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Total endovascular repair of an intraoperative stent-graft deployed in the false lumen of Stanford type A aortic dissection: A case report 被引量:3
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作者 Xu-Ran Li Yuan-Hao Tong +3 位作者 Xiao-Qiang Li Chang-Jian Liu Chen Liu Zhao Liu 《World Journal of Clinical Cases》 SCIE 2020年第5期954-962,共9页
BACKGROUND A 46-year-old male underwent ascending aortic replacement,total arch replacement,and descending aortic stent implantation for Stanford type A aortic dissection in 2016.However,an intraoperative stent-graft ... BACKGROUND A 46-year-old male underwent ascending aortic replacement,total arch replacement,and descending aortic stent implantation for Stanford type A aortic dissection in 2016.However,an intraoperative stent-graft was deployed in the false lumen inadvertently.This caused severe iatrogenic thoracic and abdominal aortic dissection,and the dissection involved many visceral arteries.CASE SUMMARY The patient had pain in the chest and back for 1 mo.A computed tomography scan showed that the patient had secondary thoracic and abdominal aortic dissection.The ascending aortic replacement,total arch replacement,and descending aortic stent implantation for Stanford type A aortic dissection were performed 2 years prior.An intraoperative stent-graft was deployed in the false lumen.Endovascular aneurysm repair was performed to address this intractable situation.An occluder was used to occlude the proximal end of the true lumen,and a covered stent was used to direct blood flow back to the true lumen.A three-dimensional printing technique was used in this operation to guide prefenestration.The computed tomography scan at the 1stmo after surgery showed that the thoracic and abdominal aortic dissection was repaired,with all visceral arteries remaining patent.The patient did not develop renal failure or neurological complications after surgery.CONCLUSION The total endovascular repair for false lumen stent-graft implantation was feasible and minimally invasive.Our procedures provided a new solution for stent-graft deployed in the false lumen,and other departments may be inspired by this case when they need to rescue a disastrous stent implantation. 展开更多
关键词 Type A dissection False lumen stent graft implantation Endovascular repair 3D printing Thoracoabdominal aortic dissection Case report
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Custom Made Fenestrated Stent Graft Collapse after Thoracic Endovascular Aortic Repair: A Case Report
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作者 Yasuhiko Kobayashi Mitsugu Fukuda +2 位作者 Shoji Sakaguchi Yoshihisa Nakao Kiyoshi Nishimine 《Case Reports in Clinical Medicine》 2023年第8期299-305,共7页
We present a case of stent graft collapse after performing thoracic endovascular aortic repair with a custom-made fenestrated stent graft. The patient was a 70-year-old woman with an asymptomatic aneurysm of the dista... We present a case of stent graft collapse after performing thoracic endovascular aortic repair with a custom-made fenestrated stent graft. The patient was a 70-year-old woman with an asymptomatic aneurysm of the distal aortic arch, and thoracic endovascular aortic repair was performed. The patient showed a blood pressure difference between the left arm and the right arm on postoperative day (POD) 17 prompting the performance of a chest computed tomography scan which revealed stent graft collapse. She then underwent staged debranching of thoracic endovascular aortic repair. Stent graft collapse is a rare but well-described complication of thoracic endovascular repair. Therefore, patients who undergo such a procedure should be carefully monitored for signs and symptoms, which suggest the possibility of stent collapse. 展开更多
