On the basis of a detailed discussion of the development of total ionizing dose （TID） effect model, a new commercial-model-independent TID modeling approach for partially depleted silicon-on-insulator metal-oxide- s...On the basis of a detailed discussion of the development of total ionizing dose （TID） effect model, a new commercial-model-independent TID modeling approach for partially depleted silicon-on-insulator metal-oxide- semiconductor field effect transistors is developed. An exponential approximation is proposed to simplify the trap charge calculation. Irradiation experiments with 60Co gamma rays for IO and core devices are performed to validate the simulation results. An excellent agreement of measurement with the simulation results is observed.展开更多
Si-PIN photodetectors having features such as low cost,small size,low weight,low voltage,and low power consumption are widely used as radiation detectors in electronic personal dosimeters(EPDs).The technical parameter...Si-PIN photodetectors having features such as low cost,small size,low weight,low voltage,and low power consumption are widely used as radiation detectors in electronic personal dosimeters(EPDs).The technical parameters of EPDs based on the Si-PIN photodetectors include photon energy response(PER),angular response,inherent error,and dose rate linearity.Among them,PER is a key parameter for evaluation of EPD measurement accuracy.At present,owing to the limitations of volume,power consumption,and EPD cost,the PER is usually corrected by a combination of single-channel counting techniques and filtering material methods.However,the above-mentioned methods have problems such as poor PER and low measurement accuracy.To solve such problems,in this study,a 1024-channel spectrometry system using a Si-PIN photodetector was developed and fullspectrum measurement in the reference radiation fields was conducted for radiation protection.The measurement results using the few-channel spectroscopy dose method showed that the PER could be controlled within±14%and±2%under the conditions of two and three energy intervals,respectively,with different channel numbers.The PER measured at 0°angle of radiation incidence meets the-29%to+67%requirements of IEC 61526:2010.Meanwhile,the channel number and counts-to-dose conversion factors formed in the experiment can be integrated into an EPD.展开更多
The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine t...The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.展开更多
Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s ...Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.展开更多
模数转换器(Analog-to-Digital Converter,ADC)是连接模拟信号域与数字信号域的关键器件,而现有研究缺乏ADC辐照效应建模的相关内容.为满足大型模数混合信号系统辐照效应建模仿真的需要,本文提出了建立具有辐照效应的ADC行为级模型的方...模数转换器(Analog-to-Digital Converter,ADC)是连接模拟信号域与数字信号域的关键器件,而现有研究缺乏ADC辐照效应建模的相关内容.为满足大型模数混合信号系统辐照效应建模仿真的需要,本文提出了建立具有辐照效应的ADC行为级模型的方法.首先根据ADC的工作原理将其拆解为不同的通用模块,使用模拟和混合信号硬件描述语言(Very High speed integrated circuit hardware Description Language for Analog and Mixed Signals,VHDL-AMS)建立了各模块的行为级模型.接着根据基本原理将各模块动态组合为未辐照情况下基本的ADC模型.对于ADC的辐照效应,通过开展辐照试验,测量了ADC芯片HWD7710和SAD9434受总剂量(Total Ionizing Dose,TID)效应和中子辐射(Neutron Radiation,NR)效应影响的工作参数,并利用最小二乘法拟合获得ADC的工作参数与辐照剂量的关系式.最后根据辐照关系式,在基本模型上添加辐照参数模块,并建立两种不同结构ADC的TID与NR模型.通过仿真结果与试验数据对比,验证了所建ADC辐射效应模型的普适性和精度.模型的静态参数仿真结果与试验结果的相对偏差在5%以内,证明该方法支持对不同ADC及不同辐射效应进行辐照效应模型建模.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 61404151 and 61574153
文摘On the basis of a detailed discussion of the development of total ionizing dose （TID） effect model, a new commercial-model-independent TID modeling approach for partially depleted silicon-on-insulator metal-oxide- semiconductor field effect transistors is developed. An exponential approximation is proposed to simplify the trap charge calculation. Irradiation experiments with 60Co gamma rays for IO and core devices are performed to validate the simulation results. An excellent agreement of measurement with the simulation results is observed.
基金This work was partly supported by the National Key Scientific Instruments to Develop Dedicated Program(Nos.2013YQ090811 and 2016YFF0103800)the National Key Research and Development Program(No.2017YFF0211100).
文摘Si-PIN photodetectors having features such as low cost,small size,low weight,low voltage,and low power consumption are widely used as radiation detectors in electronic personal dosimeters(EPDs).The technical parameters of EPDs based on the Si-PIN photodetectors include photon energy response(PER),angular response,inherent error,and dose rate linearity.Among them,PER is a key parameter for evaluation of EPD measurement accuracy.At present,owing to the limitations of volume,power consumption,and EPD cost,the PER is usually corrected by a combination of single-channel counting techniques and filtering material methods.However,the above-mentioned methods have problems such as poor PER and low measurement accuracy.To solve such problems,in this study,a 1024-channel spectrometry system using a Si-PIN photodetector was developed and fullspectrum measurement in the reference radiation fields was conducted for radiation protection.The measurement results using the few-channel spectroscopy dose method showed that the PER could be controlled within±14%and±2%under the conditions of two and three energy intervals,respectively,with different channel numbers.The PER measured at 0°angle of radiation incidence meets the-29%to+67%requirements of IEC 61526:2010.Meanwhile,the channel number and counts-to-dose conversion factors formed in the experiment can be integrated into an EPD.
文摘The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.
基金financially supported by the Natural Science Foundation of China(Grant 81072263,to Y.Z.)Chun Tsung Scholarship of Fudan University(to D.C.)
文摘Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.
基金Supported by the National Natural Science Foundation of China （Nos. 81101132, 11305203） and the Natural Science Foundation of Anhui Province （Nos. 11040606Q55, 1308085QH138）.
文摘模数转换器(Analog-to-Digital Converter,ADC)是连接模拟信号域与数字信号域的关键器件,而现有研究缺乏ADC辐照效应建模的相关内容.为满足大型模数混合信号系统辐照效应建模仿真的需要,本文提出了建立具有辐照效应的ADC行为级模型的方法.首先根据ADC的工作原理将其拆解为不同的通用模块,使用模拟和混合信号硬件描述语言(Very High speed integrated circuit hardware Description Language for Analog and Mixed Signals,VHDL-AMS)建立了各模块的行为级模型.接着根据基本原理将各模块动态组合为未辐照情况下基本的ADC模型.对于ADC的辐照效应,通过开展辐照试验,测量了ADC芯片HWD7710和SAD9434受总剂量(Total Ionizing Dose,TID)效应和中子辐射(Neutron Radiation,NR)效应影响的工作参数,并利用最小二乘法拟合获得ADC的工作参数与辐照剂量的关系式.最后根据辐照关系式,在基本模型上添加辐照参数模块,并建立两种不同结构ADC的TID与NR模型.通过仿真结果与试验数据对比,验证了所建ADC辐射效应模型的普适性和精度.模型的静态参数仿真结果与试验结果的相对偏差在5%以内,证明该方法支持对不同ADC及不同辐射效应进行辐照效应模型建模.
