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A Pair of New Spirocyclic Alkaloid Enantiomers with TrxR Inhibitory Activities Were Isolated from Marine-Derived Aspergillus ruber TX-M4-1 被引量:1
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作者 WANG Cong WANG Yufei +4 位作者 SUN Jian WANG Shiyi DU Weisheng ZHOU Liman KONG Fandong 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第6期1677-1682,共6页
One new spirocyclic alkaloid,5-isopentenyl-cryptoechinuline D(1),along with 11 known compounds(2–12),were iso-lated from a marine fungus Aspergillus ruber TX-M4-1.The structures of compounds 1–12 were elucidated by ... One new spirocyclic alkaloid,5-isopentenyl-cryptoechinuline D(1),along with 11 known compounds(2–12),were iso-lated from a marine fungus Aspergillus ruber TX-M4-1.The structures of compounds 1–12 were elucidated by spectroscopic evi-dences.Compound 1 was initially isolated as an enantiomer,and further separation of 1 by chiral HPLC afforded a pair of enantio-mers,including(-)-5-isopentenyl-cryptoechinuline D(1a)and(+)-5-isopentenyl-cryptoechinuline D(1b).Their absolute configura-tions were elucidated by ECD spectroscopic data.Compounds 1a,5 and 10 could inhibit thioredoxin reductase(TrxR)activity with IC50 values of 6.2,36.3 and 18.6μmol L^(-1),respectively.Surface plasmon resonance(SPR)study also demonsrated the interactions between compounds 6,8 and Niemann-Pick C1 Like 1(NPC1L1)respectively,which indicate that compounds 6 and 8 are potential NPC1L1 inhibitors. 展开更多
关键词 Aspergillus ruber TX-M4-1 spirocyclic alkaloid TrxR inhibitory activity
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A Facile Synthesis of N-Substituted Spirocyclic Diester of α-Aminophosphonic Acid
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作者 Qing DAI Hua WO Ru Yu CHEN(Institute and State’s Key Laboratory of Elemento-Organic Chemistry,Nankai University, Tianjin 300071) 《Chinese Chemical Letters》 SCIE CAS CSCD 1998年第1期11-12,共2页
A simple and direct method for preparation of N-substituted spirocyclic dieSter of □-amino phosphonic acid (4) in high yield is introduced. The reaction consists of the threecomponent reachon of phenylurea (1), an ar... A simple and direct method for preparation of N-substituted spirocyclic dieSter of □-amino phosphonic acid (4) in high yield is introduced. The reaction consists of the threecomponent reachon of phenylurea (1), an aromatic aldehyde (2), and 3,9-dichloro-2,4,8,10-tetraoxa- 3, 9 -diphosphaspiro [5,5] undecane (3) in anhydrous benzene. 展开更多
关键词 spirocyclic diester α-aminophosphonic acid
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A spirocyclic oxindole analogue:Synthesis and antitumor activities 被引量:5
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作者 Hui Hong Long Jiang Huang Da Wei Teng 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第9期1009-1012,共4页
A new synthesis of spirocyclic oxindole analogue spiro[piperidine-4,3'-pyrrolol2,3-b]pyridin]-2'(1'H)-one 1 is described. The key steps involve dialkylation of arylacetonitrile and cyclization of the azaoxindole ... A new synthesis of spirocyclic oxindole analogue spiro[piperidine-4,3'-pyrrolol2,3-b]pyridin]-2'(1'H)-one 1 is described. The key steps involve dialkylation of arylacetonitrile and cyclization of the azaoxindole ring by an intramolecular Buchwald-Hartwig amidation of carboxylic amide and aryl chloride. A small library was obtained by reductive amination of 1 with various aldehydes and was screened against human lung cancer cell A549, human liver cancer cell BEL7402, and human colon cancer cell HCT-8. The results show that most of the library compounds 2 have some inhibitory activities. 2-(Trifluoromethoxy) benzylic substituted spirocyclic azaoxindole 2e was identified as a nanomolar inhibitor against human lung cancer cell A-549 (IC50 = 50 nmol/L). 展开更多
关键词 spirocyclic oxindole Aryl amidation Dialkylation Antitumor activity
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Syntheses and Insecticidal Activity of Spirocyclic Tetronic Acid Derivatives Containing Oxime Ether Moiety 被引量:3
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作者 ZHAO Yang CHENG Jingli +2 位作者 XIE Zhengang FANG Shaowei ZHAO Jinhao 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2020年第5期810-815,共6页
