Acceptability of Immunization against COVID-19 by the Populations of the Kasenga State Health Area in the Uvira Health Zone, DR Congo

Introduction: COVID-19 was an emerging disease putting all public health systems in countries around the world in a state of emergency. To be able to prevent its spread and morbidity and mortality, several appropriate strategies were necessary, such as vaccination. The latter has been the subject of controversy. The objective of the present study is therefore to evaluate the factors associated with the acceptance of this vaccine within the population of the Kasenga State Health Area. A result which will shed light on future strategies to be put in place for possible new vaccines. Methodology: Is a prospective and analytical cross-sectional study conducted over a period of approximately 1 month from January 5 to February 5, 2024. A survey questionnaire in Kobotoolbox was useful for collecting data. STATA software was very important for us in analyzing the data collected. Results: Prevalence of vaccination against COVID-19 among the population of the Kasenga State Health Area is 37.5% (28.4 - 45.6). The study revealed that reluctance is observed among most of the population for different reasons, including, first and foremost, the deliberate aspect of not wanting to take the vaccine (46.6%) and rumors that this antigen is dangerous and harmful (32.9%). 72.5% of respondents believe that the COVID-19 vaccine is a fabrication, unhealthy and that the disease itself never existed. The study proved that there was a statistical relationship between age (p = 0.001) and adherence to vaccination. And the refusal of respondents to recommend the vaccine to loved ones was a factor associated with non-adherence to vaccination (OR = 7.901, 95% IC [3.028 - 20.615], p = 0.000). Conclusion: Vaccination against COVID-19 was not well accepted by the population of the study site. Raising public awareness and involving community leaders and political-administrative authorities, which has not been done well, would play an important role in the good perception of the disease, of the vaccine and therefore in its adherence.

Estimation and Prediction of Bioconcentration Factors of Nonionic Organic Chemicals in Fish by Electrotopological State Indices and Structural Parameter

Based on the characteristics of atom types, Hall＇s electrotopological state indices （En） are calculated for 165 nonionic organic compounds. On the basis of the characteristics of substituent and conjugated matrix, a novel molecular structure parameter （G） is defined and calculated for 165 molecules in this paper. En and G show good structural selectivity for organic molecules. G, a satisfactory relationship between bioconcentration factor （BCF） and En, is expressed as： 1gBCF = -0.283 ＋ 1.246G ＋ 0.079E42 ＋ 0.351E9- 0.063E17 （n＇ = 122, R = 0.967, F = 425.636, s = 0.394）, which could provide estimation and prediction for the lgBCF of nonionic organic chemicals. Furthermore, the model is examined to validate overall robustness with Jackknife tests, and the independent variables in model do not exist cross correlation with VIF. All these regression results show that the new parameter G and electrotopological state index have good rationality and efficiency. It is concluded that the En and G will be used widely in quantitative structure-property/activity relationship （QSPR/QSAR） research.

Direct Calculation of Unsteady-State Weymouth Equations for Gas Volumetric Flow Rate with Different Friction Factors in Horizontal and Inclined Pipes

Direct calculations of unsteady-state Weymouth equations for gas volumetric flow rate occur more frequently in the design and operation analysis of natural gas systems. Most of the existing gas pipelines design procedures are based on a particular friction factor and steady-state flow analysis. This paper examined the behavior of different friction factors and the need to develop model analysis capable of calculating unsteady-state gas flow rate in horizontal and inclined pipes. The results show different variation in flow rate with Panhandle A and Panhandle B attaining stability in accurate time with initial unsteadiness at the instance of flow. Chen and Jain friction factors have opposition to flow with high flow rate: The prediction also reveals that Colebrook-White degenerated to Nikuradse friction factor at high Reynolds number. The horizontal and inclined flow equations are considerably enhanced on the usage of different friction factors with the aid of Matlab to handle these calculations.

About Factorization of Quantum States with Few Qubits

Through the study of the factorization conditions of a wave function made up of two, three and four qubits, we propose an analytical expression which can characterize entangled states in terms of the coefficients of the wave function and density matrix elements.

