Short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function

BACKGROUND Hepatectomy is the first choice for treating liver cancer.However,inflammatory factors,released in response to pain stimulation,may suppress perioperative immune function and affect the prognosis of patients undergoing hepatectomies.AIM To determine the short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function.METHODS Clinical data from patients with liver cancer admitted to Suzhou Ninth People’s Hospital from January 2020 to December 2023 were retrospectively analyzed.Thirty-five patients underwent laparoscopic hepatectomy for liver cancer(liver cancer resection group)and 35 patients underwent medical image-guided microwave ablation(liver cancer ablation group).The short-term efficacy,complications,liver function,and immune function indices before and after treatment were compared between the two groups.RESULTS One month after treatment,19 patients experienced complete remission(CR),8 patients experienced partial remission(PR),6 patients experienced stable disease(SD),and 2 patients experienced disease progression(PD)in the liver cancer resection group.In the liver cancer ablation group,21 patients experienced CR,9 patients experienced PR,3 patients experienced SD,and 2 patients experienced PD.No significant differences in efficacy and complications were detected between the liver cancer ablation and liver cancer resection groups(P>0.05).After treatment,total bilirubin(41.24±7.35 vs 49.18±8.64μmol/L,P<0.001),alanine aminotransferase(30.85±6.23 vs 42.32±7.56 U/L,P<0.001),CD4+(43.95±5.72 vs 35.27±5.56,P<0.001),CD8+(20.38±3.91 vs 22.75±4.62,P<0.001),and CD4+/CD8+(2.16±0.39 vs 1.55±0.32,P<0.001)were significantly different between the liver cancer ablation and liver cancer resection groups.CONCLUSION The short-term efficacy and safety of microwave ablation and laparoscopic surgery for the treatment of liver cancer are similar,but liver function recovers quickly after microwave ablation,and microwave ablation may enhance immune function.

Short-term efficacy of laparoscopy-assisted vs open radical gastrectomy in gastric cancer

AIM:To investigate the short-term benefits of laparoscopic radical gastrectomy(LARG)and open radical gastrectomy(ORG)in patients with gastric cancer.METHODS:A total of 400 patients with gastric cancer aged≤65 years who were treated at General Hospital of Lanzhou Military Region were enrolled.Among these,200 patients underwent LARG between October2008 and August 2012(LARG group);and 200 patients underwent ORG between March 2000 and September2008(ORG group).The short-term therapeutic benefits between the two groups were analyzed.RESULTS:The LARG procedure offered significantly better benefits to the patients compared to the ORG procedure,including less intraoperative blood loss(103.1±19.5 mL vs 163.0±32.9 mL,P【0.0001),shorter postoperative hospital stay(6.8±1.2 d vs 9.5±1.6 d,P【0.0001),less frequent occurrence of postoperative complications(6.5%vs 13.5%,P=0.02),shorter time to mobilization(1.0±0.3 vs 3.3±0.4 d,P【0.0001),shorter time to bowel opening(3.3±0.7 d vs 4.5±0.7 d,P【0.0001),and shorter time to normal diet(3.0±0.4 vs d 3.8±0.5 d,P【0.0001).However,LARG required a longer time to complete than the ORG procedure(192.3±20.9 min vs 180.0±26.9 min,P【0.0001).CONCLUSION:Compared to ORG,LARG is safer,more effective,and less invasive for treating gastric cancer,with better short-term efficacy.

A PRELIMINARY STUDY OF SHORT-TERM EFFICACY OF Nd:YAG LASER PERIPHERAL IRIDOTOMY IN PATIENTS WITH PRIMARY ANGLE CLOSED GLAUCOMA

Q-switched Nd:YAG laser was used for the peripheral iridotomy in 68 cases(80 eyes) of primary angle closed glaucoma. The average number of laser shots is 20.5(1～127 shots), and the average shot energy is 2.5 mJ(0.9～5.6mJ). The successful rate of iris penetration is about 97.6%. The size of the iris hole is not smaller than 0.2mm^2. The kind of the iris is the most important factor that causes the marked variation in laser shots and in laser shot energy. The main complications of Nd:YAG laser iridotomy p...

