A general Boolean semantic modelling approach for complex and intelligent industrial systems in the framework of DES

Discrete event system(DES)models promote system engineering,including system design,verification,and assessment.The advancement in manufacturing technology has endowed us to fabricate complex industrial systems.Consequently,the adoption of advanced modeling methodologies adept at handling complexity and scalability is imperative.Moreover,industrial systems are no longer quiescent,thus the intelligent operations of the systems should be dynamically specified in the model.In this paper,the composition of the subsystem behaviors is studied to generate the complexity and scalability of the global system model,and a Boolean semantic specifying algorithm is proposed for generating dynamic intelligent operations in the model.In traditional modeling approaches,the change or addition of specifications always necessitates the complete resubmission of the system model,a resource-consuming and error-prone process.Compared with traditional approaches,our approach has three remarkable advantages:(i)an established Boolean semantic can be fitful for all kinds of systems;(ii)there is no need to resubmit the system model whenever there is a change or addition of the operations;(iii)multiple specifying tasks can be easily achieved by continuously adding a new semantic.Thus,this general modeling approach has wide potential for future complex and intelligent industrial systems.

Rare primary gastric peripheral T-cell lymphoma not otherwise specified:A case report

BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastric peripheral T-cell lymphoma-not otherwise specified(PTCL-NOS)is an extremely rare subtype.CASE SUMMARY We report a 63-year-old male presenting with epigastric pain.Esophagogastro-duodenoscopy revealed a large ulcerative lesion in the gastric cardia.Biopsy and immunohistochemical profiling confirmed PTCL-NOS.Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes.The patient is planned to undergo cyclophosphamide,doxorubicin,vincristine,and prednisone or cyclophosphamide,doxorubicin,vincristine,prednisone,and etoposide chemo-therapy.CONCLUSION This case highlights the necessity of considering PTCL-NOS in differential diag-noses of gastric lesions.Comprehensive histopathological and immunohistoche-mical analysis is crucial for accurate diagnosis and guiding treatment.

Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Background:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial.Whether the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was uncertain.Methods:In this phase 3,double-blind,placebo-controlled trial,we randomly assigned(in a 1:1 ratio)participants with clear-cell renal-cell carcinoma who had an increased risk of recurrence after surgery to receive pembrolizumab(at a dose of 200 mg)or placebo every 3 weeks for up to 17 cycles(approximately 1 year)or until recurrence,the occurrence of unacceptable toxic effects,or withdrawal of consent.A significant improvement in disease-free survival according to investigator assessment(the primary end point)was shown previously.Overall survival was the key secondary end point.Safety was a secondary end point.

Radial and longitudinal density variations in Abies cephalonica and Pinus halepensis

Basic wood density is an excellent indicator of quality,it is correlated with numerous physical,physiological and mechanical characteristics of a species and is a good descriptor of wood quality and important indicator of tree performance in community ecology.An accurate method is thus needed to estimate wood density.The standard way is to calculate the ratio of the oven-dried mass of a wood sample divided by its green volume,but wood characteristics within and between growth rings are highly variable;the density can vary in the longitudinal and the radial directions.The present study investigates the longitudinal and radial fl uctuations in the basic density of Abies cephalonica Loud and Pinus halepensis Mill.Four logs were cut from four diff erent trees for each species and 16 discs were formed(two discs from each log,one at the base and one at the top).Each disc was cut into cubes where their distance from the pith was measured and then sorted into 2 cm wide concentric zones.The results revealed a mild decreasing trend in basic density from the foot of the trunk upward for both species.The pith in both species also seems to have a relatively high density,which in the immediate next growth rings decreases only to resume increasing toward the bark.

