Laser capture microdissection: from its principle to applications in research on neurodegeneration

History and the principle of laser capture microdissection （LCM）： LCM, also known as laser microdissection and pressure catapulting, is one of the most powerful and useful techniques in various research areas where isolation of heterogeneous cell population is required. The first use of laser as a cell operation method, was originated in early 1920s （Gilbrich-Wille, 2013）, and it became widely used as a microsurgical tool ill early 1960s. In the need of extremely small tissue isolation, laser beam of LCM has been modified and developed over several decades from Ultraviolet （UV） laser beam to high-energy nitrogen, infrared and carbon dioxide lasers （Gilbrich-Wille,

The ethics of exercise in eating disorders:Can an ethical principles approach guide the next generation of research and clinical practice?

1.Introduction Eating disorders(ED)are the most common psychiatric disorders afflicting young women^1 and contribute to great detriments in psychological,social,and physical health.^(2,3)Unfortunately,ED treatments tend to be long lasting,intensive,and expensive.~4Additionally,individuals with ED seeking treatment use healthcare services more frequently than non-ED individu-

Marine Research Standardization:A Project Management Study

Using modern project managementprinciples,this paper analyzes the current state ofmarine research project management in China.Itexplains the function and significance of standardizedproject management,and then puts forwardstrategies for the implementation of standardizationof marine project management.This is done to improvemarine research project management inChina,better the level of scientific research intooceans and promote the development of marinescience and technology in China.

Strategic cooperation on South Asia standardization research

A strategic agreement was signed between Chengdu Bureau of Quality and Technological Supervision and Sichuan University on＂jointly building South Asia Standardization（Chengdu）Research Center＂on November 15,2017.The research center is designed as a national top-level think tank of integrated research on policies,rules and standards at both national and regional levels in South Asia.

Research on the Course of Principles of Concrete Structure Design

Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.

Ethical framework for artificial intelligence in healthcare research:A path to integrity

The integration of Artificial Intelligence(AI)into healthcare research promises unprecedented advancements in medical diagnostics,treatment personalization,and patient care management.However,these innovations also bring forth significant ethical challenges that must be addressed to maintain public trust,ensure patient safety,and uphold data integrity.This article sets out to introduce a detailed framework designed to steer governance and offer a systematic method for assuring that AI applications in healthcare research are developed and executed with integrity and adherence to medical research ethics.

World Medical Association Declaration of HelsinkiE thical Principles for Medical Research Involving Human Subjects

Document Of World Medical AssociationWorld medical association declaration of Helsinki Ethical principles for medical research involving human subjects

Automotive Standardization Research Institute of CATARC---Focus on Standards and Technical Regulations

Automotive Standardization Research Institute ’is, specialized in the standardization and technical regulation research for automobiles and motorcycles. Its main activities include: Nationwide Auto Standardization Technology Comprehensive

The Status and Trend of Research on Standards for Eoological Textile in China

The products of ecological textile have represented nowadays the new trend ofglobal consumption and production of textile while become an important means for some countries toutilize 'green barrier' as a limitation of import of textile products. Following the entrance ofChina into the WTO, the position of 'green barrier' becomes significantly important in the trade oftextile products. As China is a big country of textile production, speeding up the research onstandards for products of ecological textile, countering the latest situation appearing ininternational trade of textile, to take as quickly as possible responsive measures is a very urgentproblem in port, to enhancing the ability of international market competition and to promoting thestable development of foreign oriented economy.

Russian clinical research policy does not guarantee results availability

AIM： To investigate results availability from clinical studies enrolling Russian subjects and Russian clinical research policy.METHODS： We analyzed Russian legislation and ethi-cal regulations about drug and devices approval, clini-cal research registration and the results availability. In August 2012, we searched International Clinical Trials Registry Platform and clinicaltrials.gov to fnd all regis-tered studies that had an investigational site in the ter-ritory of the Russian Federation. To fnd publication sta-tus, we searched the PubMed and Scirus bibliographical databases with trial registration number to fnd journal publications of the registered studies.RESULTS： We identifed 2062 registered research pro-tocols comprising 2017 international and 45 protocols sponsored by the Russian funding agencies. The num-ber of the studies enrolling Russian subjects increased dramatically from three studies in 2002 to 252 studies in 2012. Most studies （92%） were funded exclusively by industry, were interventions （94.6%）, examined drugs （87%） and enrolled exclusively adults （86%） of both genders （89%）. Only 383 （19%） of multinational stud-ies and two （4.4%） of exclusively Russian studies werepublished. Posting of patient outcomes was available for 16% of the trials that recruited trial participants in the Russian territory including one study funded exclu-sively by Russian sponsors. Investigators terminated 99 studies of 38111 participants and did not provide the results in clinicaltrials.gov or in published manuscripts. Federal laws require clinical study registration and con-fict of interest disclosure. However, routine monitoring of compliance to clinical research policy is not available.CONCLUSION： Russian legislation does not guarantee the availability of clinical research results. Russian leg-islation should mandate transparent evidence- based market approval of the drugs and devices.

