cutaneous microbiota, regulate the internal corporal temperature, avoid the water loss from the inside of the body and constitute an incredible efficient anti-oxidant network. Nevertheless, nowadays, the skin is more and more solicited by the different elements of the cutaneous exposome, including atmospheric pollution and solar radiations, which can cause a dramatic acceleration of the skin ageing process. As a consequence, due to the multifunctional protective role of the skin, during the recent decade the cosmetic industry invested massively in the development of new raw materials and end-products (dermo-cosmetics) able to preserve an optimal state of the skin regarding the external environment. Based on their physical-chemical properties thermal spring waters, which are extremely rich in inorganics ions, are interesting and powerful candidates to be part, as integral component, of new efficient dermo-cosmetic formulations dedicated to protect the skin from the external stimuli. The aim of the present work was to investigate and characterize the activity of Jonzac thermal spring water on the skin. Using different models, we proved for the first time that Jonzac thermal spring water reinforces the barrier function of the skin by modulating the expression of key markers including filaggrin and human beta defensin 2 on ex vivo human skin. The ex vivo and in vivo hydration activity, by Raman spectroscopy and corneometry respectively, has been also demonstrated. We have also shown that Jonzac thermal spring water ameliorates significantly the cutaneous microrelief in vivo. To conclude, we characterize the soothing effect of Jonzac thermal spring water by the analysis of histamine release in Substance P treated skin explants and by measuring the redness of the skin following UV exposure of the skin in vivo. We observed that both parameters decreased following a preventive treatment of the skin with Jonzac thermal spring water. Taken together our results indicate that Jonzac thermal spring water is a promising and powerful dermo-cosmetic which can be used to preserve an optimal state of the cutaneous tissue.展开更多
Objective This study aimed to examine the sleep arrangements and soothing methods and to assess their associations with sleep problems among children aged<3 years in China.Methods A cross-sectional survey was condu...Objective This study aimed to examine the sleep arrangements and soothing methods and to assess their associations with sleep problems among children aged<3 years in China.Methods A cross-sectional survey was conducted in 2019 from six provinces in China.A total of 1,195 caregivers of children aged 0–35 months were included in the study.Data on sleep arrangements,soothing methods,and sleep problems(i.e.,frequent night awakenings and difficulty falling asleep)were assessed using the Brief Infant Sleep Questionnaire.The reasons for bed-sharing in sleep arrangements were recorded using a self-designed questionnaire.Results The bed-sharing practice was very prevalent at any age,which ranged from 69.9%to 78.3%.Most infants fell asleep while feeding or being rocked/held before age 12 months.By age 35 months,62.4%of the children fell asleep in bed near parents.The most common reasons for bed-sharing were breastfeeding/feeding and convenience.Parental involvement when falling asleep was significantly related with frequent night awakenings and difficulty falling asleep.No association was found between bed-sharing and sleep.Conclusion Bed-sharing and parental involvement were very common among Chinese children aged<3 years.Children who fall asleep with parental involvement were more likely to have sleep problems.展开更多
The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, th...The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.展开更多
Pancreatic pseudocyst, whose clinical feature is small simple cyst, is a common local complication of acute pancreatitis and will not need surgery in ordinary circumstances. However, some cases could appear secondary ...Pancreatic pseudocyst, whose clinical feature is small simple cyst, is a common local complication of acute pancreatitis and will not need surgery in ordinary circumstances. However, some cases could appear secondary disorders related to the location of the cyst and the role of decomposition enzymes of content, such as cyst rupture moving into the abdomen, bleeding, cystic infection, compression and internal fistula formation with adjacent organs and so on^([1]). But the spleen-related complications resulting from it are rare. There was 1 patient with pancreatic pseudocyst admitted to Dongfang Hospital Affiliated to Beijing University of Chinese Medicine and the report is as follows.展开更多