Health Phys.Abstracts,Volume 124,Number 5

Aligning Exposure Limits for Contact Currents with Exposure Limits for Electric Fields Robert Kavet1 and Richard A.Tell2(1.Kavet Consulting LLC,4455 Worden Way,Oakland,CA 94619;2.Richard Tell Associates,Inc.,10037 Long Meadow Road,Madison,AL 35756.)Abstract:The Institute for Electrical and Electronic Engineers(IEEE)and the International Commission on Non-ionizing Radiation Protection(ICNIRP)have established limits for exposures to electromagnetic fields across the 0-300 GHz(non-ionizing)spectrum,including limits on contact currents(CC)specified by IEEE for 0-110 MHz(ICNIRP issued a CC“guidance level”).

Differences between DSM-5-TR and ICD-11 revisions of attention deficit/hyperactivity disorder:A commentary on implications and opportunities

Current ICD-11 descriptions for attention deficit hyperactivity disorder(ADHD)were recently published online,in the same year as the DSM-5-TR(text revised edition)was released.In this commentary,we compare and contrast the DSM-5/DSM-5-TR and ICD-11 diagnostic criteria,summarize important differences,and underscore their clinical and research implications.Overall,three major differences emerge:(1)The number of diagnostic criteria for inattention(IA),hyperactivity(HY)and impulsivity(IM)symptoms(i.e.,DSM-5-TR has nine IA and nine HY/IM symptoms,whereas ICD-11 has 11 IA and 11 HY/IM symptoms);(2)the clarity and standardization of diagnostic thresholds(i.e.,the diagnostic thresholds for symptom count in IA and HY/IM domains are explicitly specified in DSM-5-TR,whereas in ICD-11 they are not);and(3)the partitioning of HY and IM symptoms into sub-dimensions(i.e.,difference in partitioning HY and IM symptom domains relates to the differences between the current and previous editions of DSM and ICD,and this has important research implications).Currently,no ICD-11 based ADHD rating scales exist and while this absence represents an obstacle for respective research and clinical practice,it also presents opportunities for research development.This article highlights these challenges,possible remedies and novel research opportunities.

A Comparative Study of News Sources in Sino-English News Reports Related to Nobel Winner Mo Yan

News,by no means a neutral vehicle,is in reality ideologically driven and controlled by news values to which the use of news sources is of great help.Geis once argued that the single most important power of the press is its capacity to say what the important issues are at any particular time and to determine whose voices will be heard on any given issue(Geis,1987:10).News sources may tell readers something,but it may also mislead readers since people cannot think about and make sense out of news events without imposing a bias on the news.It is,therefore,worth our attention and effort to understand how news source works,how it affects readers'perceptions of news events,how it is produced,how it is shaped by values and ideology.

Usefulness of CT angiography in diagnosing acute gastrointestinal bleeding:A meta-analysis

AIM: To analyze the accuracy of computed tomography (CT) angiography in the diagnosis of acute gastrointestinal (GI) bleeding. METHODS: The MEDLINE, EMBASE, Cancerlit, Cochrane Library database, Sciencedirect, Springerlink and Scopus, from January 1995 to December 2009, were searched for studies evaluating the accuracy of CT angiography in diagnosing acute GI bleeding. Studies were included if the ycompared CT angiography to a reference standard of upper GI endoscopy, colonoscopy, angiography or surgery in the diagnosis of acute GI bleeding. Meta-analysis methods were used to pool sensitivity and specificity and to construct summary receiver-operating characteristic. RESULTS: A total of 9 studies with 198 patients were included in this meta-analysis. Data were used to form 2 × 2 tables. CT angiography showed pooled sensi-tivity of 89% (95% CI: 82%-94%) and specificity of 85% (95% CI: 74%-92%), without showing significant heterogeneity (χ2 = 12.5, P = 0.13) and (χ2 = 22.95, P = 0.003), respectively. Summary receiver operating characteristic analysis showed an area under the curve of 0.9297. CONCLUSION: CT angiography is an accurate, costeffective tool in the diagnosis of acute GI bleeding and can show the precise location of bleeding, thereby directing further management.

