Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;how...Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less explored.Herein,we report the development of aggregation-enabled alkene insertion into carbon–halogen bonds.The spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated state.Additional catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such sequences.The ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory analysis.Results also show that the non-aggregated state may quench the transition state and terminate the insertion process.展开更多
A novel and concise method for the construction ofγ-nitro ketones and 1,3-dinitro compounds with chemo-selective acyl transfer has been presented under basic conditions via one-pot reactions.These reactions feature h...A novel and concise method for the construction ofγ-nitro ketones and 1,3-dinitro compounds with chemo-selective acyl transfer has been presented under basic conditions via one-pot reactions.These reactions feature high atom-and step-economic possess,mild condition and simple operation for one-pot synthesis of aliphatic nitro compounds.This protocol provides the products in good yields.The possible reaction mechanism has also been proposed.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:91940305,21933009,81874181,22271195,21871284Natural Science Foundation of Fujian Province,Grant/Award Number:2021J01525+3 种基金Major Scientific and Technological Special Project for“Significant New Drugs Creation”,Grant/Award Number:2019ZX09301158The Emerging Frontier Program of Hospital Development Centre,Grant/Award Number:SHDC12018107Shanghai Science and Technology Development Fund from Central Leading Local Government,Grant/Award Number:YDZX20223100001004Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine,Grant/Award Number:ZY(2021-2023)−0501。
文摘Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less explored.Herein,we report the development of aggregation-enabled alkene insertion into carbon–halogen bonds.The spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated state.Additional catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such sequences.The ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory analysis.Results also show that the non-aggregated state may quench the transition state and terminate the insertion process.
基金supported financially by the National Natural Science Foundation of China(21172227).
文摘A novel and concise method for the construction ofγ-nitro ketones and 1,3-dinitro compounds with chemo-selective acyl transfer has been presented under basic conditions via one-pot reactions.These reactions feature high atom-and step-economic possess,mild condition and simple operation for one-pot synthesis of aliphatic nitro compounds.This protocol provides the products in good yields.The possible reaction mechanism has also been proposed.
