Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy (IMRT) photon beams on the target volume planning and on the critical organs in the case of prostate can-cer....Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy (IMRT) photon beams on the target volume planning and on the critical organs in the case of prostate can-cer. Methods Thirty plans were generated by using either 6 MV or 15 MV beams separately, and a combination of both 6 and 15 MV beams. Al plans were generated by using suitable planning objectives and dose con-straints, which were identical across the plans, except the beam energy. The plans were analyzed in terms of their target coverage, conformity, and homogeneity, regardless of the beam energy. Results The mean percentage values of V70 Gy for the rectal wal for the plans with 6 MV, 15 MV, and mixed-energy beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were 53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 MV, 15 MV, and mixed-en-ergy plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 MV plans was 10% larger than those for the 15 MV and mixed-energy plans.Conclusion These preliminary results suggest that mixed-energy IMRT plans may be advantageous with respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the organs at risk may not be clinical y relevant, in this study, IMRT plans using mixed-energy beams exhibited better OAR sparing and overal higher plan quality for deep-seated tumors.展开更多
This article uses real engineering projects as examples to analyze how static load test technology is applied in testing the bridge-bearing capacity.The analysis covers aspects such as testing section layout,test load...This article uses real engineering projects as examples to analyze how static load test technology is applied in testing the bridge-bearing capacity.The analysis covers aspects such as testing section layout,test load and efficiency coefficient,loading plan,evaluation optimization,test result modification,and result evaluation.The aim is to support the accurate detection and evaluation of bridge-bearing capacity.展开更多
Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography (kV-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modul...Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography (kV-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modulated radiotherapy (IMRT) or fractionated stereotactic radiotherapy. Methods Eighteen patients with non-operative lung cancer who received IMRT consisting of 1.8-2.2 Gy/fraction and five fractions per week or stereotactic radiotherapy with 5-8 Gy/fraction and three fractions a week were studied, kV-CBCT was performed once per week during IMRT and at every fraction during stereotactic radiotherapy. The gross tumor volume (GTV) was contoured on the kV-CBCT images, and adaptive treatment plans were created using merged kV-CBCT and primary planning computed tomogra- phy image sets. Tumor volume changes and dosimetric parameters, including the minimum dose to 95% (D95) or 1% (D1) of the planning target volume (PTV), mean lung dose (MLD), and volume of lung tissue that received more than 5 (Vs), 10 (Vl0), 20 (V20), and 30 (V30) Gy were retrospectively analyzed. Results The average maximum change in GTV observed during IMRT or fractionated stereotactic radio- therapy was -25.85% (range, -13.09% --56.76%). The D95 and Dr of PTV for the adaptive treatment plans in all patients were not significantly different from those for the initial or former adaptive treatment plans. In patients with tumor volume changes of 〉20% in the third or fourth week of treatment during IMRT, adap- tive treatment plans offered clinically meaningful decreases in MLD and V5, V10, V20, and V30; however, in patients with tumor volume changes of 〈 20% in the third or fourth week of treatment as well as in patients with stereotactic radiotherapy, there were no significant or clinically meaningful decreases in the dosimetric parameters. Conclusion Adaptive treatment planning for decreasing tumor volume during IMRT may be beneficial for patients who experience tumor volume changes of 〉20% in the third or fourth week of treatment.展开更多
Intensity-modulated particle therapy(IMPT)with carbon ions is comparatively susceptible to various uncertainties caused by breathing motion,including range,setup,and target positioning uncertainties.To determine relat...Intensity-modulated particle therapy(IMPT)with carbon ions is comparatively susceptible to various uncertainties caused by breathing motion,including range,setup,and target positioning uncertainties.To determine relative biological effectiveness-weighted dose(RWD)distributions that are resilient to these uncertainties,the reference phase-based four-dimensional(4D)robust optimization(RP-4DRO)and each phase-based 4D robust optimization(EP-4DRO)method in carbon-ion IMPT treatment planning were evaluated and compared.Based on RWD distributions,4DRO methods were compared with 4D conventional optimization using planning target volume(PTV)margins(PTV-based optimization)to assess the effectiveness of the robust optimization methods.Carbon-ion IMPT treatment planning was conducted in a cohort of five lung cancer patients.The results indicated that the EP-4DRO method provided better robustness(P=0.080)and improved plan quality(P=0.225)for the clinical target volume(CTV)in the individual respiratory phase when compared with the PTV-based optimization.Compared with the PTV-based optimization,the RP-4DRO method ensured the robustness(P=0.022)of the dose distributions in the reference breathing phase,albeit with a slight sacrifice of the target coverage(P=0.450).Both 4DRO methods successfully maintained the doses delivered to the organs at risk(OARs)below tolerable levels,which were lower than the doses in the PTV-based optimization(P<0.05).Furthermore,the RP-4DRO method exhibited significantly superior performance when compared with the EP-4DRO method in enhancing overall OAR sparing in either the individual respiratory phase or reference respiratory phase(P<0.05).In general,both 4DRO methods outperformed the PTV-based optimization in terms of OAR sparing and robustness.展开更多
