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Approximation to the Distribution of the Least Squares Estimators in Two Dimensional Cosine Models by Randomly Weighted Bootstrap
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作者 Yuan-yuan ZHAO Rui-xing MING Yao-hua WU 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2013年第4期765-776,共12页
Recently, Kundu and Gupta (Metrika, 48:83 C 97, 1998) established the asymptotic normality of the least squares estimators in the two dimensional cosine model. In this paper, we give the approximation to the genera... Recently, Kundu and Gupta (Metrika, 48:83 C 97, 1998) established the asymptotic normality of the least squares estimators in the two dimensional cosine model. In this paper, we give the approximation to the general least squares estimators by using random weights which is called the Bayesian bootstrap or the random weighting method by Rubin (Annals of Statistics, 9:130 C 134, 1981) and Zheng (Acta Math. Appl. Sinica (in Chinese), 10(2): 247 C 253, 1987). A simulation study shows that this approximation works very well. 展开更多
关键词 two dimensional model least squares estimator Bayesian bootstrap random weighting method
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LEAST SQUARES ESTIMATION FOR ORNSTEIN-UHLENBECK PROCESSES DRIVEN BY THE WEIGHTED FRACTIONAL BROWNIAN MOTION 被引量:4
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作者 申广君 尹修伟 闫理坦 《Acta Mathematica Scientia》 SCIE CSCD 2016年第2期394-408,共15页
In this article, we study a least squares estimator (LSE) of θ for the Ornstein- Uhlenbeck process X0=0,dXt=θXtdt+dBt^ab, t ≥ 0 driven by weighted fractional Brownian motion B^a,b with parameters a, b. We obtain... In this article, we study a least squares estimator (LSE) of θ for the Ornstein- Uhlenbeck process X0=0,dXt=θXtdt+dBt^ab, t ≥ 0 driven by weighted fractional Brownian motion B^a,b with parameters a, b. We obtain the consistency and the asymptotic distribution of the LSE based on the observation {Xs, s∈[0,t]} as t tends to infinity. 展开更多
关键词 Weighted fractional Brownian motion least squares estimator Ornstein-Uhl-enbeck process
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THE LEAST SQUARES ESTIMATOR FOR AN ORNSTEIN-UHLENBECK PROCESS DRIVEN BY A HERMITE PROCESS WITH A PERIODIC MEAN 被引量:1
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作者 申广君 余迁 唐正 《Acta Mathematica Scientia》 SCIE CSCD 2021年第2期517-534,共18页
We consider the least square estimator for the parameters of Ornstein-Uhlenbeck processes dY_(s)=(∑_(j=1)^(k)μ_(j)φ_(j)(s)-βY_(s))ds+dZ_(s)^(q,H),driven by the Hermite process Z_(s)^(q,H)with order q≥1 and a Hurs... We consider the least square estimator for the parameters of Ornstein-Uhlenbeck processes dY_(s)=(∑_(j=1)^(k)μ_(j)φ_(j)(s)-βY_(s))ds+dZ_(s)^(q,H),driven by the Hermite process Z_(s)^(q,H)with order q≥1 and a Hurst index H∈(1/2,1),where the periodic functionsφ_(j)(s),,j=1,...,κare bounded,and the real numbersμ_(j),,j=1,...,κtogether withβ>0 are unknown parameters.We establish the consistency of a least squares estimation and obtain the asymptotic behavior for the estimator.We also introduce alternative estimators,which can be looked upon as an application of the least squares estimator.In terms of the fractional Ornstein-Uhlenbeck processes with periodic mean,our work can be regarded as its non-Gaussian extension. 展开更多
关键词 Least squares estimator CONSISTENCY asymptotic distribution Ornstein-Uhlenbeck processes Hermite processes
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ERRATUM TO: LEAST SQUARES ESTIMATION FOR ORNSTEIN-UHLENBECK PROCESSES DRIVEN BY THE WEIGHTED FRACTIONAL BROWNIAN MOTION (ACTA MATHEMATICA SCIENTIA 2016,36B (2) :394-408) 被引量:1
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作者 申广君 尹修伟 闫理坦 《Acta Mathematica Scientia》 SCIE CSCD 2017年第4期1173-1176,共4页
We give a correction of Theorem 2.2 of Shen, Yin and Yan (2016).
