Regime shifts from submersed macrophyte dominance to phytoplankton dominance have been widely reported in small-to medium-sized shallow lakes.However,alternative stable states in large shallow lakes(surface area>50...Regime shifts from submersed macrophyte dominance to phytoplankton dominance have been widely reported in small-to medium-sized shallow lakes.However,alternative stable states in large shallow lakes(surface area>500 km^(2))remain unconfirmed.To understand the alternative stable states and the main influencing factors of submersed macrophytes in large lakes,the ecosystem states from monitoring data from 1959 to 2019 in large shallow Taihu Lake(2338 km^(2)in average depth of 2.12 m)in China were examined.Changes in submersed macrophyte coverage(C_(Mac))and phytoplankton chlorophyll a(Chl a)in the time series and their relationships with environmental factors were analyzed.During the field investigation from August 2018 to May 2019,nutrients and Chl a showed obvious heterogeneity across the lake,being generally higher in the western and northern areas and lower in the southeast area,while C_(Mac)was only observed in the eastern areas,e.g.,East Taihu Lake,Xukou Bay,and Gonghu Bay.During the long-term monitoring from 1959 to 2019 in the Central Region,Meiliang Bay,and East Taihu Lake,Chl a increased significantly in the time series.C_(Mac)varied slightly among different subareas,always at low levels(<10%)in the Central Region and Meiliang Bay but at relatively high levels in East Taihu Lake(10%–90%).Frequency distributions of response variables had no multimodality except for C_(Mac)in East Taihu Lake,with two peaks between 15%and 20%and between 55%and 60%.A dual relationship was found between Chl a and total phosphorus(TP)in the areas with and without macrophytes,while C_(Mac)showed no relationship with TP,and submersed macrophytes did not flourish in the Central Region and Meiliang Bay even when TP was at very low levels(≈10 mg/m3).Taihu Lake had similar algal turbidity(TurbAlg)as small-to mediumsized lakes but generally presented with higher values of nonalgal turbidity(TurbNonAlg),as did their contribution to total turbidity as a percentage.This study suggested that large shallow Taihu Lake may have no alternative stable states,but more evidence is needed for East Taihu Lake,which was dominated by macrophytes,as it remains unknown whether hysteresis occurs between the processes of eutrophication and oligotrophication.Unfavorable conditions caused by wind might be the main reason due to the absence of submersed macrophytes in Taihu Lake.These results demonstrate that stricter nutrient control is needed to maintain a healthy state or to recover from a decayed state for large lakes.展开更多
Extensive oedometer tests and physical tests have been conducted on remolded and reconstituted marine soils with different initial water contents and liquid limits. The oedometer test data can be well fitted with a st...Extensive oedometer tests and physical tests have been conducted on remolded and reconstituted marine soils with different initial water contents and liquid limits. The oedometer test data can be well fitted with a straight line in the bilogarithmic ln(1+ e ) ~ lg p plot. The initial effective stress corresponding to the initial void ratio is determined by extrapolation of the bilogarithmic compression line. This new way of extrapolating oedometer test data to the initial void ratio overcomes the difficulty of measuring the residual effective stress of soils in the remolded state. The initial stable compression line of ocean floor deposits under different deposition environments corresponds to the compression line at the sensitivity equal to one. This initial stable compression line obtained in this study is consistent with the available compression line at the sensitivity equal to one which is proposed based on the experimental data of remolded undrained strength and the theoretical concept of Cam clay critical state line.展开更多
Computer simulation of grain boundaries(GB) was carried out in Fe and ordered alloys NiAl and FeAl with B2 superlattice. In this work symmetrical tilt grain boundaries =5[100](012) and = 5[100](013) are studied. The...Computer simulation of grain boundaries(GB) was carried out in Fe and ordered alloys NiAl and FeAl with B2 superlattice. In this work symmetrical tilt grain boundaries =5[100](012) and = 5[100](013) are studied. The atomic interaction has been described by Morse empirical central- force potentials.The atomic structure and energy of GB were investigated by means of construction of -surface using full atomic relaxation by method of molecular statics. It is shown that = 5 tilt GBs in Fe, Ni3Al and NiAl have several steady states. Comparison of our results with geometrical model of coincidence site lattice (CSL) was carried out. GBs in model CSL are unstable, the stabilization is achieved by additional displacement at some vector along the plane of defect.展开更多