Analysis of the Short-Term Curative Effect of Roxadustat in Treating Renal Anemia in Patients with Peritoneal Dialysis

Objective:To analyze the short-term curative effect of roxadustat in the treatment of renal anemia in patients with peritoneal dialysis.Methods:70 patients with peritoneal dialysis renal anemia admitted to the dialysis department of our hospital from March 2021-March 2023 were selected as research objects,divided into a research group and a reference group according to random number drawing method,with each group consisting of 35 cases.The patients in the research group were treated with roxadustat,and those in the reference group were treated with recombinant human erythropoietin.The total efficacy,anemia index,iron metabolism index,and occurrence of adverse reactions were compared between the two groups.Results:The total efficacy of the treatment received in the research group was significantly higher than that in the reference group(P<0.05).In terms of anemia indicators,there was no statistically significant difference between the hemoglobin(Hb),the red blood cell(RBC),and the hematocrit(HCT)of both groups(P>0.05)before treatment.After treatment,the anemia indicators of the patients in the research group were significantly better than those in the reference group,(P<0.05).In terms of iron metabolism,before treatment,there was no significant difference between the total iron-binding capacity(TIBC),the transferrin(TRF),the ferritin(FER),and iron(Fe)of both groups(P>0.05).After treatment,the research group’s iron metabolism indicators were significantly better than those of the reference group(P<0.05).The incidence of adverse reactions in the research group was significantly lower than that in the reference group(P<0.05).Conclusion:The short-term curative effect of roxadustat in the treatment of peritoneal dialysis patients was demonstrated through this study,making it a viable treatment option.

基于贝叶斯方法的混凝土强度接收准则研究

以一次计量抽样检验理论为依据,综合平衡生产方风险和使用方风险,并适当考虑保护生产方利益,提出无论对于标准差已知统计方法还是标准差未知统计方法,混凝土强度平均值的评定系数k均应对应于90%的等效保证率(0.9分位值);并以贝叶斯理论为依据确定了标准差未知统计方法的抽样方案。样本容量很小时,以平均质量标准差为依据建立了非统计方法的接收准则,并根据一次计数抽样检验理论提出最小值接收准则,并作为平均值接收准则的补充。采用贝叶斯方法,将前一检验周期内的样本和本次抽样样本合并,通过扩大样本容量,提高了标准差已知统计方法接收准则的检验功效;同时采用贝叶斯方法,综合考虑平均质量标准差和实测样本标准差,提高了非统计方法接收准则的检验功效。本文建议的接收准则具有更明确的统计学依据,通过采用统一的等效保证率使各种方法保持了较接近的检验功效,并用贝叶斯方法将各种方法统一于标准差未知统计方法。实例分析表明,本文建议的接收准则总体上略比GB/T 50107—2010严格,但变动幅度在可接受范围;采用合理的先验标准差后,本文建议的贝叶斯改进方法可以得到科学合理的评定结果。

Effects of 8-OHdG,H-FABP and CRP on the Development of Ischemic Cardiomyopathy

[Objectives]To analyze the relationship between serum 8-hydroxydeoxyguanosine(8-OHdG),heart fatty acid-binding protein(H-FABP),C-reactive protein(CRP)levels and clinical efficacy and short-term prognosis in patients with ischemic cardiomyopathy.[Methods]The clinical data of 100 patients with ischemic cardiomyopathy from October 2021 to November 2022 were retrospectively analyzed,and the serum levels of 8-OHdG,H-FABP and CRP were compared before and one week after treatment.The patients were followed up for 12 months after discharge,and the incidence of major adverse cardiovascular events(MACE)was counted during the follow-up period.Univariate and multivariate Logistic regression analysis were used to analyze the prognostic factors of patients with ischemic cardiomyopathy in the near future,and the predictive value of serum 8-OHdG,H-FABP and CRP levels for the prognosis of patients was evaluated by ROC curve.[Results]After 1 week of treatment,the serum levels of 8-OHdG,H-FABP and CRP in patients with ischemic cardiomyopathy were significantly lower than those before treatment(P<0.05).During the follow-up period,34 patients developed MACE;the serum levels of 8-OHdG,H-FABP and CRP in the MACE group were higher than those in the non-MACE group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that 8-OHdG,H-FABP and CRP were the risk factors of MACE in patients with ischemic cardiomyopathy(P<0.05).ROC curve analysis showed that the combined prediction of 8-OHdG,H-FABP and CRP for MACE in patients with ischemic cardiomyopathy was higher than that of CRP,H-FABP and 8-OHdG alone(P<0.05).[Conclusions]8-OHdG,H-FABP and CRP are closely related to the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy,and the detection of serum 8-OHdG,H-FABP and CRP levels can help to evaluate the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy.

