Many studies using diffusion tensor tractography（DTT） have demonstrated that injury of the spinothalamic tract（STT） is the pathogenetic mechanism of central post-stroke pain（CPSP） in intracerebral hemorrhage; ho...Many studies using diffusion tensor tractography（DTT） have demonstrated that injury of the spinothalamic tract（STT） is the pathogenetic mechanism of central post-stroke pain（CPSP） in intracerebral hemorrhage; however, there is no DTT study reporting the pathogenetic mechanism of CPSP in cerebral infarction. In this study, we investigated injury of the STT in patients with CPSP following cerebral infarction, using DTT. Five patients with CPSP following cerebral infarction and eight age-and sex-matched healthy control subjects were recruited for this study. STT was examined using DTT. Among DTT parameters of the affected STT, fractional anisotropy and tract volume were decreased by more than two standard deviations in two patients（patients 1 and 2） and three patients（patients 3, 4, and 5）, respectively, compared with those of the control subjects, while mean diffusivity value was increased by more than two standard deviations in one patient（patient 2）. Regarding DTT configuration, all affected STTs passed through adjacent part of the infarct and three STTs showed narrowing. These findings suggest that injury of the STT might be a pathogenetic etiology of CPSP in patients with cerebral infarction.展开更多
Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rota...Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rotation of the brain （Adams et al., 1982; Meythaler et al., 2001）. As a result, conventional brain imaging techniques including brain MRI have been limited in demon- strating neuronal degeneration in patients with DAI. However, diffusion tensor tractography （DTT）, which is derived from diffusion tensor imaging （DTI） has enabled three-dimensional reconstruction of the neural tracts （Jang and Seo, 2014）. Since the introduction of DTI, several studies have demonstrated neuronal degeneration after TBI （Tomaiuolo et al., 2005; Hong and lang, 2010; Kwon and Jang, 2014）. However, little is known about delayed neuronal degeneration in patients with TBI.展开更多
基金supported by the National Research Foundation(NRF)of Korea Grant funded by the Korean Government(MSIP),No.NRF-2015R1D1A1A01060314
文摘Many studies using diffusion tensor tractography（DTT） have demonstrated that injury of the spinothalamic tract（STT） is the pathogenetic mechanism of central post-stroke pain（CPSP） in intracerebral hemorrhage; however, there is no DTT study reporting the pathogenetic mechanism of CPSP in cerebral infarction. In this study, we investigated injury of the STT in patients with CPSP following cerebral infarction, using DTT. Five patients with CPSP following cerebral infarction and eight age-and sex-matched healthy control subjects were recruited for this study. STT was examined using DTT. Among DTT parameters of the affected STT, fractional anisotropy and tract volume were decreased by more than two standard deviations in two patients（patients 1 and 2） and three patients（patients 3, 4, and 5）, respectively, compared with those of the control subjects, while mean diffusivity value was increased by more than two standard deviations in one patient（patient 2）. Regarding DTT configuration, all affected STTs passed through adjacent part of the infarct and three STTs showed narrowing. These findings suggest that injury of the STT might be a pathogenetic etiology of CPSP in patients with cerebral infarction.
基金supported by the Medical Research Center Program(2015R1A5A2009124)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning
文摘Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rotation of the brain （Adams et al., 1982; Meythaler et al., 2001）. As a result, conventional brain imaging techniques including brain MRI have been limited in demon- strating neuronal degeneration in patients with DAI. However, diffusion tensor tractography （DTT）, which is derived from diffusion tensor imaging （DTI） has enabled three-dimensional reconstruction of the neural tracts （Jang and Seo, 2014）. Since the introduction of DTI, several studies have demonstrated neuronal degeneration after TBI （Tomaiuolo et al., 2005; Hong and lang, 2010; Kwon and Jang, 2014）. However, little is known about delayed neuronal degeneration in patients with TBI.
