Data mining analysis of Professor Liu Shangyi＇s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache

Objective： To analyze National Chinese Medicine Master Liu Shangyi’s prescription characteristics of clinical medicinefor the treatment of cancer patients with stomachache. Methods： Data on prescriptions for cancer patients withstomachache between January 2014 and July 2016 were collected. The composing principles were analyzed byunsupervised data mining methods including Apriori algorithm in association rules and complex system entropy cluster.Results： Based on the analysis of 120 prescriptions, the frequency of each herb and association rules among the herbswere computed. Four core combinations and two new prescriptions were mined from the database. Compared to thebefore treatment, the clinical symptomatic grading of stomachache after treatment was lower （P 〈 0.001）. Conclusion：Professor Liu has been successful in the treatment of cancer patients with stomachache by prescribing medication thataids in activating blood circulation, removing dampness, and alleviating pain.

Professor Xiaoquan Du's Seven Methods of Treating Stomachache

Stomachache is the main symptom of stomach duct pain near the heart.Professor Xiaoquan Du is experienced in treating spleen and stomach diseases with traditional Chinese medicine(TCM)syndrome differentiation.He has vast practical TCM experience through years of clinical diagnosis and treatment,and incorporated his own characteristic methods in treatments,thereby developing seven methods for the treatment of stomachache.Clinically,methods such as“invigorating the spleen and benefiting the stomach”and“wanning the middle and dispersing cold”are mostly adopted to treat stomach duct pain.

Meta-analysis on Efficacy and Safety of Compound Stomachache Inflammation Caused by Helicobacter Pylori

Objective:To systematically evaluate the efficacy and safety of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of digestive ulcer and inflammation Helicobacter pylori-Peptic Ulcer(Hp-PU)caused by Helicobacter pylori(Hp).Methods:Randomized controlled trials(RCTs)of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of Hp-PU were screened out by searching CNKI,VIP,Wanfang,China Biomedical Literature Service System,Cochrane Library,Pub Med,EMbase,Web of Science and Clinical Trials.gov.Meta-analysis was performed with Rev Man 5.4 software.Results:Three RCTs were included,including 331 patients of 166 patients in the experimental group(Compound Stomachache Capsule(复方胃痛胶囊)+conventional western medicine treatment)and 165 patients in the control group(conventional western medicine treatment).Meta-analysis data showed that Hp eradication rate(RR=1.10,95%CI[1.01-1.19],P=0.03)was significantly higher in the experimental group than in the control group.The experimental group was superior to the control group in improving clinical symptoms(RR=1.59,95%CI[1.22-2.06],P=0.0006).Conclusion:According to the current evidence,the Compound Stomachache Capsule(复方胃痛胶囊)combined with conventional Western medicine treatment can improve the Hp eradication rate of Hp-PU,relieve symptoms,and do not increase the incidence of adverse reactions.However,the number of included studies is small and the sample size is small,so its effectiveness and safety need further verification.

Analysis on Composition Rules of Chinese Patent Drugs Treating Pain-Related Diseases Based on Data Mining Method

Objective: To analyze the composition rules of oral prescriptions in the treatment of headache, stomachache and dysmenorrhea recorded in National Standard for Chinese Patent Drugs(NSCPD) enacted by Ministry of Public Health of China and then make comparison between them to better understand pain treatment in different regions of human body. Methods: Constructed NSCPD database had been constructed in 2014. Prescriptions treating the three pain-related diseases were searched and screened from the database. Then data mining method such as association rules analysis and complex system entropy method integrated in the data mining software Traditional Chinese Medicine Inheritance Support System(TCMISS) were applied to process the data. Results: Top 25 drugs with high frequency in the treatment of each disease were selected, and 51, 33 and 22 core combinations treating headache, stomachache and dysmenorrhea respectively were mined out as well. Conclusions: The composition rules of the oral prescriptions for treating headache, stomachache and dysmenorrhea recorded in NSCPD has been summarized. Although there were similarities between them, formula varied according to different locations of pain. It can serve as an evidence and reference for clinical treatment and new drug development.

Ten Cases Treated by LU Shou-yan

1 Stomachache 1.1 Case oneA 38-year-old male patient.