This paper investigates the collective excitation and stability of low-dimensional Bose-Einstein condensates with two- and three-body interactions by the variational analysis of the time-dependent Gross-Pitaevskii-Gin...This paper investigates the collective excitation and stability of low-dimensional Bose-Einstein condensates with two- and three-body interactions by the variational analysis of the time-dependent Gross-Pitaevskii-Ginsburg equation. The spectrum of the low-energy excitation and the effective potential for the width of the condensate axe obtained. The results show that: (i) the repulsive two-body interaction among atoms makes the frequency red-shifted for the internal excitation and the repulsive or attractive three-body interaction always makes it blue-shifted; (ii) the region for the existence of the stable bound states is obtained by identifying the critical value of the two- and three-body interactions.展开更多
Many works have investigated the problem of reparameterizing rational B^zier curves or surfaces via MSbius transformation to adjust their parametric distribution as well as weights, such that the maximal ratio of weig...Many works have investigated the problem of reparameterizing rational B^zier curves or surfaces via MSbius transformation to adjust their parametric distribution as well as weights, such that the maximal ratio of weights becomes smallerthat some algebraic and computational properties of the curves or surfaces can be improved in a way. However, it is an indication of veracity and optimization of the reparameterization to do prior to judge whether the maximal ratio of weights reaches minimum, and verify the new weights after MSbius transfor- mation. What's more the users of computer aided design softwares may require some guidelines for designing rational B6zier curves or surfaces with the smallest ratio of weights. In this paper we present the necessary and sufficient conditions that the maximal ratio of weights of the curves or surfaces reaches minimum and also describe it by using weights succinctly and straightway. The weights being satisfied these conditions are called being in the stable state. Applying such conditions, any giving rational B6zier curve or surface can automatically be adjusted to come into the stable state by CAD system, that is, the curve or surface possesses its optimal para- metric distribution. Finally, we give some numerical examples for demonstrating our results in important applications of judging the stable state of weights of the curves or surfaces and designing rational B6zier surfaces with compact derivative bounds.展开更多
Yinyang theory and wuxing theory are the core parts in the Traditional Chinese Medicine(TCM) and giving the accurate interpretation on these theories is one of directions for the modernization of TCM.In the cell,energ...Yinyang theory and wuxing theory are the core parts in the Traditional Chinese Medicine(TCM) and giving the accurate interpretation on these theories is one of directions for the modernization of TCM.In the cell,energy metabolism and gene expression are the fundamental processes which are regarded as yin and yang respectively.Furthermore,energy agents,oxygen,end metabolic products,energy releasing as well as genes are the five basic factors for maintaining the undergoing of all biochemistries in cell.Because these factors are the substrates of five essential pathways for the survival of living cell and the abnormalities of any pathways will cause the death of cells,wuxing theory should be translated as five essential pathways in cell.These medical understandings on wuxing theory will not only give some novel viewpoints on the living cell but also promote the development of system biology in future.展开更多
In order to explore the evolution law of coopetition relationship among Mcommerce information service(MIS)subjects and further reveal the allocation mechanism of information resources,the research extends Lotka-Volter...In order to explore the evolution law of coopetition relationship among Mcommerce information service(MIS)subjects and further reveal the allocation mechanism of information resources,the research extends Lotka-Volterra model,builds the coopetition relationship model of MIS subjects and simulates their coopetition relationship by Python and MATLAB to obtain the evolution trend of information resources possession(IRP)of MIS subjects in the coopetition process.The results show that the mutualism cooperation pattern dominated by promoting effect can maximize the value of information resources.This paper has significant reference value for how to optimize the allocation of information resources among MIS subjects.展开更多