Modified Static Floor Field and Exit Choice for Pedestrian Evacuation

An improved floor field model is proposed to simulate the pedestrian evacuation behavior in a room with multiple exits by modifying the static floor field.The modified static floor field is determined additionally by two cognitive coefficients of exit width and congestion degree around the exits.The logit-based discrete choice principle is used to govern the initial exit selection strategy based on the modified static floor field in such a scenario that pedestrians are distributed in the room's specified zone.Simulation results show that the proposed model can better perform the evacuation process.Sensitivity analyses of the model parameters are also presented.

Shakedown Criterion Employing Actual Residual Stress Field and Its Application in Numerical Shakedown Analysis

Construction of the static admissible residual stress field and searching the optimal field are key tasks in the shakedown analysis methods applying the static theorem. These methods always meet dimension obstacles when dealing with complex problems. In this paper, a novel shakedown criterion is proposed employing actual residual stress field based on the static shakedown theorem. The actual residual stress field used here is produced under a specified load path, which is a sequence of proportional loading and unloading from zero to all the vertices of the given load domain. This ensures that the shakedown behavior in the whole load domain can be determined based on the theorem proposed by K6nig. The shakedown criterion is then implemented in numerical shakedown analysis, The actual residual stress fields are calculated by incremental finite element elastic-plastic analysis technique for finite deformation under the specified load path with different load levels. The shakedown behavior and the shakedown limit load are determined according to the proposed criterion. The validation of the criterion is performed by a benchmark shakedown example, which is a square plate with a central hole under biaxial loading. The results are consistent with existing results in the literatures and are validated by full cyclic elastic-plastic finite element analysis. The numerical shakedown analysis applying the proposed criterion avoids processing dimension obstacles and performing full cyclic elastic-plastic analysis under arbitrary load paths which should be accounted for appearing. The effect of material model and geometric changes on shakedown behavior can he considered conveniently.

Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction

BACKGROUND:Early reperfusion can effectively treat acute myocardial infarction(AMI) and reduce the mortality signif icantly. This study aimed to compare the role of plasma microRNA-1(miR-1) and cardiac troponin T(cTnT) in early diagnosis of AMI patients.METHODS:From May 2011 to May 2012,plasma samples were collected from 56 AMI patients and 28 non-AMI controls. The expression of plasma miR-1 was measured by quantitative reverse transcription-polymerase chain reaction(qRT-PCR),and the level of plasma cTnT was measured using electrochemiluminescence-based methods on an Elecsys 2010 Immunoassay Analyzer. SPSS 16.0 was used for the statistical analysis of the results. Data were expressed as mean±standard deviation unless otherwise described. The differences about clinical characteristics between the AMI patients and controls were tested using Student's t test or Fisher's exact test. The Mann-Whitney U test was conducted to compare the expression of microRNAs between the AMI patients and controls. MicroRNAs expression between different intervals of the AMI patients was compared using Wilcoxon's signed-rank test. The receiver operating characteristic(ROC) curve was established to discriminate the AMI patients from the controls.RESULTS:In the present study,the expression of plasma miR-1 was signifi cantly increased in the AMI patients compared with the healthy controls(P<0.01). The plasma miR-1 in the AMI patients decreased to the normal level at 14 days(P>0.05). The expression of plasma miR-1 was not related to the clinical characteristics of the study population(P>0.05). ROC curve analyses demonstrated that miR-1 was specifi c and sensitive for the early diagnosis of AMI,but not superior to cTnT.CONCLUSION:Plasma miR-1 could be used in the early diagnosis of AMI,but it is similar to cTnT.

Autoimmune pancreatitis not otherwise specified(NOS): Clinical features and outcomes of the forgotten type

Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these patients.The aim of this study was to investigate clinical and radiological features of AIP type NOS-patients.Methods:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were evaluated.Epidemiological,clinical data were collected and analyzed.Results:Forty-six patients were included in the study.The clinical onset was mainly characterized by weight loss,jaundice and acute pancreatitis.Eight patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.Seven patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent relapses.Conclusions:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.The risk of relapse is low but not irrelevant.

