There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating ...There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating design guided by this behavior. The design method carries out in four steps, first step is to focus on the analysis of individual action phase, pay attention to the explora- tion of the relationship between actions and tool ,and then list the importance order in the action phase, the third step is to take out the in-depth anatomical analysis of the stage, analyze the reason of the operational difficulty .and at last carries out the design concept to resolve the problem. All in all, this method revolves around the main stage of spontaneous behavior, and analyzes it in interim and solves the problem in stage.展开更多
Autism spectrum disorders(ASD)are characterized by social and repetitive abnormalities.Although the ASD mouse model with Shank3b mutations is widely used in ASD research,the behavioral phenotype of this model has not ...Autism spectrum disorders(ASD)are characterized by social and repetitive abnormalities.Although the ASD mouse model with Shank3b mutations is widely used in ASD research,the behavioral phenotype of this model has not been fully elucidated.Here,a 3D-motion capture system and linear discriminant analysis were used to comprehensively record and analyze the behavioral patterns of male and female Shank3b mutant mice.It was found that both sexes replicated the core and accompanied symptoms of ASD,with significant sex differences.Further,Shank3b heterozygous knockout mice exhibited distinct autistic behaviors,that were significantly different from those those observed in the wild type and homozygous knockout groups.Our findings provide evidence for the inclusion of both sexes and experimental approaches to efficiently characterize heterozygous transgenic models,which are more clinically relevant in autistic studies.展开更多
文摘There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating design guided by this behavior. The design method carries out in four steps, first step is to focus on the analysis of individual action phase, pay attention to the explora- tion of the relationship between actions and tool ,and then list the importance order in the action phase, the third step is to take out the in-depth anatomical analysis of the stage, analyze the reason of the operational difficulty .and at last carries out the design concept to resolve the problem. All in all, this method revolves around the main stage of spontaneous behavior, and analyzes it in interim and solves the problem in stage.
基金National Science and Technology Innovation 2030-Major Project of China(2021ZD0201003 and 2022ZD0208300)National Natural Science Foundation of China(32171092)+3 种基金Shenzhen Key Basic Research Project(JCYJ20220818100805013)Shenzhen Key Laboratory of Viral Vectors for Biomedicine(ZDSYS20200811142401005)Guangdong Provincial Medical Products Administration Key Laboratory of Quality Control Technology for Virus-Based Therapeutics(2020ZDB26)Guangdong Provincial Medical Products Administration(2022ZDZ13).
文摘Autism spectrum disorders(ASD)are characterized by social and repetitive abnormalities.Although the ASD mouse model with Shank3b mutations is widely used in ASD research,the behavioral phenotype of this model has not been fully elucidated.Here,a 3D-motion capture system and linear discriminant analysis were used to comprehensively record and analyze the behavioral patterns of male and female Shank3b mutant mice.It was found that both sexes replicated the core and accompanied symptoms of ASD,with significant sex differences.Further,Shank3b heterozygous knockout mice exhibited distinct autistic behaviors,that were significantly different from those those observed in the wild type and homozygous knockout groups.Our findings provide evidence for the inclusion of both sexes and experimental approaches to efficiently characterize heterozygous transgenic models,which are more clinically relevant in autistic studies.