This paper introduced domestic and overseas status, the historical evolution and the development history of earthquake disaster reduction planning. The urgencies and realistic significance were analyzed to carry out e...This paper introduced domestic and overseas status, the historical evolution and the development history of earthquake disaster reduction planning. The urgencies and realistic significance were analyzed to carry out earthquake disaster reduction planning for districts or countries in the northwest. With Hongsibao District in Wuzhong City, Ningxia Province as an example, this article analyzed in detail the present situation and the special problems of earthquake disaster reduction planning in Northwest China. The relevant solving measures were put forward in order to offer a reference for the scientific establishment and effective implementation of earth- quake disaster reduction planning in Northwest China. The foundation of earthquake disaster reduction in the Hongsibao District is still very weak, there is a single earthquake monitoring means, the emergency rescue system is not complete, the working mechanism is not perfect, and the lack of funding for the work of earthquake disaster reduction.展开更多
巡检机器控制是电厂巡检自动化和智能化技术的核心,但现行方法在实际应用中存在一些不足和缺陷,不仅控制路径平滑系数较低,而且存在碰撞问题,智能巡检机器避障性能较差,无法达到预期的控制效果,为此提出基于SLAM(Simultaneous Localizat...巡检机器控制是电厂巡检自动化和智能化技术的核心,但现行方法在实际应用中存在一些不足和缺陷,不仅控制路径平滑系数较低,而且存在碰撞问题,智能巡检机器避障性能较差,无法达到预期的控制效果,为此提出基于SLAM(Simultaneous Localization And Mapping)算法和动静态规划的电厂智能巡检机器控制方法。利用激光雷达和相机获取巡检环境信息,采用YOLOv3对图像增强,通过点云旋转去除激光点云中离散点,实现对点云数据增强,采用SLAM算法对巡检环境图像和激光点云融合,构建巡检地图和定位巡检机器,采用动静态规划根据环境信息动态调整巡检机器运动轨迹,从而实现对电厂智能巡检机器导航跟踪控制。经实验证明,应用设计方法后,巡检机器路径平滑系数在0.9以上,未发生碰撞,该方法在电厂智能巡检机器控制方面具有良好的应用前景。展开更多
Plan asymmetry leads to lateral-rotational coupled effects on structural response characteristics.This investigation deals with a simplified method for performance estimation of structures with asymmetric plan.By taki...Plan asymmetry leads to lateral-rotational coupled effects on structural response characteristics.This investigation deals with a simplified method for performance estimation of structures with asymmetric plan.By taking the eccentric characteristics of structures into account,an equivalent triple-degree of freedom (ETDOF) system,which is constructed by eccentric mass,rigid links and springs,is proposed.The modal pushover analysis (MPA) method for asymmetric plan structures is proposed.The target displacement is determined by constant strength spectrum.The applicability of proposed method is discussed.A generic mass eccentric 4-story steel frame is analyzed by the proposed MPA procedure and nonlinear time history analysis (NTHA).The results show that the maximum deformation obtained from MPA has a good agreement with the NTHA results.The proposed MPA procedure is reliable and effective for evaluating the performance of asymmetric plan structures.展开更多
In the research of path planning for manipulators with many DOF, generally there is a problem in most traditional methods, which is that their computational cost (time and memory space) increases exponentially as DOF ...In the research of path planning for manipulators with many DOF, generally there is a problem in most traditional methods, which is that their computational cost (time and memory space) increases exponentially as DOF or resolution of the discrete configuration space increases. So this paper presents the collision-free trajectory planning for the space robot to capture a target based on the wavelet interpolation algorithm. We made wavelet sample on the desired trajectory of the manipulator’s end-effector to do trajectory planning by use of the proposed wavelet interpolation formula, and then derived joint vectors from the trajectory information of the end-effector based on the fixed-attitude-restrained generalized Jacobian matrix of multi-arm coordinated motion, so as to control the manipulator to capture a static body along the desired collision-free trajectory. The method overcomes the shortcomings of the typical methods, and the desired trajectory of the end-effector can be any kind of complex nonlinear curve. The algorithm is simple and highly effective and the real trajectory is close to the desired trajectory. In simulation, the planar dual-arm three DOF space robot is used to demonstrate the proposed method, and it shows that the algorithm is feasible.展开更多