标准去大骨瓣开颅减压术治疗重型颅脑损伤的临床研究

目的分析常规骨瓣开颅术以及标准去大骨瓣开颅减压术治疗重型颅脑损伤的效果和安全性。方法选择我院2020年1月至2023年12月实施标准去大骨瓣开颅减压术的重型颅脑损伤病人共140例为观察组,同期实施常规骨瓣开颅术的重型颅脑损伤病人共140例为对照组,比较两组的疗效、颅内压、并发症。结果观察组的手术总有效率为97.1%,显著高于对照组的80.0%(P<0.05)。术后第1、5、7天,观察组的颅内压均显著低于对照组(P<0.001)。观察组的并发症发生率为11.4%,显著低于对照组的28.6%(P<0.05)。结论标准去大骨瓣开颅减压术治疗重型颅脑损伤的效果显著,能有效降低颅内压,且安全性较高。

不同剂量阿替普酶超时间窗治疗急性缺血性脑卒中的效果

目的探讨发病4.5~9.0 h的急性缺血性脑卒中(acute ischemic stroke,AIS)患者经多模式CT筛选下超时间窗应用小剂量或标准剂量阿替普酶静脉溶栓的有效性和安全性。方法回顾性分析2021年1月—2023年1月在临沂市中心医院卒中中心就诊的发病时间在4.5~9.0 h的104例AIS患者。均完善一站式多模式CT检查,采用F-stroke软件处理分析脑CT灌注成像,存在核心/灌注不匹配者,给予阿替普酶静脉溶栓,并按照采用剂量大小分为小剂量组(0.6 mg/kg体质量,n=53)与标准剂量组(0.9 mg/kg体质量,n=54)。通过对比改良RanKin评分量表(modified RanKin scale,mRS)、美国国立卫生研究院卒中量表(the National Institutes of Health stroke scale,NIHSS)评分评估临床有效性,通过比较出血性转化(hemorrhagic transformation,HT)率、症状性颅内出血(symptomatic intracranial hemorrhage,SICH)率、泌尿道出血率、消化道出血率、病死率评估临床安全性。结果小剂量组预后良好率为58.49%(31/53),标准剂量组预后良好率为59.26%(32/54),差异无统计学意义(P>0.05)。2组溶栓后7 d NIHSS评分低于基线NIHSS评分,溶栓后90 d mRS评分低于入院时mRS评分,差异有统计学意义(P<0.05)。2组溶栓后7 d NIHSS评分、溶栓后90 d mRS评分比较,差异无统计学意义(P>0.05)。小剂量组24 h HT发生率、24 h SICH发生率、泌尿道出血发生率、消化道出血发生率、90 d病死率分别为1.89%(1/53)、1.89%(1/53)、3.77%(2/53)、1.89%(1/53)、1.89%(1/53),标准剂量组分别为9.26%(5/54)、7.41%(4/54)、1.85%(1/54)、5.56%(3/54)、1.85%(1/54),差异无统计学意义(P>0.05)。结论多模式CT筛选指导下发病在4.5~9.0 h的AIS患者超时间窗应用小剂量和标准剂量阿替普酶静脉溶栓有相似的临床疗效,小剂量更安全。

