China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cel...China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cells that can differentiate into specialized cells.They are now used for the treatment of many diseases.Despite a series of documents for regulating basic research and achievement transformation of stem cells,the clinical application and industrialization still face great challenges due to展开更多
Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both t...Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available thera- peutics. This therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experi- mental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. This short review will consider relevant background and poten- tial solutions to this problem in the axon regeneration domain.展开更多
Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for repro...Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for reproduction of experiments to con- firm results, 2） promote thorough analyses of data, and 3） foster the incremental advancement of valid approaches. Unfortunately, most would also agree we have far to go to reach this vital goal （Hackam and Redelmeier, 2006; Prinz et al., 2011; Baker et al., 2014）.展开更多
Water deprivation test was done in 44 healthy elderly persons, 26 were male, and 18 were female. They were deprived of the intake of water for 25 hours. The results showed that the maximal renal concentration function...Water deprivation test was done in 44 healthy elderly persons, 26 were male, and 18 were female. They were deprived of the intake of water for 25 hours. The results showed that the maximal renal concentration function both in the elderly males and females was 887 ± 91 mmol / L and 888 ± 127 mmol / L respectively. The renal excretion of waste products in 24 hours both in the elderly males and females was 815+170 mmol / d and 620+132 mmol / d respectively. On the basis of point estimation, the minimal essential urine volume per day in the elderly males and females was 926 ml / d and 708 ml / d respectively, if the daily urine volume of the elderly is less than this level, then, the metabolic products generated per day can not be excreted by the kidney, and it would result in disorders of internal environment. Therefore, the oliguric standard in elderly males and females must be less than 926 ml / d and 708 ml per day respectively.展开更多
A perceptual experiment was conducted in which stimuli sliced from 12 StandardChinese syllables spoken in isolation were identified by 10 native speakers of Beijing dialect.The results of the experiment indicate that ...A perceptual experiment was conducted in which stimuli sliced from 12 StandardChinese syllables spoken in isolation were identified by 10 native speakers of Beijing dialect.The results of the experiment indicate that when the pre-onset or post-offest of a tone is extended to a large extent, the initial voiced consonant, the medial, the nasal coda, and the vocalic ending are not related to the tonal pitch; even when the post-offset is extended to a short extent, the nasal coda and the vocalic cnding are neither related to the tona1 pitch. Thus, with regard to the tonal domain of a Standard Chinese monosyllable in isolation, not only the initial voiced consonant and the medial, but also the nasal coda and the vocalic ending are excludedi in other words, the basic contour of Standard Chincse tone in isolation is mainly related to the syllabic vowel and its adjacent transition. Because F0 in the pre-onset and post- onset are not related to the tonal pitch, there is no exact match between F0 contour and tonal pitch.展开更多
文摘China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cells that can differentiate into specialized cells.They are now used for the treatment of many diseases.Despite a series of documents for regulating basic research and achievement transformation of stem cells,the clinical application and industrialization still face great challenges due to
基金Research in the Lemmon/Bixby lab is supported by NIH grants NS080145 and NS059866by the Miami Project to Cure Paralysis
文摘Progress in developing robust therapies for spinal cord injury （SCI）, trau- matic brain injury （TBI） and peripheral nerve injury has been slow. A great deal has been learned over the past 30 years regarding both the intrinsic factors and the environmental factors that regulate axon growth, but this large body of information has not yet resulted in clinically available thera- peutics. This therapeutic bottleneck has many root causes, but a consensus is emerging that one contributing factor is a lack of standards for experi- mental design and reporting. The absence of reporting standards, and even of commonly accepted definitions of key words, also make data mining and bioinformatics analysis of neural plasticity and regeneration difficult, if not impossible. This short review will consider relevant background and poten- tial solutions to this problem in the axon regeneration domain.
文摘Commentary Most would agree that providing comprehensive detail in scientific reporting is critical for the development of mean- ingful therapies and treatments for diseases. Such stellar practices 1） allow for reproduction of experiments to con- firm results, 2） promote thorough analyses of data, and 3） foster the incremental advancement of valid approaches. Unfortunately, most would also agree we have far to go to reach this vital goal （Hackam and Redelmeier, 2006; Prinz et al., 2011; Baker et al., 2014）.
文摘Water deprivation test was done in 44 healthy elderly persons, 26 were male, and 18 were female. They were deprived of the intake of water for 25 hours. The results showed that the maximal renal concentration function both in the elderly males and females was 887 ± 91 mmol / L and 888 ± 127 mmol / L respectively. The renal excretion of waste products in 24 hours both in the elderly males and females was 815+170 mmol / d and 620+132 mmol / d respectively. On the basis of point estimation, the minimal essential urine volume per day in the elderly males and females was 926 ml / d and 708 ml / d respectively, if the daily urine volume of the elderly is less than this level, then, the metabolic products generated per day can not be excreted by the kidney, and it would result in disorders of internal environment. Therefore, the oliguric standard in elderly males and females must be less than 926 ml / d and 708 ml per day respectively.
文摘A perceptual experiment was conducted in which stimuli sliced from 12 StandardChinese syllables spoken in isolation were identified by 10 native speakers of Beijing dialect.The results of the experiment indicate that when the pre-onset or post-offest of a tone is extended to a large extent, the initial voiced consonant, the medial, the nasal coda, and the vocalic ending are not related to the tonal pitch; even when the post-offset is extended to a short extent, the nasal coda and the vocalic cnding are neither related to the tona1 pitch. Thus, with regard to the tonal domain of a Standard Chinese monosyllable in isolation, not only the initial voiced consonant and the medial, but also the nasal coda and the vocalic ending are excludedi in other words, the basic contour of Standard Chincse tone in isolation is mainly related to the syllabic vowel and its adjacent transition. Because F0 in the pre-onset and post- onset are not related to the tonal pitch, there is no exact match between F0 contour and tonal pitch.