OBJECTIVE: To study the therapeutic effects of "soothing the liver method" on stress-related non-alcoholic fatty liver and its treatment mechanism on neuroendocrine-metabolic level. METHODS: The animal model...OBJECTIVE: To study the therapeutic effects of "soothing the liver method" on stress-related non-alcoholic fatty liver and its treatment mechanism on neuroendocrine-metabolic level. METHODS: The animal model of stress-related nonalcoholic fatty liver which is more in line with the modern social and clinical conditions was established by the method of chronic restraint compound high-fat feed. AST and ALT were detected by automatic biochemical analyzer. Serum cortisol and TNF-a were detected by radioimmunoassay. The relative expression of Nr3 c1 mRNA was detected by real-time quantitative PCR. RESULTS: Compared with the blank group, the scores of open field test, Nr3 c1 mRNA decreased, and AST, ALT, FFA were significantly increased in model group. Compared with model group, the open field test scores, Nr3 c1 mRNA increased,and Cor, AST, FFA, LDL, TNF-a, were significantly decreased in SNS group. CONCLUSIONS: "Soothing the liver method" can exert its therapeutic effect on stress-related non-alcoholic fatty liver on neuroendocrine-metabolic level.展开更多
"Double Heart Disease",that is,patients with cardiovascular disease often have mental and psychological disorders such as anxiety and depression.Professor Chen Xiao-hu is guided by the holistic concept of Ch..."Double Heart Disease",that is,patients with cardiovascular disease often have mental and psychological disorders such as anxiety and depression.Professor Chen Xiao-hu is guided by the holistic concept of Chinese medicine and based on the dual physiological functions of the heart as the main blood vessel and the main god.He believes that the internal resistance of blood stasis and mental disturbance are the core pathogenesis of"Double Heart Disease".Advocating the use of activating blood to calm the nerves to treat"double heart disease",and taking advantage of the overall adjustment of traditional Chinese medicine to achieve the purpose of harmonizing viscera and balancing Yin and Yang.The article summarizes Professor Chen Xiao-hu's experience in using the method of activating blood to soothe the nerves to treat"Double Heart Disease",with a view to clinical treatment Provide new ideas.展开更多
Objective: To investigate the mechanism of inflammatory-mediated toll-like receptor 4(TLR4)-p38 mitogen-activated protein kinase(p38 MAPK) pathway in Kupffer cells(KCs) of non-alcoholic steatohepatitis(NASH) rats and ...Objective: To investigate the mechanism of inflammatory-mediated toll-like receptor 4(TLR4)-p38 mitogen-activated protein kinase(p38 MAPK) pathway in Kupffer cells(KCs) of non-alcoholic steatohepatitis(NASH) rats and the intervention effect of soothing Gan(Liver) and invigorating Pi(Spleen) recipes on this pathway. Methods: After 1 week of acclimatization, 120 Sprague-Dawley male rats were randomly divided into 8 groups using a random number table(n=15 per group): normal group, model group, low-dose Chaihu Shugan Powder(柴胡疏肝散, CHSG) group(3.2 g/kg), high-dose CHSG group(9.6 g/kg), low-dose Shenling Baizhu Powder(参苓白术散, SLBZ) group(10 g/kg), high-dose SLBZ(30 g/kg) group, and low-and highdose integrated recipe(L-IR, H-IR) groups. All rats in the model and treatment groups were fed with a high-fat diet(HFD). The treatments were administrated by gastrogavage once daily and lasted for 26 weeks. The liver tissues were detected with hematoxylin-eosin(HE) and oil red O staining. Levels of liver lipids, serum lipids and transaminases were measured. KCs were isolated from the livers of rats to evaluate the mRNA expressions of TLR4 and p38 MAPK by real-time fluorescence quantitative polymerase chain reaction, and proteins expressions of TLR4, p-p38 MAPK and p38 MAPK by Western blot. Levels of inflammatory cytokines including tumor necrosis factor α(TNF-α), interleukin(IL)-1 and IL-6 in KCs were measured by enzyme-linked immunosorbent assay. Results: After 26 weeks of HFD feeding, HE and oil red O staining showed that the NASH model rats successfully reproduced typical pathogenesis and histopathological features. Compared with the normal group, the model group exhibited significant increases in body weight, liver weight, liver index, serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol, and aspartate aminotransferase as well as TC and TG levels in liver tissues, and significant decrease in serum level of high-density lipoprotein cholesterol(P<0.05 or P<0.01), while those indices were significantly ameliorated in the H-IR group(P<0.05 or P<0.01). Higher levels of TNF-α, IL-1 and IL-6 in KCs were observed in the model group compared with the normal group(P<0.01). Significant decreases in TNF-α, IL-1 and IL-6 were observed in the H-SLBZ, H-IR and L-IR groups compared with the model group(P<0.05 or P<0.01). The m RNA expressions of TLR4 and p38 MAPK and protein expressions of TLR4, p38 MAPK and p-p38 MAPK in KCs in the model group were significantly higher than the normal group(P<0.01), while those expression levels in the L-IR and H-IR groups were significantly lower than the model group(P<0.05 or P<0.01). Conclusions: Inflammation in KCs might play an important role in the pathogenesis of NASH in rats. The data demonstrated the importance of TLR4-p38 MAPK signaling pathway in KCs for the anti-inflammatory effect of soothing Gan and invigorating Pi recipes.展开更多
