In this paper,an improved spatio-temporal alignment measurement method is presented to address the inertial matching measurement of hull deformation under the coexistence of time delay and large misalignment angle.Lar...In this paper,an improved spatio-temporal alignment measurement method is presented to address the inertial matching measurement of hull deformation under the coexistence of time delay and large misalignment angle.Large misalignment angle and time delay often occur simultaneously and bring great challenges to the accurate measurement of hull deformation in space and time.The proposed method utilizes coarse alignment with large misalignment angle and time delay estimation of inertial measurement unit modeling to establish a brand-new spatiotemporal aligned hull deformation measurement model.In addition,two-step loop control is designed to ensure the accurate description of dynamic deformation angle and static deformation angle by the time-space alignment method of hull deformation.The experiments illustrate that the proposed method can effectively measure the hull deformation angle when time delay and large misalignment angle coexist.展开更多
Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,China.Methods Information was collected on HFRS cases in Qingda...Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,China.Methods Information was collected on HFRS cases in Qingdao City from 2010 to 2022.Descriptive epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were performed.Results A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”symptoms.The HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring peak.The HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and Jiaozhou.The spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter peak.Conclusion The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering heterogeneity.The typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.展开更多
Appropriately characterising the mixed space-time relations of the contagion process caused by hybrid space and time factors remains the primary challenge in COVID-19 forecasting.However,in previous deep learning mode...Appropriately characterising the mixed space-time relations of the contagion process caused by hybrid space and time factors remains the primary challenge in COVID-19 forecasting.However,in previous deep learning models for epidemic forecasting,spatial and temporal variations are captured separately.A unified model is developed to cover all spatio-temporal relations.However,this measure is insufficient for modelling the complex spatio-temporal relations of infectious disease transmission.A dynamic adaptive spatio-temporal graph network(DASTGN)is proposed based on attention mechanisms to improve prediction accuracy.In DASTGN,complex spatio-temporal relations are depicted by adaptively fusing the mixed space-time effects and dynamic space-time dependency structure.This dual-scale model considers the time-specific,space-specific,and direct effects of the propagation process at the fine-grained level.Furthermore,the model characterises impacts from various space-time neighbour blocks under time-varying interventions at the coarse-grained level.The performance comparisons on the three COVID-19 datasets reveal that DASTGN achieves state-of-the-art results with a maximum improvement of 17.092%in the root mean-square error and 11.563%in the mean absolute error.Experimental results indicate that the mechanisms of designing DASTGN can effectively detect some spreading characteristics of COVID-19.The spatio-temporal weight matrices learned in each proposed module reveal diffusion patterns in various scenarios.In conclusion,DASTGN has successfully captured the dynamic spatio-temporal variations of COVID-19,and considering multiple dynamic space-time relationships is essential in epidemic forecasting.展开更多
Due to the time-varying topology and possible disturbances in a conflict environment,it is still challenging to maintain the mission performance of flying Ad hoc networks(FANET),which limits the application of Unmanne...Due to the time-varying topology and possible disturbances in a conflict environment,it is still challenging to maintain the mission performance of flying Ad hoc networks(FANET),which limits the application of Unmanned Aerial Vehicle(UAV)swarms in harsh environments.This paper proposes an intelligent framework to quickly recover the cooperative coveragemission by aggregating the historical spatio-temporal network with the attention mechanism.The mission resilience metric is introduced in conjunction with connectivity and coverage status information to simplify the optimization model.A spatio-temporal node pooling method is proposed to ensure all node location features can be updated after destruction by capturing the temporal network structure.Combined with the corresponding Laplacian matrix as the hyperparameter,a recovery algorithm based on the multi-head attention graph network is designed to achieve rapid recovery.Simulation results showed that the proposed framework can facilitate rapid recovery of the connectivity and coverage more effectively compared to the existing studies.The results demonstrate that the average connectivity and coverage results is improved by 17.92%and 16.96%,respectively compared with the state-of-the-art model.Furthermore,by the ablation study,the contributions of each different improvement are compared.The proposed model can be used to support resilient network design for real-time mission execution.展开更多
High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high efficiency.However,it...High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high efficiency.However,it faces challenge in dense objects tracking and 3D trajectories reconstruction due to the characteristics of small size and dense distribution of fragment swarm.To address these challenges,this work presents a warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography.Firstly,background difference algorithm is utilized to extract the center and area of each fragment in the image sequence.Subsequently,a multi-object tracking(MOT)algorithm using Kalman filtering and Hungarian optimal assignment is developed to realize real-time and robust trajectories tracking of fragment swarm.To reconstruct 3D motion trajectories,a global stereo trajectories matching strategy is presented,which takes advantages of epipolar constraint and continuity constraint to correctly retrieve stereo correspondence followed by 3D trajectories refinement using polynomial fitting.Finally,the simulation and experimental results demonstrate that the proposed method can accurately track the motion trajectories and reconstruct the spatio-temporal distribution of 1.0×10^(3)fragments in a field of view(FOV)of 3.2 m×2.5 m,and the accuracy of the velocity estimation can achieve 98.6%.展开更多
To solve the problem of target damage assessment when fragments attack target under uncertain projectile and target intersection in an air defense intercept,this paper proposes a method for calculating target damage p...To solve the problem of target damage assessment when fragments attack target under uncertain projectile and target intersection in an air defense intercept,this paper proposes a method for calculating target damage probability leveraging spatio-temporal finite multilayer fragments distribution and the target damage assessment algorithm based on cloud model theory.Drawing on the spatial dispersion characteristics of fragments of projectile proximity explosion,we divide into a finite number of fragments distribution planes based on the time series in space,set up a fragment layer dispersion model grounded in the time series and intersection criterion for determining the effective penetration of each layer of fragments into the target.Building on the precondition that the multilayer fragments of the time series effectively assail the target,we also establish the damage criterion of the perforation and penetration damage and deduce the damage probability calculation model.Taking the damage probability of the fragment layer in the spatio-temporal sequence to the target as the input state variable,we introduce cloud model theory to research the target damage assessment method.Combining the equivalent simulation experiment,the scientific and rational nature of the proposed method were validated through quantitative calculations and comparative analysis.展开更多
