Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

Surgery remains the standard treatment for spinal metastasis.However,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes.In this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril hydrogels.This superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse model.Under near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled manner.Thr-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal therapy.Our minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons

Greenblatt and his team have unveiled vertebral skeletal stem cells(vSSCs)as a critical player in the landscape of bone metastasis.This commentary delves into the transformative discoveries surrounding vSSCs,emphasizing their distinct role in bone metastasis compared to other stem cell lineages.We illuminate the unique properties and functions of vSSCs,which may account for the elevated susceptibility of vertebral bones to metastatic invasion.Furthermore,we explore the exciting therapeutic horizons opened by this newfound understanding.These include potential interventions targeting vSSCs,modulation of associated signaling pathways,and broader implications for the treatment and management of bone metastasis.By shedding light on these game-changing insights,we hope to pave the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with metastatic bone disease.

A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings

Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination. Assuming that metastasis had occurred at the time lumbar pain developed, the patient reached the level of gait disturbance within only 4 mo, showing a rapid advancement of symptoms. If early diagnosis had been possible, treatment could be performed before acute myelopathy progressed to complete paralysis. We speculate that the terminal stage of HCC is not only liver failure associated with intrahepatic lesions but also metastasis to other regions, treatment for individual pathologies therefore, will be needed, which constitutes an important issue.

Solitary Intramedullary Spinal Cord Metastasis from Colon Carcinoma: A Case Report and Literature Review

It is extremely rare for cancer to present as an intramedullary spinal cord metastasis. The authors report on a case of a 74-year-old woman presenting with progressive tetraparesis to metastatic colon adenocarcinoma in the spinal cord. A review of the literature reveals that intramedullary localization is associated with a very short life expectancy, with a median survival of 3-4 months from the time of the diagnosis;nevertheless microsurgical removal of tumor can improve quality of life.

Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor

Intramedullary spinal cord metastasis(ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor(pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date,no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon,it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here,we report the case of a 45-year-old man who presented with leg weakness and voiding difficulty,and was found to have ISCM from pNET. Surgical treatment prevented further neurological deterioration. This is the first case report of ISCM from pNET.

Case of intramedullary spinal cord metastasis of renal cell carcinoma

Intramedullary spinal cord tumors are rare. The improved survival resulting from more effective treatments formany cancers has led to an increased number of publications concerning intramedullary spinal cord metastasis(ISCM), including case reports and literature reviews; however, ISCM remains extremely rare in renal cancer. A 69-year-old man with a medical history of renal cell carcinoma(RCC) presented with urinary retention and bilateral paralysis of the lower extremities. A neurological examination revealed bilateral paraparesis below L1. Although brain magnetic resonance imaging(MRI), bone scintigraphy, and abdominal contrast-enhanced computed tomography revealed no abdominal findings, the thracolumbar MRI indicated a spot on the spinal cord at the Th12 level that exhibited hyperintensity on T2-weighted imaging and gadolinium diethylenetriaminepentaacetic acid enhancement on T1-weighted imaging. Accordingly, an ISCM of RCC was diagnosed. The patient rejected all treatments for these metastases except the steroid therapy. The patient's condition deteriorated owing to metastatic progression, and he died 3 mo after the appearance of ISCM symptoms. The prognosis of this condition was poor. The mean survival durations were 8 mo with surgical treatment, 4 mo with irradiation, and 2 mo with palliative treatments. In cases involving neurological features and if brain or bone metastasis or spinal cord compression is not clearly observed, gadolinium-enhanced MRI should be performed to determine the existence of ISCM. Recently, some authors have reported the efficacy of ISCM resection. Surgical treatment could potentially yield improvements in the nervous symptoms or a longer survival after treatment. Although the prognosis was poor in most cases of ISCM, surgical treatment may improve the patient's quality of life.

Preliminary study of transforaminal endoscope in the treatment of spinal metastasis