关键词 Thoracic Endovascular Aortic repair COLLAPSE Custom Made Fenestrated stent Graft Bird-Beak Deformity
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Old canalicular laceration repair:a retrospective study of the curative effects and prognostic factors 被引量:16
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作者 Fang Bai Hai Tao +4 位作者 Yan Zhang Peng Wang Cui Han Yi-Fei Huang Ye Tao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第6期902-907,共6页
AIM: To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS: A retrospective review of all old canalicular la... AIM: To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS: A retrospective review of all old canalicular laceration repairs from Jan. 1, 2008 to Dec. 30, 2015 was performed. Analyzed data included demographics, mechanisms of injury, the time from injury to repair, causes for delayed repair, old associated injuries, the types of surgery, and the effects of repair using canaliculus anastomosis combined with bicanalicular stent intubation. RESULTS: Totally 148 patients with old canalicular laceration received surgical repair and were enrolled. The mean age at presentation was 32.52 years old (ranged from 3 to 63 years old). The 110 patients (74.32%) were male and 127 patients (85.81%) were adults (__.18 years old). The old upper, lower, and bicanalicular lacerations were found in 5 (3.38%), 39 (26.35%), and 104 patients (70.27%), respectively. The mechanism of old injury was primarily due to motor vehicle accidents (n=53, 35.81%). The mean time from injury to repair was 43.61mo (ranged from 1 to 360mo). Associated old ocular and orbit injuries were found in 65 patients (43.92%), and chronic dacryocystitis in 18 patients (12.16%). The main cause of delayed repair was that doctors or patients didn't pay attention to the canalicular laceration because of the concurrent severe injuries (n=71, 47.97%). Totally 136 patients (91.89%) with old canalicular laceration underwent canaliculus anastomosis combined with bicanalicular stent intubation. In all of them, 20 patients (13.51%) were combined with dacryocystorhinostomy. In these cases, 132 patients (97.06%) attained anatomic success, 121 patients (88.97%)reported no epiphora (functional success), 11 patients (8.09%) reported significant epiphora anesis (functional improvement), and 4 (2.94%) reported no significant anesis (functional failure). Rates of anatomic success and functional success were significantly correlated with different canaliculus involved. However, rates of anatomic success and functional success were not significantly affected by the time from injury to repair. CONCLUSION: The canalicular anastomosis combined with bicanalicular stent intubation could act as an effective therapeutics for old canalicular laceration. 展开更多
关键词 old canalicular laceration canalicular repair bicanalicular stent
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Endovascular stent-grafts for acute and chronic type B aortic dissection: comparison of clinical outcomes 被引量:2
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作者 Quanming Jing Yaling Han Xiaozheng Wang Jie Deng Bo Luan Hongxu Jin Xiaojiang Liu Fei Li Ying Liu 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2007年第2期67-71,共5页