Objective: To explore the effect of Soothing Gan (肝) and invigorating Pi (脾) (SGIP) acupuncture treatment on the clinical symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable b...Objective: To explore the effect of Soothing Gan (肝) and invigorating Pi (脾) (SGIP) acupuncture treatment on the clinical symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: With a single-blinded randomized control study adopted, 63 patients who met the inclusion criteria were assigned by a random number table to two groups, 31 in the treatment group and 32 in the drug control group. The treatment group received SGIP acupuncture therapy; while the control group was treated orally with pinaverium bromide. The treatment duration of both groups was 28 days. The clinical efficacy was evaluated and compared by scoring patient's symptom and QOL. Results: A significant difference was found by variance analysis in efficacies between the two groups (P〈0.01), shown as the quicker initiation of effect (P〈0.05) and the more evident clinical improvement in symptoms along the increase in treatment duration, as well as the more significant elevation of QOL in the acupuncture treatment group (P〈0.01). SGIP displayed its superiority especially in improving dysphoria, conflict behavior, dietary restrictions, and social responses. Conclusion: SGIP acupuncture treatment could effectively alleviate the degree and frequency of symptoms' attack in IBS-D patients, such as abdominal pain, diarrhea, abdominal distension, etc., markedly relieve the tenesmic sensation, with the efficacy better than that of pinaverium bromide, showing a preponderance in improving patient's QOL.展开更多
Objective To investigate the mechanism of lipid metabolism disorders in Kupffer cells (KCs) of non-alcoholic fatty liver disease (NAFLD) rats mediated by LXRα-SREBP-lc pathway and the interference of soothing liv...Objective To investigate the mechanism of lipid metabolism disorders in Kupffer cells (KCs) of non-alcoholic fatty liver disease (NAFLD) rats mediated by LXRα-SREBP-lc pathway and the interference of soothing liver and invigorating spleen recipe (SLISR) on it. Methods SD male rats were randomly divided into five groups: normal, model, soothing liver recipe (SLR), invigorating spleen recipe (ISR), and soothing liver and invigorating spleen recipe (SLISR) groups. The rats in treatment groups were administered for 8 weeks. The liver tissue was stained with H&E and oil red O. The levels of hepatic lipid and blood lipid were measured by biochemical analyzer. KCs were isolated from the livers of rats to evaluate the expression of LXRα, SREBP-1 C, and FAS mRNA by real-time fluorescence quantitative PCR tests; LXRα, SREBP-1C, and FAS proteins were measured by Western blotting. Results The H&E and oil red O staining results showed that the model rats successfully reproduced typical pathogenetic and histopathological features of NAFLD. The levels of hepatic lipid and blood lipid in the model rats were dramatically increased. Compared with the model group, the values of hepatic lipid and blood lipid in the treatment groups were significantly ameliorated (P〈 0.05, 0.01 ). The yields of purified KCs from each rat were 2×10^7-3×10^7. The viability of KCs was higher than 95%, with the purity over 90.18%. Compared with the model group, the expression of LXRα, SREBP-1C, and FAS mRNA and proteins was decreased in all treatment groups, especially in the SLR group (P〈 0.05). Conclusion SLISR may protect liver against injury included by lipid metabolism disorders in KCs through LXRα/ SREBP-1 c signaling pathway, which may be an important mechanism for the prevention and treatment of NAFLD.展开更多
Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide ad...Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.展开更多
目的:研究疏肝滋肾汤治疗膝骨关节炎的临床疗效。方法:80例患者随机分为2组,治疗组40例患者予疏肝滋肾汤,每次300 m L,早晚各1次;对照组40例给予非甾体抗炎药(NSAIDS)美洛昔康口服,1粒/次,1次/日,连服2月,应用WOMAC积分表、膝关节X线评...目的:研究疏肝滋肾汤治疗膝骨关节炎的临床疗效。方法:80例患者随机分为2组,治疗组40例患者予疏肝滋肾汤,每次300 m L,早晚各1次;对照组40例给予非甾体抗炎药(NSAIDS)美洛昔康口服,1粒/次,1次/日,连服2月,应用WOMAC积分表、膝关节X线评价,对比治疗前后、随访6月指标变化。结果:治疗组与对照组总有效率分别为90.0%、77.5%(P<0.05);2组WOMAC评价积分均下降,但治疗组效果明显优于对照组;2组膝关节X线评分均下降,治疗组优于对照组,差异有显著性。结论:疏肝滋肾汤治疗膝骨关节炎疗效确切,能有效缓解膝骨关节炎症状,且副作用少,安全可靠。展开更多
It is crucial to correctly predict the passenger flow of an air route for the construction and development of an airport.Based on the passenger flow data of Sanya Airport from 2008 to 2016,this paper respectively adop...It is crucial to correctly predict the passenger flow of an air route for the construction and development of an airport.Based on the passenger flow data of Sanya Airport from 2008 to 2016,this paper respectively adopted Holt-Winter Seasonal Model,ARMA and linear regression model to predict the passenger flow of Sanya Airport from 2017 to 2018.In order to reduce the prediction error and improve the prediction accuracy at meanwhile,the combinatorial weighted method is adopted to predict the data in a combined manner.Upon verification,this method has been proved to be an effective approach to predict the airport passenger flow.展开更多
