Since high magnetic field（MF） intensity can improve the image quality and reduce magnetic resonance imaging（MRI） acquisition time, the field intensity of MRIs has continued to increase over the past few decades. A...Since high magnetic field（MF） intensity can improve the image quality and reduce magnetic resonance imaging（MRI） acquisition time, the field intensity of MRIs has continued to increase over the past few decades. Although MRIs in most current hospitals are 0.5 T–3 T, there are preclinical studies have been carried out using 9.4 T MRI, and engineers are also putting efforts on building MRIs with even higher MFs. However, the accompanied safety issue of high-field MRIs is an emergent question to address before their clinical applications. In the meantime, the static magnetic field（SMF） has been shown to inhibit tumor growth in previous studies. Here, we investigated both the safety issue and the anti-tumor potentials of 3.7 T–24.5 T SMFs on GIST-T1 gastrointestinal stromal tumor-bearing nude mice. We followed up the mice three weeks after their exposure to high SMF and found that none of the mice died or had severe organ damage, except for slightly decreased food intake, weight gain, and liver function. Moreover, the tumor growth was inhibited by 3.7 T–24.5 T SMFs（up to ～54%）. It is interesting that the effects are more dependent on MF gradient than intensities, and for the same gradient and intensity, mice responded differently to hypogravity and hypergravity conditions. Therefore, our study not only demonstrated the safeness of high SMFs up to 24.5 T on mice but also revealed their anti-tumor potentials in the future.展开更多
Academic biology-medicine refers to a couple of philosophies, Organicism and Mechanism, which translates into an association of Cybernetic diagrams and molecular Reductionism. This association presents logical difficu...Academic biology-medicine refers to a couple of philosophies, Organicism and Mechanism, which translates into an association of Cybernetic diagrams and molecular Reductionism. This association presents logical difficulties which make it unsuitable to describe correctly biological effects of electromagnetic fields, EMF. But these logical difficulties may be overcome when renewing the organic cell idea by means of a Philosophy of Nature which juxtaposes causality order and sense order in the cell. The signalsome, the set of descriptive components resulting from the genome, is constantly reorganized. This remodeling may become epigenetic when the phenotype becomes transformed by experience of perceptions in a given medium, because the perception of overall information coming from the extracellular medium becomes functional within the system. In that cellular perception, it is stated that the significance base which contributes to the sense order results from the qualitative topological structure of the extracellular medium. Therefore the EMF interactions target is not only the membrane and its molecules;it is also the structure of the extracellular medium which bathes the membrane. Knowing that the sense order modulation constitutes the global soil of the (localized) causality order, it is possible to obtain a same EMF bioeffect on a membrane molecule by treating a culture of cells in its bath or by treating only the extracellular aqueous medium. Consequently, the double bioeffect resulting from EMF exposure is described simply, because the sense order, such as it results from the qualitative structuring of the medium, forms the significance base which directs the causal mechanics of the cellular answer.展开更多
Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Fol...Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Following SMF stimulation, we measured blood flow volume in the paw and then reactive speed response to thermal stimulation. The AA groups exhibited significantly lower blood volume and reactivity to thermal stimulation compared to the control group. Compared to non-SMF, SMF exhibited increased blood flow volume in both the tail and paw, along with an increased reactive speed response to thermal stimulation. Our findings suggest that an improved of blood flow and reactive speed response, induced by SMF, appears to be effective for the relief of pain induced by chronic inflammation.展开更多
According to its own purposes, including survival, the cell reacts to the conditions of its medium. Such a vital phenomenon implies relational energetics. It includes unconscious psychic energy whose regulating model ...According to its own purposes, including survival, the cell reacts to the conditions of its medium. Such a vital phenomenon implies relational energetics. It includes unconscious psychic energy whose regulating model is the Life and Sense archetype. Its relational power could result from a natural algebraic property of extension. This extension can extend any organic magnitude to 4D event. Thus it allows some perception of the extracellular structure variations. This perception applies to moving forces of the cell signaling activators, through psychic energy. This psychical energy includes a potential, the cell attitude or status, and psychic moving forces, or tendencies. Insofar as the psychic potential is sensitive to proton structures, and the psychic moving forces are excitable by electron exchanges, a phase shift between us may occur. Medium stimulation by adequate magnetic fields could modulate this phase shift in a therapeutic direction.展开更多