False data injection attack(FDIA)can affect the state estimation of the power grid by tampering with the measured value of the power grid data,and then destroying the stable operation of the smart grid.Existing work u...False data injection attack(FDIA)can affect the state estimation of the power grid by tampering with the measured value of the power grid data,and then destroying the stable operation of the smart grid.Existing work usually trains a detection model by fusing the data-driven features from diverse power data streams.Data-driven features,however,cannot effectively capture the differences between noisy data and attack samples.As a result,slight noise disturbances in the power grid may cause a large number of false detections for FDIA attacks.To address this problem,this paper designs a deep collaborative self-attention network to achieve robust FDIA detection,in which the spatio-temporal features of cascaded FDIA attacks are fully integrated.Firstly,a high-order Chebyshev polynomials-based graph convolution module is designed to effectively aggregate the spatio information between grid nodes,and the spatial self-attention mechanism is involved to dynamically assign attention weights to each node,which guides the network to pay more attention to the node information that is conducive to FDIA detection.Furthermore,the bi-directional Long Short-Term Memory(LSTM)network is introduced to conduct time series modeling and long-term dependence analysis for power grid data and utilizes the temporal selfattention mechanism to describe the time correlation of data and assign different weights to different time steps.Our designed deep collaborative network can effectively mine subtle perturbations from spatiotemporal feature information,efficiently distinguish power grid noise from FDIA attacks,and adapt to diverse attack intensities.Extensive experiments demonstrate that our method can obtain an efficient detection performance over actual load data from New York Independent System Operator(NYISO)in IEEE 14,IEEE 39,and IEEE 118 bus systems,and outperforms state-of-the-art FDIA detection schemes in terms of detection accuracy and robustness.展开更多
Due to the increasingly severe challenges brought by various epidemic diseases,people urgently need intelligent outbreak trend prediction.Predicting disease onset is very important to assist decision-making.Most of th...Due to the increasingly severe challenges brought by various epidemic diseases,people urgently need intelligent outbreak trend prediction.Predicting disease onset is very important to assist decision-making.Most of the exist-ing work fails to make full use of the temporal and spatial characteristics of epidemics,and also relies on multi-variate data for prediction.In this paper,we propose a Multi-Scale Location Attention Graph Neural Networks(MSLAGNN)based on a large number of Centers for Disease Control and Prevention(CDC)patient electronic medical records research sequence source data sets.In order to understand the geography and timeliness of infec-tious diseases,specific neural networks are used to extract the geography and timeliness of infectious diseases.In the model framework,the features of different periods are extracted by a multi-scale convolution module.At the same time,the propagation effects between regions are simulated by graph convolution and attention mechan-isms.We compare the proposed method with the most advanced statistical methods and deep learning models.Meanwhile,we conduct comparative experiments on data sets with different time lengths to observe the predic-tion performance of the model in the face of different degrees of data collection.We conduct extensive experi-ments on real-world epidemic-related data sets.The method has strong prediction performance and can be readily used for epidemic prediction.展开更多
Decline in wildlife populations is manifest globally, regionally and locally. A wildlife decline of 68% has been reported in Kenya’s rangelands with Baringo County experiencing more than 85% wildlife loss in the last...Decline in wildlife populations is manifest globally, regionally and locally. A wildlife decline of 68% has been reported in Kenya’s rangelands with Baringo County experiencing more than 85% wildlife loss in the last four decades. Greater Kudu (Tragelaphus strepsiceros) is endemic to Lake Bogoria landscape in Baringo County and constitutes a major tourist attraction for the region necessitating use of its photo on the County’s logo and thus a flagship species. Tourism plays a central role in Baringo County’s economy and is a major source of potential growth and employment creation. The study was carried out to assess spatio-temporal change of dispersal areas of Greater Kudu (GK) in Lake Bogoria landscape in the last four years for enhanced adaptive management and improved livelihoods. GK population distribution primary data collected in December 2022 and secondary data acquired from Lake Bogoria National Game Reserve (LBNGR) for 2019 and 2020 were digitized using in a Geographic Information System (GIS). Measures of dispersion and point pattern analysis (PPA) were used to analyze dispersal of GK population using GIS. Spatio-temporal change of GK dispersal in LBNR was evident thus the null hypothesis was rejected. It is recommended that anthropogenic activities contributing to GK’s habitat degradation be curbed by providing alternative livelihood sources and promoting community adoption of sustainable technologies for improved livelihoods.展开更多
Green space,as a medium for carrying out urban functions and guiding urban development,is becoming a scarce resource along with the urbanization process and the intensification of environmental problems.In the face of...Green space,as a medium for carrying out urban functions and guiding urban development,is becoming a scarce resource along with the urbanization process and the intensification of environmental problems.In the face of the spatial mismatch between high demand and low supply,it is of great significance to clarify the evolution mechanism of green space to undertake national spatial planning,protect the natural strategic resources in the urban fringe area,and promote the sustainable development of the“three living spaces.”The study focuses on the Zunyi City Center,selecting the 20 years of rapid development following its establishment as a city as the study period.It explores the dynamic evolution of green space and the main driving forces during different periods using remote-sensing image data.The study shows that from 2003 to 2023,the total scale of green space has an obvious decreasing trend along with the expansion of the urban built-up area.A large amount of arable land is being converted to construction land,resulting in a sudden decrease in arable land area.In the past 10 years,the comprehensive land use dynamics have accelerated.Still,the spatial difference has gradually narrowed,indicating that the overall development intensity of Zunyi City’s central urban area has increased.There is a gradual spread of the trend to the hilly areas.The limiting effect of the mountainous natural environment on the city’s development has gradually diminished under the superposition of external factors,such as economic development,industrial technological upgrading,and policy orientation so the importance of the effective protection and rational utilization of urban green space has become more prominent.展开更多
