Integration between Genomic and Computational Statistical Surveys for the Screening of SNP Genetic Variants in Inflammatory Bowel Disease (IBD) Pediatric Patients*

Inflammatory bowel diseases (IBD) are complex multifactorial disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). Considering that IBD is a genetic and multifactorial disease, we screened for the distribution dynamism of IBD pathogenic genetic variants (single nucleotide polymorphisms;SNPs) and risk factors in four (4) IBD pediatric patients, by integrating both clinical exome sequencing and computational statistical approaches, aiming to categorize IBD patients in CD and UC phenotype. To this end, we first aligned genomic read sequences of these IBD patients to hg19 human genome by using bowtie 2 package. Next, we performed genetic variant calling analysis in terms of single nucleotide polymorphism (SNP) for genes covered by at least 20 read genomic sequences. Finally, we checked for biological and genomic functions of genes exhibiting statistically significant genetic variant (SNPs) by introducing Fitcon genomic parameter. Findings showed Fitcon parameter as normalizing IBD patient’s population variability, as well as inducing a relative good clustering between IBD patients in terms of CD and UC phenotypes. Genomic analysis revealed a random distribution of risk factors and as well pathogenic SNPs genetic variants in the four IBD patient’s genome, claiming to be involved in: i) Metabolic disorders, ii) Autoimmune deficiencies;iii) Crohn’s disease pathways. Integration of genomic and computational statistical analysis supported a relative genetic variability regarding IBD patient population by processing IBD pathogenic SNP genetic variants as opposite to IBD risk factor variants. Interestingly, findings clearly allowed categorizing IBD patients in CD and UC phenotypes by applying Fitcon parameter in selecting IBD pathogenic genetic variants. Considering as a whole, the study suggested the efficiency of integrating clinical exome sequencing and computational statistical tools as a right approach in discriminating IBD phenotypes as well as improving inflammatory bowel disease (IBD) molecular diagnostic process.

Brief Introduction to and Review on Elements of Computational Statistics

A brief introduction and review of new book about the Elements of Computational Statistics is given.

Stochastic Resonance in a Time-Delayed Mono-Stable System with Multiplicative and Additive Noise

The stochastic resonance （SR） in a time-delayed mono-stable system driven by multiplicative white noise, additive white noise, additive dichotomous noise as well as a periodic square-wave signal is considered from the view of the signal-to-noise ratio （SNR）. It is found that the SNR increases monotonically with the increase of the delay time. The SNR exhibits the SR behavior when it is plotted as a function of intensities of the noises, displaying the asymmetry of the dichotomous noise. The SNR varies non-monotonically with the increase of the system parameter and the amplitude of the input square-wave signal.

Entropic Stochastic Resonance Driven by Colored Noise

The phenomenon of entropic stochastic resonance （ESR） in a two-dimensional confined system driven by a transverse periodic force is investigated when the colored fluctuation is included in the system. Applying the method of unified colored noise approximation, the approximate Fokker-Planck equation can be derived in the absence of the periodic force. Through the escaping rate of the Brownian particle from one well to the other, the power spectral amplification can be obtained. It is found that increasing the values of the noise correlation time and the signal frequency can suppress the ESR of the system.

Periodic, Quasiperiodic and Chaotic q-Breathers in a Fermi-Pasta-Ulam Lattice

We study the features of a single q-breather （SQB） in a Fermi-Pasta-Ulam lattice by the numerical method, and obtain that the stability of SQB correlates to coupling constant K and nonlinear parameter β. No matter whether K or β increases, the periodic SQB can be transformed into a quasiperiodic SQB or a chaotic SQB. We also obtain the conditions of excitation of periodic, quasiperiodic and chaotic SQBs.

Condensation of Self-Driven Particles in Scale-Free Networks

A new simple model of self-driven particles in scale-free networks is introduced to understand the emergence of condensation in the natural world. In the model, at each time step, particles are driven to choose their next habitats according to the particle numbers at both the present habitats and neighbors. It is found that the hub effect results in the condensation. The present numerical results as well as the theoretical analysis of condensation transition show the criterion of condensation. Both simulations and theoretical analysis display that there are three phases for different hopping probabilities δ： non-condensation （δ〈δc）, partial condensation （δc≤ δ〈1）, and complete condensation （δ≥δc＇= 1）, and the mean occupation particle number at the stationary state is also obtained. Moreover, the noise effect on self-driven particles is studied, and it makes particle numbers at nodes tend towards being identical.

A New Scheme to Projective Synchronization of Fractional-Order Chaotic Systems

We demonstrate that the projective synchronization can be observed in coupled fractional-order chaotic systems. A new systematic and powerful coupling scheme is developed to investigate the projective synchronization via the open-plus-closed-loop control, which allows us to arbitrarily manipulate the scaling factor of projective synchronization. The proposed scheme is proved analytically on the basis of the stability theorem of the fractional differential equations. Numerical simulations on the fraction-order chaotic Chen system are presented to justify the theoretical analysis.

Prisoner＇s Dilemma on Co-Evolving Networks without Strategy Update

We investigate the game theory in a structured population with the assumption that the evolution of network structure is far faster than that of strategy update. We find that the degree distribution for the finM network consists of two distinct parts： the low degree part which is contributed to by defectors and a broadband in the regime with high degree which is formed by cooperators. The structure of the final network and the final strategy pattern have also been numerically proved to be independent of the game parameters.

Effect of Time Delay on Stochastic Tumor Growth

We study the dynamics of tumor cell growth with time-delayed feedback driven by multiplicative noise in an asymmetrical bistable potential well. For a small delay time, the analytical solutions of the probability distribution and the first passage time show that, with the increasing delay time, the peak of the probability distribution in a lower population state would increase, but in a higher population state it decreases. It is shown that the multiplicative noise and the time delay play opposite roles in the tumor cell growth.

Security Analysis of a Block Encryption Algorithm Based on Dynamic Sequences of Multiple Chaotic Systems

Recently, the cryptosystem based on chaos has attracted much attention. Wang and Yu （Commun. Nonlin. Sci. Numer. Simulat. 14（2009）574） proposed a block encryption algorithm based on dynamic sequences of multiple chaotic systems. We analyze the potential flaws in the algorithm. Then, a chosen-plaintext attack is presented. Some remedial measures are suggested to avoid the flaws effectively. Furthermore, an improved encryption algorithm is proposed to resist the attacks＂ and to keep all the merits of the original cryptosystem.

Tensor Bernstein concentration inequalities with an application to sample estimators for high-order moments

This paper develops the Bernstein tensor concentration inequality for random tensors of general order,based on the use of Einstein products for tensors.This establishes a strong link between these and matrices,which in turn allows exploitation of existing results for the latter.An interesting application to sample estimators of high-order moments is presented as an illustration.