EFFECTS OF ACUPUNCTURE ON THE HIGH HEMAGGLUTINATION STATE, BLOOD-SUGAR-RAISING HORMONE AND IMMUNOCYTE FACTOR LEVELS IN TYPE-II DIABETES PATIENTS

Objective: To investigate the effect of acupuncture on high hemagglutination state, blood sugar raising hormone and immunocyte factor levels in type II diabetes patients. Methods: A total of 120 inpatients and outpatients were randomly divided into acupuncture plus medication group (n=52) and medication group (n=50). In addition, 18 type II diabetes patients formed acupuncture group for comparing their therapeutic effects. Main acupoints used were Pishu (BL 20), Geshu (BL 17), Yishu, Shenshu (BL 23), Zusanli (ST 36), Sanyinjiao (SP 6), etc.. combined with other acupoints according to different sydroms. These acupoints were stimulated by manipulaing the filiform needles with uniform reinforcing and reducing method for 15 min and then stimulated electrically for 15 min with an electroacupuncture therapeutic apparatus. Western medicines used were Glipizide, Dimethyldiguanide Hydrochloride, etc.. The treatment was given once daily, with 10 sessions being a therapeutic course, 2～3 courses altogether. Indexes of external thrombosis length (ETL), platelet agglutination rate (PAgR), fibrinogen (FG), activated partial thromboplastin time (APTT), fasting blood glucose (FBG), prothrombin time(PT), adrenocoticortropic hormone (ACTH), cortisol (CS), growth hormone (GH), glucagon (GL), tumor necrosis factor alpha (TNF α), interleukin 6 (IL 6), insulin (INS) and C peptide (C P) were determined using radioimmunoassay. Results: After 2～3 courses of treatment, both acupuncture group and medication plus acupuncture group could significantly improve high hemagglutination state, lower blood sugar raising hormone level, regulate immunocyte factor level and raise the sensitivity of insulin, which were apparently superior to those of medication group (P<0.05～0.01). Conclusion: Acupuncture therapy can effectively regulate plasma blood sugar raising hormone, immunocyte factor levels, increase the sensitivity of insulin to target cells, resist blood coagulation and improve microcirculation.

Seroprevalence of <i>Helicobacter pylori</i>Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria

Aim: The study aimed at evaluating the seroprevalence of H. pylori infection and its associated risk factors in a cross-section of asymptomatic adult population in Niger-Delta, Nigeria. Methodology: 408 apparently healthy volunteers, aged between 18 - 87 years were recruited for this study. Blood samples were collected from participants and analyzed for H. pylori antibody (IgG) qualitatively with Combo rapid kits and quantitatively with Accu-Bind ELISA Kits. Results: The overall prevalence of Helicobacter pylori colonization in 408 asymptomatic adults was 52.5% (n = 214) and 48.3% (n = 197) by qualitative (Combo rapid kits) and quantitative (Accu-Bind ELISA Kits) serological test methods respectively. H. pylori infection did not differ statistically between genders (p = 0.962) and among age groups (p = 0.185). In addition, multivariate logistic regression indicated that sex and age were not associated with risk of H. pylori. However, participants from Delta Central were at greater risk (OR = 1.89;p = 0.014) of H. pylori infection compared with those from Delta South, but those from Delta North were not at greater risk of infection compared with those from Delta South (p = 0.476). Conclusion: This study indicated an intermediate seroprevalence of H. pylori among asymptomatic adults in Delta state, Nigeria. The prevalence of H. pylori infection was linked to geographical regions but not with sex and age.

Seroprevalence and Associated Risk Factors of Peste des Petits Ruminants among Sheep and Goats in Kassala State, Sudan

Peste des petits ruminant (PPR) is a contagious disease of small ruminants caused by a virus that belongs to the genus Morbillivirus of the family Paramyxoviridae. This study aimed to determine the seroprevalence of PPR disease in sheep and goats and its associated risk factors in Kassala State, Eastern Sudan. Across sectional study was conducted during the period from 30th August to 25th November 2015. The study was carried out using a structured questionnaire survey and a total of 918 blood samples were collected from apparently healthy unvaccinated sheep and goats in different localities in State of Kassala. A total of 546 sheep and 372 goats were tested for specific antibodies to nucleoprotein (NP) by competitive enzyme linked immunosorbent assay (cELISA). The apparent overall prevalence of PPR antibodies in Kassala was 58.2% while the true prevalence was calculated to be 61.3%. The apparent prevalence in sheep and goats was 68.1% and 43.5% respectively. Univariate analysis showed that the risk factors had significant associations with a cELISA positive status: locality, species, age, breed, husbandry system, housing mode, animals movement (p = 0.000) and animals sharing pasture and water (p = 0.003), while sex and newly introduced animals were not significant risk factors (p = 0.771) (p = 0.050) respectively. Factors found that significantly associated (p < 0.05) with increased odds of being cELISA positive in multivariate analysis were localities, species, age and newly introduced animals. The prevalence differed between localities and was the highest in the River Atbara (84.0%) locality, whereas it was lowest in Delta North (29.0%). No significant difference was observed among the sexes. However, the prevalence differed in different age groups and was 52.25% in animals of less than six months old;49.3% were between seven months and two years old and 65.5% were above two years old. In different husbandry systems, the prevalence was 47.9%, 73.0% and 49.2% in intensive, open grazing and pastoral systems respectively. Housing type effects were also observed;the highest prevalence was in animals housed in metal fence (83.3%). The movement pattern showed significant effect, where the prevalence was the highest (81.3%) in animals that move inter-states/inter-localities. It is concluded that the disease is endemic in Kassala State, high prevalent in sheep and goats, posing a threat to animal exportation, and may have a serious economic influence. Owners and herders should compulsorily vaccinate their animals yearly and animals should be investigated periodically for implementation of crucial eradication program.