Addressing skin challenges in baby care formulations is quite a challenge itself, as the formulation not only needs to be active, but it should also meet specific requirements in terms of ingredients, agreability and ...Addressing skin challenges in baby care formulations is quite a challenge itself, as the formulation not only needs to be active, but it should also meet specific requirements in terms of ingredients, agreability and rational of the formulation design. Object of this study was the realization of a few different cosmetic formulations blending soundly documented natural active ingredients in systems matching the most common requirements of the baby care products. Additionaly, compatibility evidences of the employed natural actives within the tested systems have also been observed. We are therefore presenting the formulation design of four different formulations for baby care: a baby wash, an immediate rash recovery, an after sun emulsion and a calming and soothing product, each one described for the rational of the actives it contains and provided with a detailed formulation design. Specific attention will be directed to those ingredients for which clinical data supporting the expected skin benefits are available.展开更多
Cubital tunnel syndrome is a disease in which ulnar nerve is compressed by its surrounding tissues,and its main clinical manifestations are pain,sensory disturbance and dyskinesia.Its incidence rate is the second high...Cubital tunnel syndrome is a disease in which ulnar nerve is compressed by its surrounding tissues,and its main clinical manifestations are pain,sensory disturbance and dyskinesia.Its incidence rate is the second highest among peripheral nerve entrapment diseases,and it is one of the common clinical diseases.The theory of liver,spleen and kidney can guide the treatment of cubital tunnel syndrome with traditional Chinese medicine and acupuncture.By discussing the traditional Chinese medicine(TCM)pathogenesis and treatment principles of cubital tunnel syndrome,it provides modern medical theoretical support for TCM treatment of cubital tunnel syndrome.展开更多
文摘In order to assess the responses of different skin types stimulated by tape stripping,after which two kinds of brand cosmetics of cream and hydrogel,were separately applied to evaluate the individual soothing effect of the product on different skin types.A total of 30 volunteers aged 18~65 years were recruited,which were divided into four groups(oily,dry,normal and combined)according to the self-oiling ability of facial and T zones.Four 3 cm×3 cm of skins on inner forearm of each volunteer were chosen and randomly marked as blank,negative control,soothing cream and soothing gel.The blank area was kept untreated,and the remaining areas were tape-stripped by 10 times(Transparent universal 1527C-1,3M China Co.,Ltd.,)to disrupt the skin corneum and induce erythema.Images,erythema index(EI)and transcutaneous water loss rate(TEWL)of the marked skin areas before and 5 min after tape-stripping were taken to assess the distinct responses of different skin type to the taping treatment;Ten minutes after tape-stripping,The soothing products were applied to the test area,the skin images,EI and TEWL at 20 min and 50 min(corresponding to 30 min and 60 min after tape-stripping,respectively)were measured after cosmetics application to compare and evaluate the soothing effects of cream and hydrogel on different skin types.Results showed that different skin displayed diverse reactions to the tape-stripping,and the oily skin was more sensitive with longer duration of erythema than other skin types.After the application of soothing products,both cream and hydrogel could relieve skin erythema,while the soothing effects are dependent both on skin types and the cosmetic base materials:Hydrogel has a better efficacy in alleviating erythema and TEWL of dry skin,while the cream was more effective on normal,oily and combined skin types.The results suggest that the modelling method for soothing evaluation should consider the skin types of the volunteers,and the cosmetics of different base materials might have the target skin types.
文摘To explore the method of evaluating the soothing effect of human skin damage,a human skin damage model was established using UV light induction.Four test areas were set up,namely blank control area,UV damage prevention and soothing area,immediate soothing area after UV damage and soothing area after UV damage.Five skin parameters,including skin melanin,red pigment value,skin pigmentation value,a*value,and skin redness value,were used to characterize skin pigmentation before and after using the sample Changes in properties such as skin erythema and skin pigment.The results showed that the method showed significant changes in the skin condition of volunteers before and after using the sample,and could achieve a soothing effect,which has certain reference significance.
