First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of be...First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol.展开更多
A convenient and stereoselective approach to the synthesis of(3S. 4R. 6S)- 2-oxo-3, 4-dihydroxy-6-methyl-octanate derivative, a key intermediate for the synthesis of HIV-1 protease inhibitor of didemnaketals analogue,...A convenient and stereoselective approach to the synthesis of(3S. 4R. 6S)- 2-oxo-3, 4-dihydroxy-6-methyl-octanate derivative, a key intermediate for the synthesis of HIV-1 protease inhibitor of didemnaketals analogue, has been developed successfully from L-(-)-menthone.展开更多
基金We are grateful to the National Natural Science Foundation of China (No. 29372050) for financial support.
文摘First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol.
文摘A convenient and stereoselective approach to the synthesis of(3S. 4R. 6S)- 2-oxo-3, 4-dihydroxy-6-methyl-octanate derivative, a key intermediate for the synthesis of HIV-1 protease inhibitor of didemnaketals analogue, has been developed successfully from L-(-)-menthone.