标准化测量流程在酚类抗氧化剂效能评价中的应用

酚类抗氧化剂在多个领域备受青睐的主要原因是其卓越的抗氧化性能,但不同种类的酚类抗氧化剂存在明显的效能差异,因此,建立标准化测量流程十分必要。本研究通过实验室管理规范化、流程标准化、质量标准化、作业标准化和制度标准化等措施,建立了一个完整的标准化测量流程。在实施标准化管理后,发现抗氧化剂样品的合格率显著提高,检验设备问题所致的差错率和实验人员所致的差错率显著降低。统计学分析进一步证实了这些结果的显著性,标准化测量流程管理在酚类抗氧化剂效能评价中发挥了重要作用,提升了评价结果的准确性和可靠性。展望未来,将进一步完善管理体系,优化评价流程,以推动该领域的持续发展。

标准化早期康复理疗联合手法松解治疗肩周炎的效果分析

目的:研究标准化早期康复理疗联合手法松解治疗肩周炎的效果。方法:选择2020年1月—2023年6月南充市中医医院收治的肩周炎患者104例,均分为对照组与试验组,对照组(52例)实施常规药物治疗,试验组(52例)在对照组的基础上,实施标准化早期康复理疗+手法松解治疗,对比两组治疗效果。结果:治疗10 d后,试验组日常生活能力水平、肩关节综合功能评分、临床疗效优良率,对比对照组均更高(P﹤0.05)。治疗10 d后,试验组疼痛评分、并发症发生率,对比对照组更低(P﹤0.05)。结论:对肩周炎患者实施标准化早期康复理疗+手法松解治疗,疗效更佳。

基于SPOC平台联合ISS和SP混合教学模式在老年医学教学中的应用

目的评估基于小规模限制性网络在线课程(small private online course,SPOC)平台联合原位模拟(in situ simulation,ISS)和标准化病人(standardized patients,SP)混合教学模式在老年医学教学中的应用效果。方法选取2021年7月—2022年12月在中国科学技术大学附属第一医院老年科接受轮转的99名住培医师,随机分为试验组(n=50)和对照组(n=49)。试验组采用基于SPOC平台联合ISS和SP混合教学模式,对照组采用传统教学模式,比较2组住培医师的理论知识、临床技能、教学质量、教学评分、考试成绩和推荐评分。结果试验组的理论知识、临床技能、教学质量和教学评价评分均高于对照组,差异有统计学意义(P<0.001)。试验组的考试成绩为(80.50±7.53)分,高于对照组[(75.88±6.11)分],差异有统计学意义(P<0.001)。试验组的认可推荐评分为(8.66±0.75)分,高于对照组[(6.02±0.72)分],差异有统计学意义(P<0.001)。结论基于SPOC平台联合ISS和SP混合教学模式可提高老年医学的教学效果,提升住培医师的理论知识和临床技能水平。

规范化推拿手法处方治疗腰椎间盘突出症的临床效果

目的探讨规范化推拿手法处方治疗腰椎间盘突出症(LDH)的临床效果。方法选取2022年1月至2022年12月梧州市中医院住院的100例LDH患者作为研究对象,按照随机数字表法分为参照组与研究组,每组50例。参照组给予《2013-2017年全国24所高等中医药院校针灸推拿学科发展调查报告》中LDH推拿方法治疗,研究组给予规范化推拿手法处方治疗,比较两组临床疗效及治疗前后视觉模拟评分法(VAS)评分、日本骨科协会(JOA)下腰痛评分量表评分与世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分。结果研究组治疗总有效率为96.00%,高于参照组的80.00%,差异有统计学意义(P<0.05)。治疗后,研究组VAS评分低于参照组,JOA评分高于参照组,差异有统计学意义(P<0.05)。治疗后,研究组环境领域、社会领域、生理领域及心理领域评分均高于参照组,差异有统计学意义(P<0.05)。结论规范化推拿手法处方可有效缓解LDH患者疼痛,改善其腰椎功能障碍,提高患者生命质量,值得临床推广应用。