In this paper, a spiral magnetic field electromagnetic stirrer, which can separately induce two different magnetic fields ,is introduced. The corresponding central magnetic flux curves of the stirrer were measured by ...In this paper, a spiral magnetic field electromagnetic stirrer, which can separately induce two different magnetic fields ,is introduced. The corresponding central magnetic flux curves of the stirrer were measured by two different probes of the Tesla meter. Meanwhile, the mentioned spiral magnetic field electromagnetic stirrer was used, the effect of the two different magnetic fields on solidification of Sn-I 1% Sb binary alloy was studied,and the segregations and metallographic structures of the ingot samples were analyzed. The research results show that, with the same electromagnetic stirring parameters,the spiral magnetic field electromagnetic stirring is more effective in reducing the composition difference between the upper and lower parts of the ingot. The microstructure photos show that the grain size was more refined.展开更多
The effect of spiral magnetic field （SMF） on the solidification process of Sn-20 wt.%Pb hypoeutectic alloy was studied in this work. The temperature distribution and the macrosegregation together with the eutectic l...The effect of spiral magnetic field （SMF） on the solidification process of Sn-20 wt.%Pb hypoeutectic alloy was studied in this work. The temperature distribution and the macrosegregation together with the eutectic lamellar spacing during solidification were measured under different magnetic fields. The results indicate that the compositions in the top and bottom portions of the sample are nearly the same and the segregation phenomenon is basically eliminated by SMF at an exciting current of 125 A. The morphology of the primary phase transforms from coarse dendrite to rosette or ellipsoidal equiaxed crystal and the spacing of the eutectic lamellar increases from 1.6 to 3.9 μm when the exciting current increases from 0 to 125 A. Moreover, if the exciting current is high enough, the forced fluid flow caused by SMF will enhance the process of transition from lamellar eutectic structure to anomalous rod-like one.展开更多
Multiply-connected Hall plates show different phenomena than singly connected Hall plates. In part I (published in Journal of Applied Physics and Mathematics), we discussed topologies where a stream function can be de...Multiply-connected Hall plates show different phenomena than singly connected Hall plates. In part I (published in Journal of Applied Physics and Mathematics), we discussed topologies where a stream function can be defined, with special reference to Hall/Anti-Hall bar configurations. In part II, we focus on topologies where no conventional stream function can be defined, like Corbino disks. If current is injected and extracted at different boundaries of a multiply-connected conductive region, the current density shows spiral streamlines at strong magnetic field. Spiral streamlines also appear in simply-connected Hall plates when current contacts are located in their interior instead of their boundary, particularly if the contacts are very small. Spiral streamlines and circulating current are studied for two complementary planar device geometries: either all boundaries are conducting or all boundaries are insulating. The latter case means point current contacts and it can be treated similarly to singly connected Hall plates with peripheral contacts through the definition of a so-called loop stream function. This function also establishes a relation between Hall plates with complementary boundary conditions. The theory is explained by examples.展开更多
The strong static magnetic fields (SMFs) have caused great health concerns on the potential occupational and public exposure in recent year. However, the evidence in support of
基金Project supported by the National Key R&D Program of China(Grant Nos.2016YFA0400900 and 2017YFA0402903)the National Natural Science Foundation of China(Grant Nos.U1532151 and 51627901)+2 种基金the Major/Innovative Program of Development Foundation of Hefei Center for Physical Science,Technology(Grant No.2016FXCX004)Hefei Science Center,CAS(Grant No.2016HSC-IU007)the CASHIPS Director’s Fund(Grant No.YZJJ201704)to Qingyou Lu and Xin Zhang
文摘Since high magnetic field（MF） intensity can improve the image quality and reduce magnetic resonance imaging（MRI） acquisition time, the field intensity of MRIs has continued to increase over the past few decades. Although MRIs in most current hospitals are 0.5 T–3 T, there are preclinical studies have been carried out using 9.4 T MRI, and engineers are also putting efforts on building MRIs with even higher MFs. However, the accompanied safety issue of high-field MRIs is an emergent question to address before their clinical applications. In the meantime, the static magnetic field（SMF） has been shown to inhibit tumor growth in previous studies. Here, we investigated both the safety issue and the anti-tumor potentials of 3.7 T–24.5 T SMFs on GIST-T1 gastrointestinal stromal tumor-bearing nude mice. We followed up the mice three weeks after their exposure to high SMF and found that none of the mice died or had severe organ damage, except for slightly decreased food intake, weight gain, and liver function. Moreover, the tumor growth was inhibited by 3.7 T–24.5 T SMFs（up to ～54%）. It is interesting that the effects are more dependent on MF gradient than intensities, and for the same gradient and intensity, mice responded differently to hypogravity and hypergravity conditions. Therefore, our study not only demonstrated the safeness of high SMFs up to 24.5 T on mice but also revealed their anti-tumor potentials in the future.
