Stochastic responses of tumor-immune system with periodic treatment

We investigate the stochastic responses of a tumor–immune system competition model with environmental noise and periodic treatment. Firstly, a mathematical model describing the interaction between tumor cells and immune system under external fluctuations and periodic treatment is established based on the stochastic differential equation. Then, sufficient conditions for extinction and persistence of the tumor cells are derived by constructing Lyapunov functions and Ito＇s formula. Finally, numerical simulations are introduced to illustrate and verify the results. The results of this work provide the theoretical basis for designing more effective and precise therapeutic strategies to eliminate cancer cells, especially for combining the immunotherapy and the traditional tools.

具有免疫反应的随机病毒感染模型的持久与灭绝的阈值

【目的】研究具有免疫反应的随机病毒感染模型的持久与灭绝的阈值。【方法】理论推导并举例进行验证。【结果】首先,建立了一个描述具有免疫反应的随机病毒感染的数学模型。其次,通过严格的证明得到此模型的全局解的存在与唯一性。最后建立Lyapunov函数,获得此模型持久与灭绝的充分条件。【结论】噪声能够对模型的持久性和灭绝产生影响。