Influencing factors and growth state classification of a natural Metasequoia population

By analyzing the importance of influencing factors and conducting a comparative study of the effects of different sorting algorithms, a new method is proposed that is suitable for classifying the growth state of a natural Metasequoia glyptostroboides Hu and W.C. Cheng population. We studied 2817 M. glyptostroboides trees over 100 years old and analyzed their growth state by measuring 15 factors from stumpage, site condition, and environmental data. The dimensionality of all factors were reduced using the random forest algorithm, and we classified the remaining factors using the following algorithms: random forest, back-propagation(BP) neural networks, and support vector machine(SVM). The applicability of each sorting algorithm was analyzed. When all the d factors are used for classification and modeling, the model's overall accuracy,kappa coefficient and test accuracy were 85.5%, 0.739 and 85.8%, respectively. By reducing the dimensionality of the factors using the random forest algorithm, 11 factors most strongly influenced the classifications of the growth state of the Metasequoia population: diameter at breast height,height, crown width, age from stumpage data; longitude,latitude, elevation, slope aspect, gradient and slope position from the site condition data; and the edge of the field from the environmental data. For classifying the Metasequoia population, the random forest algorithm has the highest overall accuracy at 87.2%, which is 3.4 and 2.3% higher than the BP neural networks and SVM algorithms,respectively. The SVM algorithm is superior to the random forest algorithm with respect to classifying the state of mortality. The combination of the random forest and SVM algorithms and their combined information can be used to classify and predict the growth state of this natural M.glyptostroboides population to provide a scientific basis for its effective protection.

Latent Tuberculosis Infection among Household Contacts of Pulmonary Tuberculosis Cases in Central State, Sudan: Prevalence and Associated Factors

Introduction: Tuberculosis is a major health problem in developing countries including Sudan. Screening for TB cases through Household contacts (HHCs) investigation is an appropriate strategy to interrupt transmission of TB. Objectives: To determine the prevalence tuberculosis infection and risk factors for tuberculosis infection among household contacts in Wadimadani locality, Central State, Sudan, between November 2015 and April 2016. Methods: An analytical cross-sectional study conducted. During study period, to confirm TB diagnosis, all suspect contacts were tested through sputum samples, tuberculin skin test or chest X-ray. Structured questionnaire was used to collect socio-demographic and environmental factors. Results: One hundred forty six patients of smear-positive pulmonary tuberculosis were included in the study, 657 household contacts were identified and screened. Forty three new TB cases were detected from household contacts, yielding a prevalence of 6.5% (95% confidence interval = 0.05, 0.09) of latent tuberculosis infection (LTBI). Two factors were significantly associated with LTBI among HHCs: duration of contact with a TB patient ≤ 4 months (P = 0.03) and the educational status (P = 0.02). Conclusion: Screening of HHCs of index case of TB will contribute in early detection and treatment of new cases, and considered as a forward step towards eliminating TB.

Non-Abelian Berry phase Factor of the Degenerate states

Suppose the degenerate states wave function of a Hamitonian operatorHis accompanied by a natural phase factor, then we can own it to the role of sometransformation generator played by some non--degenerate Hermitian operator containedin the complete set of conserved mechanical quantities. When this idea is extended tothe spece coordinated by parameters and the momentum--like operator is introduced,thenon-Abelian Berry phose factor of degenerate wave function can be easily gotter afterthe system evolves along a closed adiabatic curve.