文摘Present study is aimed to investigate in vitro biological efficacy of Tambourissa trichophylla leaf extract(TTLE),a plant-derived ingredient in cosmetic,on antioxidant activity and soothing efficacy.The total phenols content of TTLE was determined by the Folin-Ciocalteu method,antioxidant activity was tested by DPPH free radical scavenging assay,hyaluronidase inhibition activity was performed by using in vitro enzyme inhibitory assays based on spectrophotometric evaluation,and the soothing efficacy of TTLE was performed by the expression of nitric oxide(NO)and interleukin-6(IL-6)produced by LPS-induced RAW264.7 cells.The results shown that the total phenolic content of TTLE was as high as 54%,the DPPH scavenging activity was 81.18%at the concentration of 25μg/mL,the hyaluronidase inhibition activity was 69.04%at the concentration of 5 mg/mL,and the inhibition of NO and IL-6 were 15.70%and 76.57%at 0.05 mg/mL,respectively.TTLE has a high content of total phenols,high antioxidant activity and soothing effects,which indicated that TTLE was a promising ingredient in the development and application of cosmetics.
文摘p-Hydroxyacetophenone(p-HAP)was used as preservatives in cosmetics recently,their new efficacy was rarely reported.Here,We evaluate the soothing and oil control efficacy of p-HAP in vitro cells,providing a new efficacy basis for its application in cosmetics.The content of nitric oxide(NO),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were determined in LPS-induced RAW264.7 and lipid contents were determined in testosterone-induced SZ95.The results revealed that p-HAP attenuated pro-inflammatory cytokines,such as NO,TNF-αand IL-6(P<0.01).Simultaneously,0.05mg/mL of p-HAP also inhibited the formation of lipid droplets in human sebocytes,with 17.64%of inhibition(P<0.001).These findings may be beneficial in the application of p-HAP as an efficacy ingredient in cosmetics,which may have a soothing and oil control efficacy according to the inhibition of pro-inflammatory cytokines and lipid contents.
文摘In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed that the concentration of NO and IL-6 was significantly reduced in LPS-induced RAW264.7 cells when applied to two essences.The inhibition rate of NO-release was 85.87%and 84.57%,while IL-6 was 44.18%and 38.76%,respectively.Furthermore,the spontaneous rotating of zebrafish embryos was significantly decreased to 51.85%and 76.54%in SDS-stimulated zebrafish embryos model.In the 28 days of clinical assessment,the concentration of hydration was significantly increased to 55.56%and 39.61%,while the erythrodesis was significantly decreased to 4.75%and 6.68%.This indicates that the three evaluation methods of soothing efficacy in this research were effective,and can be used in the evaluation of cosmetics.
文摘The skin is a formidable physical and biological barrier which communicates continuously with the outside of the body. And the stratum corneum, the outermost layer of human epidermis, plays a central role in the interaction between the cutaneous tissue and the external environment. The horny layer, and more generally the whole skin layers, avoid the penetration of harmful exogenous agents, produce molecules named anti-microbial peptides which impact the composition of the cutaneous microbiota, regulate the internal corporal temperature, avoid the water loss from the inside of the body and constitute an incredible efficient anti-oxidant network. Nevertheless, nowadays, the skin is more and more solicited by the different elements of the cutaneous exposome, including atmospheric pollution and solar radiations, which can cause a dramatic acceleration of the skin ageing process. As a consequence, due to the multifunctional protective role of the skin, during the recent decade the cosmetic industry invested massively in the development of new raw materials and end-products (dermo-cosmetics) able to preserve an optimal state of the skin regarding the external environment. Based on their physical-chemical properties thermal spring waters, which are extremely rich in inorganics ions, are interesting and powerful candidates to be part, as integral component, of new efficient dermo-cosmetic formulations dedicated to protect the skin from the external stimuli. The aim of the present work was to investigate and characterize the activity of Jonzac thermal spring water on the skin. Using different models, we proved for the first time that Jonzac thermal spring water reinforces the barrier function of the skin by modulating the expression of key markers including filaggrin and human beta defensin 2 on ex vivo human skin. The ex vivo and in vivo hydration activity, by Raman spectroscopy and corneometry respectively, has been also demonstrated. We have also shown that Jonzac thermal spring water ameliorates significantly the cutaneous microrelief in vivo. To conclude, we characterize the soothing effect of Jonzac thermal spring water by the analysis of histamine release in Substance P treated skin explants and by measuring the redness of the skin following UV exposure of the skin in vivo. We observed that both parameters decreased following a preventive treatment of the skin with Jonzac thermal spring water. Taken together our results indicate that Jonzac thermal spring water is a promising and powerful dermo-cosmetic which can be used to preserve an optimal state of the cutaneous tissue.
