The 19th National Congress of the Communist Party of China has proposed a national strategy for a healthy China,which includes the formulation of a new plan to promote high-quality development.Oral diseases have been ...The 19th National Congress of the Communist Party of China has proposed a national strategy for a healthy China,which includes the formulation of a new plan to promote high-quality development.Oral diseases have been included in the national“Medium-and Long-term Plan for the Prevention and Treatment of Chronic Diseases”.Chinas national oral health strategy provides great opportunities for advancements in stomatology and for the improvement of the people s oral health.This article discusses these opportunities for advancement in the field of stomatology in China from six aspects:societal needs of oral health;advances in science and technology;changed diagnosis and treatment modes;application of big data;multidistiplinary integration;and talent training.展开更多
Introduction: Epulis is a pseudotumor very common in women. If neglected, it can reach a considerable volume. The marginal gingiva is very involved in the tumor either in isolation or with periodontal and alveolar bon...Introduction: Epulis is a pseudotumor very common in women. If neglected, it can reach a considerable volume. The marginal gingiva is very involved in the tumor either in isolation or with periodontal and alveolar bone. The epulis sits classically on the vestibular gum, rarely on the palatal side. We report a case of palatal giant epulis which posed a diagnostic problem. Case report: This was a 50-year-old patient with a large tumor occupying the entire oral cavity and pushing all nearby organs. This lesion had been evolving for ten years, with a tendency to gradually increase of its volume. The orthopantomogram revealed the destruction of the underlying alveolar bone without signs of tumor invasion. Surgical excision was performed, removing all the tumor in the vicinity of the nasopalatine vascular pedicle. The pathological examination concludes with an inflammatory epulis. Conclusion: The epulis is a benign tumor of the gum, circumscribed, localized preferentially at the neck of one or two contiguous teeth. It occurs more in women, with a predilection for the vestibular side, rarely the palatal side. In the absence of appropriate treatment it can lead to a large tumor, posing a diagnostic problem and causing functional or aesthetic discomfort. Complete surgical excision with histological examination remains the solution. Healing without sequelae is the rule.展开更多
Objective: To understand the status and characteristics of hepatitis B, hepatitis C, syphilis and HIV antibody screening in one dental hospital, and to provide scientific basis for the prevention and treatment of comm...Objective: To understand the status and characteristics of hepatitis B, hepatitis C, syphilis and HIV antibody screening in one dental hospital, and to provide scientific basis for the prevention and treatment of common infectious diseases in dental medical institutions. Methods: Collect all samples of patients screened for hepatitis B, hepatitis C, syphilis and HIV from one stomatological hospital in 2018-2019, and make statistics on the distribution of common infectious diseases among patients in stomatology, such as age, gender, type of treatment, department of treatment, etc. Results: The positive rate of hepatitis B was 2.27%, 39.42% in males and 60.58% in females. It was mainly detected by outpatient department, accounting for 87.5%. The age was concentrated in 30 - 60 years old, accounting for 77.88%. It was mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 82.69%. The positive rate of hepatitis C was 0.1%, 33.33% in men and 66.67% in women. It was mainly detected by outpatient department, accounting for 83.33%. The age is concentrated in 20 - 50 years old, accounting for 100%. It is mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 100%. The positive rate of syphilis was 0.18%, 33.33% for men and 66.67% for women. It was mainly detected by outpatient department, accounting for 83.33%. The age is concentrated in 30 - 50 years old, accounting for 100%. It was mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 83.33%. HIV was not detected. Conclusion: The positive detection rate of common infectious diseases in the stomatological hospitals is generally lower than the average level. It is mainly distributed in the department of implant, oral and maxillofacial surgery and orthodontics. The highest positive detection rate of common infectious diseases is hepatitis B which is 2.27%, and the lowest is HIV which is 0.展开更多
As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior...As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior doctors, teachers and scientific researchers in the field. This journal has been included in CA and MEDLINE and is published as a bimonthly periodical, 6 issues a year. To ensure the quality of articles and standardization of editing, please read these instructions carefully and abide by them strictly before writing and submitting manuscripts. All manuscripts that do not adhere to the requirements detailed in these instructions will be returned to the corresponding author(s) for revision. The instructions can be downloaded from : http://www.omschina.org.cn/sjs/baseinfo.asp?ClassID=newsroomcontribute2.展开更多
Congratulations to the publisher,members of the editorial board of the journal,all the authors and readers for launching the World Journal of Stomatology(WJS)as a new member of the World series journal family!Signific...Congratulations to the publisher,members of the editorial board of the journal,all the authors and readers for launching the World Journal of Stomatology(WJS)as a new member of the World series journal family!Significant scientific advances and important breakthroughs need to be published to impact dental care and reach an audience of researchers and clinicians who can create more effective dental treatments for their patients.There is a need to share scientific information,methodologies,therapies,and hypotheses related to stomatology,through an open-access format,to reach the widest possible audience.The WJS was created to fulfill the role of disseminating the most significant,innovative and transformational cutting edge research in dentistry.The WJS is a peer-reviewed open-access periodical centered in stomatology,with a multidisciplinary coverage that will publish high-impact articles in all areas of the dental clinical specialties,applied science,epidemiology,trauma and dental care,dental materials,oral biology and microbiology.The WJS is not scared of controversy or challenges to existing doctrine,since they are supported by high-quality science or unequivocal clinical outcomes.The WJS will avoid publishing confirmatory and low-impact articles.The WJS will only publish articles directly relevant to stomatology and dentistry because this is what our readers expect.If you need to share any exciting dental research discoveries and reach the widest possible audience,you will find in the WJS the most helpful resource to publish your papers!展开更多