Background:Due to the effects of climate change and overgrazing in recent decades,alternative stable states in the alpine Kobresia meadow degradation process have coexisted in the same geographical and climatic enviro...Background:Due to the effects of climate change and overgrazing in recent decades,alternative stable states in the alpine Kobresia meadow degradation process have coexisted in the same geographical and climatic environment,with variations occurring among microsites.Methods:We used a space-for-time substitution approach to explore the synergies of microsite variation according to its numerical characteristics and the proportion of each stable state at various stages of succession in alpine Kobresia meadows on the Qinghai-Tibetan Plateau.Results:(1)The highest average aboveground biomass in summer was 196.2±20.3 gm^(-2),with significantly higher levels of biomass in≤3.65 sheep unit ha^(-1) than in other levels of grazing intensity,while the parameters showed no significant differences among grazing intensity levels in>3.65 sheep unit ha^(-1).(2)The importance of plant functional groups,aboveground biomass,and niche breadth of Poaceae and Cyperaceae significantly decreased as the grazing intensity increased.(3)The effects of≥0°C accumulated temperature,total precipitation,altitude,longitude,and latitude cumulatively contributed less than 20%of the variation in the distribution of functional group characteristics across microsites.Conclusions:(1)Overgrazing decreases primary production in alpine Kobresia meadows,but ecosystem responses regulate plant community structure and botanical components so as to partially counteract grazing disturbance.(2)Overgrazing changed the proportion of microsites,which in turn led to regime shift in the plant community and subsequent synergies between the microsites of plant communities and their stable states.展开更多
Regarding a single-layered PLN network with feedback connections as an associative memory network,the complexity of recognition is discussed.We have the main result:if the size of the network N is m,then the complexit...Regarding a single-layered PLN network with feedback connections as an associative memory network,the complexity of recognition is discussed.We have the main result:if the size of the network N is m,then the complexity of recognition is an exponential function of m.The necessary condition under which the complexity of recognition is polynomial is given.展开更多
A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network pers...A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained. In this paper we wish to test such idea from a different angle: the connection between a normal biological process and the network dynamics. We have taken early myelopoiesis as our biological model. A standard roadmap for the cell-fate diversification during hematopoiesis has already been well established experimentally, yet little was known for its underpinning dynamical mechanisms. Compounding this difficulty there were additional experimental challenges, such as the seemingly conflicting hematopoietic roadmaps and the cell-fate inter-conversion events. With early myeloid cell-fate determination in mind, we constructed a core molecular endogenous network from well-documented gene regulation and signal transduction knowledge. Turning the network into a set of dynamical equations, we found computationally several structurally robust states. Those states nicely correspond to known cell phenotypes. We also found the states connecting those stable states.They reveal the developmental routes—how one stable state would most likely turn into another stable state. Such interconnected network among stable states enabled a natural organization of cell-fates into a multi-stable state landscape. Accordingly, both the myeloid cell phenotypes and the standard roadmap were explained mechanistically in a straightforward manner. Furthermore,recent challenging observations were also explained naturally. Moreover, the landscape visually enables a prediction of a pool of additional cell states and developmental routes, including the non-sequential and cross-branch transitions, which are testable by future experiments. In summary, the endogenous network dynamics provide an integrated quantitative framework to understand the heterogeneity and lineage commitment in myeloid progenitors.展开更多
Ecological regime shift is the rapid transition from one stable community structure to another, often ecologically infe- rior, stable community. Such regime shifts are especially common in shallow marine communities, ...Ecological regime shift is the rapid transition from one stable community structure to another, often ecologically infe- rior, stable community. Such regime shifts are especially common in shallow marine communities, such as the transition of kelp forests to algal turfs that harbour far lower biodiversity. Stable regimes in communities are a result of balanced interactions be- tween species, and predicting new regimes therefore requires an evaluation of new species interactions, as well as the resilience of the 'stable' position. While computational optimisation techniques can predict new potential regimes, predicting the most likely community state of the various options produced is currently educated guess work. In this study we integrate a stable regime op- timisation approach with a Bayesian network used to