Objective To evaluate the early and mid-term results of endovascular repair for acute and chronic type B aortic dissection, and to compare the clinical outcomes between the 2 groups. Methods From May 2002 to December ... Objective To evaluate the early and mid-term results of endovascular repair for acute and chronic type B aortic dissection, and to compare the clinical outcomes between the 2 groups. Methods From May 2002 to December 2006, 50 patients with type B aortic dissection were treated by endovascular stent-graft. There were 23 patients in the acute aortic dissection (AAD) group and 27 patients in the chronic aortic dissection (CAD) group. All patients were followed up from 1 to 54 months (average, 17±16 months).The immediate and follow-up clinical outcomes were documented and compared between the 2 groups. Results Placement of endovascular stent-grafts across the primary entry tears was technically successful in all 50 patients. Compared to the CAD group, the AAD group had a higher percentage of pleural effusion (17.4% vs. 0%, P=0.04) and visceral /leg ischemia (26.1% vs 3.7%, P=0.04). Procedure related complications, including endoleak and post-implantation syndrome, occurred more frequently in the AAD group than in the CAD group (21.7% vs 3.7% and 30.4% vs 11.1%, respectively; P=0.08 and P=0.04). Kaplan–Meier analysis showed no difference in the survival rate at 4 years between the 2 groups (86.4% vs 92.3%, P=0.42 by log-rank test). However, the event-free survival rate was higher in patients with chronic dissection than in patients with acute aortic dissection(96.2% vs 73.9%; P=0.02 by log-rank test). Conclu- sions Endovascular repair with stent-graft was safe and effective for the treatment of both acute and chronic type B aortic dissection. However, both immediate and long term major complications occurred more frequently in patients with acute dissection than in those with chronic dissection. 展开更多
关键词 AORTIC DISSECTION ENDOVASCULAR repairing stent-GRAFT
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Endovascular treatment of aortoiliac aneurysms: From intentional occlusion of the internal iliac artery to branch iliac stent graft 被引量:2
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作者 Stevo Duvnjak 《World Journal of Radiology》 CAS 2016年第3期275-280,共6页
Approximately 20%-40% of patients with abdominal aortic aneurysms can have unilateral or bilateral iliac artery aneurysms and/or ectasia. This influences and compromises the distal sealing zone during endovascular ane... Approximately 20%-40% of patients with abdominal aortic aneurysms can have unilateral or bilateral iliac artery aneurysms and/or ectasia. This influences and compromises the distal sealing zone during endovascular aneurysm repair. There are a few endovascular techniques that are used to treat these types of aneurysms, including intentional occlusion/over-stenting of the internal iliac artery on one or both sides, the "bell-bottom" technique, and the more recent method of using an iliac branch stent graft. In some cases, other options include the "snorkel and sandwich" technique and hybrid interventions. Pelvic ischemia, represented as buttock claudication, has been reported in 16%-55% of cases; this is followed by impotence, which has been described in 10%-17% of cases following internal iliac artery occlusion. The bellbottom technique can be used for a common iliac artery up to 24 mm in diameter given that the largest diameter of the stent graft is 28 mm. There is a paucity of data and evidence regarding the "snorkel and sandwich" technique, which can be used in a few clinical scenarios. The hybrid intervention is comprised of a surgical operation, and is not purely endovascular. The