围产期规范化心理护理对自然分娩初产妇母亲角色适应及分娩自我效能的影响

目的分析围产期规范化心理护理对自然分娩初产妇母亲角色适应及分娩自我效能的影响。方法选择我院2020年3月至2023年7月收治的82例自然分娩初产妇,随机分为对照组与观察组各41例。对照组采用常规护理,观察组在对照组基础上予以围产期规范化心理护理。比较两组负面情绪、母亲角色适应能力和分娩自我效能。结果护理后,观察组SAS、SDS评分低于对照组,母亲角色适应能力中角色认知、照顾行为、亲子依附评分,以及GSES评分高于对照组(P<0.05)。结论围产期规范化心理护理可有效缓解自然分娩初产妇的负面情绪,提高其母亲角色适应能力及分娩自我效能感。

周围型非小细胞肺癌病人经单孔电视胸腔镜和标准三孔胸腔镜治疗的临床观察分析

目的:探究单孔胸腔镜、标准三孔胸腔镜治疗周围型早期非小细胞肺癌患者临床效果。方法:选取2020年4月至2023年4月期间云南临沧市人民医院临床手术治疗的100例患者作为研究对象,将标准三孔胸腔镜设为对照组,单孔电视胸腔镜设为研究组,对照组、研究组每组50例,分析并发症、疼痛情况、手术指标、恢复效果等情况。结果:研究组患者并发症(0.00%)比对照组并发症(10.00%)更低;研究组术后疼痛情况比对照组疼痛情况较弱。研究组临床手术指标比对照组手术指标更优异;研究组术后恢复效果较对照组恢复时间更短;对比差异显著具有统计学意义(P﹤0.05)。结论:临床治疗非小细胞肺癌患者,予以单孔电视胸腔镜治疗出血量较少,术后恢复时间短,患者疼痛感较弱,无明显并发症,值得临床推广使用。

香菇的营养价值及深加工食品质量安全研究进展

香菇是药食两用的食用菌,具有极高的营养价值和保健功能,随着乡村振兴的全面推进,香菇种植及加工产业得到了快速发展,香菇也成了功能性食品申报中常见的原料。对香菇的营养成分、功效因子、香菇加工的普通食品、功能性食品、香菇食品质量标准及安全控制等内容进行了综述,为香菇产业的可持续发展提供参考。

基于多中心医疗联盟高尿酸血症患者管理模式研究

目的探讨基于多中心医疗联盟高尿酸血症患者管理模式研究。方法选取2022年1月至2023年8月首诊在番禺区中心医院、随诊在医疗联盟的镇属医院的高尿酸血症患者98例,采用随机数表法分为两组,对照组应用常规管理模式,研究组在此基础上应用基于多中心医疗联盟的管理模式。对两组的尿酸达标率、满意度、肝肾功能指标[谷氨酰转肽酶(GGT)、谷丙转氨酶(ALT)、甘油三酯(TG)、血肌酐(Scr)、血尿酸(UA)]以及自我管理能力、饮食控制知信行、生活质量情况进行比较。结果研究组尿酸达标率、满意度均高于对照组,差异有统计学意义(P<0.05);与对照组比较,干预后研究组UA、Scr、TG、ALT、GGT指标数值均更低,差异有统计学意义(P<0.05);相较于对照组,研究组自我效能、健康状况、管理行为评分均更高,差异有统计学意义(P<0.05);与对照组比较,干预后研究组DCKAPHG及生活质量评分均更高,差异有统计学意义(P<0.05)。结论高尿酸血症患者应用基于多中心医疗联盟的管理模式不仅可以提高其自我管理行为、饮食控制知信行情况以及患者的尿酸达标率,同时可以改善其肝肾功能检查指标,有利于患者生活质量以及满意度的提高,值得推广应用。

Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer

Objective To investigate variation in levels of transforming growth factor beta 1(TGF-β1)before and after radiotherapy in patients with esophageal cancer in order to evaluate the predictive value of TGF-β1 for the effects of radiotherapy Methods A total of 140 patients with esophageal squamous carcinoma undergoing radical radiation therapy in the Department of Oncology from March 2015 to December 2017 were enrolled.The patients were divided into the effective(115 cases)and ineffective(25 cases)groups according to World Health Organization(WHO)criteria for the evaluation of solid tumors(2009 RECIST standard).TGF-β1 levels were measured in all patients by using enzyme-linked immunosorbent assay(ELISA).Multiple-factor analysis of the predictive value of the treatment efficacy was performed by Cox regression analysis.Results After radiotherapy,36,79,and 25 cases experienced complete response(CR),partial response(PR),and no response(NR),respectively,with a total effective rate of 82.14%.The TGF-β1 level was significantly lower in the effective group than that in the ineffective group(P<0.05)and covariance analysis revealed significantly reduced TGF-β1 level in esophageal cancer patients following radiotherapy.The multi-factor Cox regression model revealed that the predictive value of TGF-β1 for the effect of radiotherapy was largest,with a hazard ratio[HR]of 1.955(P=0.002),followed by exposure dose,with(HR=1.367;P=0.035).Conclusion Serum TGF-β1 level can serve as a predictor for the short-term effects of radiotherapy in patients with esophageal cancer.

Progress and Challenge of the Short-Term Climate Prediction

The experience of developing a short-term climate prediction system at the Institute of Atmospheric Science of the Chinese Academy of Sciences is summarized,and some problems to be solved in future are discussed in this paper.It is suggested that a good system for short-term climate prediction should at least consist of (1) well-tested model(s),(2) sufficient data and good methods for the initialization and assimilation,(3) a good system for quantitative corrections,(4) a good ensemble prediction method,and (5) appropriate prediction products,such as mathematical expectation,standard deviation,probability,among others.

Effect and safety of mark-guided vs standard peroral endoscopic myotomy: A retrospective case control study

BACKGROUND Peroral endoscopic myotomy(POEM)is a promising therapeutic modality for esophageal achalasia worldwide.However,clinical failure and adverse events of POEM have still been concerned.AIM To compare the efficacy and safety of a novel mark-guided POEM with standard POEM.METHODS A total of 133 patients with esophageal achalasia who underwent POEM from May 2013 to May 2019 were enrolled in this retrospective study.Of the 133 patients,there were 64 patients in the mark-guided POEM group and 69 patients in the standard POEM group.The clinical success,procedural duration and adverse events were compared between the two groups at 3 mo,12 mo and 24 mo postoperatively.RESULTS Characteristic baseline was similar in the mark-guided POEM group and standard POEM group.The clinical success was comparable between the two groups,ranging from 92%to 98%,at 3 mo,12 mo and 24 mo postoperatively(all P>0.5).Eckart score,Gastroesophageal Reflux Disease Questionnaire score and SF-36 score were not different between the two groups after treatment(all P>0.05).No severe adverse events occurred in the two groups.However,markguided POEM required shorter procedural duration,and less use of proton pump inhibitors and lower incidence of reflux symptoms than the standard POEM(all P<0.001).CONCLUSION Mark-guided POEM and standard POEM were both effective and safe for the treatment of esophageal achalasia.However,the mark-guided POEM was characterized by shorter procedural duration,less use of proton pump inhibitors and lower incidence of reflux symptoms.

Effects of Chaihu Guizhi Ganjiang Decoction Combined with Standard Triple Therapy on Reducing Serum CagA and Hp-NAP in Patients with H.pylori-Related Gastritis

OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay(ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention(P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were(19.21±6.27) ng/L and(24.37±6.10) ng/L respectively which were lower than(25.81±7.14) ng/L and(32.09±5.73) ng/L of control group. The differences were statistically significant(P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group(31 cases, 75.61%). There was statistically significant difference between the 2 groups(P < 0.05). The eradication rate of H.pylori was 38 cases(92.68%) in the experimental group, which was significantly higher than 31 cases(75.61%) of the control group. The difference between the 2 groups was statistically significant(P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.