In this paper, we studied the traveling wave solutions of a SIR epidemic model with spatial-temporal delay. We proved that this result is determined by the basic reproduction number R0and the minimum wave speed c*of t...In this paper, we studied the traveling wave solutions of a SIR epidemic model with spatial-temporal delay. We proved that this result is determined by the basic reproduction number R0and the minimum wave speed c*of the corresponding ordinary differential equations. The methods used in this paper are primarily the Schauder fixed point theorem and comparison principle. We have proved that when R0>1and c>c*, the model has a non-negative and non-trivial traveling wave solution. However, for R01and c≥0or R0>1and 0cc*, the model does not have a traveling wave solution.展开更多
Human Activity Recognition(HAR)is an active research area due to its applications in pervasive computing,human-computer interaction,artificial intelligence,health care,and social sciences.Moreover,dynamic environments...Human Activity Recognition(HAR)is an active research area due to its applications in pervasive computing,human-computer interaction,artificial intelligence,health care,and social sciences.Moreover,dynamic environments and anthropometric differences between individuals make it harder to recognize actions.This study focused on human activity in video sequences acquired with an RGB camera because of its vast range of real-world applications.It uses two-stream ConvNet to extract spatial and temporal information and proposes a fine-tuned deep neural network.Moreover,the transfer learning paradigm is adopted to extract varied and fixed frames while reusing object identification information.Six state-of-the-art pre-trained models are exploited to find the best model for spatial feature extraction.For temporal sequence,this study uses dense optical flow following the two-stream ConvNet and Bidirectional Long Short TermMemory(BiLSTM)to capture longtermdependencies.Two state-of-the-art datasets,UCF101 and HMDB51,are used for evaluation purposes.In addition,seven state-of-the-art optimizers are used to fine-tune the proposed network parameters.Furthermore,this study utilizes an ensemble mechanism to aggregate spatial-temporal features using a four-stream Convolutional Neural Network(CNN),where two streams use RGB data.In contrast,the other uses optical flow images.Finally,the proposed ensemble approach using max hard voting outperforms state-ofthe-art methods with 96.30%and 90.07%accuracies on the UCF101 and HMDB51 datasets.展开更多
To illuminate the spatio-temporal variation characteristics and geochemical driving mechanism of soil pH in the Nenjiang River Basin,the National Multi-objective Regional Geochemical Survey data of topsoil,the Second ...To illuminate the spatio-temporal variation characteristics and geochemical driving mechanism of soil pH in the Nenjiang River Basin,the National Multi-objective Regional Geochemical Survey data of topsoil,the Second National Soil Survey data and Normalized Difference Vegetation Index(NDVI)were analyzed.The areas of neutral and alkaline soil decreased by 21100 km^(2)and 30500 km^(2),respectively,while that of strongly alkaline,extremely alkaline,and strongly acidic soil increased by 19600 km^(2),18200 km^(2),and 15500 km^(2),respectively,during the past 30 years.NDVI decreased with the increase of soil pH when soil pH>8.0,and it was reversed when soil pH<5.0.There were significant differences in soil pH with various surface cover types,which showed an ascending order:Arbor<reed<maize<rice<high and medium-covered meadow<low-covered meadow<Puccinellia.The weathering products of minerals rich in K_(2)O,Na_(2)O,CaO,and MgO entered into the low plain and were enriched in different parts by water transportation and lake deposition,while Fe and Al remained in the low hilly areas,which was the geochemical driving mechanism.The results of this study will provide scientific basis for making scientific and rational decisions on soil acidification and salinization.展开更多
An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of ...An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 tokamak.The E//B NPA contains three main units,i.e.the stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping unit.The results of the simulations and beam tests for the stripping chamber are presented.Parallel electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing unit.The calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)platform.The detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two rows.The response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS platform.The overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.展开更多
Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to ...Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to reflect drought conditions in the North-Eastern coastal region of Vietnam. The drought events and their characteristics from 1981 to 2019 are detected at 9 meteorological stations and 10 Chirps rainfall stations. The spatio-temporal variation of drought in the study region is analyzed on the basis of the number, duration, severity, intensity, and peak of the detected drought events at the 19 stations. The results show that from 1981 to 2019 the drought events mainly occurred with 1-season duration and moderate intensity and peak. The number, duration, severity, and peak of the drought events were the greatest in the period 2001-2010 and were the smallest in the period 2011-2019. Among the 19 stations, the drought duration tends to decrease at 11 stations, increase at 7 stations, and has a slight variant at 1 station;the drought severity tends to decrease at 14 stations, increase at 4 stations, and has not a significant trend at 1 station;the drought intensity tends to decrease at 17 stations, increase at 1 station, and has a slight variant at 1 station;and the drought peak tends to decrease at 18 stations and increase at 1 station.展开更多
Spatio-temporal models are valuable tools for disease mapping and understanding the geographical distribution of diseases and temporal dynamics. Spatio-temporal models have been proven empirically to be very complex a...Spatio-temporal models are valuable tools for disease mapping and understanding the geographical distribution of diseases and temporal dynamics. Spatio-temporal models have been proven empirically to be very complex and this complexity has led many to oversimply and model the spatial and temporal dependencies independently. Unlike common practice, this study formulated a new spatio-temporal model in a Bayesian hierarchical framework that accounts for spatial and temporal dependencies jointly. The spatial and temporal dependencies were dynamically modelled via the matern exponential covariance function. The temporal aspect was captured by the parameters of the exponential with a first-order autoregressive structure. Inferences about the parameters were obtained via Markov Chain Monte Carlo (MCMC) techniques and the spatio-temporal maps were obtained by mapping stable posterior means from the specific location and time from the best model that includes the significant risk factors. The model formulated was fitted to both simulation data and Kenya meningitis incidence data from 2013 to 2019 along with two covariates;Gross County Product (GCP) and average rainfall. The study found that both average rainfall and GCP had a significant positive association with meningitis occurrence. Also, regarding geographical distribution, the spatio-temporal maps showed that meningitis is not evenly distributed across the country as some counties reported a high number of cases compared with other counties.展开更多