Objective:To investigate the therapeutic effect of transforaminal endoscope in patients with spinal metastases.Methods:Clinical data of 28 patients with spinal metastases admitted to our hospital from May 2015 to May 2019 were retrospectively collected.According to different surgical methods,they were divided into control group(20 cases)and experimental group(8 cases),among which control group was treated with traditional open palliative decompression,while the experimental group was treated with transforaminal endoscopic decompression.The surgery and recovery indicators were compared between the two groups,including surgery time,incision length,postoperative drainage volume,out of bed activity time,length of hospital stay,the Japanese Orthopaedic Association(JOA)scores of 7 days after surgery,pain degree,complications(wound infection,transient reduction of muscle strength,hypoproteinemia with wound drainage and delayed healing),and activity of daily living.Results:The surgery time,incision length,postoperative drainage volume,out of bed activity time,and postoperative length of hospital stay of the experimental group were all less than those of the control group,and the JOA score of 7 days after surgery was higher than that of the control group,showing statistically significant differences(P<0.05).VAS scores of the experimental group on the day 1 and day 7 after surgery were lower than those of the control group,with statistically significant differences(P<0.05).The incidence of complications in the experimental group was slightly lower than that in the control group,but the difference was not significant(P>0.05).Conclusions:Transforaminal endoscope used in suitable patients with spinal metastases can greatly reduce the incision length,soft tissue and bone tissue damages,and postoperative drainage,promote early mobilization and early discharge,and reduce a series of complications due to hemorrhage and hypoproteinemia,which has a better early clinical effect in comparison with the traditional open palliative decompression.

First description of cervical intradural thymoma metastasis

Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic"(types A, AB, B1, B2, and B3) and "non-organotypic"(thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma.

Intramedullary Metastasis of Medulloblastoma: A Case Report

Medulloblastoma (MB) is a malignant brain tumor with a usual potential for leptomeningeal spread. Intramedullary metastases of MB are rare and there are very few cases reported in the literature. Here, we report the case of an 18-year-old man with intramedullary spinal cord metastasis of MB occurring 9 years after the first diagnosis. The patient presented a 2-month history of progressive weakness in both lower limbs associated with urinary incontinence. Magnetic resonance imaging (MRI) demonstrated a large intramedullary spinal cord tumor extending from T10 to L1. The patient underwent surgical decompression and adjuvant therapy. Histological examination confirmed the diagnosis of classic MB metastasis. Postoperatively, the neurological status was stationary. Intramedullary metastasis of medulloblastoma is rare and difficult to manage with a poor prognosis. Comprehensive studies on the medulloblastoma dissemination mechanisms and clinical trials are needed to assess combined therapeutic approaches on metastases of MB.

miR-550a-5p诊断非小细胞肺癌脊柱骨转移的价值

目的探究微小RNA(miR)-550a-5p诊断非小细胞肺癌(non-small cell lung cancer,NSCLC)脊柱骨转移的价值,为临床防治提供参考。方法选取2019年1月~2023年1月承德医学院附属医院收治的62例存在脊柱骨转移NSCLC患者,44例无脊柱骨转移NSCLC患者,根据磁共振成像或CT检查证实,分别纳入脊柱骨转移组、无脊柱骨转移组。检测比较两组血清miR-550a-5p、肺肿瘤标志物[癌胚抗原(CEA)、细胞角蛋白19可溶性片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)]、骨代谢标志物[Ⅰ型胶原吡啶交联氨基末端肽(NTx)、骨转异性碱性磷酸酶(bone alkaline phosphatase,BALP)、Ⅰ型胶原羧基末端肽(typeⅠcollagen carboxy-terminal cross-linked peptide,ICTP)]水平,比较不同临床特征NSCLC患者血清miR-550a-5p水平,分析NSCLC脊柱骨转移分级与血清miR-550a-5p水平的相关性,受试者工作特征曲线(ROC)分析血清miR-550a-5p对NSCLC脊柱骨转移的诊断价值。结果脊柱骨转移组血清miR-550a-5p、CEA、NSE、CYFRA21-1、BALP、ICTP、NTx水平均高于无脊柱骨转移组(P<0.05);脊柱骨转移组不同肿瘤直径、分化程度、TNM分期、骨转移数量、淋巴结转移、骨相关事件、伴骨痛症状等临床特征NSCLC患者miR-550a-5p水平比较,差异有统计学意义(P<0.05);不同骨转移分级NSCLC患者血清miR-550a-5p、NSE、BALP、CEA、ICTP、CYFRA21-1、NTx水平比较差异有统计学意义(P<0.05),随骨转移分级增加血清miR-550a-5p水平、肺肿瘤标志物、骨代谢标志物均呈升高趋势。Spearman相关性分析显示,血清miR-550a-5p水平与骨转移分级、CEA、NSE、CYFRA21-1、BALP、ICTP、NTx均呈正相关(P<0.05);血清miR-550a-5p、肺肿瘤标志物、骨代谢标志物联合诊断的AUC值0.941(95%CI:0.878~0.978)(P<0.05),大于肺肿瘤标志物、骨代谢标志物联合诊断的AUC值0.902(95%CI:0.829~0.951)。结论miR-550a-5p应用于NSCLC脊柱骨转移诊断的价值较高,其水平与骨转移分级、肺肿瘤标志物、骨代谢标志物联系密切,加入miR-550a-5p可提高诊断价值。