MULTI-HOP RELAYING IN 5G： FROM RESEARCH TO SYSTEMS, STANDARDS, AND APPLICATIONS

In recent years,the demands of high traffic transmission motivate the rapid development of wireless access techniques,and it becomes promising to design the fifth generation(5G)wireless networks.Essential requirements for 5G involve higher traffic volume,indoor or hotspot traffic,and spectrum,energy,and cost efficien-

Overview of Quality Standardization for Traditional Chinese Medicine

This paper presentsan overview of the standardizationprocess for TraditionalChinese Medicine (TCM)Quality,and reports on the latestresearch projects.It also highlightsthe roles of quality andmodernization in this standardization.

The Preliminary Research on Integrated Management Systems Standards in China

The modern history of management systems is almost the same as the history ofmodem management science. Implicit management systems have been in existence for many 100s ofyears. ISO has paid attention to the issue of the integrated management systems since the ISO 9000family standards for quality management systems (QMS) and ISO 14000 series standards for environmentmanagement system (EMS) were published. ISO/TAG (Technical Advisory Group) 12 was formed by theISO/TM (Technical Management Board) in early 1997 with the mandate to achieve greater compatibilitybetween the relevant ISO/TC 176 and ISO/TC 207 standards in the field of management systems,auditing, terms and definitions. The report was submitted to TMB by TAG 12 in 1999.

Empirical Research of Complex Adaptive Blended Learning in English Intensive Reading Teaching

This research intends to employ Complex Adaptive Blended Learning(CABL)in English Intensive Reading teaching.This empirical research tries to work out what is Complex Adaptive Blended Learning Literature review,Definition of blended learning.It would further analyze the core concepts and framework of CABL and discuss the principles of CABL.This empirical study of Complex Adaptive Blended Learning in English Intensive Reading Teaching would be conducted on the Super-star Learning Management System(SLMS).The activities designed in the Complex Adaptive Blended Learning would be analyzed and how they work before class,in class,and after class would be described.The Complex Adaptive Blended Learning not only offers a platform for students to develop their potential in English Intensive Reading class,but also facilitates the data collection for the teachers in their teaching research.

Generalized Lob’s Theorem.Strong Reflection Principles and Large Cardinal Axioms

In this article, a possible generalization of the Lob’s theorem is considered. Main result is: let κ be an inaccessible cardinal,

Compilation Principles and Methods of China’s First Mongolian Standard in Meteorological Industry

Mongolian Terms Commonly Used in Meteorological Services that was issued by the China Meteorological Administration is China s first traditional Mongolian standard in meteorological industry. In the process of formulation, the compilation unit fully complied with the principles of scientificity, practicability, universality and versatility, and used literal translation, free translation, and the combination of literal translation and free translation to translate and compile 71 mongolian terms commonly used in meteorological services. The standard fills the blank of standardization construction of basic traditional Mongolian language in the meteorological industry of China.

Towards building consensus: Revisiting key principles of CBPR within the First Nations/Aboriginal context

Community based participatory research as a preferred approach to research with First Nations and Aboriginal communities has contributed to new terminologies, new methodologies, and new directions in research relationships. One of the ongoing challenges is to articulate and operationalize the principles for CBPR with these communities. This paper reflects on the nine principles articulated by LaVeaux and Christopher in the context of a long term community-academic research partnership at Standing Buffalo First Nations, Saskatchewan, Canada. Within this application, we begin to critique the various principles and to reframe these principles to increase their utility in informing community based research in the First Nations/Aboriginal context.

‘Disciplining Oneself’and‘Disciplining Others’in Social Life:On the Contemporary Significance of Confucius’s Principle of Loyalty and Reciprocity

In a moral sense,there is an essential di erence between“disciplining oneself”and“disciplining others”in that the former means one setting rules for and giving orders to oneself in regard to one’s own conduct,which are unconditionally compulsory,while the latter is exible in the sense that one’s rules and orders for oneself are not compulsory to others and cannot prohibit others from doing something.In principle,Confucius’s sayings,“do not impose upon others that which you would not wish for yourself”and“establish others in seeking to establish yourself and promote others in s eeking to promote yourself”have epitomized the line of demarcation between them.His doctrine of“not imposing upon others that which you would not wish for yourself,”though based on self-preservation and self-interest,represents a standard of conduct of highly universal value.If the overwhelming majority of a society follows it as their standard of conduct,refraining from harming others in order to protect oneself from harm,then the whole society will endure little,if not no,strife and struggle.