Disordered eating behaviors in type 1 diabetic patients

Patients with type 1 diabetes mellitus are at high risk for disordered eating behaviors (DEB). Due to the fact that type 1 diabetes mellitus is one of the most common chronic illnesses of childhood and adolescence, the coexistence of eating disorders (ED) and diabetes often affects adolescents and young adults. Since weight management during this state of development can be especially diff icult for those with type 1 diabetes, some diabetics may restrict or omit insulin, a condition known as diabulimia, as a form of weight control. It has been clearly shown that ED in type 1 diabetics are associated with impaired metabolic control, more frequent episodes of ketoacidosis and an earlier than expected onset of diabetes-related microvascular complications, particularly retinopathy. The management of these conditions requires a multidisciplinary team formed by an endocrinologist/diabetologist, a nurse educator, a nutritionist, a psychologist and, frequently, a psychiatrist. The treatment of type 1 diabetes patients with DEB and ED should have the following compo- nents: diabetes treatment, nutritional management and psychological therapy. A high index of suspicion of the presence of an eating disturbance, particularly among those patients with persistent poor metabolic control, repeated episodes of ketoacidosis and/or weight andshape concerns are recommended in the initial stage of diabetes treatment, especially in young women. Given the extent of the problem and the severe medical risk associated with it, more clinical and technological research aimed to improve its treatment is critical to the future health of this at-risk population.

Modulation of lysophosphatidic acid (LPA) receptor activity: the key to successful neural regeneration?

The central nervous system(CNS)is characterized by a remarkably elaborate cellular architecture comprising large numbers of glial and neuronal cells with enormous functional diversity,organized into highly complex and specific networks.During development,the various neural cell types must first be correctly specified,then assume their appropriate positions through carefully choreographed cellular migration,and finally establish and refine their functional connections,often over long distances.The end result of all these processes is an extraordinarily intricate anatomical structure,able to receive,integrate,and store information and orchestrate appropriate responses.

Functional food products in Japan:A review

Japan has a long history of using foods with health benefits and Japanese people are well-known for their longevity.In 1991,the Ministry of Health,Labor and Welfare introduced a functional food regulation called“foods for specified health uses”(FOSHU)in Japan.After the introduction of the functional food system,many clinically proven FOSHU products with health benefits have been developed and launched in the market.As a result,the net sales of FOSHU products reached 6.2 billion dollars in 2007.Most of the health claims relate to improving gastro-intestinal health using probiotics.Triglycerides,high blood pressure,high LDL-cholesterol,and high blood glucose are mainly associated with the related health claims.After 2007,the market for FOSHU products was almost saturated.However,a novel functional regulatory system\called“Foods with Function Claims”was established in 2015 based on the Dietary Supplement Health and Education Act system established in the USA.Major health claims in the new regulation system are associated with fatigue,eyes,memory,stress,sleep,joints,blood flow,body temperature,muscles,and Body Mass Index.After the introduction of the new system,the total sales for functional foods including FOSHU products reached 8 billion dollars in 2018.The new functional regulatory system is more flexible in terms of health claims,the protocol for clinical studies,and the required results.Therefore,the market for new regulatory products is still growing.In the present paper,the potential of both regulatory systems and some related issues will be discussed.

Design of adaptive intuitionistic fuzzy controller for synchronisation of uncertain chaotic systems

This study presents the synchronisation between two non-linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller(AIFC).This problem is solved in the presence of external disturbances and uncertainties.Two classes of Lorenz systems have been formulated one as the master and the other as the slave.The master and slave systems have different initial conditions.Under different initial conditions,both systems diverge.This is called the butterfly effect that rules the behaviour of chaotic systems.AIFC is chosen as a different method that has not been used before to synchronise the chaotic systems.The scaling factors of the inputs and the output of the intuitionistic fuzzy controller(IFC)are tuned using the artificial bee colony(ABC)algorithm depending on a specified objective function.Then IFC stability is studied when it is applied to synchronise the Lorenz system.The simulation results achieved to assess the adequacy of the proposed control and to exhibit its dependability to synchronise the Lorenz system.