GNSS/MEMS IMU车载组合导航中IMU比例因子误差的影响分析

从系统状态模型出发,分析比例因子误差对组合导航精度和计算量的影响,同时基于车载运动的特点分析比例因子误差的观测性,提出一种仅保留航向陀螺仪和水平加速度计比例因子误差的降维状态模型。实验结果表明,当比例因子误差大于6×10^(-3)时,增广比例因子误差有助于提高导航精度,但计算量增加约170%;降维模型能够达到高维模型的导航精度,与不增广比例因子误差相比,计算量仅增加约70%。

计及氢气注入与压缩因子的综合能源系统能流计算

为实现“双碳”目标,综合能源系统(integrated energy systems, IES)成为了近几年的重要研究方向之一,然而传统的IES能流计算已经无法精确地反映电制气(power-to-gas, P2G)技术带来的氢气注入天然气网络后的混合燃气的参数变化对IES的影响。为此,在传统天然气系统稳态分析方法的基础上加入了SRK(Soawk-Redlich-Kwong)气体状态方程,将压缩因子作为状态变量,提出可以反映氢气注入天然气系统,对气体流量和混合燃气热值产生影响的稳态分析方法。以此为基础,提出了计及氢气注入与压缩因子的电-热-气IES能流分解求解计算方法。最后通过算例验证了所提方法可有效反映混合燃气的参数变化对IES的影响。

卵巢癌化疗患者凝血状态观察及影响因素分析

目的观察卵巢癌化疗患者的凝血状态,并探讨其影响因素。方法回顾性分析首都医科大学附属北京妇产医院2018年2月至2022年1月收治的105例卵巢癌化疗患者的临床资料,根据化疗后是否存在高凝状态将患者分为高凝组和非高凝组,探讨高凝状态的发生率及影响因素。结果105例患者中,48例出现了化疗后高凝状态,发生率为45.7%(48/105)。其中2项凝血指标升高为64.6%(31/48),3项凝血指标升高为33.3%(16/48),4项凝血指标升高为2.1%(1/48)。单因素分析显示,年龄、体质量指数、慢性内科合并症数量、化疗后糖类抗原125(CA125)水平、化疗后白细胞水平、肿瘤分期是卵巢癌化疗后高凝状态的潜在影响因素(P<0.05)。多因素Logistic回归分析显示,慢性内科合并症数量(OR=7.152,95%CI:1.991~25.695,P=0.003)和化疗后CA125水平(OR=1.005,95%CI:1.001~1.009,P=0.018)是卵巢癌化疗后高凝状态的独立影响因素。结论血液高凝状态在卵巢癌化疗患者中较为常见,尤其应重视多项慢性内科合并症和化疗后CA125水平较高的患者,应积极地展开相关防治措施。

T细胞亚群水平可预测主动脉夹层患者入院30天生存状态

目的:探究主动脉夹层患者T细胞亚群水平与30 d生存状态的关系。方法:收集184例接受手术治疗的主动脉夹层患者的临床资料,根据入院30 d生存状态分为生存组(149例)和死亡组(35例),比较2组T细胞亚群(CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+))水平。采用多元Logistic回归分析患者入院30 d死亡的影响因素,受试者工作特征曲线分析CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)T细胞的预测价值。结果:184例主动脉夹层患者入院30 d内全因死亡35例(19.02%)。死亡组Stanford A型、低氧血症、高血压患者占比、入院收缩压及舒张压、CD3^(+)CD8^(+)T细胞水平高于生存组,CD3^(+)与CD3^(+)CD4^(+)T细胞水平低于生存组(P均<0.05)。Logistic回归分析结果显示,CD3^(+)CD8^(+)T细胞、Stanford A型、低氧血症、高血压是主动脉夹层患者入院30 d死亡的危险因素,CD3^(+)、CD3^(+)CD4^(+)T细胞是其保护性因素(P均<0.05)。CD3^(+)与CD3^(+)CD4^(+)、CD3^(+)CD8^(+)T细胞预测主动脉夹层患者入院30 d死亡的曲线下面积分别为0.731(95%CI 0.644~0.819)、0.801(95%CI 0.726~0.875)、0.824(95%CI 0.731~0.918)。结论:主动脉夹层患者T细胞亚群CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)水平与入院30 d生存状态相关,三者与Stanford A型、低氧血症、高血压共同影响患者入院30 d生存状态。

Regulatory effect of vascular endothelial growth factor on blood spinal cord barrier in presyrinx state of experimental syringomyelia

