In the present study we have found that proto-oncogene c-fos protein can expressin the noradrenergic neurons of rat hindbrain following peripheral electrical stimulation. Ratswere given peripheral electrical stimulati...In the present study we have found that proto-oncogene c-fos protein can expressin the noradrenergic neurons of rat hindbrain following peripheral electrical stimulation. Ratswere given peripheral electrical stimulation via thin stainless steel pins inserted into the pointsnear knee joint (S36) and ankle joint (Sp6) which mimic the manipulation of electroacupuncture(EA) performed in humans. Animals were perfused for double staining immunohistochemistry 2hafter the termination of EA. In rats subjected to EA stimulation Fos-like protein was found in thetyrosine hydroxylase (TH)-like immunoreactive neurons in rat hindbrain. The Fos and TH coex-isting neurons were distributed in the locus coeruleus, solitary tract nucleus, ventrolateral medul-la, periaqeductal gray, as well as superior colliculus. The percentage of the coexisting neuronscompared with the total number of neurons containing Fos-like protein in these nuclei rangedfrom 6% to 32%. The results suggest that the noradrenergic neurons in these regions may be ac-tivted by acupuncture stimulation.展开更多
目的探讨黄芪桂枝五物汤加味联合中频脉冲电刺激治疗糖尿病合并脑卒中偏瘫的临床疗效。方法选取2019年4月—2022年3月河北北方学院附属第一医院康复科及内分泌科老年糖尿病合并脑卒中偏瘫患者120例,依据随机表分为对照组60例和治疗组60...目的探讨黄芪桂枝五物汤加味联合中频脉冲电刺激治疗糖尿病合并脑卒中偏瘫的临床疗效。方法选取2019年4月—2022年3月河北北方学院附属第一医院康复科及内分泌科老年糖尿病合并脑卒中偏瘫患者120例,依据随机表分为对照组60例和治疗组60例,对照组给予中频脉冲电刺激加常规康复运动疗法,治疗组在对照组基础上给予黄芪桂枝五物汤加味治疗,比较两组患者治疗前后血糖水平、运动神经电生理指标[运动诱发电位潜伏期(motor evoked potentials,MEP)、中枢运动传导时间(central motor conduction time,CMCT)]、运动功能[Fugl-Meyer运动功能评分(Fugl-Meyer Assessment,FMA)]、生活质量及神经功能相关评分[脑卒中专用生活质量量表(Stroke Specific Quality of Life Scale,SS-QOL)、改良Barthel指数(modified Barthel Index,MBI)、美国国立卫生研究所卒中评分量表(National Institutes of Health Stroke Scale,NIHSS)、临床神经功能缺损评分(China Stroke Scale,CSS)量表、抑郁自评量表(Self-Rating Depression Scale,SDS)]。结果(1)血糖水平:治疗12周后,治疗组和对照组空腹血糖和餐后血糖均有所下降,降血糖效果明显;与对照组比较,治疗组血糖水平下降幅度更大(P<0.05)。(2)运动神经电生理指标:两组各项指标(MEP、CMCT)较治疗前均明显降低(P<0.05),且治疗组与对照组比较,治疗组降低幅度更大(P<0.05)。(3)上肢、下肢FMA评分:治疗12周后,对照组和治疗组评分均有明显升高,且治疗组分值提升显著高于对照组(P<0.05)。(4)生活质量评分:治疗后,对照组和治疗组各项评分(SS-QOL、MBI)均明显高于治疗前,且治疗组得分上升幅度显著优于对照组(P<0.05)。(5)神经功能评分:治疗后,两组各项评分(NIHSS、CSS、SDS)均有明显降低(P<0.05),且治疗组比对照组各项评分降低幅度更为显著(P<0.05)。结论黄芪桂枝五物汤加味联合中频脉冲电刺激可有效治疗糖尿病合并脑卒中偏瘫患者的运动功能,有利于改善生活质量,值得临床推广。展开更多
基金Chinese postdoctoral foundationa grand from the National Institute of Drug Abuse, USA (DA 03983)
文摘In the present study we have found that proto-oncogene c-fos protein can expressin the noradrenergic neurons of rat hindbrain following peripheral electrical stimulation. Ratswere given peripheral electrical stimulation via thin stainless steel pins inserted into the pointsnear knee joint (S36) and ankle joint (Sp6) which mimic the manipulation of electroacupuncture(EA) performed in humans. Animals were perfused for double staining immunohistochemistry 2hafter the termination of EA. In rats subjected to EA stimulation Fos-like protein was found in thetyrosine hydroxylase (TH)-like immunoreactive neurons in rat hindbrain. The Fos and TH coex-isting neurons were distributed in the locus coeruleus, solitary tract nucleus, ventrolateral medul-la, periaqeductal gray, as well as superior colliculus. The percentage of the coexisting neuronscompared with the total number of neurons containing Fos-like protein in these nuclei rangedfrom 6% to 32%. The results suggest that the noradrenergic neurons in these regions may be ac-tivted by acupuncture stimulation.
文摘目的探讨黄芪桂枝五物汤加味联合中频脉冲电刺激治疗糖尿病合并脑卒中偏瘫的临床疗效。方法选取2019年4月—2022年3月河北北方学院附属第一医院康复科及内分泌科老年糖尿病合并脑卒中偏瘫患者120例,依据随机表分为对照组60例和治疗组60例,对照组给予中频脉冲电刺激加常规康复运动疗法,治疗组在对照组基础上给予黄芪桂枝五物汤加味治疗,比较两组患者治疗前后血糖水平、运动神经电生理指标[运动诱发电位潜伏期(motor evoked potentials,MEP)、中枢运动传导时间(central motor conduction time,CMCT)]、运动功能[Fugl-Meyer运动功能评分(Fugl-Meyer Assessment,FMA)]、生活质量及神经功能相关评分[脑卒中专用生活质量量表(Stroke Specific Quality of Life Scale,SS-QOL)、改良Barthel指数(modified Barthel Index,MBI)、美国国立卫生研究所卒中评分量表(National Institutes of Health Stroke Scale,NIHSS)、临床神经功能缺损评分(China Stroke Scale,CSS)量表、抑郁自评量表(Self-Rating Depression Scale,SDS)]。结果(1)血糖水平:治疗12周后,治疗组和对照组空腹血糖和餐后血糖均有所下降,降血糖效果明显;与对照组比较,治疗组血糖水平下降幅度更大(P<0.05)。(2)运动神经电生理指标:两组各项指标(MEP、CMCT)较治疗前均明显降低(P<0.05),且治疗组与对照组比较,治疗组降低幅度更大(P<0.05)。(3)上肢、下肢FMA评分:治疗12周后,对照组和治疗组评分均有明显升高,且治疗组分值提升显著高于对照组(P<0.05)。(4)生活质量评分:治疗后,对照组和治疗组各项评分(SS-QOL、MBI)均明显高于治疗前,且治疗组得分上升幅度显著优于对照组(P<0.05)。(5)神经功能评分:治疗后,两组各项评分(NIHSS、CSS、SDS)均有明显降低(P<0.05),且治疗组比对照组各项评分降低幅度更为显著(P<0.05)。结论黄芪桂枝五物汤加味联合中频脉冲电刺激可有效治疗糖尿病合并脑卒中偏瘫患者的运动功能,有利于改善生活质量,值得临床推广。
