AIM：To compare the diagnostic performance of isolatedcheck visual evoked potential（ic VEP） and standard automated perimetry（SAP）,for evaluating the application values of ic VEP in the detection of early glaucoma....AIM：To compare the diagnostic performance of isolatedcheck visual evoked potential（ic VEP） and standard automated perimetry（SAP）,for evaluating the application values of ic VEP in the detection of early glaucoma.METHODS：Totally 144 subjects（288 eyes） were enrolled in this study.ic VEP testing was performed with the Neucodia visual electrophysiological diagnostic system.A 15% positive-contrast（bright） condition pattern was used in this device to differentiate between glaucoma patients and healthy control subjects.Signal-to-noise ratios（SNR） were derived based on a multivariate statistic.The eyes were judged as abnormal if the test yielded an SNR≤1.SAP testing was performed with the Humphrey Field Analyzer II.The visual fields were deemed as abnormality if the glaucoma hemifield test results outside normal limits;or the pattern standard deviation with P〈0.05;or the cluster of three or more non-edge points on the pattern deviation plot in a single hemifield with P〈0.05,one of which must have a P〈0.01.Disc photographs were graded as either glaucomatous optic neuropathy or normal by two experts who were masked to all other patient information.Moorfields regression analysis（MRA） used as a separate diagnostic classification was performed by Heidelberg retina tomograph（HRT）.RESULTS：When the disc photograph grader was used as diagnostic standard,the sensitivity for SAP and ic VEP was 32.3% and 38.5% respectively and specificity was 82.3% and 77.8% respectively.When the MRA Classifier was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 48.6% and 51.4% respectively and specificity was 84.1% and 78.0% respectively.When the combined structural assessment was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 59.2%and 53.1% respectively and specificity was 84.2% and 84.6% respectivlely.There was no statistical significance between the sensitivity or specificity of SAP and ic VEP,regardless of which diagnostic standard was based on.CONCLUSION：The diagnostic performance of ic VEP is not better than that of SAP in the detection of early glaucoma.展开更多
海量远程数据完整性检测是云计算安全领域的一个研究热点,可证数据持有(Provable Data Possession,PDP)是一种轻量级远程数据完整性概率检测模型。从不同的公钥基础架构的角度,综述了PDP的研究进展。首先,针对公钥架构(Public Key Infra...海量远程数据完整性检测是云计算安全领域的一个研究热点,可证数据持有(Provable Data Possession,PDP)是一种轻量级远程数据完整性概率检测模型。从不同的公钥基础架构的角度,综述了PDP的研究进展。首先,针对公钥架构(Public Key Infrastructure,PKI)、身份基公钥密码和无证书公钥密码体制,分别阐述了PDP的研究背景和主要研究进展。其次,给出了结合新型网络技术的PDP方案,如区块链技术、DNA技术等。最后,展望了未来PDP研究的一些重要方向,包括量子计算和抗量子PDP、新型智慧城市和基于我国商用密码标准的PDP、6G和内生安全PDP等。展开更多
基金Supported by the Plan of Wenzhou Science and Technology(No.Y20160439)
文摘AIM：To compare the diagnostic performance of isolatedcheck visual evoked potential（ic VEP） and standard automated perimetry（SAP）,for evaluating the application values of ic VEP in the detection of early glaucoma.METHODS：Totally 144 subjects（288 eyes） were enrolled in this study.ic VEP testing was performed with the Neucodia visual electrophysiological diagnostic system.A 15% positive-contrast（bright） condition pattern was used in this device to differentiate between glaucoma patients and healthy control subjects.Signal-to-noise ratios（SNR） were derived based on a multivariate statistic.The eyes were judged as abnormal if the test yielded an SNR≤1.SAP testing was performed with the Humphrey Field Analyzer II.The visual fields were deemed as abnormality if the glaucoma hemifield test results outside normal limits;or the pattern standard deviation with P〈0.05;or the cluster of three or more non-edge points on the pattern deviation plot in a single hemifield with P〈0.05,one of which must have a P〈0.01.Disc photographs were graded as either glaucomatous optic neuropathy or normal by two experts who were masked to all other patient information.Moorfields regression analysis（MRA） used as a separate diagnostic classification was performed by Heidelberg retina tomograph（HRT）.RESULTS：When the disc photograph grader was used as diagnostic standard,the sensitivity for SAP and ic VEP was 32.3% and 38.5% respectively and specificity was 82.3% and 77.8% respectively.When the MRA Classifier was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 48.6% and 51.4% respectively and specificity was 84.1% and 78.0% respectively.When the combined structural assessment was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 59.2%and 53.1% respectively and specificity was 84.2% and 84.6% respectivlely.There was no statistical significance between the sensitivity or specificity of SAP and ic VEP,regardless of which diagnostic standard was based on.CONCLUSION：The diagnostic performance of ic VEP is not better than that of SAP in the detection of early glaucoma.
文摘海量远程数据完整性检测是云计算安全领域的一个研究热点,可证数据持有(Provable Data Possession,PDP)是一种轻量级远程数据完整性概率检测模型。从不同的公钥基础架构的角度,综述了PDP的研究进展。首先,针对公钥架构(Public Key Infrastructure,PKI)、身份基公钥密码和无证书公钥密码体制,分别阐述了PDP的研究背景和主要研究进展。其次,给出了结合新型网络技术的PDP方案,如区块链技术、DNA技术等。最后,展望了未来PDP研究的一些重要方向,包括量子计算和抗量子PDP、新型智慧城市和基于我国商用密码标准的PDP、6G和内生安全PDP等。
