Studies on the Total Synthesis of Pseudolaric Acid A Stereocontrolled Synthesis of the Seven-membered Lactone

The lactone 16 was obtained stereo- and regioselectively by a reaction sequence of 9 steps in 21% overall yield.

Stereoselective Synthesis of 3(R) and 3(S)-Hydroxyeicos-4(E)-en-1-yne, a Component of the Marine Sponge Cribrochalina Vasculum

Stereocontrolled synthesis of 3(R) and 3(S)-hydroxyeicos-4(E)-en-1-yne has been achieved through double elimination of chloride intermediates 8 and 11, which were prepared from acetylenic alcohol intermediates 1 and 10.