文摘Academic biology-medicine refers to a couple of philosophies, Organicism and Mechanism, which translates into an association of Cybernetic diagrams and molecular Reductionism. This association presents logical difficulties which make it unsuitable to describe correctly biological effects of electromagnetic fields, EMF. But these logical difficulties may be overcome when renewing the organic cell idea by means of a Philosophy of Nature which juxtaposes causality order and sense order in the cell. The signalsome, the set of descriptive components resulting from the genome, is constantly reorganized. This remodeling may become epigenetic when the phenotype becomes transformed by experience of perceptions in a given medium, because the perception of overall information coming from the extracellular medium becomes functional within the system. In that cellular perception, it is stated that the significance base which contributes to the sense order results from the qualitative topological structure of the extracellular medium. Therefore the EMF interactions target is not only the membrane and its molecules;it is also the structure of the extracellular medium which bathes the membrane. Knowing that the sense order modulation constitutes the global soil of the (localized) causality order, it is possible to obtain a same EMF bioeffect on a membrane molecule by treating a culture of cells in its bath or by treating only the extracellular aqueous medium. Consequently, the double bioeffect resulting from EMF exposure is described simply, because the sense order, such as it results from the qualitative structuring of the medium, forms the significance base which directs the causal mechanics of the cellular answer.
文摘Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Following SMF stimulation, we measured blood flow volume in the paw and then reactive speed response to thermal stimulation. The AA groups exhibited significantly lower blood volume and reactivity to thermal stimulation compared to the control group. Compared to non-SMF, SMF exhibited increased blood flow volume in both the tail and paw, along with an increased reactive speed response to thermal stimulation. Our findings suggest that an improved of blood flow and reactive speed response, induced by SMF, appears to be effective for the relief of pain induced by chronic inflammation.
文摘According to its own purposes, including survival, the cell reacts to the conditions of its medium. Such a vital phenomenon implies relational energetics. It includes unconscious psychic energy whose regulating model is the Life and Sense archetype. Its relational power could result from a natural algebraic property of extension. This extension can extend any organic magnitude to 4D event. Thus it allows some perception of the extracellular structure variations. This perception applies to moving forces of the cell signaling activators, through psychic energy. This psychical energy includes a potential, the cell attitude or status, and psychic moving forces, or tendencies. Insofar as the psychic potential is sensitive to proton structures, and the psychic moving forces are excitable by electron exchanges, a phase shift between us may occur. Medium stimulation by adequate magnetic fields could modulate this phase shift in a therapeutic direction.
文摘In this paper, a spiral magnetic field electromagnetic stirrer, which can separately induce two different magnetic fields ,is introduced. The corresponding central magnetic flux curves of the stirrer were measured by two different probes of the Tesla meter. Meanwhile, the mentioned spiral magnetic field electromagnetic stirrer was used, the effect of the two different magnetic fields on solidification of Sn-I 1% Sb binary alloy was studied,and the segregations and metallographic structures of the ingot samples were analyzed. The research results show that, with the same electromagnetic stirring parameters,the spiral magnetic field electromagnetic stirring is more effective in reducing the composition difference between the upper and lower parts of the ingot. The microstructure photos show that the grain size was more refined.
基金supported by the National Natural Science Foundation of China (No.50875031)High-Tech Project of Bao Steel (No.10K029ECES)
文摘The effect of spiral magnetic field （SMF） on the solidification process of Sn-20 wt.%Pb hypoeutectic alloy was studied in this work. The temperature distribution and the macrosegregation together with the eutectic lamellar spacing during solidification were measured under different magnetic fields. The results indicate that the compositions in the top and bottom portions of the sample are nearly the same and the segregation phenomenon is basically eliminated by SMF at an exciting current of 125 A. The morphology of the primary phase transforms from coarse dendrite to rosette or ellipsoidal equiaxed crystal and the spacing of the eutectic lamellar increases from 1.6 to 3.9 μm when the exciting current increases from 0 to 125 A. Moreover, if the exciting current is high enough, the forced fluid flow caused by SMF will enhance the process of transition from lamellar eutectic structure to anomalous rod-like one.
文摘Multiply-connected Hall plates show different phenomena than singly connected Hall plates. In part I (published in Journal of Applied Physics and Mathematics), we discussed topologies where a stream function can be defined, with special reference to Hall/Anti-Hall bar configurations. In part II, we focus on topologies where no conventional stream function can be defined, like Corbino disks. If current is injected and extracted at different boundaries of a multiply-connected conductive region, the current density shows spiral streamlines at strong magnetic field. Spiral streamlines also appear in simply-connected Hall plates when current contacts are located in their interior instead of their boundary, particularly if the contacts are very small. Spiral streamlines and circulating current are studied for two complementary planar device geometries: either all boundaries are conducting or all boundaries are insulating. The latter case means point current contacts and it can be treated similarly to singly connected Hall plates with peripheral contacts through the definition of a so-called loop stream function. This function also establishes a relation between Hall plates with complementary boundary conditions. The theory is explained by examples.
基金supported by National Nature Science Foundation of China under Grant nos. 30570442Hundred Talents Program of The Chinese Academy of SciencesKey Talent Program of Hefei institutes of Physical Science, CAS
文摘The strong static magnetic fields (SMFs) have caused great health concerns on the potential occupational and public exposure in recent year. However, the evidence in support of