关键词 weighted fractional Brownian motion least squares estimator Ornstein-Uhlenbeck process
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Asymptotic Properties of Estimators for Ornstein-Uhlenbeck Processes with Small Symmetricα-Stable Motions
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作者 潘玉荣 贾朝勇 刘晓雁 《Journal of Donghua University(English Edition)》 EI CAS 2020年第4期357-364,共8页
The asymptotic behaviors for estimators of the drift parameters in the Ornstein-Uhlenbeck process driven by small symmetricα-stable motion are studied in this paper.Based on the discrete observations,the conditional ... The asymptotic behaviors for estimators of the drift parameters in the Ornstein-Uhlenbeck process driven by small symmetricα-stable motion are studied in this paper.Based on the discrete observations,the conditional least squares estimators(CLSEs)of all the parameters involved in the Ornstein–Uhlenbeck process are proposed.We establish the consistency and the asymptotic distributions of our estimators asεgoes to 0 and n goes to∞simultaneously. 展开更多
关键词 Ornstein-Uhlenbeck process symmetricα-stable motion conditional least squares estimator(CLSE) consistency asymptotic distribution
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Comparison of Two Time Series Decomposition Methods: Least Squares and Buys-Ballot Methods
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作者 I. S. Iwueze E. C. Nwogu +1 位作者 V. U. Nlebedim J. C. Imoh 《Open Journal of Statistics》 2016年第6期1123-1137,共15页
This paper discusses comparison of two time series decomposition methods: The Least Squares Estimation (LSE) and Buys-Ballot Estimation (BBE) methods. As noted by Iwueze and Nwogu (2014), there exists a research gap f... This paper discusses comparison of two time series decomposition methods: The Least Squares Estimation (LSE) and Buys-Ballot Estimation (BBE) methods. As noted by Iwueze and Nwogu (2014), there exists a research gap for the choice of appropriate model for decomposition and detection of presence of seasonal effect in a series model. Estimates of trend parameters and seasonal indices are all that are needed to fill the research gap. However, these estimates are obtainable through the Least Squares Estimation (LSE) and Buys-Ballot Estimation (BBE) methods. Hence, there is need to compare estimates of the two methods and recommend. The comparison of the two methods is done using the Accuracy Measures (Mean Error (ME)), Mean Square Error (MSE), the Mean Absolute Error (MAE), and the Mean Absolute Percentage Error (MAPE). The results from simulated series show that for the additive model;the summary statistics (ME, MSE and MAE) for the two estimation methods and for all the selected trending curves are equal in all the simulations both in magnitude and direction. For the multiplicative model, results show that when a series is dominated by trend, the estimates of the parameters by both methods become less precise and differ more widely from each other. However, if conditions for successful transformation (using the logarithmic transform in linearizing the multiplicative model to additive model) are met, both of them give similar results. 展开更多
关键词 Decomposition Models Least squares Estimates Buys-Ballot Estimates Accuracy Measures Successful Transformation Trending Curves
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Hepatic MR imaging using IDEAL-IQ sequence:Will Gd-EOB-DTPA interfere with reproductivity of fat fraction quantification?
