A multi-gap and multi-channel gas switch with convexo-convex discal planet electrodes was designed and investigated. Eight gaps are formed in series by a trigger electrode, six intermediate electrodes and two high vol...A multi-gap and multi-channel gas switch with convexo-convex discal planet electrodes was designed and investigated. Eight gaps are formed in series by a trigger electrode, six intermediate electrodes and two high voltage electrodes with a uniform gap length of 5 ram. The self breakdown and triggered breakdown performance of the switch are reported. Both the delay time and jitter decrease with the increase in the trigger voltage, switching coefficient and the decrease in the trigger isolating resistor. The delay time of the switch is about 40 ns, and the jitter is less than 2 ns when charged with 4-85 kV and triggered by a voltage pule of -75 kV. The inductance of the switch is about 30 nH.展开更多
The present study attempted to test a novel hypothesis that Ca^2＋ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus（10 μmol/L）...The present study attempted to test a novel hypothesis that Ca^2＋ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus（10 μmol/L） increased the frequency of Ca^2＋ sparks, which could be reversed by ryanodine（10 μmol/L）. Electrophysiological experiments revealed that tacrolimus（10 μmol/L） increased the large-conductance Ca^2＋-activated K＋ currents（BKCa） in rat aortic vascular smooth muscle cells（AVSMCs）, which could be blocked by ryanodine（10 μmol/L）. Furthermore, tacrolimus（10 and 50 μmol/L） reduced the contractile force induced by norepinephrine（NE） or KCl in aortic vascular smooth muscle in a concentration-dependent manner, which could be also significantly attenuated by iberiotoxin（100 nmol/L） and ryanodine（10 μmol/L） respectively. In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca^2＋ sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta.展开更多
An air-spark switch plasma was diagnosed by the Mach–Zehnder laser interferometer with ultra-high spatial and temporal resolution. The interferograms containing plasma phase shift information at different time were o...An air-spark switch plasma was diagnosed by the Mach–Zehnder laser interferometer with ultra-high spatial and temporal resolution. The interferograms containing plasma phase shift information at different time were obtained. The phase shift distributions of the plasma were extracted by numerically processing the interferograms. The three-dimensional(3 D) electron density distributions of the air-spark switch plasma were then obtained. The working process of the air-spark switch was described by analyzing the temporal and spatial evolution of the plasma electron density.展开更多
基金supported by National Natural Science Foundation of China(Nos.50477019,50637010)the State Key Laboratory of Electrical Insulation and Power Equipment of China(EIPE.09207)
文摘A multi-gap and multi-channel gas switch with convexo-convex discal planet electrodes was designed and investigated. Eight gaps are formed in series by a trigger electrode, six intermediate electrodes and two high voltage electrodes with a uniform gap length of 5 ram. The self breakdown and triggered breakdown performance of the switch are reported. Both the delay time and jitter decrease with the increase in the trigger voltage, switching coefficient and the decrease in the trigger isolating resistor. The delay time of the switch is about 40 ns, and the jitter is less than 2 ns when charged with 4-85 kV and triggered by a voltage pule of -75 kV. The inductance of the switch is about 30 nH.
基金supported by the National Natural Science Foundation of China(No.81102439)
文摘The present study attempted to test a novel hypothesis that Ca^2＋ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus（10 μmol/L） increased the frequency of Ca^2＋ sparks, which could be reversed by ryanodine（10 μmol/L）. Electrophysiological experiments revealed that tacrolimus（10 μmol/L） increased the large-conductance Ca^2＋-activated K＋ currents（BKCa） in rat aortic vascular smooth muscle cells（AVSMCs）, which could be blocked by ryanodine（10 μmol/L）. Furthermore, tacrolimus（10 and 50 μmol/L） reduced the contractile force induced by norepinephrine（NE） or KCl in aortic vascular smooth muscle in a concentration-dependent manner, which could be also significantly attenuated by iberiotoxin（100 nmol/L） and ryanodine（10 μmol/L） respectively. In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca^2＋ sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta.
文摘An air-spark switch plasma was diagnosed by the Mach–Zehnder laser interferometer with ultra-high spatial and temporal resolution. The interferograms containing plasma phase shift information at different time were obtained. The phase shift distributions of the plasma were extracted by numerically processing the interferograms. The three-dimensional(3 D) electron density distributions of the air-spark switch plasma were then obtained. The working process of the air-spark switch was described by analyzing the temporal and spatial evolution of the plasma electron density.