基金supported by the Science and Technology Innovation and Development Project of National Center for Women and Children’s Health,China CDC[2019KJ08]。
文摘Objective This study aimed to examine the sleep arrangements and soothing methods and to assess their associations with sleep problems among children aged<3 years in China.Methods A cross-sectional survey was conducted in 2019 from six provinces in China.A total of 1,195 caregivers of children aged 0–35 months were included in the study.Data on sleep arrangements,soothing methods,and sleep problems(i.e.,frequent night awakenings and difficulty falling asleep)were assessed using the Brief Infant Sleep Questionnaire.The reasons for bed-sharing in sleep arrangements were recorded using a self-designed questionnaire.Results The bed-sharing practice was very prevalent at any age,which ranged from 69.9%to 78.3%.Most infants fell asleep while feeding or being rocked/held before age 12 months.By age 35 months,62.4%of the children fell asleep in bed near parents.The most common reasons for bed-sharing were breastfeeding/feeding and convenience.Parental involvement when falling asleep was significantly related with frequent night awakenings and difficulty falling asleep.No association was found between bed-sharing and sleep.Conclusion Bed-sharing and parental involvement were very common among Chinese children aged<3 years.Children who fall asleep with parental involvement were more likely to have sleep problems.
文摘The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.
文摘Pancreatic pseudocyst, whose clinical feature is small simple cyst, is a common local complication of acute pancreatitis and will not need surgery in ordinary circumstances. However, some cases could appear secondary disorders related to the location of the cyst and the role of decomposition enzymes of content, such as cyst rupture moving into the abdomen, bleeding, cystic infection, compression and internal fistula formation with adjacent organs and so on^([1]). But the spleen-related complications resulting from it are rare. There was 1 patient with pancreatic pseudocyst admitted to Dongfang Hospital Affiliated to Beijing University of Chinese Medicine and the report is as follows.
文摘OBJECTIVE: To study the therapeutic effects of "soothing the liver method" on stress-related non-alcoholic fatty liver and its treatment mechanism on neuroendocrine-metabolic level. METHODS: The animal model of stress-related nonalcoholic fatty liver which is more in line with the modern social and clinical conditions was established by the method of chronic restraint compound high-fat feed. AST and ALT were detected by automatic biochemical analyzer. Serum cortisol and TNF-a were detected by radioimmunoassay. The relative expression of Nr3 c1 mRNA was detected by real-time quantitative PCR. RESULTS: Compared with the blank group, the scores of open field test, Nr3 c1 mRNA decreased, and AST, ALT, FFA were significantly increased in model group. Compared with model group, the open field test scores, Nr3 c1 mRNA increased,and Cor, AST, FFA, LDL, TNF-a, were significantly decreased in SNS group. CONCLUSIONS: "Soothing the liver method" can exert its therapeutic effect on stress-related non-alcoholic fatty liver on neuroendocrine-metabolic level.
基金Leading Talents Project of Traditional Chinese Medicine in Jiangsu Province(No.SLJ0204)Chinese Medicine Science and Technology Project of Jiangsu Province(No.ZD201703)Coronary Heart Disease Evidence-based Ability Enhancement Project of the National Administration of Traditional Chinese Medicine of China(No.2019XZZXXXG004)。
文摘"Double Heart Disease",that is,patients with cardiovascular disease often have mental and psychological disorders such as anxiety and depression.Professor Chen Xiao-hu is guided by the holistic concept of Chinese medicine and based on the dual physiological functions of the heart as the main blood vessel and the main god.He believes that the internal resistance of blood stasis and mental disturbance are the core pathogenesis of"Double Heart Disease".Advocating the use of activating blood to calm the nerves to treat"double heart disease",and taking advantage of the overall adjustment of traditional Chinese medicine to achieve the purpose of harmonizing viscera and balancing Yin and Yang.The article summarizes Professor Chen Xiao-hu's experience in using the method of activating blood to soothe the nerves to treat"Double Heart Disease",with a view to clinical treatment Provide new ideas.