In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compound... In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compounds were characterized by lH NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilapmyata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L)against A.fabae as the spirotetramat(LC50=4.56 mg/L)and had better efIects(LC50=l.64 mg/L)against N.lugens in comparison with spirotetramat(LC5o=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests. 展开更多
关键词 spirocyclic tetronic acid derivative Insecticidal activity Oxime ether moiety
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Asymmetric Double Michael Reaction Catalyzed by Simple Primary Amine Catalysts: A Straightforward Approach to Construct Spirocyclic Oxindoles 被引量:2
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作者 罗西娅 汪亮亮 +6 位作者 彭林 摆建飞 贾利娜 贺光云 田芳 徐小英 王立新 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第5期1185-1188,共4页
The enantioselective double Michael reaction of N-Boc-3-nonsubstitued oxindoles with dienones catalyzed by chiral monoimide protected cyclohexane-1,2-diamines was developed. A wide range of optically active spirocycli... The enantioselective double Michael reaction of N-Boc-3-nonsubstitued oxindoles with dienones catalyzed by chiral monoimide protected cyclohexane-1,2-diamines was developed. A wide range of optically active spirocyclic oxindoles were obtained up to 98% yield and up to 89% ee. 展开更多
关键词 double Michael reaction spirocyclic oxindole amine catalyst ORGANOCATALYSIS
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Aromatic and olefinic C–H alkenylation by catalysis with spirocyclic NHC Ru(Ⅳ) pincer complex 被引量:1
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作者 Heng Cai Yong-Qiang Tu +5 位作者 Ka Lu Qi-Long Chen Fu-Min Zhang Xiao-Ming Zhang Yuan-Jiang Pan Zhi-Bo Yan 《Science China Chemistry》 SCIE EI CAS CSCD 2023年第10期2791-2796,共6页
Catalyst innovation lies at the heart of transition-metal-catalyzed reaction development. In this article, we have explored the C(sp2)–H alkenylation activity with novel spirocyclic N-heterocyclic carbene(NHC)-based ... Catalyst innovation lies at the heart of transition-metal-catalyzed reaction development. In this article, we have explored the C(sp2)–H alkenylation activity with novel spirocyclic N-heterocyclic carbene(NHC)-based cyclometalated ruthenium pincer catalyst system, SNRu-X. After screening catalyst and condition, a high valent Ru(Ⅳ) dioxide(X = O_(2)) species has demonstrated superior reactivity in the catalytic alkenylation of aromatic and olefinic C–H bonds with unactivated alkenyl bromides and triflates. This reaction has achieved the easy construction of a wide range of(hetero)aromatic alkenes and dienes, in good to excellent yields with exclusive selectivity. Preliminary mechanistic studies indicate that this reaction may proceed through a single electron transfer(SET) triggered oxidative addition, by doing so, providing valuable complementary to classical alkenylation reactions that are dependent on activated alkenyl precursors. 展开更多
关键词 transitionmetal catalysis spirocyclic NHC-Ru pincer catalyst C-H alkenylation single electron transfer pathway unactivated alkenyl bromides and triflates
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Development of unique dianionic Ir(Ⅲ) CCC pincer complexes with a favourable spirocyclic NHC framework 被引量:1
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作者 Zhi-Bo Yan Kun-Long Dai +7 位作者 Bin-Miao Yang Zi-Hao Li Yong-Qiang Tu Fu-Min Zhang Xiao-Ming Zhang Meng Peng Qi-Long Chen Ze-Ran Jing 《Science China Chemistry》 SCIE EI CAS CSCD 2020年第12期1761-1766,共6页
A new type of dianionic Ir(Ⅲ) CCC pincer complexes(SNHC-Ir, 1a–1c) is successfully designed and synthesized by developing a one-step methodology, which involves an initial coordination of Ir(I) with the NHC and subs... A new type of dianionic Ir(Ⅲ) CCC pincer complexes(SNHC-Ir, 1a–1c) is successfully designed and synthesized by developing a one-step methodology, which involves an initial coordination of Ir(I) with the NHC and subsequent metallation of double sp2C–H bonds. This method is considerably useful over those reported by using strong coordination ligand or carbonic anion exchange,and would provide an alternative efficient template of organometallics synthesis. Experimental and density functional theory(DFT) calculation results indicate that the spirocyclic framework is a favourable factor for the facile formation and stabilization of these complexes. Primary investigation shows that chloride 1b can well catalyze homo and hetero addition of styrene derivatives and remote olefin isomerization, which represents the first catalytic application of the dianionic CCC pincer complexes. 展开更多