文摘Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy (IMRT) photon beams on the target volume planning and on the critical organs in the case of prostate can-cer. Methods Thirty plans were generated by using either 6 MV or 15 MV beams separately, and a combination of both 6 and 15 MV beams. Al plans were generated by using suitable planning objectives and dose con-straints, which were identical across the plans, except the beam energy. The plans were analyzed in terms of their target coverage, conformity, and homogeneity, regardless of the beam energy. Results The mean percentage values of V70 Gy for the rectal wal for the plans with 6 MV, 15 MV, and mixed-energy beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were 53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 MV, 15 MV, and mixed-en-ergy plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 MV plans was 10% larger than those for the 15 MV and mixed-energy plans.Conclusion These preliminary results suggest that mixed-energy IMRT plans may be advantageous with respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the organs at risk may not be clinical y relevant, in this study, IMRT plans using mixed-energy beams exhibited better OAR sparing and overal higher plan quality for deep-seated tumors.
文摘This article uses real engineering projects as examples to analyze how static load test technology is applied in testing the bridge-bearing capacity.The analysis covers aspects such as testing section layout,test load and efficiency coefficient,loading plan,evaluation optimization,test result modification,and result evaluation.The aim is to support the accurate detection and evaluation of bridge-bearing capacity.
文摘Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography (kV-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modulated radiotherapy (IMRT) or fractionated stereotactic radiotherapy. Methods Eighteen patients with non-operative lung cancer who received IMRT consisting of 1.8-2.2 Gy/fraction and five fractions per week or stereotactic radiotherapy with 5-8 Gy/fraction and three fractions a week were studied, kV-CBCT was performed once per week during IMRT and at every fraction during stereotactic radiotherapy. The gross tumor volume (GTV) was contoured on the kV-CBCT images, and adaptive treatment plans were created using merged kV-CBCT and primary planning computed tomogra- phy image sets. Tumor volume changes and dosimetric parameters, including the minimum dose to 95% (D95) or 1% (D1) of the planning target volume (PTV), mean lung dose (MLD), and volume of lung tissue that received more than 5 (Vs), 10 (Vl0), 20 (V20), and 30 (V30) Gy were retrospectively analyzed. Results The average maximum change in GTV observed during IMRT or fractionated stereotactic radio- therapy was -25.85% (range, -13.09% --56.76%). The D95 and Dr of PTV for the adaptive treatment plans in all patients were not significantly different from those for the initial or former adaptive treatment plans. In patients with tumor volume changes of 〉20% in the third or fourth week of treatment during IMRT, adap- tive treatment plans offered clinically meaningful decreases in MLD and V5, V10, V20, and V30; however, in patients with tumor volume changes of 〈 20% in the third or fourth week of treatment as well as in patients with stereotactic radiotherapy, there were no significant or clinically meaningful decreases in the dosimetric parameters. Conclusion Adaptive treatment planning for decreasing tumor volume during IMRT may be beneficial for patients who experience tumor volume changes of 〉20% in the third or fourth week of treatment.
基金supported by National Key Research and Development Program of China(No.2022YFC2401503)National Natural Science Foundation of China(Nos.11875299,61631001,U1532264,and 12005271).
文摘Intensity-modulated particle therapy(IMPT)with carbon ions is comparatively susceptible to various uncertainties caused by breathing motion,including range,setup,and target positioning uncertainties.To determine relative biological effectiveness-weighted dose(RWD)distributions that are resilient to these uncertainties,the reference phase-based four-dimensional(4D)robust optimization(RP-4DRO)and each phase-based 4D robust optimization(EP-4DRO)method in carbon-ion IMPT treatment planning were evaluated and compared.Based on RWD distributions,4DRO methods were compared with 4D conventional optimization using planning target volume(PTV)margins(PTV-based optimization)to assess the effectiveness of the robust optimization methods.Carbon-ion IMPT treatment planning was conducted in a cohort of five lung cancer patients.The results indicated that the EP-4DRO method provided better robustness(P=0.080)and improved plan quality(P=0.225)for the clinical target volume(CTV)in the individual respiratory phase when compared with the PTV-based optimization.Compared with the PTV-based optimization,the RP-4DRO method ensured the robustness(P=0.022)of the dose distributions in the reference breathing phase,albeit with a slight sacrifice of the target coverage(P=0.450).Both 4DRO methods successfully maintained the doses delivered to the organs at risk(OARs)below tolerable levels,which were lower than the doses in the PTV-based optimization(P<0.05).Furthermore,the RP-4DRO method exhibited significantly superior performance when compared with the EP-4DRO method in enhancing overall OAR sparing in either the individual respiratory phase or reference respiratory phase(P<0.05).In general,both 4DRO methods outperformed the PTV-based optimization in terms of OAR sparing and robustness.
