The Role of the Halted Baroclinic Mode at the Central Equatorial Pacific in El Nifn Event

The role of halted ＂baroclinic modes＂ in the central equatorial Pacific is analyzed. It is found that dominant anomaly signals corresponding to ＂baroclinic modes＂ occur in the upper layer of the equatorial Pacific, in a two-and-a-half layer oceanic model, in assimilated results of a simple OGCM and in the ADCP observation of TAO. A second ＂baroclinic mode＂ is halted in the central equatorial Pacific corresponding to a positive SST anomaly while the first ＂baroclinic mode＂ propagates eastwards in the eastern equatorial Pacific. The role of the halted second ＂baroclinic mode＂ in the central equatorial Pacific is explained by a staged ocean-atmosphere interaction mechanism in the formation of El Nifio： the westerly bursts in boreal winter over the western equatorial Pacific generate the halted second ＂baroclinic mode＂ in the central equatorial Pacific, leading to the increase of heat content and temperature in the upper layer of the central Pacific which induces the shift of convection from over the western equatorial Pacific to the central equatorial Pacific; another wider, westerly anomaly burst is induced over the western region of convection above the central equatorial Pacific and the westerly anomaly burst generates the first ＂baroclinic mode＂ propagating to the eastern equatorial Pacific, resulting in a warm event in the eastern equatorial Pacific. The mechanism presented in this paper reveals that the central equatorial Pacific is a key region in detecting the possibility of ENSO and, by analyzing TAO observation data of ocean currents and temperature in the central equatorial Pacific, in predicting the coming of an El Nino several months ahead.

Identification of TWIST-interacting genes in prostate cancer

Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen(PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers. We have investigated two largest prostate cancer patient cohorts available in GEO database and found that TWIST expression is positive correlated with Gleason score and associated with poorer survival. By using a prostate cancer cohort and a prostate cancer cell line dataset, we have identified three potential downstream targets of TWIST, PPM1 A, SRP72 and TBCB. TWIST's prognostic capacity is lost when the gene is mutated. Further investigation in the prostate cancer cohort revealed that gene expression of SERPINA, STX7, PDIA2, FMP5, GP1 BB, VGLL4,KCNMA1, SHMT2, SAA4 and DIDO1 influence the prognostic significance of TWIST and vice versa. Importantly, eight out of these ten genes are prognostic indicator by itself. In conclusion, our study has further confirmed that TWIST is a prognostic marker in prostate cancer, identified its potential downstream targets and genes that could possibly give additional prognostic value to predict TWIST-mediated prostate cancer progression.