newest branch stent graft technology enables preservation of the anterograde flow of important side branches. Technical success with the newest technique ranges from 85%-96.3%, and in some small series, technical success is 100%. Buttock claudication was reported in up to 4% of patients treated with a branch stent graft at 5-year follow-up. Mid- and short-term follow-up results showed branch patency of up to 88% during the 5-6-year period. Furthermore, branch graft occlusion is a potential complication, and it has been described to occur in 1.2%-11% of cases. Iliac branch stent graft placement represents a further development in endovascular medicine, and it has a high technical success rate without serious complications. 展开更多
关键词 Aortoiliac artery ANEURYSM Branch ILIAC stent GRAFT stent GRAFT ENDOVASCULAR ANEURYSM repair Angiography
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Short-term efficacy of unibody single-branched stent in the treatment of lesions involving the left subclavian artery:two-year follow-up outcomes 被引量:3
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作者 Bai-Lang CHEN Xian-Mian ZHUANG Min-Xin WEI 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2020年第2期120-123,共4页
The development of thoracic endovascular aortic repair(TEVAR)technology avoids the risk of patients opening the chest and is widely used in Stanford B-type dissection.[1–3]However,because TEVAR technology has clear r... The development of thoracic endovascular aortic repair(TEVAR)technology avoids the risk of patients opening the chest and is widely used in Stanford B-type dissection.[1–3]However,because TEVAR technology has clear requirements for vascular anatomy of the lesion,it limits its application to some patients.In the shortcomings of the proximal anchor zone,coverage of the left subclavian artery(LSA)origin without revascularization during TEVAR appears to have increased risk of stroke,upper extremity ischemia and paraplegia.[4] 展开更多
关键词 Aortic dissection Left subclavian artery Single-branched stent graft Thoracic endovascular aortic repair
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Angioscopic Observation of an Endoluminal Stent Graft: CT Imaging versus Angioscopic Imaging 被引量:1
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作者 Yasuhiko Kobayashi Takahiro Yamaguchi +7 位作者 Sei Komatsu Tomoki Ohara Junichi Yoshida Mitsuhiko Takewa Satoru Takahashi Chikao Yutani Kazuhisa Kodama Shizuo Yoshida 《World Journal of Cardiovascular Surgery》 2016年第6期87-92,共6页
We could observe the endoluminal stent graft (SG) following thoracic endovascular aneurysm repair (TEVAR) by a coronary artery angioscope and establish intravascular visualization of SG. The patient was a 70-year-old ... We could observe the endoluminal stent graft (SG) following thoracic endovascular aneurysm repair (TEVAR) by a coronary artery angioscope and establish intravascular visualization of SG. The patient was a 70-year-old woman with the distal aortic arch aneurysm and the descending aortic aneurysm, and debranching TEVAR were performed. After 12 months follow up, urgent hospitalization was required for chest pain, and cardiac catheter examination with a coronary artery angioscope was performed. The endoluminal SG was observed. The observation in angioscope which is a video image is better than CT that is a still image, and observation in blood vessel or SG is possible. It may be possible to observe the endoluminal SG, allowing potential investigation of an endoleak, or the covering status of the SG with the native aortic vessel wall, or the state of intimal membrane formation in the endoluminal graft. 展开更多