infer prior knowledge of the likely stress of climate change (or, in practice, any other disturbance) on each component species of a representative rocky shore community model. Combining the results, by calculating the product of the match between resilient computational predictions and the posterior probabilities of the Bayesian network, gives a refined set of model predictors, and demonstrates the use of the process in determining community changes, as might occur through processes such as climate change. To inform Bayesian priors, we conduct a review of molecular approaches applied to the analysis of the transcriptome of rocky shore organisms, and show how such an approach could be linked to meas- ureable stress variables in the field. Hence species-specific microarrays could be designed as biomarkers of in situ stress, and used to inform predictive modelling approaches such as those described here.展开更多
基金Supported by the National Key Research and Development Program of China(No.2021YFC3200103)the Major Science and Technology Program for Water Pollution Control and Treatment of China(No.2017ZX07302-002)+2 种基金the State Key Laboratory of Freshwater Ecology and Biotechnology(No.2019FBZ01)the Wuhan Science and Technology Plan Project(No.2020020602012152),the Research Project of Wuhan Municipal Construction Group Co.,Ltd.(No.wszky202014)Haijun WANG was supported by the Youth Innovation Association of Chinese Academy of Sciences as an excellent member(No.Y201859)。
文摘Regime shifts from submersed macrophyte dominance to phytoplankton dominance have been widely reported in small-to medium-sized shallow lakes.However,alternative stable states in large shallow lakes(surface area>500 km^(2))remain unconfirmed.To understand the alternative stable states and the main influencing factors of submersed macrophytes in large lakes,the ecosystem states from monitoring data from 1959 to 2019 in large shallow Taihu Lake(2338 km^(2)in average depth of 2.12 m)in China were examined.Changes in submersed macrophyte coverage(C_(Mac))and phytoplankton chlorophyll a(Chl a)in the time series and their relationships with environmental factors were analyzed.During the field investigation from August 2018 to May 2019,nutrients and Chl a showed obvious heterogeneity across the lake,being generally higher in the western and northern areas and lower in the southeast area,while C_(Mac)was only observed in the eastern areas,e.g.,East Taihu Lake,Xukou Bay,and Gonghu Bay.During the long-term monitoring from 1959 to 2019 in the Central Region,Meiliang Bay,and East Taihu Lake,Chl a increased significantly in the time series.C_(Mac)varied slightly among different subareas,always at low levels(<10%)in the Central Region and Meiliang Bay but at relatively high levels in East Taihu Lake(10%–90%).Frequency distributions of response variables had no multimodality except for C_(Mac)in East Taihu Lake,with two peaks between 15%and 20%and between 55%and 60%.A dual relationship was found between Chl a and total phosphorus(TP)in the areas with and without macrophytes,while C_(Mac)showed no relationship with TP,and submersed macrophytes did not flourish in the Central Region and Meiliang Bay even when TP was at very low levels(≈10 mg/m3).Taihu Lake had similar algal turbidity(TurbAlg)as small-to mediumsized lakes but generally presented with higher values of nonalgal turbidity(TurbNonAlg),as did their contribution to total turbidity as a percentage.This study suggested that large shallow Taihu Lake may have no alternative stable states,but more evidence is needed for East Taihu Lake,which was dominated by macrophytes,as it remains unknown whether hysteresis occurs between the processes of eutrophication and oligotrophication.Unfavorable conditions caused by wind might be the main reason due to the absence of submersed macrophytes in Taihu Lake.These results demonstrate that stricter nutrient control is needed to maintain a healthy state or to recover from a decayed state for large lakes.
文摘Extensive oedometer tests and physical tests have been conducted on remolded and reconstituted marine soils with different initial water contents and liquid limits. The oedometer test data can be well fitted with a straight line in the bilogarithmic ln(1+ e ) ~ lg p plot. The initial effective stress corresponding to the initial void ratio is determined by extrapolation of the bilogarithmic compression line. This new way of extrapolating oedometer test data to the initial void ratio overcomes the difficulty of measuring the residual effective stress of soils in the remolded state. The initial stable compression line of ocean floor deposits under different deposition environments corresponds to the compression line at the sensitivity equal to one. This initial stable compression line obtained in this study is consistent with the available compression line at the sensitivity equal to one which is proposed based on the experimental data of remolded undrained strength and the theoretical concept of Cam clay critical state line.