关键词 spirocyclic NHC framework dianionic CCC pincer complexes iridium-catalyzed C–H activation
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Rapid assembly of 1,3-indanedione-based spirocyclic tetrahydroquinolines for inducing human lung cancer cell apoptosis 被引量:1
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作者 Fen Tan Luojia Chen +6 位作者 Yuncong Yuan Xiaoyu He Yiwen Su Shuqiang Cao Conghua Xie Meijia Gu Youquan Zou 《Green Synthesis and Catalysis》 2022年第4期357-372,共16页
The rapid collection of a library of biologically relevant molecules is essential in new drug discovery.Here we show a variety of bioactive 1,3-indanedione-based spirocyclic tetrahydroquinolines that have been concise... The rapid collection of a library of biologically relevant molecules is essential in new drug discovery.Here we show a variety of bioactive 1,3-indanedione-based spirocyclic tetrahydroquinolines that have been concisely and efficiently constructed under the guidance of biology-oriented synthesis(BIOS).Using Pd(PPh_(3))_(4) as a catalyst,various 2-arylidene-1,3-indanediones can react with vinyl benzoxazinanones under the mild condition to afford a new class of spirocyclic tetrahydroquinolines in moderate to excellent yields(45%-99%)with high stereocontrol(>95:5 diastereoselectivity).Their structures were unambiguously confirmed by X-ray single crystal analysis.The biological evaluation revealed that two of the 1,3-indanedione-based spirocyclic tetrahydroquinolines show remarkable apoptosis-inducing activities over A549 human lung cancer cells,exceeding that of cisplatin.The antitur activities were triggered by reactive oxygen species,commonly overproduced in cancer cells.The clinical demand for antitumor chemotherapy for lung cancer has encouraged an all-out search for analogues with lower toxcity,improved therapeutic index and increased activity. 展开更多
关键词 spirocyclic tetrahydroquinoline 1 3-Indanedione Lung cancer Apoptosis MITOCHONDRIA
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Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination
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作者 Zhiwei Xiao Huiyi Wei +19 位作者 Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong Li Weibin Zhang Huangcan Chen Yuefeng Li Lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.Liang Lu Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第4期1963-1975,共13页
As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium... As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological disorders.Indeed,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A inhibitors.In this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards PDE10A.Further,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer kinetics.Preclinical studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]MNI659.Further,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher species.In conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation. 展开更多
关键词 Phosphodiesterase 10A PET radioligand 18F spirocyclic iodonium ylide Nonhuman primate Target occupancy
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Polycyclic polyprenylated acylphloroglucinol with an unprecedented spirocyclic core from Hypericum patulum
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作者 Yansong Ye Nana Jiang +1 位作者 Xianwen Yang Gang Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第9期2433-2436,共4页