关键词 Intravascular Visualization ANGIOSCOPY Endoluminal stent Graft Endovascular Aneurysm repair
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Carotid-subclavian bypass and endovascular aortic repair of Kommerell’s diverticulum with aberrant left subclavian artery:A case report
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作者 Wajeehullahi Akilu Yi Feng +4 位作者 Xiao-Xue Zhang Shi-Liang Li Xian-Tao Ma Min Hu Cai Cheng 《World Journal of Clinical Cases》 SCIE 2023年第33期8038-8043,共6页
BACKGROUND Kommerell’s diverticulum(KD)with aberrant left subclavian artery is a rare congenital deformity and also has very little research literature about it(35%of case study).There are three types of aortic arch ... BACKGROUND Kommerell’s diverticulum(KD)with aberrant left subclavian artery is a rare congenital deformity and also has very little research literature about it(35%of case study).There are three types of aortic arch diverticulum.Even literature concerning the treatment options are limited.CASE SUMMARY We present a case report of a 50-year-old male with KD in the right aortic arch with aberrant left subclavian artery.We conducted a total endovascular repair procedure,which is innovative and will spread more light in the medical world.Our patient has no past medical history and is a non-smoker and non-alcoholic.Patient presented with shortness of breath,chest pain and dizziness for six months.Blood tests were done and computerized tomography(CT)angiogram of the chest confirmed the diagnosis,illustrating showed a 3.9 cm KD.On Day 1,the CT angiogram showed mild dilatation of the thoracic aorta,adjacent esophagus,trachea was compressed and displaced.Surgery was planned as the treatment modality.Carotid-Subclavian artery bypass and endovascular aortic repair was conducted.We used prolene 5-0 C1 sutures to precisely anastomose a 6-mm Dacron graft to the left subclavian artery.Haemostasis was secured and wounds were closed.Protamine was administered and patient was shifted to intensive care unit.Post-operative,patient responded favorably and was discharged.Regular follow-up is done.CONCLUSION The procedure we performed is novel.This will help the cardio-thoracic surgeons a better insight about the full procedures we conducted,thereby bringing more light and better treatment options in managing KD with aberrant subclavian artery. 展开更多
关键词 Kommerell’s diverticulum Left common carotid artery Aberrant left subclavian artery Carotid-subclavian bypass Medtronic stent catheter endovascular repair Case report
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Endovascular Repair for Abdominal Aortic Aneurysm Reduces Postoperative Blood Endotoxin Levels Assayed by the EAA Method Compared with Open Abdominal Surgery
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作者 Atsumi Ohishi Satoshi Matsushita +4 位作者 Shizuyuki Dohi Taira Yamamoto Hirotaka Inaba Kenji Kuwaki Atsushi Amano 《World Journal of Cardiovascular Surgery》 2014年第6期87-94,共8页
Introduction: We hypothesized to demonstrate whether there are significant differences in blood endotoxin (Et) levels after abdominal aortic surgery between endovascular aortic repair (EVAR) and open abdominal surgery... Introduction: We hypothesized to demonstrate whether there are significant differences in blood endotoxin (Et) levels after abdominal aortic surgery between endovascular aortic repair (EVAR) and open abdominal surgery. Methods: The patients who underwent the surgical treatment for abdominal aortic aneurysm were divided into two groups according to the procedures: open abdomen surgery (OP) and EVAR (SG). The value of Endotoxin Activity Assay (EAA) was compared between groups. Results: After surgery, Et level was significantly higher in the OP group than in the SG group on postoperative day 3. Neutrophil count was significantly higher in the OP group immediately after treatment, but no significant difference was seen thereafter. There were no differences between the groups in other inflammatory markers. Conclusions: This study indicated that EVAR was less invasive compared to an open abdominal surgery from the standpoint of assessing postoperative endotoxin activity (EA) levels measured by EAA. 展开更多
关键词 Inflammation Infection stentS ENDOVASCULAR AORTIC repair
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Endovascular repair of type B aortic dissection: a study by computational fluid dynamics
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作者 Yi Fan Stephen Wing-Keung Cheng +1 位作者 Kai-Xiong Qing Kwok-Wing Chow 《Journal of Biomedical Science and Engineering》 2010年第9期900-907,共8页
Aortic dissection is a dangerous pathological condition where blood intrudes into the layers of the arterial walls, creating an artificial channel (false lumen). In the absence of thrombosis or surgical intervention, ... Aortic dissection is a dangerous pathological condition where blood intrudes into the layers of the arterial walls, creating an artificial channel (false lumen). In the absence of thrombosis or surgical intervention, blood will enter the false lumen through the proximal tear, and join the true lumen again through a distal tear. Rupture of the weakened outer wall will result in extremely high mortality rates. Type B thoracic aortic dissection (TAD), occurring along the descending aorta, can be repaired surgically by the deployment of an endovascular stent graft, concealing the proximal entry tear. Blood might still flow into the false lumen (FL) through the distal tear. The domain of such flow should be minimized, as complete thrombosis of the FL is generally believed to be more beneficial for the patient. The dependence on the area ratios of the lumens and size of these tears is studied by computational fluid dynamics. 展开更多
关键词 AORTIC DISSECTION ENDOVASCULAR repair stent GRAFT Computational Fluid Dynamics
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覆膜支架腔内修复术对StanfordB型主动脉夹层治疗效果与安全性的Meta分析
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作者 卫紫琼 贾静静 王红雷 《中国循证心血管医学杂志》 2024年第11期1295-1299,共5页
目的使用Meta分析的方法系统评价覆膜支架腔内修复术对Stanford B型主动脉夹层(TBAD)的治疗效果与安全性。方法系统检索中国知网、万方数据库、维普、中国生物医学文献数据库、PubMed、Embase、the Cochrane Library和Web of Science等... 目的使用Meta分析的方法系统评价覆膜支架腔内修复术对Stanford B型主动脉夹层(TBAD)的治疗效果与安全性。方法系统检索中国知网、万方数据库、维普、中国生物医学文献数据库、PubMed、Embase、the Cochrane Library和Web of Science等中英文数据库,收集覆膜支架腔内修复术治疗TBAD的随机对照试验(RCTs),检索时间为建库至2023年10月31日。对纳入文献进行质量评价并提取数据,应用Stata 16.0和RevMan 5.4软件对各项结局指标进行Meta分析。结果共纳入13篇RCTs进行Meta分析,包括1114例TBAD患者,其中575例接受覆膜支架腔内修复术。Meta分析结果显示,接受覆膜支架腔内修复术的试验组在生存率(OR=6.51,95%CI:3.50~12.11,P<0.01),再次手术或介入率(OR=0.33,95%CI:0.21~0.52,P<0.01),天门冬氨酸氨基转移酶(MD=-23.02 U/L,95%CI:-25.01~-21.03,P<0.01)、丙氨酸氨基转氨酶(MD=-14.28 U/L,95%CI:-15.58~-12.99,P<0.01)、血尿素氮(MD=-1.35 mmol/L,95%CI:-1.63~-1.06,P<0.01)和肌酐(MD=-23.43 mmol/L,95%CI:-26.30~-20.57,P<0.01)等肝肾功能指标上较对照组均显著改善。试验组TBAD患者内漏(OR=6.11,95%CI:0.73~51.34,P=0.10)和血管梗塞(OR=3.00,95%CI:0.31~29.16,P=0.34)的发生率与对照组差异无统计学意义;试验组脑梗塞(OR=0.14,95%CI:0.03~0.65,P=0.01)、肝肾功能障碍(OR=0.22,95%CI:0.07~0.74,P=0.01)和总并发症发生率(OR=0.30,95%CI:0.17~0.54,P<0.01)低于对照组,组间差异具有统计学意义。结论覆膜支架腔内修复术可有效改善TBAD患者的生存率,降低再次手术或介入率,在整体并发症上具有较好的安全性,在具体并发症方面尚需更多高质量文献进一步验证。 展开更多
关键词 STANFORDB型主动脉夹层 覆膜支架腔内修复术 有效性 安全性 META分析
