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Human induced pluripotent stem cell based in vitro models of the blood-brain barrier: the future standard?
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作者 Winfried Neuhaus 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第10期1607-1609,共3页
There is an urgent and tremendous need for human dis- ease models in drug development in order to improve pre- clinical predictability. In the case of brain disorders drugs have to cross the blood-brain barrier (BBB... There is an urgent and tremendous need for human dis- ease models in drug development in order to improve pre- clinical predictability. In the case of brain disorders drugs have to cross the blood-brain barrier (BBB) to enter the central nervous system (CNS). It was estimated that more than 95% of the drugs cannot cross the BBB. 展开更多
关键词 Human induced pluripotent stem cell based in vitro models of the blood-brain barrier:the future standard BBB
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