Spirohypatone A(1),a spirocyclic PPAP(polycyclic polyprenylated acylphloroglucinol) bearing an unprecedented hexahydro-1’H-spiro[cyclohexane-1,2’-pentalene]-2,4,6-trione core and a new homologue(spirohypatone B,2) w... Spirohypatone A(1),a spirocyclic PPAP(polycyclic polyprenylated acylphloroglucinol) bearing an unprecedented hexahydro-1’H-spiro[cyclohexane-1,2’-pentalene]-2,4,6-trione core and a new homologue(spirohypatone B,2) were isolated from Hypericum patulum together with two known biosynthetic precursors.Compound 1 represents the first spirocyclic PPAP possessing a 5/5/6 carbon ring system,biogenetically derived from the intermediate 3(attack from C-3 to C-12),which was differed from normal spirocyclic PPAPs(attack from C-3 to C-11).In addition,through extensive spectroscopic analysis,an interconversion mechanism of keto-enol of 1 was postulated and confirmed by its methylated reaction.The structures and absolute configurations of 1 and 2 were determined by comprehensive spectroscopic and chemical derivatized methods and X-ray crystallography.Compounds 1,2,and 4 were tested to exhibit cytotoxic activities against several cancer cell lines. 展开更多
关键词 spirocyclic PPAP Hypericum patulum Structural elucidation DERIVATIVES Cytotoxic activities
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Palladium-catalyzed cascade synthesis of spirocyclic oxindoles via regioselective C2-H arylation and C8-H alkylation of naphthalene ring
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作者 Xiai Luo Wenguang Li +4 位作者 Haiyan Lu Guobo Deng Yuan Yang Chunming Yang Yun Liang 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第2期713-716,共4页
A simultaneous C2-H arylation and C8-H alkylation of naphthalene ring has been achieved by palladiumcatalyzed cascade reaction of N-(2-halophenyl)-2-(naphthalen-1-yl)acrylamides with aryl iodides,which provides an eff... A simultaneous C2-H arylation and C8-H alkylation of naphthalene ring has been achieved by palladiumcatalyzed cascade reaction of N-(2-halophenyl)-2-(naphthalen-1-yl)acrylamides with aryl iodides,which provides an efficient method for synthesizing various aryl-substituted spirocyclic oxindoles.The protocol enables three C-C bonds formation via an intramolecular Heck reaction and sequentially regioselective C-H bond activation. 展开更多
关键词 PALLADIUM-CATALYZED Cascade reaction Regioselective C-H activation Naphthalene ring spirocyclic oxindoles
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Organocatalytic Asymmetric Double Michael Reaction of Benzofuranone with Dienones to Construct Spirocyclic Benzofuranones
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作者 罗西娅 汪亮完 +5 位作者 彭林 摆建飞 贾利娜 田芳 徐小英 王立新 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第11期2703-2706,共4页
The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% ... The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee. 展开更多
关键词 double Michael reaction spirocyclic compounds BENZOFURANONE ORGANOCATALYSIS
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Visible-light-induced novel cyclization of 2-(2-(arylethynyl)benzylidene)-malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol to bridged spirocyclic compounds
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作者 Xiaofei Xie Lei Wang +3 位作者 Quan Zhou Yongmin Ma Zhi-Ming Wang Pinhua Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第12期5069-5073,共5页
A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-met... A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol(BHT)at room temperature was developed.The photoinduced radical reactions generated the corresponding products in good yields under simple and mild reaction conditions. 展开更多
关键词 2-(2-(Arylethynyl)benzylidene)malononitriles 2 6-Di(tert-butyl)-4-methylphenol Bridged spirocyclic compounds Visible-light-induced organosynthesis
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Multiresponsive Luminescent Behaviors of Assembled Spirocyclic Nonanuclear Silver(I)Clusters
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作者 Han Wu Siqi Zhang Liang Zhao 《CCS Chemistry》 CAS 2022年第10期3364-3377,共14页
Supramolecular assembly is regarded as an effective strategy to endow metal clusters with rich and unique photophysical properties.However,the detailed mechanisms and influential factors for intercluster assemblies an... Supramolecular assembly is regarded as an effective strategy to endow metal clusters with rich and unique photophysical properties.However,the detailed mechanisms and influential factors for intercluster assemblies and their effects on luminescent properties remain unclear to date.In this work,we constructed a series of spirocyclic nonanuclear silver cluster compounds with varying alkyl chain lengths,which demonstrated distinct supramolecular assembly behaviors depending on temperature,concentration,and solvent polarity. 展开更多