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作者 Yuan Tian Peng-Fei Liu +2 位作者 Jia-Yu Li Ya-Nan Li Peng Sun 《World Journal of Clinical Cases》 SCIE 2023年第25期5887-5896,共10页
BACKGROUND Iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence(IDEAL-IQ)is based on chemical shift-based water and fat separation technique to get proton d... BACKGROUND Iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence(IDEAL-IQ)is based on chemical shift-based water and fat separation technique to get proton density fat fraction.Multiple studies have shown that using IDEAL-IQ to test the stability and repeatability of liver fat is acceptable and has high accuracy.AIM To explore whether Gadoxetate Disodium(Gd-EOB-DTPA)interferes with the measurement of the hepatic fat content quantified with the IDEAL-IQ and to evaluate the robustness of this technique.METHODS IDEAL-IQ was used to quantify the liver fat content at 3.0T in 65 patients injected with Gd-EOB-DTPA contrast.After injection,IDEAL-IQ was estimated four times,and the fat fraction(FF)and R2* were measured at the following time points:Precontrast,between the portal phase(70 s)and the late phase(180 s),the delayed phase(5 min)and the hepatobiliary phase(20 min).One-way repeated-measures analysis was conducted to evaluate the difference in the FFs between the four time points.Bland-Altman plots were adopted to assess the FF changes before and after injection of the contrast agent.P<0.05 was considered statistically significant.RESULTS The assessment of the FF at the four time points in the liver,spleen and spine showed no significant differences,and the measurements of hepatic FF yielded good consistency between T1 and T2[95%confidence interval:-0.6768%,0.6658%],T1 and T3(-0.3900%,0.3178%),and T1 and T4(-0.3750%,0.2825%).R2* of the liver,spleen and spine increased significantly after injection(P<0.0001).CONCLUSION Using the IDEAL-IQ sequence to measure the FF,we can obtain results that will not be affected by Gd-EOB-DTPA.The high reproducibility of the IDEAL-IQ sequence makes it available in the scanning interval to save time during multiphase examinations. 展开更多
关键词 Gadoxetate Disodium Iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence Fat fraction Enhanced-Magnetic resonance imaging R2*
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The Consistency of LSE Estimators in Partial Linear Regression Models under Mixing Random Errors
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作者 Yun Bao YAO Yu Tan LÜ +2 位作者 Chao LU Wei WANG Xue Jun WANG 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2024年第5期1244-1272,共29页
In this paper,we consider the partial linear regression model y_(i)=x_(i)β^(*)+g(ti)+ε_(i),i=1,2,...,n,where(x_(i),ti)are known fixed design points,g(·)is an unknown function,andβ^(*)is an unknown parameter to... In this paper,we consider the partial linear regression model y_(i)=x_(i)β^(*)+g(ti)+ε_(i),i=1,2,...,n,where(x_(i),ti)are known fixed design points,g(·)is an unknown function,andβ^(*)is an unknown parameter to be estimated,random errorsε_(i)are(α,β)-mix_(i)ng random variables.The p-th(p>1)mean consistency,strong consistency and complete consistency for least squares estimators ofβ^(*)and g(·)are investigated under some mild conditions.In addition,a numerical simulation is carried out to study the finite sample performance of the theoretical results.Finally,a real data analysis is provided to further verify the effect of the model. 展开更多
关键词 β)-mixing random variables partial linear regression model least squares estimator CONSISTENCY
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Power Inverted Topp–Leone Distribution in Acceptance Sampling Plans 被引量:1
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作者 Tahani A.Abushal Amal S.Hassan +1 位作者 Ahmed R.El-Saeed Said G.Nassr 《Computers, Materials & Continua》 SCIE EI 2021年第4期991-1011,共21页
We introduce a new two-parameter model related to the inverted Topp–Leone distribution called the power inverted Topp–Leone(PITL)distribution.Major properties of the PITL distribution are stated;including;quantile m... We introduce a new two-parameter model related to the inverted Topp–Leone distribution called the power inverted Topp–Leone(PITL)distribution.Major properties of the PITL distribution are stated;including;quantile measures,moments,moment generating function,probability weighted moments,Bonferroni and Lorenz curve,stochastic ordering,incomplete moments,residual life function,and entropy measure.Acceptance sampling plans are developed for the PITL distribution,when the life test is truncated at a pre-specified time.The truncation time is assumed to be the median lifetime of the PITL distribution with pre-specified factors.The minimum sample size necessary to ensure the specified life test is obtained under a given consumer’s risk.Numerical results for given consumer’s risk,parameters of the PITL distribution and the truncation time are obtained.The estimation of the model parameters is argued using maximum likelihood,least squares,weighted least squares,maximum product of spacing and Bayesian methods.A simulation study is confirmed to evaluate and compare the behavior of different estimates.Two real data applications are afforded in order to examine the flexibility of the proposed model compared with some others distributions.The results show that the power inverted Topp–Leone distribution is the best according to the model selection criteria than other competitive models. 展开更多
关键词 Inverted Topp-Leone distribution acceptance sampling plans maximum likelihood estimators weighted least squares estimators Bayesian estimators