BACKGROUND： Vascular endothelial growth factor （VEGF） is able to regulate blood spinal cord barrier function as well as influence neovascularization and cause edema. OBJECTIVE： Through establishment of a rabbit model of syringomyelia, to explore the correlation between VEGF protein and mRNA expressions and function of blood spinal cord barrier and edema degree of spinal cord in presyrinx state. DESIGN, TIME AND SETTING： Randomized controlled animal study was performed in the Tumor Institute of the Fourth Hospital, Hebei Medical University from January to June 2007. MATERIALS： Atotal of 0.6 mL Kaolin solution （250 g/L, 37℃） was injected into the cisterna magna of 40 rabbits in the kaolin group to establish syringomyelia models. Goat anti-rabbit VEGF monoclonal antibody was provided by DIACLONE Company, USA; RT-PCR related reagents were provided by Huamei Bioengineering Co., Ltd., Beijing. METHODS： Sixty Chinese white rabbits were divided randomly into two groups： Kaolin group （n = 40） and control group （n = 20）. Physiological saline （0.6 mL at 37℃） was injected in rabbits of control group. On days 1,3, 7, 14 and 21 after kaolin injection, cervical cords samples were harvested after sacrifice of animal. MAIN OUTCOME MEASURES： VEGF protein and mRNA expressions were detected by immunohistochemistry and RT-PCR on days 1, 3, 7, 14, and 21 after kaolin injection. A quantitative analysis of blood spinal cord barrier function was performed by Evans blue technique. Water content of the spinal cord was measured by dry-wet weight technique. The correlation between the expression of VEGF protein and mRNA and the function of blood spinal cord barrier in the upper cervical cord of the presyrinx state was analyzed by linear correlation analysis. RESULTS： The water content and Evans blue content increased in the kaolin group on days 1 and 3 postoperatively compared with the control group （F = 7.387, 61.35, P 〈 0.05, 0.01）, and reached a peak on day 7 （F = 135.94, 528.35, P 〈 0.01）. They declined slowly to day 21 postoperatively, but both contents were still higher than the control group （F = 11.51, 58.63, P 〈 0.01）. VEGF protein expression increased on day 1, and stronger positive expression was seen on days 3, 7 and 14. It decreased on day 21. VEGF protein expression was higher than the control group at each time point （F = 137.4-468.5, P 〈 0.01 ）. VEGF mRNA expression showed the same pattern in the cervical cord at different time points. By statistical analysis, the expression of VEGF protein and mRNA had a significantly positive correlation with the structural and functional changes of the blood spinal cord barrier in the presyrinx state （r = 0.604-0.979, P 〈 0.05）. CONCLUSION： In the presyrinx state of syringomyelia, the expressions of VEGF protein and mRNA can influence the structure and function of the blood spinal cord barrier and play an important role in the formation and development of spinal cord edema and syringomyelia.

Barut-Girardello and Gilmore-Perelomov coherent states for pseudoharmonic oscillators and their nonclassical properties: Factorization method

In this paper we try to introduce the ladder operators associated with the pseudoharmonic oscillator, after solving the corresponding Schrrdinger equation by using the factorization method. The obtained generalized raising and lowering operators naturally lead us to the Dirac representation space of the system which is much easier to work with, in comparison to the functional Hilbert space. The SU（1, 1） dynamical symmetry group associated with the considered system is exactly established through investigating the fact that the deduced operators satisfy appropriate commutation relations. This result enables us to construct two important and distinct classes of Barut-Girardello and Gilmore-Perelomov coherent states associated with the system. Finally, their identities as the most important task are exactly resolved and some of their nonclassical properties are illustrated, numerically.

煤层气水平井筒倾斜-水平耦合流动规律影响分析

精确掌握煤层气水平井井筒内气液流动规律,对煤层气水平井的合理开发工艺和设备的选择具有重要意义。基于气液两相流理论采用Fluent软件模拟分析的方法,研究了煤层气水平井段倾斜-水平耦合条件下变状态流动规律。分析结果表明:水平段井筒中,上倾斜段井筒内的流动会加剧井筒内气液两相界面的波动。高气、液量下水平段井筒内持液率在流体流动方向上不断增大,低气、液量下水平段井筒内持液率在流体流动方向上不断减小。上倾段倾斜角小于20°时,倾斜角对水平段平均持液率影响较大;下水平段井筒中,倾斜段井筒的长度和倾斜角会影响水平井筒中假想断面的位置,同一流动条件下,出口上倾井筒的倾斜角越大、长度越大,假想断面位置越远离出口端上倾井筒。研究结果可为煤层气水平井下泵深度等排采工艺设计和优选提供理论依据。