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胸主动脉腔内隔绝术在破裂性胸降主动脉瘤治疗中的应用
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作者 朱洪江 赵鹏鹏 +3 位作者 颜峰 屈长征 符延波 彭长铁 《介入放射学杂志》 CSCD 北大核心 2024年第7期728-732,共5页
目的 评价破裂性胸降主动脉瘤腔内治疗的效果,并总结治疗经验。方法 回顾性分析2016年1月至2023年6月张家界市人民医院血管介入外科收治的8例破裂性胸降主动脉瘤患者的临床资料。其中男性4例,女性4例,中位年龄70.5岁(61~78岁)。8例术前... 目的 评价破裂性胸降主动脉瘤腔内治疗的效果,并总结治疗经验。方法 回顾性分析2016年1月至2023年6月张家界市人民医院血管介入外科收治的8例破裂性胸降主动脉瘤患者的临床资料。其中男性4例,女性4例,中位年龄70.5岁(61~78岁)。8例术前均行主动脉CTA检查明确胸降主动脉瘤且存在胸腔或(和)纵隔血肿,均急诊行胸主动脉腔内隔绝术。结果 6例患者胸降主动脉瘤隔绝彻底,其中2例患者采用烟囱支架技术重建左锁骨下动脉。另外2例患者存在少量Ⅰa型内漏,在近端植入CUFF支架后内漏消失。住院期间1例患者发生食管主动脉瘘导致脓毒性休克死亡,3例患者术后出现呼吸衰竭,行胸腔穿刺引流、抗感染、呼吸机辅助呼吸治疗后恢复。2例患者术后出现缺血性脑卒中,1例表现为患侧肢体肌力3级伴语言障碍,1例表现为患侧肢体肌力4级伴语言障碍。随访期间1例术后7个月再次突发胸痛死亡,1例未植入烟囱支架的患者于术后18个月出现Ⅰa型内漏,近端植入CUFF支架后内漏消失。其余5例病例随访期间情况良好。结论 破裂性胸降主动脉瘤行腔内治疗安全、有效。 展开更多
关键词 破裂性胸降主动脉瘤 胸主动脉瘤 胸主动脉腔内隔绝术 覆膜支架
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Stanford B型主动脉夹层腔内修复术后主动脉扩张性病变的研究进展
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作者 李天祎 《介入放射学杂志》 CSCD 北大核心 2024年第4期443-448,共6页
胸主动脉腔内修复术(thoracic endovascular aortic repair,TEVAR)目前是Stanford B型主动脉夹层(type B aortic dissection,TBAD)的主要治疗方法,当下治疗原则以封堵近端破口为主,而旷置远端破口导致假腔血栓化受阻;主动脉形态及支架... 胸主动脉腔内修复术(thoracic endovascular aortic repair,TEVAR)目前是Stanford B型主动脉夹层(type B aortic dissection,TBAD)的主要治疗方法,当下治疗原则以封堵近端破口为主,而旷置远端破口导致假腔血栓化受阻;主动脉形态及支架远端弹性应力变化,导致管腔局部点压力扩大,形成新发破口或再发夹层导致假腔瘤样扩张,甚至急性破裂致死。术后应通过定期CTA随访,严密监测支架远端管径变化、残留破口直径及假腔血栓化程度。本文通过总结国内外文献,对TEVAR后主动脉扩张性病变的发病原因、机制及处理方法等进行归纳并作综述。 展开更多
关键词 胸主动脉腔内修复术 主动脉夹层 支架移植物远端新发破口
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外泌体介导的组织工程在骨修复中的作用
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作者 游永刚 陈苏丽 +1 位作者 王晓凤 李占清 《中国骨科临床与基础研究杂志》 2024年第2期137-144,共8页
严重创伤、骨肿瘤等导致的骨不连及骨缺损治疗是骨科医生面临的难题,以细胞为基础的骨组织工程技术为骨缺损修复治疗提供有效方法。随着对干细胞在骨组织再生中作用的深入理解,研究人员发现干细胞外泌体释放是其引导骨再生的治疗机制之... 严重创伤、骨肿瘤等导致的骨不连及骨缺损治疗是骨科医生面临的难题,以细胞为基础的骨组织工程技术为骨缺损修复治疗提供有效方法。随着对干细胞在骨组织再生中作用的深入理解,研究人员发现干细胞外泌体释放是其引导骨再生的治疗机制之一。外泌体能够通过旁分泌信号在细胞间发挥通讯作用,调节骨形成过程中的骨再生和血管生成。本文阐述外泌体的生物学来源、成分及功能,从分子生物学角度探讨外泌体在骨修复中的调控作用,同时对外泌体在骨组织工程中促进骨缺损修复的研究成果进行总结,以期更加深入理解外泌体的作用机制,为骨缺损修复提供新的治疗思路。 展开更多
关键词 外泌体 组织工程 骨折 不愈合 骨缺损 骨修复 间质干细胞 巨噬细胞 支架
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胸主动脉腔内覆膜支架修复术联合外科转流术或“烟囱”支架置入术对Stanford B型主动脉夹层术后并发症的影响 被引量:16
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作者 周子凡 王龙飞 +5 位作者 董松坡 潘旭东 刘宁宁 许尚栋 朱俊明 孙立忠 《中国医药》 2018年第10期1481-1484,共4页
目的探讨胸主动脉腔内覆膜支架修复术联合外科转流术或"烟囱"支架置入术对Stanford B型主动脉夹层(AD)术后并发症的影响。方法对首都医科大学附属北京安贞医院2015年3月至2017年3月108例接受血管修复手术治疗的胸主动脉腔内St... 目的探讨胸主动脉腔内覆膜支架修复术联合外科转流术或"烟囱"支架置入术对Stanford B型主动脉夹层(AD)术后并发症的影响。方法对首都医科大学附属北京安贞医院2015年3月至2017年3月108例接受血管修复手术治疗的胸主动脉腔内Stanford B型AD患者的临床资料进行回顾性分析,将所有患者按照手术方法分为Ⅰ组(65例)和Ⅱ组(43例)。Ⅰ组患者采用胸主动脉腔内覆膜支架修复术联合外科转流术治疗,Ⅱ组患者采用胸主动脉腔内覆膜支架修复术联合"烟囱"支架置入术治疗。比较2组患者术后并发症发生情况。结果所有患者手术均成功,Ⅰ组患者住院时间明显长于Ⅱ组[(22±6)d比(16±3) d],差异有统计学意义(P <0.01)。住院期间,Ⅰ组65例患者中有25例(38.5%)出现术后并发症(4例术后感染、2例脑梗死、2例逆行性A型夹层、13例肾功能异常、4例死亡),Ⅱ组43例患者中有11例(25.6%)出现术后并发症(3例脑梗死、2例肾功能异常、6例Ⅰ型内漏),2组患者住院期间术后并发症发生率比较差异无统计学意义(P=0. 17)。108例患者中85例随访1年,随访率78.7%;Ⅰ组51例患者中4例(7. 8%)出现术后并发症(2例移植物感染、2例持续存在逆行性A型夹层),Ⅱ组34例患者中11例(32.4%)出现术后并发症(2例脑梗死、6例Ⅰ型内漏、3例血栓形成)。Ⅱ组术后并发症发生率明显高于Ⅰ组,差异有统计学意义(P=0.01)。结论对于Stanford B型AD患者而言,随访期间胸主动脉腔内覆膜支架修复术联合"烟囱"支架置入术的术后并发症发生率明显高于胸主动脉腔内覆膜支架修复术联合外科转流术。胸主动脉腔内覆膜支架修复术联合外科转流术更适合外科手术风险较低者,而胸主动脉腔内覆膜支架修复术联合"烟囱"支架置入术更适合外科手术风险较高者。 展开更多
关键词 主动脉夹层 支架修复术 外科转流术 “烟囱”支架置入术 术后并发症
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Stanford B型主动脉夹层覆膜支架血管腔内修复术后的中、远期严重并发症 被引量:7
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作者 王国权 翟水亭 +3 位作者 李天晓 史帅涛 张克伟 李坤 《中国介入影像与治疗学》 CSCD 2012年第2期87-90,共4页