In crime science, understanding the dynamics and interactions between crime events is crucial for comprehending the underlying factors that drive their occurrences. Nonetheless, gaining access to detailed spatiotempor...In crime science, understanding the dynamics and interactions between crime events is crucial for comprehending the underlying factors that drive their occurrences. Nonetheless, gaining access to detailed spatiotemporal crime records from law enforcement faces significant challenges due to confidentiality concerns. In response to these challenges, this paper introduces an innovative analytical tool named “stppSim,” designed to synthesize fine-grained spatiotemporal point records while safeguarding the privacy of individual locations. By utilizing the open-source R platform, this tool ensures easy accessibility for researchers, facilitating download, re-use, and potential advancements in various research domains beyond crime science.展开更多
AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutiv...AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutive measurements and subsequent analysis of interferometry,TMH,and MBG were recorded by two examiners using the LacryDiag.To assess intra-and interobserver reliability,we used Cohen’s kappa for categorical variables(interferometry),or intraclass correlation coefficient for continuous variables(TMH,MBG).RESULTS:Thirty eyes of 30 examinees were included.For both observers,there was excellent intraobserver reliability for MBG(0.955 and 0.970 for observer 1 and 2,respectively).Intraobserver reliability for observer 1 was substantial for interferometry(0.799),and excellent for TMH(0.863).Reliability for observer 2 was moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobserver reliability was poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUSION:LacryDiag ocular surface analyzer in our study proves to be a reliable noninvasive tool for the evaluation of TMH and MBG.As for interferometry,poor interobserver reliability,fair to good intraobserver reliability for observer 1,and moderate for observer 2,leave room for improvement.展开更多
To verify the effectiveness of digital optical 3D image analyzer EvaSKIN in the objective and quantitative evaluation of wrinkles.A total of 115 subjects were recruited,the facial images of the subjects were collected...To verify the effectiveness of digital optical 3D image analyzer EvaSKIN in the objective and quantitative evaluation of wrinkles.A total of 115 subjects were recruited,the facial images of the subjects were collected by digital optical 3D image analyzer and manual camera,the changes of crow’s feet with age were analyzed.Pictures obtained by manual photography can be directly used for observation and preliminary grading of wrinkles.However,the requirements for evaluators are high,and the results are prone to errors,which will affect the accuracy of the evaluation.Therefore,skilled raters are needed.Compared with the manual photography method,the digital optical 3D image analyzer EvaSKIN can realize three-dimensional extraction of wrinkles,and obtain the change trend of crow’s feet with age.20~30 years old,wrinkles begin to appear slowly;wrinkles will increase rapidly at the age of 30~50;The length of 50~60 year old wrinkles is basically fixed,the wrinkles develop longitudewise,gradually widen and deepen,and the area,depth and volume increase is obvious,and the skin aging condition is intensified.the digital optical 3D image analyzer EvaSKIN realizes the 3D extraction of wrinkles,quantifies the circumference,area,average depth,maximum depth and volume of wrinkles,realizes the objective and quantitative evaluation of wrinkle state,is more accurate in the measurement of wrinkles,and provides a new instrument and method for the evaluation of wrinkles.it is a perfect and supplement to the traditional evaluation methods,and to a certain extent,it helps the research and development and evaluation institutions of cosmetics to obtain more abundant and three-dimensional data support.展开更多
Objective:To investigate the hook effect in the detection of beta2-microglobulin(β2-MG)with different reagents as well as on two fully automated biochemical analyzers and their solutions.Methods:Using immunoturbidime...Objective:To investigate the hook effect in the detection of beta2-microglobulin(β2-MG)with different reagents as well as on two fully automated biochemical analyzers and their solutions.Methods:Using immunoturbidimetric assay forβ2-MG as the research object,β2-MG levels were detected by different concentration gradients ofβ2-microglobulin samples in Liedemann,Mack,and Myriad reagents of three manufacturers on two automatic biochemical analyzers,and the difference of the hook effect was comparatively analyzed.Results:Leadman reagent showed the hook effect on the Beckman AU5800 automated biochemistry analyzer,while both Maccura and Mindray reagents did not show the hook effect.After the experiments,we found the limit value of the pre-zone check of Leadman reagent,and changed the parameters of the instrument,when the limit value of the pre-zone check was reached,the instrument automatically diluted the specimen five times and then detected it again.After changing the parameters of the instrument,the correlation between the three methods of detecting samples of different concentrations was r>0.99.Conclusion:Before selecting the application of immunoturbidimetric reagents,we have to carry out the risk assessment of the hook effect and selectively set the parameters of the pre-zone check based on the highest concentration that may occur in the clinic;for the items that may have the hook effect,we have to selectively set the parameters of the pre-zone check when the ratio of average reaction rate and the immediate reaction rate is at the limit value,and the phenomenon of antigen excess may occur,the instrument will carry out automatic dilution before detection,so as to avoid the issuance of erroneous results of high-value samples due to the hook effect.展开更多
基金supported by Beijing Insititute of Technology Research Fund Program for Young Scholars(2020X04104)。
文摘In this paper,an improved spatio-temporal alignment measurement method is presented to address the inertial matching measurement of hull deformation under the coexistence of time delay and large misalignment angle.Large misalignment angle and time delay often occur simultaneously and bring great challenges to the accurate measurement of hull deformation in space and time.The proposed method utilizes coarse alignment with large misalignment angle and time delay estimation of inertial measurement unit modeling to establish a brand-new spatiotemporal aligned hull deformation measurement model.In addition,two-step loop control is designed to ensure the accurate description of dynamic deformation angle and static deformation angle by the time-space alignment method of hull deformation.The experiments illustrate that the proposed method can effectively measure the hull deformation angle when time delay and large misalignment angle coexist.