CT检查与MRI检查诊断肺癌脊柱骨转移的准确性

目的:探讨CT检查与磁共振成像(MRI)检查对肺癌脊柱骨转移的诊断价值和准确性。方法:选取2021年5月—2023年5月广州市胸科医院收治的40例肺癌脊柱骨转移患者作为研究对象,回顾性分析其临床及影像资料,均实施螺旋CT、MRI检查,患者均经病理学检查确诊,评估分析CT、MRI对肺癌脊柱骨转移的诊断准确率、病灶类型检出情况。结果:40例患者经病理诊断均确诊为阳性,提示脊柱区均有骨转移;CT检查结果显示阳性29例,假阴性11例;MRI检查结果显示阳性29例,假阴性11例;MRI检查对肺癌脊柱骨转移的诊断准确率明显高于CT检查,差异有统计学意义(P<0.05);MRI检查对骨转移病灶类型检出率较CT检查高,差异有统计学意义(P<0.05)。结论:肺癌患者发生脊柱骨转移的风险高,相较于CT检查,应用MRI检查对肺癌脊柱骨转移的敏感度和准确率更高,可为疾病早期诊断和治疗提供可靠参考信息。

经皮椎体成形术与经皮椎体后凸成形术治疗脊柱转移瘤合并病理性骨折患者的临床疗效比较

目的比较经皮椎体成形术(PVP)与经皮椎体后凸成形术(PKP)治疗脊柱转移瘤合并病理性骨折患者的临床疗效。方法根据治疗方式的不同将86例脊柱转移瘤合并病理性骨折患者分为PVP组(n=40,PVP联合射频消融术)和PKP组(n=46,PKP联合射频消融术)。比较两组患者的疼痛程度[视觉模拟评分法(VAS)]、脊柱稳定性、脊髓神经功能改善情况、临床疗效、术后并发症发生情况及复发率。结果术后,两组患者VAS评分均低于本组术前,Cobb角均小于本组术前,PKP组患者VAS评分低于PVP组,Cobb角小于PVP组,差异均有统计学意义(P﹤0.05)。术后,PKP组患者脊髓神经功能优于PVP组,差异有统计学意义(P﹤0.05)。PKP组患者的总有效率高于PVP组,差异有统计学意义(P﹤0.05)。两组患者的术后并发症发生总发生率比较,差异无统计学意义(P﹥0.05)。随访3个月,PKP组患者的复发率低于PVP组,差异有统计学意义(P﹤0.05)。结论与PVP联合射频消融术相比,PKP联合射频消融术更能够缓解脊柱转移瘤合并病理性骨折患者的疼痛,改善脊柱稳定性和脊髓神经功能,临床疗效更好,术后复发率更低。

脊柱转移瘤术后再入院和再手术的驱动因素

目的探讨脊柱转移瘤(SM)患者术后再入院和再手术(RDRP)的驱动因素。方法选择2015年1月至2021年12月在该院接受手术治疗的203例SM患者临床资料进行回顾性分析,根据是否RDRP将患者分为RDRP组和非RDRP组,采用t检验、非参数检验、卡方检验等进行单因素分析,采用Logistic回归模型进行多因素分析,观察影响SM患者术后发生RDRP的独立风险因素。结果203例患者中,有34例出院后30 d内非计划内再次入院,发生率为16.75%。单因素分析显示,RDRP和非RDRP组患者的年龄、性别、体质量指数、吸烟、糖尿病、高血压、原发肿瘤部位、KPS评分、术前栓塞、术前WBC、Hb、PLT、MPV、手术入路、切口长度、输血及器械应用等差异均无统计学意义(P>0.05);RDRP组患者改良查尔森共病指数(CCI)、ASA分级>2级、术前放疗、住院时间、RDW等指标数据均高于非RDRP组患者(P<0.05)。多因素Logistic回归分析结果显示,仅改良CCI是SM患者术后发生RDRP的风险因素(P<0.05)。结论改良CCI是SM手术患者术后30 d内发生RDRP的重要风险因素。