基于变遗忘因子的改进卡尔曼滤波锂电池荷电状态估算研究

目的 为了解决锂电池在不同放电阶段和噪声干扰下荷电状态(SOC)估算结果发散问题,方法 通过分析锂电池机理特性,查找影响估算结果的因素和原因。选取适当的数学模型并得到开路电压特性-荷电状态(OCV-SOC)试验曲线后,针对传统算法估算误差波动较大的问题,提出变遗忘因子递推最小二乘(VFF-RLS)与自适应平方根无迹卡尔曼滤波(ASRUKF)算法联合估算SOC。结果 以动态应力测试(DST)为例,遗忘因子最小二乘(FFRLS)算法的开路电压初期误差最大值为0.02 V,稳定后端电压误差为0.004~0.010 V,误差收敛时间约45 s;UKF算法的SOC估算初期最大误差为0.03,在400 s左右逐渐收敛到理论值附近,稳定后的波动误差为0.83%;VFF-RLS算法在相同的条件下,开路电压实验初期误差最大值为0.04 V,稳定后端电压误差为0.003~0.007 V,误差收敛时间约10 s;ASRUKF的SOC估算初期最大误差为0.1,随着算法迭代,200 s内收敛到理论值附近,稳定后最大波动误差0.413%。结论 为了保证算法适用的普遍性,在不同初值下观察算法的收敛性,结果表明,在复杂的试验工况下,与传统算法比较,改进算法的参数辨识速度明显加快,精度提高,在估算SOC阶段,波动范围明显变小;在实际值误差较大的情况下,依然能够迅速收敛,证明本文方法的改进切实可行,可用于实际电池研究。

反腐败斗争对推动共同富裕的正向作用——基于省际平衡面板数据(2005—2021)比较分析的实证研究

党的十八大以来,全面从严治党取得了历史性、开创性成就,反腐败斗争取得了压倒性胜利并得到了全面巩固,在此过程中,“反腐败影响经济增长”的论调“若隐若现”。以翔实数据论证反腐败斗争促进经济发展、推动共同富裕目标的事实成为当前极为重要的一个课题。本研究基于2005—2021年省际平衡面板数据,运用双重差分法探讨党的十八大之前和之后两时期反腐败斗争对推动共同富裕的影响。研究发现,进入新时代,反腐败斗争显著促进了共同富裕目标,反腐败斗争可通过促进非国有经济发展与整个要素市场发育而提高地区共同富裕水平。在稳健性分析中,通过安慰剂检验以解决不可观测到的因素对回归结果产生的影响,该结果依然成立。该研究结果价值主要体现在两方面:一者,能有力回应“反腐败影响经济增长”之荒谬论调;另者,能够丰富“反腐败”“共同富裕”等研究领域的相关文献。

基于肿瘤因子、炎症状态探究紫杉醇白蛋白辅助铂类化疗治疗复发转移性宫颈癌的疗效及安全性

目的:基于肿瘤因子、炎症状态探究紫杉醇白蛋白辅助铂类化疗治疗复发转移性宫颈癌的疗效及安全性。方法:选取2020年1月至2023年1月本院100例复发转移性宫颈癌患者,采用电脑随机数字表法随机分为两组,其中对照组50例,采用紫杉醇辅助奈达铂方案治疗,研究组50例,采用紫杉醇白蛋白辅助奈达铂方案治疗。比较两组近期疗效、肿瘤因子、炎症因子、复发转移相关指标、生存质量、功能状态、不良反应。结果:研究组总缓解率(72.00%)高于对照组(48.00%)(P<0.05);研究组治疗1个周期、3个周期后血清细胞角蛋白19片段抗原21-1(CYFRA21-1)、糖链抗原724(CA724)、鳞状细胞癌抗原(SCC-Ag)、白介素-4(IL-4)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组,血清微小RNA-367(mi R-367)、微小RNA-383(miR-383)水平、肿瘤患者生活质量评分(QOL)、卡氏功能状态评分(KPS)评分高于对照组(P<0.05);研究组治疗期间恶心/呕吐、腹泻、疲倦、白细胞减少、过敏反应发生率与对照组比较,差异无统计学意义(P>0.05),但总不良反应发生率(12.00%)低于对照组(32.00%)(P<0.05)。结论:紫杉醇白蛋白辅助奈达铂在复发转移性宫颈癌治疗中疗效可靠,能进一步下调肿瘤因子水平,缓解炎症状态,且安全性较高。