基金supported by the Chinese Field Epidemiology Training Program,the Research and Development of Standards and Standardization of Nomenclature in the Field of Public Health-Research Project on the Development of the Disciplines of Public Health and Preventive Medicine[242402]the Shandong Medical and Health Science and Technology Development Plan[202112050731].
文摘Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,China.Methods Information was collected on HFRS cases in Qingdao City from 2010 to 2022.Descriptive epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were performed.Results A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”symptoms.The HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring peak.The HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and Jiaozhou.The spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter peak.Conclusion The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering heterogeneity.The typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.
基金Youth Innovation Promotion Association CAS,Grant/Award Number:2021103Strategic Priority Research Program of Chinese Academy of Sciences,Grant/Award Number:XDC02060500。
文摘Appropriately characterising the mixed space-time relations of the contagion process caused by hybrid space and time factors remains the primary challenge in COVID-19 forecasting.However,in previous deep learning models for epidemic forecasting,spatial and temporal variations are captured separately.A unified model is developed to cover all spatio-temporal relations.However,this measure is insufficient for modelling the complex spatio-temporal relations of infectious disease transmission.A dynamic adaptive spatio-temporal graph network(DASTGN)is proposed based on attention mechanisms to improve prediction accuracy.In DASTGN,complex spatio-temporal relations are depicted by adaptively fusing the mixed space-time effects and dynamic space-time dependency structure.This dual-scale model considers the time-specific,space-specific,and direct effects of the propagation process at the fine-grained level.Furthermore,the model characterises impacts from various space-time neighbour blocks under time-varying interventions at the coarse-grained level.The performance comparisons on the three COVID-19 datasets reveal that DASTGN achieves state-of-the-art results with a maximum improvement of 17.092%in the root mean-square error and 11.563%in the mean absolute error.Experimental results indicate that the mechanisms of designing DASTGN can effectively detect some spreading characteristics of COVID-19.The spatio-temporal weight matrices learned in each proposed module reveal diffusion patterns in various scenarios.In conclusion,DASTGN has successfully captured the dynamic spatio-temporal variations of COVID-19,and considering multiple dynamic space-time relationships is essential in epidemic forecasting.
基金the National Natural Science Foundation of China(NNSFC)(Grant Nos.72001213 and 72301292)the National Social Science Fund of China(Grant No.19BGL297)the Basic Research Program of Natural Science in Shaanxi Province(Grant No.2021JQ-369).
文摘Due to the time-varying topology and possible disturbances in a conflict environment,it is still challenging to maintain the mission performance of flying Ad hoc networks(FANET),which limits the application of Unmanned Aerial Vehicle(UAV)swarms in harsh environments.This paper proposes an intelligent framework to quickly recover the cooperative coveragemission by aggregating the historical spatio-temporal network with the attention mechanism.The mission resilience metric is introduced in conjunction with connectivity and coverage status information to simplify the optimization model.A spatio-temporal node pooling method is proposed to ensure all node location features can be updated after destruction by capturing the temporal network structure.Combined with the corresponding Laplacian matrix as the hyperparameter,a recovery algorithm based on the multi-head attention graph network is designed to achieve rapid recovery.Simulation results showed that the proposed framework can facilitate rapid recovery of the connectivity and coverage more effectively compared to the existing studies.The results demonstrate that the average connectivity and coverage results is improved by 17.92%and 16.96%,respectively compared with the state-of-the-art model.Furthermore,by the ablation study,the contributions of each different improvement are compared.The proposed model can be used to support resilient network design for real-time mission execution.
基金Key Basic Research Project of Strengthening the Foundations Plan of China (Grant No.2019-JCJQ-ZD-360-12)National Defense Basic Scientific Research Program of China (Grant No.JCKY2021208B011)to provide fund for conducting experiments。
文摘High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high efficiency.However,it faces challenge in dense objects tracking and 3D trajectories reconstruction due to the characteristics of small size and dense distribution of fragment swarm.To address these challenges,this work presents a warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography.Firstly,background difference algorithm is utilized to extract the center and area of each fragment in the image sequence.Subsequently,a multi-object tracking(MOT)algorithm using Kalman filtering and Hungarian optimal assignment is developed to realize real-time and robust trajectories tracking of fragment swarm.To reconstruct 3D motion trajectories,a global stereo trajectories matching strategy is presented,which takes advantages of epipolar constraint and continuity constraint to correctly retrieve stereo correspondence followed by 3D trajectories refinement using polynomial fitting.Finally,the simulation and experimental results demonstrate that the proposed method can accurately track the motion trajectories and reconstruct the spatio-temporal distribution of 1.0×10^(3)fragments in a field of view(FOV)of 3.2 m×2.5 m,and the accuracy of the velocity estimation can achieve 98.6%.
