Energy properties and spatial plume profile of ionic liquid ion sources based on an array of porous metal strips

An ionic liquid ion source(ILIS)is a kind of high brightness ion source capable of providing high-speed positive or negative ion beams.This paper presents a miniaturized ILIS based on an array of porous metal strips.The porous emitter array,integrated with seven 10 mm long strips,is fabricated using wire electrical discharge machining(WEDM)combined with electrochemical etching.The assembled ILIS is 30 mm×30 mm×17.5 mm in size and weighs less than 25 g.A series of experiments,including anⅠ-Ⅴcharacteristic test,a retarding potential analyzer(RPA)test,and a spatial plume distribution test,have been conducted in vacuo to characterize the performance of the ILIS.Results show that the emitted current is up to about 800μA and ion transparency is as high as 94%.Besides,RPA curves reveal that the total fragmentation rate of the emitted particles accounts for 48.8%in positive mode and 59.8%in negative mode.Further,with the increase in applied acceleration voltage,the voltage loss rises while the energy efficiency decreases.It is also found that the plume perpendicular to the strips has a higher divergence than the one parallel to the strips.A numerical simulation by COMSOL reveals that the electric field distribution between the two electrodes results in such a spatial plume profile.

Spatial resolved temperature measurement based on absorption spectroscopy using a single tunable diode laser

A novel method based on wavelength-multiplexed line-of-sight absorption and profile fitting for nonuniform flow field measurement is reported. A wavelength scanning combing laser temperature and current modulation WMS scheme is used to implement the wavelength-multi- plexed-profile fitting method. Second harmonic （2f） signal of eight H20 transitions features near 7,170 cm^-1 are measured in one period using a single tunable diode laser. Spatial resolved temperature distribution upon a CH4/air premixed flat flame burner is obtained. The result validates the feasibility of strategy for non-uniform flow field diagnostics by means of WMS-2f TDLAS.

Minimizing the effects of unmodulated light and uneven intensity profile on the holographic images reconstructed by pixelated spatial light modulators

A simple and effective approach is proposed to minimize the effect of unmodulated light and uneven intensity caused by the pixelated structure of the spatial light modulator in a holographic display. A more uniform image is produced by purposely shifting the holographic images of multiple reconstructed lights with different incident angles from the zero-diffraction-order and overlapping those selected different orders. The simulation and optical experimental results show that the influence of the zero-diffraction-order can be reduced, while keeping the good uniformity of the target images by this new approach.

Cell type specificity of signaling:view from membrane receptors distribution and their downstream transduction networks

Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities.To overview the specificity of cell signaling,we integrated human receptome data with proteome spatial expression profiles to systematically investigate the specificity of receptors and receptor-triggered transduction networks across 62 normal cell types and 14 cancer types.Six percent receptors showed cell-type-specific expression,and 4% signaling networks presented enriched cell-specific proteins induced by the receptors.We introduced a concept of“response context”to annotate the cell-type dependent signaling networks.We found that most cells respond similarly to the same stimulus,as the“response contexts”presented high functional similarity.Despite this,the subtle spatial diversity can be observed from the difference in network architectures.The architecture of the signaling networks in nerve cells displayed less completeness than that in glandular cells,which indicated cellular-context dependent signaling patterns are elaborately spatially organized.Likewise,in cancer cells most signaling networks were generally dysfunctional and less complete than that in normal cells.However,glioma emerged hyper-activated transduction mechanism in malignant state.Receptor ATP6AP2 and TNFRSF21 induced rennin-angiotensin and apoptosis signaling were found likely to explain the glioma-specific mechanism.This work represents an effort to decipher context-specific signaling network from spatial dimension.Our results indicated that although a majority of cells engage general signaling response with subtle differences,the spatial dynamics of cell signaling can not only deepen our insights into different signaling mechanisms,but also help understand cell signaling in disease.