文摘Computer simulation of grain boundaries(GB) was carried out in Fe and ordered alloys NiAl and FeAl with B2 superlattice. In this work symmetrical tilt grain boundaries =5[100](012) and = 5[100](013) are studied. The atomic interaction has been described by Morse empirical central- force potentials.The atomic structure and energy of GB were investigated by means of construction of -surface using full atomic relaxation by method of molecular statics. It is shown that = 5 tilt GBs in Fe, Ni3Al and NiAl have several steady states. Comparison of our results with geometrical model of coincidence site lattice (CSL) was carried out. GBs in model CSL are unstable, the stabilization is achieved by additional displacement at some vector along the plane of defect.
基金supported by the Natural Science Foundation of Shaanxi University of Science and Technology,China (Grant Nos SUST-ZX08-27 and SUST-ZX07-32)
文摘This paper investigates the collective excitation and stability of low-dimensional Bose-Einstein condensates with two- and three-body interactions by the variational analysis of the time-dependent Gross-Pitaevskii-Ginsburg equation. The spectrum of the low-energy excitation and the effective potential for the width of the condensate axe obtained. The results show that: (i) the repulsive two-body interaction among atoms makes the frequency red-shifted for the internal excitation and the repulsive or attractive three-body interaction always makes it blue-shifted; (ii) the region for the existence of the stable bound states is obtained by identifying the critical value of the two- and three-body interactions.
基金Supported by the National Nature Science Foundations of China(61070065)
文摘Many works have investigated the problem of reparameterizing rational B^zier curves or surfaces via MSbius transformation to adjust their parametric distribution as well as weights, such that the maximal ratio of weights becomes smallerthat some algebraic and computational properties of the curves or surfaces can be improved in a way. However, it is an indication of veracity and optimization of the reparameterization to do prior to judge whether the maximal ratio of weights reaches minimum, and verify the new weights after MSbius transfor- mation. What's more the users of computer aided design softwares may require some guidelines for designing rational B6zier curves or surfaces with the smallest ratio of weights. In this paper we present the necessary and sufficient conditions that the maximal ratio of weights of the curves or surfaces reaches minimum and also describe it by using weights succinctly and straightway. The weights being satisfied these conditions are called being in the stable state. Applying such conditions, any giving rational B6zier curve or surface can automatically be adjusted to come into the stable state by CAD system, that is, the curve or surface possesses its optimal para- metric distribution. Finally, we give some numerical examples for demonstrating our results in important applications of judging the stable state of weights of the curves or surfaces and designing rational B6zier surfaces with compact derivative bounds.
基金supported by The National Natural Science Foundation of China:microRNA-194在非酒精性脂肪肝发病机制中的作用的研究(81300302)
文摘Yinyang theory and wuxing theory are the core parts in the Traditional Chinese Medicine(TCM) and giving the accurate interpretation on these theories is one of directions for the modernization of TCM.In the cell,energy metabolism and gene expression are the fundamental processes which are regarded as yin and yang respectively.Furthermore,energy agents,oxygen,end metabolic products,energy releasing as well as genes are the five basic factors for maintaining the undergoing of all biochemistries in cell.Because these factors are the substrates of five essential pathways for the survival of living cell and the abnormalities of any pathways will cause the death of cells,wuxing theory should be translated as five essential pathways in cell.These medical understandings on wuxing theory will not only give some novel viewpoints on the living cell but also promote the development of system biology in future.
基金The authors gratefully acknowledge the research support of National Social Science Fund Youth Project(CN)(No.19CTQ021).
文摘In order to explore the evolution law of coopetition relationship among Mcommerce information service(MIS)subjects and further reveal the allocation mechanism of information resources,the research extends Lotka-Volterra model,builds the coopetition relationship model of MIS subjects and simulates their coopetition relationship by Python and MATLAB to obtain the evolution trend of information resources possession(IRP)of MIS subjects in the coopetition process.The results show that the mutualism cooperation pattern dominated by promoting effect can maximize the value of information resources.This paper has significant reference value for how to optimize the allocation of information resources among MIS subjects.