关键词 silver compound supramolecular assembly mechanochromic luminescence aggregation-induced emission spirocyclic cluster
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Synthesis, Structure and Antimicrobial Activity of 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxaza- phosphinine-3,3′-indolin]-2′-one 2-oxide 被引量:1
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作者 刘仁蝶 孔杜林 +2 位作者 吴明书 李高楠 李国柱 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2014年第2期204-208,共5页
A novel spiro-compound(C20 H15 N2 O3 P) has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, s... A novel spiro-compound(C20 H15 N2 O3 P) has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 /c with a = 9.1628(7), b = 12.9490(7), c = 15.7898(11), β = 103.952(8)o, Mr = 36.08, V = 1818.2(2)3, Z = 4, Dc = 1.382 g/cm3, F(000) = 788, μ = 0.179 mm-1, R = 0.0701 and wR = 0.1513. The preliminary biological test showed that the title compound has activities against Escherichia coli, S.albus, Bacillus subtilis, Staphylocc- ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg/mL, respectively. 展开更多
关键词 SYNTHESIS crystal structure HETEROCYCLE spirocyclic
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Syntheses and Crystal Structures of Two Tin(Ⅳ) Complexes with Aminosilane Bearing Ligand
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作者 丁毅 杨智 +2 位作者 郝鹏飞 钟明东 杨鹰 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2013年第6期799-804,共6页
Aminosilane bearing bulky substituents on nitrogen: LH2 (L = Me2Si(NDipp')2, Dipp = 2,6-diisopropylphenyl) was reacted with BuLi in toluene. The resulting bulky chelating dianion Me2Si(NDipp)2 was used to synt... Aminosilane bearing bulky substituents on nitrogen: LH2 (L = Me2Si(NDipp')2, Dipp = 2,6-diisopropylphenyl) was reacted with BuLi in toluene. The resulting bulky chelating dianion Me2Si(NDipp)2 was used to synthesize the unusual spirocyclic heterotriatomic complex [MeESi(NDipp)2]ESn (1) by its reaction with SnCl4 and the bulky heterotriatomic complex Me2Si(NDipp)2SnPh2 (2) with Ph2SnC12. 1 belongs to the monoclinic system, space group P21/n with a = 13.193(2), b = 20.663(3), c = 20.403(3)A, β = 99.954(2)°, V = 5478.3(15) A3, C55H85.5N4Si2Sn, Mr = 977.64, Z = 4, Dc. = 1.185 Mg/m3, μ(MoKa) = 0.547 mm-1, F(000) = 2086, S = 1.000, the final R = 0.0614 and wR = 0.1322 for 14446 observed reflections (1 〉 2σ(I)) and R = 0.0797 and wR = 0.1456 for all data. 2 belongs to the triclinic system, space group P1 with a = 10.36(15), b = 13.204(7), c = 14.363(7) A, a = 90.214(10), β = 106.182(7), y = 109.854(8)°, V = 1764.4(15) A3, C38HsoN2SiSn, M,. = 681.58, Z = 2, Dc = 1.283 Mg/m^3,μ(MoKa) = 0.785 mm-1, F(000) = 712, S = 1.002, the final R = 0.0498 and wR = 0.0955 for 7533 observed reβections (I 〉 2σ(I)) and R = 0.0676 and wR = 0.1018 for all data. In the structure of 1, the tin atom is located in the spirocyclic center of the two fused four-membered SnN2Si rings. The two complexes were characterized by ^1H NMR, elemental analysis, and single-crystal X-ray structural analysis. 展开更多
关键词 AMINOSILANE bulky chelating ligand tin(IV) spirocyclic
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“Steric Armor”Strategy of Blue Fluorescent Emitters against Photooxidation-Induced Degradation
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作者 Sha-Sha Wang Jing-Rui Zhang +8 位作者 Kuan-De Wang Hao-Ran Li Peng-Hui Meng Yang Zhou Xiang Yu Ying Wei Quan-You Feng Yu-He Kan Ling-Hai Xie 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第11期1223-1229,共7页