Prevalence of functional dyspepsia and its subgroups in patients with eating disorders

AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.Twentytwo healthy volunteers matched for age and gender were enrolled as healthy controls.All participants underwent a careful clinical examination.Demographic and anthropometric characteristics were obtained from a structured questionnaires.The presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome(PDS) were diagnosed according to Rome Ⅲ criteria.The intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire(0-6).Analysis of variance and post-hoc Sheffè tests were used for comparisons.RESULTS:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria(χ 2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome diagnosis.Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group(4.15 ± 2.08 vs 1.44 ± 2.35,P = 0.003;5.00 ± 2.45vs 1.44 ± 2.35,P = 0.003;4.10 ± 2.23vs 1.44 ± 2.35,P = 0.002,respectively),the obese group(4.15 ± 2.08vs 0.00 ± 0.00,P < 0.001;5.00 ± 2.45vs 0.00 ± 0.00,P < 0.001;4.10 ± 2.23 vs 0.00 ± 0.00,P < 0.001,respectively) and healthy volunteers(4.15 ± 2.08 vs 0.36 ± 0.79,P < 0.001;5.00 ± 2.45 vs 0.36 ± 0.79,P < 0.001;4.10 ± 2.23 vs 0.36 ± 0.79,P < 0.001,respectively).Early satiety intensity-frequency score was prominent in anorectic patients compared to bulimic patients(3.85 ± 2.23 vs 1.17 ± 1.83,P = 0.015),obese patients(3.85 ± 2.23 vs 0.00 ± 0.00,P < 0.001) and healthy volunteers(3.85 ± 2.23 vs 0.05 ± 0.21,P < 0.001).Nausea and epigastric pressure were increased in bulimic and ED not otherwise specified patients.Specifically,nausea intensity-frequencyscore was significantly higher in bulimia nervosa and ED not otherwise specified patients compared to anorectic patients(3.17 ± 2.56 vs 0.89 ± 1.66,P = 0.04;2.70 ± 2.91 vs 0.89 ± 1.66,P = 0.05,respectively),constitutional thinner subjects(3.17 ± 2.56 vs 0.00 ± 0.00,P = 0.004;2.70 ± 2.91 vs 0.00 ± 0.00,P = 0.005,respectively),obese patients(3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001;3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001 respectively) and,healthy volunteers(3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.002;3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.001,respectively).Epigastric pressure intensityfrequency score was significantly higher in bulimic and ED not otherwise specified patients compared to constitutional thin subjects(4.67 ± 2.42 vs 1.22 ± 1.72,P = 0.03;4.20 ± 2.21 vs 1.22 ± 1.72,P = 0.03,respectively),obese patients(4.67 ± 2.42 vs 0.75 ± 1.32,P = 0.001;4.20 ± 2.21vs 0.75 ± 1.32,P < 0.001,respectively) and,healthy volunteers(4.67 ± 2.42 vs 0.67 ± 1.46,P = 0.001;4.20 ± 2.21vs 0.67 ± 1.46,P = 0.001,respectively).Vomiting was referred in 100% of bulimia nervosa patients,in 20% of ED not otherwise specified patients,in 15% of anorexia nervosa patients,in 22% of constitutional thinner subjects,and,in 5.6% healthy volunteers(χ 2,P < 0.001).CONCLUSION:PDS is common in eating disorders.Is it mandatory in outpatient gastroenterological clinics to investigate eating disorders in patients with PDS?