基金Supported by State Key Laboratory of Loess and Quaternary Geology Open-end Fund(SKLLQG1426)Post-doctoral Foundation and National Natural Science Foundation of China(41102107)~~
文摘This paper introduced domestic and overseas status, the historical evolution and the development history of earthquake disaster reduction planning. The urgencies and realistic significance were analyzed to carry out earthquake disaster reduction planning for districts or countries in the northwest. With Hongsibao District in Wuzhong City, Ningxia Province as an example, this article analyzed in detail the present situation and the special problems of earthquake disaster reduction planning in Northwest China. The relevant solving measures were put forward in order to offer a reference for the scientific establishment and effective implementation of earth- quake disaster reduction planning in Northwest China. The foundation of earthquake disaster reduction in the Hongsibao District is still very weak, there is a single earthquake monitoring means, the emergency rescue system is not complete, the working mechanism is not perfect, and the lack of funding for the work of earthquake disaster reduction.
文摘巡检机器控制是电厂巡检自动化和智能化技术的核心,但现行方法在实际应用中存在一些不足和缺陷,不仅控制路径平滑系数较低,而且存在碰撞问题,智能巡检机器避障性能较差,无法达到预期的控制效果,为此提出基于SLAM(Simultaneous Localization And Mapping)算法和动静态规划的电厂智能巡检机器控制方法。利用激光雷达和相机获取巡检环境信息,采用YOLOv3对图像增强,通过点云旋转去除激光点云中离散点,实现对点云数据增强,采用SLAM算法对巡检环境图像和激光点云融合,构建巡检地图和定位巡检机器,采用动静态规划根据环境信息动态调整巡检机器运动轨迹,从而实现对电厂智能巡检机器导航跟踪控制。经实验证明,应用设计方法后,巡检机器路径平滑系数在0.9以上,未发生碰撞,该方法在电厂智能巡检机器控制方面具有良好的应用前景。
基金Sponsored by the National Natural Science Foundation of China (Grant No. 90815014,90715021 and 51008208)
文摘Plan asymmetry leads to lateral-rotational coupled effects on structural response characteristics.This investigation deals with a simplified method for performance estimation of structures with asymmetric plan.By taking the eccentric characteristics of structures into account,an equivalent triple-degree of freedom (ETDOF) system,which is constructed by eccentric mass,rigid links and springs,is proposed.The modal pushover analysis (MPA) method for asymmetric plan structures is proposed.The target displacement is determined by constant strength spectrum.The applicability of proposed method is discussed.A generic mass eccentric 4-story steel frame is analyzed by the proposed MPA procedure and nonlinear time history analysis (NTHA).The results show that the maximum deformation obtained from MPA has a good agreement with the NTHA results.The proposed MPA procedure is reliable and effective for evaluating the performance of asymmetric plan structures.
文摘In the research of path planning for manipulators with many DOF, generally there is a problem in most traditional methods, which is that their computational cost (time and memory space) increases exponentially as DOF or resolution of the discrete configuration space increases. So this paper presents the collision-free trajectory planning for the space robot to capture a target based on the wavelet interpolation algorithm. We made wavelet sample on the desired trajectory of the manipulator’s end-effector to do trajectory planning by use of the proposed wavelet interpolation formula, and then derived joint vectors from the trajectory information of the end-effector based on the fixed-attitude-restrained generalized Jacobian matrix of multi-arm coordinated motion, so as to control the manipulator to capture a static body along the desired collision-free trajectory. The method overcomes the shortcomings of the typical methods, and the desired trajectory of the end-effector can be any kind of complex nonlinear curve. The algorithm is simple and highly effective and the real trajectory is close to the desired trajectory. In simulation, the planar dual-arm three DOF space robot is used to demonstrate the proposed method, and it shows that the algorithm is feasible.