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Parameter identification of hysteretic model of rubber-bearing based on sequential nonlinear least-square estimation 被引量:9
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作者 Yin Qiang Zhou Li Wang Xinming 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2010年第3期375-383,共9页
In order to evaluate the nonlinear performance and the possible damage to rubber-bearings (RBs) during their normal operation or under strong earthquakes, a simplified Bouc-Wen model is used to describe the nonlinea... In order to evaluate the nonlinear performance and the possible damage to rubber-bearings (RBs) during their normal operation or under strong earthquakes, a simplified Bouc-Wen model is used to describe the nonlinear hysteretic behavior of RBs in this paper, which has the advantages of being smooth-varying and physically motivated. Further, based on the results from experimental tests performed by using a particular type of RB (GZN 110) under different excitation scenarios, including white noise and several earthquakes, a new system identification method, referred to as the sequential nonlinear least- square estimation (SNLSE), is introduced to identify the model parameters. It is shown that the proposed simplified Bouc- Wen model is capable of describing the nonlinear hysteretic behavior of RBs, and that the SNLSE approach is very effective in identifying the model parameters of RBs. 展开更多
关键词 parameter identification rubber-bearing hysteretic behavior Bouc-Wen model sequential nonlinear least- square estimation
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An Imperfect-debugging Fault-detection Dependent-parameter Software 被引量:11
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作者 Hoang Pham 《International Journal of Automation and computing》 EI 2007年第4期325-328,共4页
Software reliability growth models (SRGMs) incorporating the imperfect debugging and learning phenomenon of developers have recently been developed by many researchers to estimate software reliability measures such ... Software reliability growth models (SRGMs) incorporating the imperfect debugging and learning phenomenon of developers have recently been developed by many researchers to estimate software reliability measures such as the number of remaining faults and software reliability. However, the model parameters of both the fault content rate function and fault detection rate function of the SRGMs are often considered to be independent from each other. In practice, this assumption may not be the case and it is worth to investigate what if it is not. In this paper, we aim for such study and propose a software reliability model connecting the imperfect debugging and learning phenomenon by a common parameter among the two functions, called the imperfect-debugging fault-detection dependent-parameter model. Software testing data collected from real applications are utilized to illustrate the proposed model for both the descriptive and predictive power by determining the non-zero initial debugging process. 展开更多
关键词 Non-homogeneous Poisson process software reliability growth least squares estimate predictive power predictive-ratio risk.
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Estimation for nearly unit root processes with GARCH errors 被引量:4
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作者 YUAN Yu-ze ZHANG Rong-mao Department of Mathematics, Zhejiang University, Hangzhou 310027, China 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2010年第3期297-306,共10页
In this paper the limiting distribution of the least square estimate for the autoregressive coefficient of a nearly unit root model with GARCH errors is derived. Since the limiting distribution depends on the unknown ... In this paper the limiting distribution of the least square estimate for the autoregressive coefficient of a nearly unit root model with GARCH errors is derived. Since the limiting distribution depends on the unknown variance of the errors, an empirical likelihood ratio statistic is proposed from which confidence intervals can be constructed for the nearly unit root model without knowing the variance. To gain an intuitive sense for the empirical likelihood ratio, a small simulation for the asymptotic distribution is given. 展开更多
关键词 Nearly unit root GARCH error least square estimation Ornstein-Uhlenbeck process empirical likelihood.
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Asymptotic Behavior of the Drift Coefficient Estimator of Stochastic Differential Equations Driven by Small Noises 被引量:3
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作者 沈亮 许青松 《Journal of Donghua University(English Edition)》 EI CAS 2015年第1期19-22,共4页
The parametric estimation problem for diffusion processes with small white noise based on continuous time observations is well developed. However,in parametric inference,it is more realistic and interesting to conside... The parametric estimation problem for diffusion processes with small white noise based on continuous time observations is well developed. However,in parametric inference,it is more realistic and interesting to consider asymptotic estimation for diffusion processes based on discrete observations. The least squares method is used to obtain the estimator of the drift parameter for stochastic differential equations( SDEs) driven by general Lévy noises when the process is observed discretely. Its strong consistency and the rate of convergence of the squares estimator are studied under some regularity conditions. 展开更多
关键词 stochastic differential equations(SDEs) consistency least squares estimator(LSE) discrete observations NOISES
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Predictive Models for Cumulative Confirmed COVID-19 Cases by Day in Southeast Asia 被引量:2