Design of a DSLM-based cerebral palsy action rehabilitation training system

Based on domain specified language mechanism(DSLM),the architecture of the robotic training system for the rehabilitation of children with cerebral palsy(CP)is designed.Application of human-computer interaction(HCI)motion recognition technology is combined with Kinect to improve the effect of cerebral palsy rehabilitation training.In this system,Kinect's bone recognition method is used to judge the patient's training movements,and the collected bone movement information is judged.The human-computer interaction function is based on the Microsoft foundation classes function of Visual Studio based on DSLM development,which can realize real-time interactive training and evaluation of people and actions,and record the training information of patients.The system combines the designed small game to train the upper limb movement ability and reaction ability of the cerebral palsy patient,and provides key technology for improving the cerebral palsy rehabilitation training system.

Determination of the Fracture Toughness of Optomechanical Devices

Static fracture toughness characteristics are traditionally determined in tests of standard notched specimens using a P-V curve, where P is the load and V is the notch-opening displacement. This curve has a characteristic point Q. At the load PQ corresponding to this point, the crack starts to propagate. For this load, the fracture toughness characteristics are then calculated. In brittle (elastic) fracture, the P-V curve at the onset of crack propagation has an extremum (or a local extremum), from whose ordinate PQ is determined with sufficient accuracy. In ductile and elastic-ductile fracture, P-V curves are monotonically increasing, and PQ is calculated using the 5% secant offset method without taking into account the characteristics of the material, so that the PQ is determined inaccurately. To improve the accuracy of PQ determination, we propose a thermographic method for determining the fracture toughness of metals. This method involves plotting the load P against the temperature change ΔТ over a relatively short period of time at the notch tip. This plot is then transformed to a P-ΔS curve, where ΔS is the specific entropy increment at the notch tip, which is calculated through ΔТ. This thermodynamic diagram has a characteristic step at the beginning of crack propagation, and from the ordinate of this step, PQ can be determined much more accurately. Furthermore, in the thermographic method, the preparation of test specimens can be simplified by replacing the process of growing a fatigue crack at the tip of a notch by making a sharp cut, which provides significant time savings. Statistical processing and comparison of test results of steel 20 specimens using the conventional and thermographic methods have shown the advantages of the thermographic method in accuracy and complexity.

Comparison of sedimentary organic carbon loading in the Yap Trench and other marine environments

Knowledge about organic carbon loadings(ratio of sedimentary organic carbon(SOC)content to specific surface area(SSA))and the fate of organic carbon(OC)is critical to understand the marine carbon cycle.We investigated the variations in the patterns of OC loadings and the preservation capacities of sedimentary OC in the Yap Trench and other marine environments.The average OC loading in sediment cores from various marine environments decreases with increasing water depth at a rate of^0.06 mg OC/(m^2·km)(R^2=0.23,P<0.01).Distinct low OC loadings(0.09±0.04 mg OC/m^2)were observed in the Yap Trench,with the lowest values as^0.02 mg OC/m^2.A further comparative analysis indicated that OC/SSA=0.2 mg OC/m^2 is a good indicator to distinguish between oxic deep-sea regions and suboxic energetic deltaic areas.Regression analysis between OC loading and bulk carbon isotope compositions indicates that marine OC(δ13C^-20.4‰to-18.6‰)dominates the lost OC within the Yap Trench and does not differ from that of the abyssal zone.In contrast,terrestrial OC withδ13C values of approximately-27.4‰to-20.5‰was the major source of remineralized OC in the sublittoral zone.The ratios of OC loadings in the bottom layer relative to those in the top layers of sediment cores indicate that the preservation capacities of hadal trenches are much lower than those of other environments,and only approximately 30%of the SOC deposited in hadal trenches is finally buried.The value is equivalent to 0.066%of the primary production-derived OC and much lower than the global ocean average(~0.3%).Overall,the hadal zone exhibits the lowest OC loading and preservation capacity of SOC of the different marine environments investigated,despite the occurrence of a notable funneling effect.