三阶梯止痛法联合心理护理在脊柱转移瘤难治性癌痛患者中的应用效果

目的 探究三阶梯止痛法联合心理护理对脊柱转移瘤难治性癌痛患者的应用效果。方法 选取2020年1月至2022年12月浙江省丽水市中心医院收治的脊柱转移瘤难治性癌痛患者96例,采用随机数字表法将其分为常规干预组(48例)及联合干预组(48例)。常规干预组接受三阶梯止痛法联合常规护理干预;联合干预组在常规干预组的基础上联合心理护理干预。比较两组干预前后视觉模拟评分法(VAS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、医学应对问卷(MC-MQ)评分;比较两组干预后满意度评分。结果 干预后,两组VAS、SAS、SDS评分低于干预前,且联合干预组低于常规干预组,差异有统计学意义(P<0.05)。干预后,两组面对评分高于干预前,回避、屈服评分低于干预前,且联合干预组面对评分高于常规干预组,回避、屈服评分低于常规干预组,差异有统计学意义(P<0.05)。联合干预组疼痛管理、用药指导、心理干预、环境舒适度评分高于常规干预组,差异有统计学意义(P<0.05)。结论 三阶梯止痛法联合心理护理应用于脊柱转移瘤难治性癌痛患者具有较高的应用价值。

接受放疗的脊柱骨转移瘤患者总生存期与日常生活能力的关系

目的探讨接受放疗的脊柱骨转移瘤(SM)患者总生存期与日常生活能力(ADL)的关系。方法回顾性分析2018年1月~2021年1月在该院接受放疗的SM患者201例作为研究对象,收集患者临床参数和总生存期数据,以患者总生存期中位值进行划分,将患者分为分为预后良好组(≥2年)和预后不良组(<2年)。采用卡方检验、t检验或非参数检验比较预后良好组和预后不良组患者的临床资料,采用Cox风险模型进行多因素分析。结果单变量分析显示,预后良好组和预后不良组的ADL差异存在统计学意义(P<0.05);两组患者年龄、性别、医学共病、脊柱转移水平等资料差异均无统计学意义(P>0.05),两组患者NRS评分、原发部位、脑转移、其他脏器转移、脊柱稳定性和治疗策略等资料差异存在统计学意义(P<0.05)。Cox风险模型显示,高ADL、原发部位为乳腺、化疗是预后不良的保护性因素(P<0.05)。结论ADL是接受放疗的SM患者总生存期的影响因素之一,高ADL患者的总生存期高于低ADL患者。

基于能谱CT测定CT值、曲线斜率与脊柱转移瘤病人血管新生及预后的关系

目的探讨能谱CT测定CT值、能谱曲线斜率与脊柱转移瘤(SM)病人血管新生标志物及预后的关系。方法选取2021年5月至2023年5月我院85例SM病人作为研究组,另选同期85例恶性肿瘤无骨转移病人作为对照组,两组均行能谱CT测定,比较两组一般资料、能谱CT值(40~90 keV)及曲线斜率,并比较研究组SM肿瘤组织和瘤旁正常组织血管新生标志物[血管内皮生长因子(VEGF)、金属基质蛋白酶-9(MMP-9)]表达情况,分析能谱CT参数与SM肿瘤组织血管新生标志物的相关性。研究组随访1年,统计预后情况,比较死亡与存活病人临床资料,分析SM病人预后为死亡的影响因素,并分析能谱CT参数预测SM病人死亡的价值。结果研究组40~90 keV对应的CT值、曲线斜率均显著低于对照组(P<0.05);研究组肿瘤组织VEGF、MMP-9阳性表达率(76.47%、83.53%)高于瘤旁正常组织(44.71%、17.65%)(P<0.05);研究组CT值(40~90 keV)、曲线斜率与SM肿瘤组织VEGF、MMP-9阳性表达呈负相关(P<0.05);研究组完成随访的病人中,死亡病人确诊至转移时间短于存活病人,脏器转移占比、脊柱外骨转移占比高于存活病人,术后局部放疗占比、40 keV对应CT值、50 keV对应CT值、曲线斜率低于存活病人(P<0.05);确诊至转移时间、脏器转移、脊柱外骨转移、术后局部放疗、40 keV对应CT值、曲线斜率均为SM病人预后为死亡的独立影响因素(P<0.05);40 keV对应CT值、曲线斜率单独预测预后为死亡的AUC分别为0.805、0.798,联合预测的AUC为0.931,大于二者单独预测的AUC(P<0.05)。结论能谱CT测定CT值(40~90 keV)、曲线斜率与SM肿瘤组织血管新生标志物密切相关,其中40 keV对应CT值、曲线斜率均为SM病人预后为死亡的独立影响因素,二者联合可为临床预测预后提供可靠参考依据。