基金National Natural Science Foundation of China,Grant/Award Number:U20A2006Youth Project of Qinghai Province,Grant/Award Number:2023-ZJ-967Q Abstract。
文摘Background:Due to the effects of climate change and overgrazing in recent decades,alternative stable states in the alpine Kobresia meadow degradation process have coexisted in the same geographical and climatic environment,with variations occurring among microsites.Methods:We used a space-for-time substitution approach to explore the synergies of microsite variation according to its numerical characteristics and the proportion of each stable state at various stages of succession in alpine Kobresia meadows on the Qinghai-Tibetan Plateau.Results:(1)The highest average aboveground biomass in summer was 196.2±20.3 gm^(-2),with significantly higher levels of biomass in≤3.65 sheep unit ha^(-1) than in other levels of grazing intensity,while the parameters showed no significant differences among grazing intensity levels in>3.65 sheep unit ha^(-1).(2)The importance of plant functional groups,aboveground biomass,and niche breadth of Poaceae and Cyperaceae significantly decreased as the grazing intensity increased.(3)The effects of≥0°C accumulated temperature,total precipitation,altitude,longitude,and latitude cumulatively contributed less than 20%of the variation in the distribution of functional group characteristics across microsites.Conclusions:(1)Overgrazing decreases primary production in alpine Kobresia meadows,but ecosystem responses regulate plant community structure and botanical components so as to partially counteract grazing disturbance.(2)Overgrazing changed the proportion of microsites,which in turn led to regime shift in the plant community and subsequent synergies between the microsites of plant communities and their stable states.
文摘Regarding a single-layered PLN network with feedback connections as an associative memory network,the complexity of recognition is discussed.We have the main result:if the size of the network N is m,then the complexity of recognition is an exponential function of m.The necessary condition under which the complexity of recognition is polynomial is given.
基金supported by the National Basic Research Program of China(2010CB529200)National Natural Science Foundation of China(91029738)
文摘A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained. In this paper we wish to test such idea from a different angle: the connection between a normal biological process and the network dynamics. We have taken early myelopoiesis as our biological model. A standard roadmap for the cell-fate diversification during hematopoiesis has already been well established experimentally, yet little was known for its underpinning dynamical mechanisms. Compounding this difficulty there were additional experimental challenges, such as the seemingly conflicting hematopoietic roadmaps and the cell-fate inter-conversion events. With early myeloid cell-fate determination in mind, we constructed a core molecular endogenous network from well-documented gene regulation and signal transduction knowledge. Turning the network into a set of dynamical equations, we found computationally several structurally robust states. Those states nicely correspond to known cell phenotypes. We also found the states connecting those stable states.They reveal the developmental routes—how one stable state would most likely turn into another stable state. Such interconnected network among stable states enabled a natural organization of cell-fates into a multi-stable state landscape. Accordingly, both the myeloid cell phenotypes and the standard roadmap were explained mechanistically in a straightforward manner. Furthermore,recent challenging observations were also explained naturally. Moreover, the landscape visually enables a prediction of a pool of additional cell states and developmental routes, including the non-sequential and cross-branch transitions, which are testable by future experiments. In summary, the endogenous network dynamics provide an integrated quantitative framework to understand the heterogeneity and lineage commitment in myeloid progenitors.
文摘Ecological regime shift is the rapid transition from one stable community structure to another, often ecologically infe- rior, stable community. Such regime shifts are especially common in shallow marine communities, such as the transition of kelp forests to algal turfs that harbour far lower biodiversity. Stable regimes in communities are a result of balanced interactions be- tween species, and predicting new regimes therefore requires an evaluation of new species interactions, as well as the resilience of the 'stable' position. While computational optimisation techniques can predict new potential regimes, predicting the most likely community state of the various options produced is currently educated guess work. In this study we integrate a stable regime op- timisation approach with a Bayesian network used to infer prior knowledge of the likely stress of climate change (or, in practice, any other disturbance) on each component species of a representative rocky shore community model. Combining the results, by calculating the product of the match between resilient computational predictions and the posterior probabilities of the Bayesian network, gives a refined set of model predictors, and demonstrates the use of the process in determining community changes, as might occur through processes such as climate change. To inform Bayesian priors, we conduct a review of molecular approaches applied to the analysis of the transcriptome of rocky shore organisms, and show how such an approach could be linked to meas- ureable stress variables in the field. Hence species-specific microarrays could be designed as biomarkers of in situ stress, and used to inform predictive modelling approaches such as those described here.