基金supported by National Natural Science Foundation of China(Grant No.62073256)the Shaanxi Provincial Science and Technology Department(Grant No.2023-YBGY-342).
文摘To solve the problem of target damage assessment when fragments attack target under uncertain projectile and target intersection in an air defense intercept,this paper proposes a method for calculating target damage probability leveraging spatio-temporal finite multilayer fragments distribution and the target damage assessment algorithm based on cloud model theory.Drawing on the spatial dispersion characteristics of fragments of projectile proximity explosion,we divide into a finite number of fragments distribution planes based on the time series in space,set up a fragment layer dispersion model grounded in the time series and intersection criterion for determining the effective penetration of each layer of fragments into the target.Building on the precondition that the multilayer fragments of the time series effectively assail the target,we also establish the damage criterion of the perforation and penetration damage and deduce the damage probability calculation model.Taking the damage probability of the fragment layer in the spatio-temporal sequence to the target as the input state variable,we introduce cloud model theory to research the target damage assessment method.Combining the equivalent simulation experiment,the scientific and rational nature of the proposed method were validated through quantitative calculations and comparative analysis.
基金supported in part by the Research Fund of Guangxi Key Lab of Multi-Source Information Mining&Security(MIMS21-M-02).
文摘False data injection attack(FDIA)can affect the state estimation of the power grid by tampering with the measured value of the power grid data,and then destroying the stable operation of the smart grid.Existing work usually trains a detection model by fusing the data-driven features from diverse power data streams.Data-driven features,however,cannot effectively capture the differences between noisy data and attack samples.As a result,slight noise disturbances in the power grid may cause a large number of false detections for FDIA attacks.To address this problem,this paper designs a deep collaborative self-attention network to achieve robust FDIA detection,in which the spatio-temporal features of cascaded FDIA attacks are fully integrated.Firstly,a high-order Chebyshev polynomials-based graph convolution module is designed to effectively aggregate the spatio information between grid nodes,and the spatial self-attention mechanism is involved to dynamically assign attention weights to each node,which guides the network to pay more attention to the node information that is conducive to FDIA detection.Furthermore,the bi-directional Long Short-Term Memory(LSTM)network is introduced to conduct time series modeling and long-term dependence analysis for power grid data and utilizes the temporal selfattention mechanism to describe the time correlation of data and assign different weights to different time steps.Our designed deep collaborative network can effectively mine subtle perturbations from spatiotemporal feature information,efficiently distinguish power grid noise from FDIA attacks,and adapt to diverse attack intensities.Extensive experiments demonstrate that our method can obtain an efficient detection performance over actual load data from New York Independent System Operator(NYISO)in IEEE 14,IEEE 39,and IEEE 118 bus systems,and outperforms state-of-the-art FDIA detection schemes in terms of detection accuracy and robustness.
文摘Due to the increasingly severe challenges brought by various epidemic diseases,people urgently need intelligent outbreak trend prediction.Predicting disease onset is very important to assist decision-making.Most of the exist-ing work fails to make full use of the temporal and spatial characteristics of epidemics,and also relies on multi-variate data for prediction.In this paper,we propose a Multi-Scale Location Attention Graph Neural Networks(MSLAGNN)based on a large number of Centers for Disease Control and Prevention(CDC)patient electronic medical records research sequence source data sets.In order to understand the geography and timeliness of infec-tious diseases,specific neural networks are used to extract the geography and timeliness of infectious diseases.In the model framework,the features of different periods are extracted by a multi-scale convolution module.At the same time,the propagation effects between regions are simulated by graph convolution and attention mechan-isms.We compare the proposed method with the most advanced statistical methods and deep learning models.Meanwhile,we conduct comparative experiments on data sets with different time lengths to observe the predic-tion performance of the model in the face of different degrees of data collection.We conduct extensive experi-ments on real-world epidemic-related data sets.The method has strong prediction performance and can be readily used for epidemic prediction.
文摘Decline in wildlife populations is manifest globally, regionally and locally. A wildlife decline of 68% has been reported in Kenya’s rangelands with Baringo County experiencing more than 85% wildlife loss in the last four decades. Greater Kudu (Tragelaphus strepsiceros) is endemic to Lake Bogoria landscape in Baringo County and constitutes a major tourist attraction for the region necessitating use of its photo on the County’s logo and thus a flagship species. Tourism plays a central role in Baringo County’s economy and is a major source of potential growth and employment creation. The study was carried out to assess spatio-temporal change of dispersal areas of Greater Kudu (GK) in Lake Bogoria landscape in the last four years for enhanced adaptive management and improved livelihoods. GK population distribution primary data collected in December 2022 and secondary data acquired from Lake Bogoria National Game Reserve (LBNGR) for 2019 and 2020 were digitized using in a Geographic Information System (GIS). Measures of dispersion and point pattern analysis (PPA) were used to analyze dispersal of GK population using GIS. Spatio-temporal change of GK dispersal in LBNR was evident thus the null hypothesis was rejected. It is recommended that anthropogenic activities contributing to GK’s habitat degradation be curbed by providing alternative livelihood sources and promoting community adoption of sustainable technologies for improved livelihoods.