健康教育护理模式在前列腺癌脊柱转移行手术治疗患者中的应用效果

目的 观察健康教育护理模式在前列腺癌脊柱转移行手术治疗患者中的应用效果。方法 选取2016年10月至2021年10月收治的185例前列腺癌脊柱转移行手术治疗患者为研究对象,根据纳入时间将其分为对照组(2016年10月至2019年10月,89例)与观察组(2019年11月至2021年10月,96例)。对照组实施常规护理干预,观察组实施健康教育护理模式干预。比较两组的干预效果。结果 干预后,观察组的疼痛分级指数(PRI)、视觉模拟评分(VAS)、现在疼痛情况(PPI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)及Oswetry功能障碍指数(ODI)评分低于对照组,卡氏评分(KPS)评分高于对照组(P<0.05)。观察组的护理满意率高于对照组(P<0.05)。结论 健康教育护理模式在前列腺癌脊柱转移行手术治疗患者中的应用效果较好,值得推广及应用。

Evaluate the characteristics and clinical significance of “toxic twin-leaf” sign in spinal epidural metastases before percutaneous vertebroplasty

Objective: Our study aimed to analyze morphological features of spinal epidural metastases using magnetic resonance imaging(MRI) and investigate the formation mechanism and clinical significance of the "toxic twinleaf" sign in spinal epidural metastasis.Materials and methods: We retrospectively studied 108 patients with spinal epidural metastases who underwent MRI. Patients were divided into "toxic twin-leaf" sign group(group A) and irregular group(group B). Chi-square test was used to analyze data on sex, vertebra location, presence of fracture in the corresponding vertebral body,involvement of the corresponding pedicle, and the primary tumor. Further, group data were analyzed using the rank sum test;p < 0.05 was considered significant.Results: The "twin-leaf" sign was noted in 88 cases with 136 epidural masses and 20 cases of irregular shape in 108 patients;the "toxic twin-leaf" sign accounted for 87.18% of spinal epidural metastases. A difference between groups in the vertebra location(p < 0.01) was observed, but no differences were found in sex, presence of fractures in the corresponding vertebral body, involvement of the corresponding pedicle, and primary tumor(p >0.05). Intergroup differences in the rate of spinal stenosis on axial and sagittal images were significant.Conclusions: MRI axial sequences clearly revealed the morphology of spinal epidural metastases. Detection of the"toxic twin-leaf" sign in spinal epidural metastases was of great clinical significance. Furthermore, determining the degree of spinal stenosis in the axial sequence provided a more accurate evaluation of patients’ condition compared to the sagittal sequence.

Metastatic Spinal Cord Compression (MSCC) —The Evolving Story from Kashmir

Aim: To know the demographics of the patients most commonly involved by metastatic cord compression in Kashmir and to find the commonest primary organ to metastasize to spine causing cord compression. Methods: A hospital-based 10-year retro-prospective study was carried out in the Department of Neurosurgery of Sher-i-Kashmir Institute of Medical Sciences, Soura from July 2002 to June 2012, which is the premier tertiary care institute of the Kashmir valley. Patients were evaluated for metastatic spinal cord compression based on a standard proforma and specialized investigations were carried out and were deemed necessary by the concerned neurosurgical unit. Results: The commonest primary malignancy to metastasize to the spinal column in our study was Non-Hodgkin’s lymphoma, followed in turn by metastatic squamous cell carcinoma lung, metastatic intraductal carcinoma breast and metastatic adenocarcinoma prostate. Predominantly dorsal spine was the commonest region of spine involved by MSCC. Conclusion: Metastatic spinal cord compression is coming up in a big way. As the long-term cancer survivors increase due to multi-modality treatment protocols aimed at treating cancers and prolonging survival, there will be a proportionate increase in the number of patients who will potentially land up in metastatic spinal cord compression.

Intramedullary Spinal Cord Metastases in Breast Cancer: Report a Case

Background: Intramedullary spinal cord metastasis (ISCM) from breast cancer is a relatively rare disease. We present this disease. Case presentation: The patient was a 67-year-old woman with lung metastasis appearing 3 years after breast cancer surgery. Complete remission was achieved for the metastatic lesion with chemotherapy, but multiple cerebellar metastases were found 3 months after the completion of chemotherapy. Whole-brain irradiation was administered, resulting in symptomatic improvement. Approximately 6 months later, the patient experienced weakness in the lower extremities and difficulty walking. Magnetic resonance imaging detected a well-defined intraspinal tumor measuring 13 × 13 × 30 mm at the level of Th12-L1. After 20-Gy irradiation to the tumor, oral steroid administration, and rehabilitation, the patient regained the ability to walk. Eight months have passed, to date, since these interventions and the patient is currently receiving treatment for metastases to bones, including the spine, but is still capable of walking without difficulty. We herein report this case with a review of the relevant literature. Conclusion: ISCM in the breast cancer is relatively rare. But, it is the clinical condition which it should always place in the mind.