基金Supported by the National Natural Science Foundation of China(No.30973694)
文摘Objective: To investigate the mechanism of inflammatory-mediated toll-like receptor 4(TLR4)-p38 mitogen-activated protein kinase(p38 MAPK) pathway in Kupffer cells(KCs) of non-alcoholic steatohepatitis(NASH) rats and the intervention effect of soothing Gan(Liver) and invigorating Pi(Spleen) recipes on this pathway. Methods: After 1 week of acclimatization, 120 Sprague-Dawley male rats were randomly divided into 8 groups using a random number table(n=15 per group): normal group, model group, low-dose Chaihu Shugan Powder(柴胡疏肝散, CHSG) group(3.2 g/kg), high-dose CHSG group(9.6 g/kg), low-dose Shenling Baizhu Powder(参苓白术散, SLBZ) group(10 g/kg), high-dose SLBZ(30 g/kg) group, and low-and highdose integrated recipe(L-IR, H-IR) groups. All rats in the model and treatment groups were fed with a high-fat diet(HFD). The treatments were administrated by gastrogavage once daily and lasted for 26 weeks. The liver tissues were detected with hematoxylin-eosin(HE) and oil red O staining. Levels of liver lipids, serum lipids and transaminases were measured. KCs were isolated from the livers of rats to evaluate the mRNA expressions of TLR4 and p38 MAPK by real-time fluorescence quantitative polymerase chain reaction, and proteins expressions of TLR4, p-p38 MAPK and p38 MAPK by Western blot. Levels of inflammatory cytokines including tumor necrosis factor α(TNF-α), interleukin(IL)-1 and IL-6 in KCs were measured by enzyme-linked immunosorbent assay. Results: After 26 weeks of HFD feeding, HE and oil red O staining showed that the NASH model rats successfully reproduced typical pathogenesis and histopathological features. Compared with the normal group, the model group exhibited significant increases in body weight, liver weight, liver index, serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol, and aspartate aminotransferase as well as TC and TG levels in liver tissues, and significant decrease in serum level of high-density lipoprotein cholesterol(P<0.05 or P<0.01), while those indices were significantly ameliorated in the H-IR group(P<0.05 or P<0.01). Higher levels of TNF-α, IL-1 and IL-6 in KCs were observed in the model group compared with the normal group(P<0.01). Significant decreases in TNF-α, IL-1 and IL-6 were observed in the H-SLBZ, H-IR and L-IR groups compared with the model group(P<0.05 or P<0.01). The m RNA expressions of TLR4 and p38 MAPK and protein expressions of TLR4, p38 MAPK and p-p38 MAPK in KCs in the model group were significantly higher than the normal group(P<0.01), while those expression levels in the L-IR and H-IR groups were significantly lower than the model group(P<0.05 or P<0.01). Conclusions: Inflammation in KCs might play an important role in the pathogenesis of NASH in rats. The data demonstrated the importance of TLR4-p38 MAPK signaling pathway in KCs for the anti-inflammatory effect of soothing Gan and invigorating Pi recipes.
基金Supported by the Funds of ChineseMedicine Hospital of Jiangsu Province,China(No.Y09039-1)Chinese Medicine Leading Talent Project of Jiangsu Province,China(No.LJ 200905)
文摘Objective: To explore the effect of Soothing Gan (肝) and invigorating Pi (脾) (SGIP) acupuncture treatment on the clinical symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: With a single-blinded randomized control study adopted, 63 patients who met the inclusion criteria were assigned by a random number table to two groups, 31 in the treatment group and 32 in the drug control group. The treatment group received SGIP acupuncture therapy; while the control group was treated orally with pinaverium bromide. The treatment duration of both groups was 28 days. The clinical efficacy was evaluated and compared by scoring patient's symptom and QOL. Results: A significant difference was found by variance analysis in efficacies between the two groups (P〈0.01), shown as the quicker initiation of effect (P〈0.05) and the more evident clinical improvement in symptoms along the increase in treatment duration, as well as the more significant elevation of QOL in the acupuncture treatment group (P〈0.01). SGIP displayed its superiority especially in improving dysphoria, conflict behavior, dietary restrictions, and social responses. Conclusion: SGIP acupuncture treatment could effectively alleviate the degree and frequency of symptoms' attack in IBS-D patients, such as abdominal pain, diarrhea, abdominal distension, etc., markedly relieve the tenesmic sensation, with the efficacy better than that of pinaverium bromide, showing a preponderance in improving patient's QOL.