目的评价应用覆膜支架血管腔内修复术治疗Stanford B型主动脉夹层后的中、远期严重并发症。方法 2005年1月—2011年1月,189例症状性Stanford B型主动脉夹层患者接受覆膜支架血管腔内修复术治疗,其中男157例,女32例。分析治疗术后中、远... 目的评价应用覆膜支架血管腔内修复术治疗Stanford B型主动脉夹层后的中、远期严重并发症。方法 2005年1月—2011年1月,189例症状性Stanford B型主动脉夹层患者接受覆膜支架血管腔内修复术治疗,其中男157例,女32例。分析治疗术后中、远期严重并发症的发生率。结果随访时间平均为32个月(3~63个月),随访率71.43%(135/189),失访率28.57%(54/189)。术后中、远期随访,19例(19/135,14.07%)发生严重并发症,包括死亡8例(8/135,5.93%),截瘫2例(2/135,1.48%),Stanford B型夹层转为逆行性Stanford A型夹层2例(2/135,1.48%),严重内瘘7例(7/135,5.19%)。结论覆膜支架血管腔内修复术治疗Stanford B型主动脉夹层与外科手术相比较有重要意义,但术后严重的并发症仍时有发生,应该引起重视。 展开更多
关键词 主动脉疾病 夹层 血管腔内修复术 并发症 支架
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Stanford B型主动脉夹层多型支架介入治疗的临床体会 被引量:7
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作者 夏金国 施海彬 +4 位作者 杨正强 刘圣 周春高 赵林波 李麟荪 《介入放射学杂志》 CSCD 北大核心 2010年第5期369-372,共4页
目的应用多种类型支架行Stanford B型主动脉夹层介入治疗,探讨扩大介入治疗适应证的可行性。方法回顾性分析2004年5月-2009年12月,18例Stanford B型主动脉夹层患者行介入性腔内修复术治疗的临床资料。根据CTA和DSA结果 ,个体化选择合适... 目的应用多种类型支架行Stanford B型主动脉夹层介入治疗,探讨扩大介入治疗适应证的可行性。方法回顾性分析2004年5月-2009年12月,18例Stanford B型主动脉夹层患者行介入性腔内修复术治疗的临床资料。根据CTA和DSA结果 ,个体化选择合适覆膜支架,透视下将覆膜支架经股动脉导入封闭夹层破口。术后CTA随访观察内漏、支架移位、假腔变化等。结果 18例中2例放置分体式主动脉覆膜支架、1例放置分支型覆膜支架、2例放置预留孔型主动脉覆膜支架,13例放置普通主动脉覆膜支架。1例封堵左锁骨下动脉、2例不全封堵左锁骨下动脉均未出现左上肢和椎基底动脉缺血症状;1例因解剖变异右锁骨下动脉起自主动脉弓而行旁路手术。术后发生8例(44.4%)即刻I型内漏,其中1例腔内修复术后持续I型内漏再次放置支架后进展为StandfordA型主动脉夹层瘤而行升主动脉人工血管置换术,其余CTA随访内漏逐渐消失;所有患者均无支架移位、断裂、塌陷以及术后截瘫及脑血管意外发生。结论采取不同方法延长近端锚定区的距离、应用分体式主动脉支架可扩大介入治疗Standford B型主动脉夹层的适应证,且近期疗效好,中、远期疗效有待进一步观察。 展开更多
关键词 主动脉夹层 支架 腔内修复 适应证
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腹主动脉瘤手术切除与腔内治疗疗效的比较 被引量:15
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作者 黄建华 刘光强 +5 位作者 符洋 汤恢焕 吕新生 李刚 郭曲练 蔡宏伟 《中国普通外科杂志》 CAS CSCD 2008年第6期542-545,共4页
目的比较腹主动脉瘤(AAA)手术切除与腔内治疗的效果,探讨手术时机及治疗方式的选择。方法回顾性分析我院近4年多来进行手术治疗的51例肾下腹主动脉瘤患者的临床资料,比较传统手术切除组(37例)与腔内支架植入组(14例)围手术期及术后近期... 目的比较腹主动脉瘤(AAA)手术切除与腔内治疗的效果,探讨手术时机及治疗方式的选择。方法回顾性分析我院近4年多来进行手术治疗的51例肾下腹主动脉瘤患者的临床资料,比较传统手术切除组(37例)与腔内支架植入组(14例)围手术期及术后近期情况。结果支架组手术时间、重症监护时间均短于切除组(P<0.05),支架组术后住院天数明显短于切除组(P<0.01),但住院费用远较切除组高[(13.7±4.7)万元vs.(3.4±0.7)万元]。术后近期并发症两组间差异无统计学意义。结论腔内支架治疗较为安全,创伤更小,患者恢复速度较快。但腔内治疗的费用目前仍过高,且远期疗效尚需大规模随机对照实验进行验证。 展开更多
关键词 主动脉瘤 腹/外科学 支架 腔内治疗
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两点入路血管支架修复钝性腘动脉损伤 被引量:4
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作者 钟山 张希全 +2 位作者 陈众 董鹏 孙业全 《介入放射学杂志》 CSCD 北大核心 2017年第4期309-312,共4页
目的探讨患侧股动脉及胫后动脉两点入路血管支架技术修复钝性腘动脉损伤的临床疗效。方法回顾性分析2011年3月至2015年3月采用两点入路血管支架技术修复11例钝性腘动脉损伤患者临床资料。术中先顺行穿刺患侧股动脉并造影评估动脉损伤情... 目的探讨患侧股动脉及胫后动脉两点入路血管支架技术修复钝性腘动脉损伤的临床疗效。方法回顾性分析2011年3月至2015年3月采用两点入路血管支架技术修复11例钝性腘动脉损伤患者临床资料。术中先顺行穿刺患侧股动脉并造影评估动脉损伤情况,捻转导丝通过损伤段失败即刻穿刺胫后动脉并送入4 F单弯导管和圈套器,采用导丝抓捕技术将损伤段导丝捕捉住,使其通过损伤段,并建立工作轨道,经导丝植入血管支架修复损伤动脉;对远端流出道血栓阻塞用6 F导引导管抽吸动脉远端血栓,对肢体末梢动脉血栓予动脉内留置导管小剂量尿激酶溶栓治疗。结果手术成功率100%。动脉造影显示动脉部分断裂7例,完全断裂4例,共植入支架16枚。无围手术期死亡及手术相关并发症。术后随访13~24个月,平均(18.7±3.8)个月,2例出现支架内血栓形成,经溶栓治疗后血流恢复;3例支架腔内狭窄>70%,给予球囊扩张治疗后血流恢复通畅;6例支架腔内狭窄<30%,未作特殊处理。随访期未发现支架断裂、变形、移位,无截肢患者。结论两点入路血管支架修复钝性腘动脉损伤可减少手术时间,快速恢复受损动脉血流,减少肢体缺血时间,近期临床效果显著。 展开更多
关键词 血管支架修复 钝性损伤 胭动脉
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腔内修复术治疗113例主动脉夹层瘤的临床分析 被引量:10
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作者 罗剑渊 王家平 +9 位作者 杨达宽 杨绍军 李迎春 童玉云 周云 袁曙光 杨青 李松蔚 李琳 丁丽丽 《介入放射学杂志》 CSCD 北大核心 2011年第4期269-272,共4页
目的评价腔内修复术治疗主动脉夹层的疗效,探讨主动脉夹层的治疗策略。方法回顾分析2002年3月-2010年6月,113例采用腔内修复术治疗的主动脉夹层患者的临床资料、治疗和随访结果。结果腔内修复术治疗主动脉夹层的手术成功率99.1%(112/11... 目的评价腔内修复术治疗主动脉夹层的疗效,探讨主动脉夹层的治疗策略。方法回顾分析2002年3月-2010年6月,113例采用腔内修复术治疗的主动脉夹层患者的临床资料、治疗和随访结果。结果腔内修复术治疗主动脉夹层的手术成功率99.1%(112/113),围手术期无严重并发症发生,术后30 d病死率1.8%(2/113)。105例患者获术后随访,平均随访时间28个月,术后1、5年累计生存率分别为99.1%和97.1%。结论腔内修复术具有微创、安全、有效的优点,逐渐成为治疗Standford B型主动脉夹层的首选方法。Standford A型主动脉夹层的腔内修复术正处于探索阶段。 展开更多
关键词 动脉瘤 夹层 血管腔内修复 支架
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