The homogeneous quadratic riemann boundary value problem (1) with H?lder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its gene...The homogeneous quadratic riemann boundary value problem (1) with H?lder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. Key words homogeneous quadratic Riemann boundary value problem - ordinary and special nodes - index - sectionally holomorphic function CLC number O 175.5 Foundation item: Supported by the National Natural Science Foundation of China (19871064)Biography: Lu Jian-ke (1922-), male, Professor, research direction: complex analysis and its applications.展开更多
目的探讨乳腺浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)和浸润性癌(非特殊型)(invasive carcinoma of no special type,NST)的临床病理特征差异及其与腋窝淋巴结转移的相关性。方法回顾性分析2010年8月至2013年...目的探讨乳腺浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)和浸润性癌(非特殊型)(invasive carcinoma of no special type,NST)的临床病理特征差异及其与腋窝淋巴结转移的相关性。方法回顾性分析2010年8月至2013年8月北京协和医院92例IMPC手术患者的临床病理资料,随机选取368例同期手术的NST患者作为对照组。比较IMPC和NST的临床病理特征并分析其腋窝淋巴结转移的影响因素。结果 IMPC与NST在肿瘤大小[(2.9±1.9)cm比(2.1±1.4)cm,P=0.001]、脉管浸润率(85.9%比6.0%,P〈0.001)、腋窝淋巴结转移率(71.7%比47.3%,P〈0.001)及转移个数(8.2±9.9比2.9±5.7,P〈0.001)、孕激素受体表达(P=0.047)、人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER-2)表达(P=0.009)、Ki-67指数(P〈0.001)以及TNM分期(P〈0.001)、分子分型(P〈0.001)方面的差异均具有统计学意义。肿瘤组织中IMPC成分≤24%、25%~49%、50%~75%以及≥76%者淋巴结转移率分别为73.9%、56.3%、72.2%和77.1%,IMPC的腋窝淋巴结转移率与其在肿瘤中所占比例无关(P=0.347),与肿瘤T分期(P=0.001)、HER-2表达(P=0.029)、分子分型(P=0.003)、P53表达(P=0.003)以及Ki-67指数(P=0.045)相关。NST的腋窝淋巴结转移与肿瘤T分期(P〈0.001)、组织学分级(P=0.001)、脉管浸润(P〈0.001)、雌激素受体α(P=0.007)、孕激素受体(P=0.031)、HER-2表达(P=0.008)及分子分型(P〈0.001)均相关。结论 IMPC是一种具有高脉管侵袭性、高腋窝淋巴结转移率的浸润性乳腺癌,具有与NST不同的病理特征。IMPC成分的多少并不影响腋窝淋巴结转移的程度,其腋窝淋巴结转移的影响因素明显少于NST。展开更多
文摘The homogeneous quadratic riemann boundary value problem (1) with H?lder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. Key words homogeneous quadratic Riemann boundary value problem - ordinary and special nodes - index - sectionally holomorphic function CLC number O 175.5 Foundation item: Supported by the National Natural Science Foundation of China (19871064)Biography: Lu Jian-ke (1922-), male, Professor, research direction: complex analysis and its applications.
文摘目的探讨乳腺浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)和浸润性癌(非特殊型)(invasive carcinoma of no special type,NST)的临床病理特征差异及其与腋窝淋巴结转移的相关性。方法回顾性分析2010年8月至2013年8月北京协和医院92例IMPC手术患者的临床病理资料,随机选取368例同期手术的NST患者作为对照组。比较IMPC和NST的临床病理特征并分析其腋窝淋巴结转移的影响因素。结果 IMPC与NST在肿瘤大小[(2.9±1.9)cm比(2.1±1.4)cm,P=0.001]、脉管浸润率(85.9%比6.0%,P〈0.001)、腋窝淋巴结转移率(71.7%比47.3%,P〈0.001)及转移个数(8.2±9.9比2.9±5.7,P〈0.001)、孕激素受体表达(P=0.047)、人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER-2)表达(P=0.009)、Ki-67指数(P〈0.001)以及TNM分期(P〈0.001)、分子分型(P〈0.001)方面的差异均具有统计学意义。肿瘤组织中IMPC成分≤24%、25%~49%、50%~75%以及≥76%者淋巴结转移率分别为73.9%、56.3%、72.2%和77.1%,IMPC的腋窝淋巴结转移率与其在肿瘤中所占比例无关(P=0.347),与肿瘤T分期(P=0.001)、HER-2表达(P=0.029)、分子分型(P=0.003)、P53表达(P=0.003)以及Ki-67指数(P=0.045)相关。NST的腋窝淋巴结转移与肿瘤T分期(P〈0.001)、组织学分级(P=0.001)、脉管浸润(P〈0.001)、雌激素受体α(P=0.007)、孕激素受体(P=0.031)、HER-2表达(P=0.008)及分子分型(P〈0.001)均相关。结论 IMPC是一种具有高脉管侵袭性、高腋窝淋巴结转移率的浸润性乳腺癌,具有与NST不同的病理特征。IMPC成分的多少并不影响腋窝淋巴结转移的程度,其腋窝淋巴结转移的影响因素明显少于NST。