文摘Green space,as a medium for carrying out urban functions and guiding urban development,is becoming a scarce resource along with the urbanization process and the intensification of environmental problems.In the face of the spatial mismatch between high demand and low supply,it is of great significance to clarify the evolution mechanism of green space to undertake national spatial planning,protect the natural strategic resources in the urban fringe area,and promote the sustainable development of the“three living spaces.”The study focuses on the Zunyi City Center,selecting the 20 years of rapid development following its establishment as a city as the study period.It explores the dynamic evolution of green space and the main driving forces during different periods using remote-sensing image data.The study shows that from 2003 to 2023,the total scale of green space has an obvious decreasing trend along with the expansion of the urban built-up area.A large amount of arable land is being converted to construction land,resulting in a sudden decrease in arable land area.In the past 10 years,the comprehensive land use dynamics have accelerated.Still,the spatial difference has gradually narrowed,indicating that the overall development intensity of Zunyi City’s central urban area has increased.There is a gradual spread of the trend to the hilly areas.The limiting effect of the mountainous natural environment on the city’s development has gradually diminished under the superposition of external factors,such as economic development,industrial technological upgrading,and policy orientation so the importance of the effective protection and rational utilization of urban green space has become more prominent.
文摘In this paper, we studied the traveling wave solutions of a SIR epidemic model with spatial-temporal delay. We proved that this result is determined by the basic reproduction number R0and the minimum wave speed c*of the corresponding ordinary differential equations. The methods used in this paper are primarily the Schauder fixed point theorem and comparison principle. We have proved that when R0>1and c>c*, the model has a non-negative and non-trivial traveling wave solution. However, for R01and c≥0or R0>1and 0cc*, the model does not have a traveling wave solution.
基金This work was supported by financial support from Universiti Sains Malaysia(USM)under FRGS grant number FRGS/1/2020/TK03/USM/02/1the School of Computer Sciences USM for their support.
文摘Human Activity Recognition(HAR)is an active research area due to its applications in pervasive computing,human-computer interaction,artificial intelligence,health care,and social sciences.Moreover,dynamic environments and anthropometric differences between individuals make it harder to recognize actions.This study focused on human activity in video sequences acquired with an RGB camera because of its vast range of real-world applications.It uses two-stream ConvNet to extract spatial and temporal information and proposes a fine-tuned deep neural network.Moreover,the transfer learning paradigm is adopted to extract varied and fixed frames while reusing object identification information.Six state-of-the-art pre-trained models are exploited to find the best model for spatial feature extraction.For temporal sequence,this study uses dense optical flow following the two-stream ConvNet and Bidirectional Long Short TermMemory(BiLSTM)to capture longtermdependencies.Two state-of-the-art datasets,UCF101 and HMDB51,are used for evaluation purposes.In addition,seven state-of-the-art optimizers are used to fine-tune the proposed network parameters.Furthermore,this study utilizes an ensemble mechanism to aggregate spatial-temporal features using a four-stream Convolutional Neural Network(CNN),where two streams use RGB data.In contrast,the other uses optical flow images.Finally,the proposed ensemble approach using max hard voting outperforms state-ofthe-art methods with 96.30%and 90.07%accuracies on the UCF101 and HMDB51 datasets.
基金supported by China Geological Survey(DD20230554,DD20230089)the Strategic Priority Research Program of the Chinese Academy of Science(XDA28020302)the funding project of Northeast Geological S&T Innovation Center of China Geological Survey(QCJJ2022-40).
文摘To illuminate the spatio-temporal variation characteristics and geochemical driving mechanism of soil pH in the Nenjiang River Basin,the National Multi-objective Regional Geochemical Survey data of topsoil,the Second National Soil Survey data and Normalized Difference Vegetation Index(NDVI)were analyzed.The areas of neutral and alkaline soil decreased by 21100 km^(2)and 30500 km^(2),respectively,while that of strongly alkaline,extremely alkaline,and strongly acidic soil increased by 19600 km^(2),18200 km^(2),and 15500 km^(2),respectively,during the past 30 years.NDVI decreased with the increase of soil pH when soil pH>8.0,and it was reversed when soil pH<5.0.There were significant differences in soil pH with various surface cover types,which showed an ascending order:Arbor<reed<maize<rice<high and medium-covered meadow<low-covered meadow<Puccinellia.The weathering products of minerals rich in K_(2)O,Na_(2)O,CaO,and MgO entered into the low plain and were enriched in different parts by water transportation and lake deposition,while Fe and Al remained in the low hilly areas,which was the geochemical driving mechanism.The results of this study will provide scientific basis for making scientific and rational decisions on soil acidification and salinization.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China(No.2018YFE0310200)National Natural Science Foundation of China(Nos.11705242,11805138 and 12175156)the Fundamental Research Funds for the Central Universities in China(Nos.YJ201820 and YJ201954)。
文摘An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of Physics.The main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 tokamak.The E//B NPA contains three main units,i.e.the stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping unit.The results of the simulations and beam tests for the stripping chamber are presented.Parallel electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing unit.The calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)platform.The detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two rows.The response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS platform.The overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.
文摘Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to reflect drought conditions in the North-Eastern coastal region of Vietnam. The drought events and their characteristics from 1981 to 2019 are detected at 9 meteorological stations and 10 Chirps rainfall stations. The spatio-temporal variation of drought in the study region is analyzed on the basis of the number, duration, severity, intensity, and peak of the detected drought events at the 19 stations. The results show that from 1981 to 2019 the drought events mainly occurred with 1-season duration and moderate intensity and peak. The number, duration, severity, and peak of the drought events were the greatest in the period 2001-2010 and were the smallest in the period 2011-2019. Among the 19 stations, the drought duration tends to decrease at 11 stations, increase at 7 stations, and has a slight variant at 1 station;the drought severity tends to decrease at 14 stations, increase at 4 stations, and has not a significant trend at 1 station;the drought intensity tends to decrease at 17 stations, increase at 1 station, and has a slight variant at 1 station;and the drought peak tends to decrease at 18 stations and increase at 1 station.