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作者 Yupaporn Areepong Rapin Sunthornwat 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第12期927-942,共16页
Coronavirus disease 2019 outbreak has spread as a pandemic since the end of year 2019.This situation has been causing a lot of problems of human beings such as economic problems,health problems.The forecasting of the ... Coronavirus disease 2019 outbreak has spread as a pandemic since the end of year 2019.This situation has been causing a lot of problems of human beings such as economic problems,health problems.The forecasting of the number of infectious people is required by the authorities of all countries including Southeast Asian countries to make a decision and control the outbreak.This research is to investigate the suitable forecasting model for the number of infectious people in Southeast Asian countries.A comparison of forecasting models between logistic growth curve which is symmetric and Gompertz growth curve which is asymmetric based on the maximumof Coefficient of Determination and theminimumof RootMean Squared Percentage Error is also proposed.The estimation of parameters of the forecasting models is evaluated by the least square method.In addition,spreading of the outbreak is estimated by the derivative of the number of cumulative cases.The findings show that Gompertz growth curve is a suitable forecasting model for Indonesia,Philippines,andMalaysia and logistic growth curve suits the other countries in South Asia. 展开更多
关键词 Coronavirus disease 2019 Gompertz function least square estimation logistic function
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Pattern synthesis optimization of 3-D ODAR based on improved GA using LSFE method 被引量:3
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作者 龙伟军 贲德 +1 位作者 BAKHSHI ASIM D 张弓 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第1期96-100,共5页
Pattern synthesis in 3-D opportunistic digital array radar(ODAR) becomes complex when a multitude of antennas are considered to be randomly distributed in a three dimensional space.In order to obtain an optimal patter... Pattern synthesis in 3-D opportunistic digital array radar(ODAR) becomes complex when a multitude of antennas are considered to be randomly distributed in a three dimensional space.In order to obtain an optimal pattern,several freedoms must be constrained.A new pattern synthesis approach based on the improved genetic algorithm(GA) using the least square fitness estimation(LSFE) method is proposed.Parameters optimized by this method include antenna locations,stimulus states and phase weights.The new algorithm demonstrates that the fitness variation tendency of GA can be effectively predicted after several "eras" by the LSFE method.It is shown that by comparing the variation of LSFE curve slope,the GA operator can be adaptively modified to avoid premature convergence of the algorithm.The validity of the algorithm is verified using computer implementation. 展开更多
关键词 antenna radiation patterns genetic algorithm(GA) opportunistic digital array radar(ODAR) pattern synthesis the least square fitness estimation(LSFE)
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THE SUPERIORITY OF EMPIRICAL BAYES ESTIMATION OF PARAMETERS IN PARTITIONED NORMAL LINEAR MODEL 被引量:4
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作者 张伟平 韦来生 《Acta Mathematica Scientia》 SCIE CSCD 2008年第4期955-962,共8页
In this article,the empirical Bayes(EB)estimators are constructed for the estimable functions of the parameters in partitioned normal linear model.The superiorities of the EB estimators over ordinary least-squares... In this article,the empirical Bayes(EB)estimators are constructed for the estimable functions of the parameters in partitioned normal linear model.The superiorities of the EB estimators over ordinary least-squares(LS)estimator are investigated under mean square error matrix(MSEM)criterion. 展开更多
关键词 Partitioned linear model empirical Bayes estimator least-squares estimator mean square error matrix
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Neuro-fuzzy system modeling based on automatic fuzzy clustering 被引量:1
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作者 Yuangang TANG Fuchun SUN Zengqi SUN 《控制理论与应用(英文版)》 EI 2005年第2期121-130,共10页
A neuro-fuzzy system model based on automatic fuzzy dustering is proposed. A hybrid model identification algorithm is also developed to decide the model structure and model parameters. The algorithm mainly includes th... A neuro-fuzzy system model based on automatic fuzzy dustering is proposed. A hybrid model identification algorithm is also developed to decide the model structure and model parameters. The algorithm mainly includes three parts:1) Automatic fuzzy C-means (AFCM), which is applied to generate fuzzy rttles automatically, and then fix on the size of the neuro-fuzzy network, by which the complexity of system design is reducesd greatly at the price of the fitting capability; 2) R.ecursive least square estimation (RLSE). It is used to update the parameters of Takagi-Sugeno model, which is employed to describe the behavior of the system;3) Gradient descent algorithm is also proposed for the fuzzy values according to the back propagation algorithm of neural network. Finally,modeling the dynamical equation of the two-link manipulator with the proposed approach is illustrated to validate the feasibility of the method. 展开更多
关键词 Neuro-fuzzy system Automatic fuzzy C-means Gradient descent Back propagation Recursive least square estimation Two-link manipulator
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Asymptotic inference for AR(1) panel data 被引量:1