基金National Natural Science Foundation of China (81173216)Foundation for Scientific Research Fostering and Innovation of Jinan University (21612118)
文摘Objective To investigate the mechanism of lipid metabolism disorders in Kupffer cells (KCs) of non-alcoholic fatty liver disease (NAFLD) rats mediated by LXRα-SREBP-lc pathway and the interference of soothing liver and invigorating spleen recipe (SLISR) on it. Methods SD male rats were randomly divided into five groups: normal, model, soothing liver recipe (SLR), invigorating spleen recipe (ISR), and soothing liver and invigorating spleen recipe (SLISR) groups. The rats in treatment groups were administered for 8 weeks. The liver tissue was stained with H&E and oil red O. The levels of hepatic lipid and blood lipid were measured by biochemical analyzer. KCs were isolated from the livers of rats to evaluate the expression of LXRα, SREBP-1 C, and FAS mRNA by real-time fluorescence quantitative PCR tests; LXRα, SREBP-1C, and FAS proteins were measured by Western blotting. Results The H&E and oil red O staining results showed that the model rats successfully reproduced typical pathogenetic and histopathological features of NAFLD. The levels of hepatic lipid and blood lipid in the model rats were dramatically increased. Compared with the model group, the values of hepatic lipid and blood lipid in the treatment groups were significantly ameliorated (P〈 0.05, 0.01 ). The yields of purified KCs from each rat were 2×10^7-3×10^7. The viability of KCs was higher than 95%, with the purity over 90.18%. Compared with the model group, the expression of LXRα, SREBP-1C, and FAS mRNA and proteins was decreased in all treatment groups, especially in the SLR group (P〈 0.05). Conclusion SLISR may protect liver against injury included by lipid metabolism disorders in KCs through LXRα/ SREBP-1 c signaling pathway, which may be an important mechanism for the prevention and treatment of NAFLD.
文摘Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.
文摘目的:研究疏肝滋肾汤治疗膝骨关节炎的临床疗效。方法:80例患者随机分为2组,治疗组40例患者予疏肝滋肾汤,每次300 m L,早晚各1次;对照组40例给予非甾体抗炎药(NSAIDS)美洛昔康口服,1粒/次,1次/日,连服2月,应用WOMAC积分表、膝关节X线评价,对比治疗前后、随访6月指标变化。结果:治疗组与对照组总有效率分别为90.0%、77.5%(P<0.05);2组WOMAC评价积分均下降,但治疗组效果明显优于对照组;2组膝关节X线评分均下降,治疗组优于对照组,差异有显著性。结论:疏肝滋肾汤治疗膝骨关节炎疗效确切,能有效缓解膝骨关节炎症状,且副作用少,安全可靠。
文摘It is crucial to correctly predict the passenger flow of an air route for the construction and development of an airport.Based on the passenger flow data of Sanya Airport from 2008 to 2016,this paper respectively adopted Holt-Winter Seasonal Model,ARMA and linear regression model to predict the passenger flow of Sanya Airport from 2017 to 2018.In order to reduce the prediction error and improve the prediction accuracy at meanwhile,the combinatorial weighted method is adopted to predict the data in a combined manner.Upon verification,this method has been proved to be an effective approach to predict the airport passenger flow.
文摘Addressing skin challenges in baby care formulations is quite a challenge itself, as the formulation not only needs to be active, but it should also meet specific requirements in terms of ingredients, agreability and rational of the formulation design. Object of this study was the realization of a few different cosmetic formulations blending soundly documented natural active ingredients in systems matching the most common requirements of the baby care products. Additionaly, compatibility evidences of the employed natural actives within the tested systems have also been observed. We are therefore presenting the formulation design of four different formulations for baby care: a baby wash, an immediate rash recovery, an after sun emulsion and a calming and soothing product, each one described for the rational of the actives it contains and provided with a detailed formulation design. Specific attention will be directed to those ingredients for which clinical data supporting the expected skin benefits are available.
基金TCM science and Technology project of Hebei Provincial Administration of Traditional Chinese Medicine in 2021(No.2021352):The therapeutic effect of cubital tunnel expansion plasty combined with Huangqi Guizhi Wuwu Decoction on cubital tunnel syndrome。
文摘Cubital tunnel syndrome is a disease in which ulnar nerve is compressed by its surrounding tissues,and its main clinical manifestations are pain,sensory disturbance and dyskinesia.Its incidence rate is the second highest among peripheral nerve entrapment diseases,and it is one of the common clinical diseases.The theory of liver,spleen and kidney can guide the treatment of cubital tunnel syndrome with traditional Chinese medicine and acupuncture.By discussing the traditional Chinese medicine(TCM)pathogenesis and treatment principles of cubital tunnel syndrome,it provides modern medical theoretical support for TCM treatment of cubital tunnel syndrome.