文摘Spatio-temporal models are valuable tools for disease mapping and understanding the geographical distribution of diseases and temporal dynamics. Spatio-temporal models have been proven empirically to be very complex and this complexity has led many to oversimply and model the spatial and temporal dependencies independently. Unlike common practice, this study formulated a new spatio-temporal model in a Bayesian hierarchical framework that accounts for spatial and temporal dependencies jointly. The spatial and temporal dependencies were dynamically modelled via the matern exponential covariance function. The temporal aspect was captured by the parameters of the exponential with a first-order autoregressive structure. Inferences about the parameters were obtained via Markov Chain Monte Carlo (MCMC) techniques and the spatio-temporal maps were obtained by mapping stable posterior means from the specific location and time from the best model that includes the significant risk factors. The model formulated was fitted to both simulation data and Kenya meningitis incidence data from 2013 to 2019 along with two covariates;Gross County Product (GCP) and average rainfall. The study found that both average rainfall and GCP had a significant positive association with meningitis occurrence. Also, regarding geographical distribution, the spatio-temporal maps showed that meningitis is not evenly distributed across the country as some counties reported a high number of cases compared with other counties.
文摘In crime science, understanding the dynamics and interactions between crime events is crucial for comprehending the underlying factors that drive their occurrences. Nonetheless, gaining access to detailed spatiotemporal crime records from law enforcement faces significant challenges due to confidentiality concerns. In response to these challenges, this paper introduces an innovative analytical tool named “stppSim,” designed to synthesize fine-grained spatiotemporal point records while safeguarding the privacy of individual locations. By utilizing the open-source R platform, this tool ensures easy accessibility for researchers, facilitating download, re-use, and potential advancements in various research domains beyond crime science.
文摘AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutive measurements and subsequent analysis of interferometry,TMH,and MBG were recorded by two examiners using the LacryDiag.To assess intra-and interobserver reliability,we used Cohen’s kappa for categorical variables(interferometry),or intraclass correlation coefficient for continuous variables(TMH,MBG).RESULTS:Thirty eyes of 30 examinees were included.For both observers,there was excellent intraobserver reliability for MBG(0.955 and 0.970 for observer 1 and 2,respectively).Intraobserver reliability for observer 1 was substantial for interferometry(0.799),and excellent for TMH(0.863).Reliability for observer 2 was moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobserver reliability was poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUSION:LacryDiag ocular surface analyzer in our study proves to be a reliable noninvasive tool for the evaluation of TMH and MBG.As for interferometry,poor interobserver reliability,fair to good intraobserver reliability for observer 1,and moderate for observer 2,leave room for improvement.
文摘To verify the effectiveness of digital optical 3D image analyzer EvaSKIN in the objective and quantitative evaluation of wrinkles.A total of 115 subjects were recruited,the facial images of the subjects were collected by digital optical 3D image analyzer and manual camera,the changes of crow’s feet with age were analyzed.Pictures obtained by manual photography can be directly used for observation and preliminary grading of wrinkles.However,the requirements for evaluators are high,and the results are prone to errors,which will affect the accuracy of the evaluation.Therefore,skilled raters are needed.Compared with the manual photography method,the digital optical 3D image analyzer EvaSKIN can realize three-dimensional extraction of wrinkles,and obtain the change trend of crow’s feet with age.20~30 years old,wrinkles begin to appear slowly;wrinkles will increase rapidly at the age of 30~50;The length of 50~60 year old wrinkles is basically fixed,the wrinkles develop longitudewise,gradually widen and deepen,and the area,depth and volume increase is obvious,and the skin aging condition is intensified.the digital optical 3D image analyzer EvaSKIN realizes the 3D extraction of wrinkles,quantifies the circumference,area,average depth,maximum depth and volume of wrinkles,realizes the objective and quantitative evaluation of wrinkle state,is more accurate in the measurement of wrinkles,and provides a new instrument and method for the evaluation of wrinkles.it is a perfect and supplement to the traditional evaluation methods,and to a certain extent,it helps the research and development and evaluation institutions of cosmetics to obtain more abundant and three-dimensional data support.
基金Baoding Science and Technology Bureau(2141ZF313)。
文摘Objective:To investigate the hook effect in the detection of beta2-microglobulin(β2-MG)with different reagents as well as on two fully automated biochemical analyzers and their solutions.Methods:Using immunoturbidimetric assay forβ2-MG as the research object,β2-MG levels were detected by different concentration gradients ofβ2-microglobulin samples in Liedemann,Mack,and Myriad reagents of three manufacturers on two automatic biochemical analyzers,and the difference of the hook effect was comparatively analyzed.Results:Leadman reagent showed the hook effect on the Beckman AU5800 automated biochemistry analyzer,while both Maccura and Mindray reagents did not show the hook effect.After the experiments,we found the limit value of the pre-zone check of Leadman reagent,and changed the parameters of the instrument,when the limit value of the pre-zone check was reached,the instrument automatically diluted the specimen five times and then detected it again.After changing the parameters of the instrument,the correlation between the three methods of detecting samples of different concentrations was r>0.99.Conclusion:Before selecting the application of immunoturbidimetric reagents,we have to carry out the risk assessment of the hook effect and selectively set the parameters of the pre-zone check based on the highest concentration that may occur in the clinic;for the items that may have the hook effect,we have to selectively set the parameters of the pre-zone check when the ratio of average reaction rate and the immediate reaction rate is at the limit value,and the phenomenon of antigen excess may occur,the instrument will carry out automatic dilution before detection,so as to avoid the issuance of erroneous results of high-value samples due to the hook effect.