Stability against oxygen is an important factor affecting the performance of organic semiconductor devices.Improving photooxidation stability can prolong the service life of the device and maintain the mechanical and ... Stability against oxygen is an important factor affecting the performance of organic semiconductor devices.Improving photooxidation stability can prolong the service life of the device and maintain the mechanical and photoelectric properties of the device.Generally,various encapsulation methods from molecular structure to macroscopic device level are used to improve photooxidation stability.Here,we adopted a crystallization strategy to allow 14H-spiro[dibenzo[c,h]acridine-7,9′-fluorene](SFDBA)to pack tightly to resist fluorescence decay caused by oxidation.In this case,the inert group of SFDBA acts as a“steric armor”,protecting the photosensitive group from being attacked by oxygen.Therefore,compared with the fluorescence quenching of SFDBA powder under 2 h of sunlight,SFDBA crystal can maintain its fluorescence emission for more than 8 h under the same conditions.Furthermore,the photoluminescence quantum yields(PLQYs)of the crystalline film is 327%higher than that of the amorphous film.It shows that the crystallization strategy is an effective method to resist oxidation. 展开更多
关键词 Organic semiconductor PHOTOOXIDATION spirocyclic aromatic hydrocarbons Crystal engineering Fluorescence
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Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell
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作者 Ting Liu Zhaojiang Shi +2 位作者 Yaofeng Yuan Yuqi Lin Ke-Yin Ye 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第9期980-984,共5页
The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals.Herein,we disclose an electrochemical d... The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals.Herein,we disclose an electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow cell.The reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis. 展开更多
关键词 Electrochemistry CONTINUOUS-FLOW DEAROMATIZATION SPIROCYCLIZATION SULFONAMIDES CYCLIZATION Methodology and reactions
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Cobalt-Catalyzed Switchable[4+1]and[4+1+1]Spirocyclization of Aromatic Amides with 2-Diazo-1H-indene-1,3(2H)-dione:Access to Spiro Indene-2,1'-isoindolinones and Spiro Isochroman-3,1'-isoindolinones
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作者 Bin Li Mengmeng Xie +3 位作者 Jingyu Li Nana Shen Xinying Zhang Xuesen Fan 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第4期363-369,共7页
Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromat... Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-dione.When the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]spirocyclization.When the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen source.In general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility. 展开更多
关键词 Spiro indene-2 1'-isoindolinones Spiro isochroman-3 1'-isoindolinones 3d Transition metals Cobalt-catalyzed C-H Activation Switchable[4+1]and[4+1+1]spirocyclization Aromatic amides 2-Diazo-1H-indene-1 3(2H)-dione
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Chemical Constituents from Hypericum beanii 被引量:12
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作者 Da-song Yang Zi-lei Li +2 位作者 Yong-ping Yang Xiao-li Li Wei-lie Xiao 《Chinese Herbal Medicines》 CAS 2015年第4期375-379,共5页
Objective To study the chemical constituents from the aerial parts of Hypericum beani/. Methods Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the bas... Objective To study the chemical constituents from the aerial parts of Hypericum beani/. Methods Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results Fifteen compounds were isolated from the aerial parts of H. beanii. Their structures were identified as hyperbeanol E (1), (E)-Iinalool-l-oic acid (2), (4S,5R)-5-(4'-methyl-3'-pentenyl)-4-hydroxy-5-methyl- dihydrofuran-2-one (3), benzoic acid (4), 4-(3-O-3")-3"-methylbutenyl-6-phenyl- pyran-2-one (5), 4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxJn-2(3H)- one (6), isoimperatorin (7), 2,3-dimethoxyxanthone (8), 3,4-dihydroxy-2- methoxyxanthone (9), osajaxanthone (10), nigrolineaxanthone F (1 1), hypercohone G (12), betulinic acid (1 3), oleanolic acid 3.13-caffeate (14), and isoastilbin (1 5). Conclusion Compound 1 is a new menthane monoterpene derivative which owns an extra lactone ring. Compounds 2-7 and 10-1 5 are isolated from genus Hypericum Linn. for the first time and the other compounds are first obtained from the plants in H. beanii. 展开更多
关键词 hyperbeanol E Hypericum Linn. Hypericum beanii menthane monoterpene spirocyclic acylphloroglucinol XANTHONE
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