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作者 SHEN Jian-fei PANG Tian-xiao 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2020年第3期265-280,共16页
A general asymptotic theory is given for the panel data AR(1) model with time series independent in different cross sections. The theory covers the cases of stationary process, local to unity process, unit root proces... A general asymptotic theory is given for the panel data AR(1) model with time series independent in different cross sections. The theory covers the cases of stationary process, local to unity process, unit root process, mildly integrated, mildly explosive and explosive processes. It is assumed that the cross-sectional dimension and time-series dimension are respectively N and T. The results in this paper illustrate that whichever the process is, with an appropriate regularization, the least squares estimator of the autoregressive coefficient converges in distribution to a normal distribution with rate at least O(N-1/3). Since the variance is the key to characterize the normal distribution, it is important to discuss the variance of the least squares estimator. We will show that when the autoregressive coefficient ρ satisfies |ρ| < 1, the variance declines at the rate O((NT)-1), while the rate changes to O(N^(-1) T^(-2)) when ρ = 1 and O(N^(-1)ρ^(-2 T+4)) when |ρ| > 1. ρ = 1 is the critical point where the convergence rate changes radically. The transition process is studied by assuming ρ depending on T and going to 1. An interesting phenomenon discovered in this paper is that, in the explosive case, the least squares estimator of the autoregressive coefficient has a standard normal limiting distribution in the panel data case while it may not has a limiting distribution in the univariate time series case. 展开更多
关键词 AR(1)model Least squares estimator Limiting distribution Non-stationray Panel data
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Using self-location to calibrate the errors of observer positions for source localization 被引量:2
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作者 Wanchun Li Wanyi Zhang Liping Li 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第2期194-202,共9页
The uncertainty of observers' positions can lead to significantly degrading in source localization accuracy. This pa-per proposes a method of using self-location for calibrating the positions of observer stations in ... The uncertainty of observers' positions can lead to significantly degrading in source localization accuracy. This pa-per proposes a method of using self-location for calibrating the positions of observer stations in source localization to reduce the errors of the observer positions and improve the accuracy of the source localization. The relative distance measurements of the two coordinative observers are used for the linear minimum mean square error (LMMSE) estimator. The results of computer si-mulations prove the feasibility and effectiveness of the proposed method. With the general estimation errors of observers' positions, the MSE of the source localization with self-location calibration, which is significantly lower than that without self-location calibra-tion, is approximating to the Cramer-Rao lower bound (CRLB). 展开更多
关键词 self-location errors of the observer positions linearminimum mean square error (LMMSE) estimator accuracy of thesource localization Cramer-Rao lower bound (CRLB).
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A computational model of the human glucose-insulin regulatory system 被引量:2
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作者 Keh-Dong Shiang Fouad Kandeel 《The Journal of Biomedical Research》 CAS 2010年第5期347-364,共18页
Objective:A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced.The proposed method for the estimation of parameters for... Objective:A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced.The proposed method for the estimation of parameters for a system of ordinary differential equations(ODEs)that represent the time course of plasma glucose and insulin concentrations during glucose tolerance test(GTT)in physiological studies is presented.The aim of this study was to explore how to interpret those laboratory glucose and insulin data as well as enhance the Ackerman mathematical model.Methods:Parameters estimation for a system of ODEs was performed by minimizing the sum of squared residuals(SSR)function,which quantifies the difference between theoretical model predictions and GTT's experimental observations.Our proposed perturbation search and multiple-shooting methods were applied during the estimating process.Results:Based on the Ackerman's published data,we estimated the key parameters by applying R-based iterative computer programs.As a result,the theoretically simulated curves perfectly matched the experimental data points.Our model showed that the estimated parameters,computed frequency and period values,were proven a good indicator of diabetes.Conclusion:The present paper introduces a computational algorithm to biomedical problems,particularly to endocrinology and metabolism fields,which involves two coupled differential equations with four parameters describing the glucose-insulin regulatory system that Ackerman proposed earlier.The enhanced approach may provide clinicians in endocrinology and metabolism field insight into the transition nature of human metabolic mechanism from normal to impaired glucose tolerance. 展开更多
关键词 Coupled ordinary differential equations glucose tolerance test parameters estimation sum of squared residuals cost function multiple shooting method
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