Stomatology English as an international language in the academic field, it is the basic skill that oral medicine students uses to understand the academic from, master new technologies in clinical, and expand professio...Stomatology English as an international language in the academic field, it is the basic skill that oral medicine students uses to understand the academic from, master new technologies in clinical, and expand professional horizons. The study targets for the training the ability of applying stomatology English, exploring and practicing in the teaching materials, teacher training, teaching methods and the language application environment, thus forming a "three-step" stomatology English teaching mode and gaining effective results.展开更多
The Journal of Stomatology is an academic joural in the field of oral medicine, mainly covering the latest achievements and trends in both basic and clinical researches, aiming at providing the up-to-date information ...The Journal of Stomatology is an academic joural in the field of oral medicine, mainly covering the latest achievements and trends in both basic and clinical researches, aiming at providing the up-to-date information for the clinicians, teachers,展开更多
Research in stomatology(dental medicine)continues to expand globally and is oriented towards solving clinical issues,focusing on clarifying the clinical relevance and potential mechanisms of oral–systemic connections...Research in stomatology(dental medicine)continues to expand globally and is oriented towards solving clinical issues,focusing on clarifying the clinical relevance and potential mechanisms of oral–systemic connections via clinical epidemiology,oral microecological characterization,and the establishment of animal models.Interdisciplinary integration of materials science and tissue engineering with stomatology is expected to lead to the creation of innovative materials and technologies to better resolve the most prevalent and challenging clinical issues such as peri-implantitis,soft and hard tissue defects,and dentin hypersensitivity.With the rapid development of artificial intelligence(AI),5th generation mobile communication technology(5G),and big data applications,“intelligent stomatology”is emerging to build models for better clinical diagnosis and management,accelerate the reform of education,and support the growth and advancement of scientific research.Here,we summarized the current research status,and listed the future prospects and limitations of these three aspects,aiming to provide a basis for more accurate etiological exploration,novel treatment methods,and abundant big data analysis in stomatology to promote the translation of research achievements into practical applications for both clinicians and the public.展开更多
This literature review aims to determine the applications of optimization design in the field of stomatology,to investigate its current usages,methods and benefits.This review was performed following the Preferred Rep...This literature review aims to determine the applications of optimization design in the field of stomatology,to investigate its current usages,methods and benefits.This review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR)guidelines.The electronic literature search was performed through MEDLINE,Scopus,Web of Science databases with a 10-year time restriction:January 2012 till April 2022.Abundant studies focused on optimization design of dental implants,maxillofacial surgery fixation plates or implants,prosthodontics were published.Shape optimization has been commonly used in implant prostheses,and various studies have proved it to be an effective method to improve initial stability and reduce maximum stress.Shape optimization and topology optimization have been widely used in maxillofacial surgery to reduce strain,volume,and weight of internal fixation plates or bone block implants.The lack of further in vivo and in invitro tests is one of the main limitations of current published studies.展开更多
The multi-piece post-crown technique is more effective in restoring residual root than other restoration techniques.Various types of adhesives have different material properties that affect restoration.Therefore,the c...The multi-piece post-crown technique is more effective in restoring residual root than other restoration techniques.Various types of adhesives have different material properties that affect restoration.Therefore,the choice of adhesive is particularly important for patients.However,the effect of different kinds of adhesives was not too precise by experimental methods when concerning about individual differences of teeth.One tooth root can only be restored with one type of adhesive in experiment.After the mechanical test,this tooth root cannot be restored with other adhesives.With the help of medical imaging technology,reverse engineering and finite element analysis,a molar model can be reconstructed precisely and restored using different types of adhesives.The same occlusal and chewing loads were exerted on the same restored residual root models with different types of adhesives separately.Results of von Mises stress analysis showed that the adhesives with low Young’s modulus can protect the root canal effectively.However,a root canal concentration is apparently produced around the root canal orifice when chewing.Adhesives with large Young’s modulus can buffer the stress concentration of the root canal orifice.However,the root canal tissue may be destroyed because the adhesive is too hard to buffer the load.展开更多
The burden of dental diseases is increasing in the Chinese population.However,the development of the dental industry falls behind the average development level of medical industry in China.The emergence of digital den...The burden of dental diseases is increasing in the Chinese population.However,the development of the dental industry falls behind the average development level of medical industry in China.The emergence of digital dental technologies has created significant opportunities for the development of the dental industry in China.This article explores the innovative development background of the Chinese dental industry,describes the current innovation status in Chinese medical colleges and enterprises,highlights key problems faced by the nation,enterprises,and hospitals,proposes solutions to these issues,and puts forwards a new concept of building an open and collaborative service system,a transformation path,and a whole-chain support system for innovations in dentistry.展开更多
China is the most highly populated developing country. As with other scientific disciplines, dentistry (stomatology) is progressively growing since 1949 when the new China was founded. Due to the closing of the countr...China is the most highly populated developing country. As with other scientific disciplines, dentistry (stomatology) is progressively growing since 1949 when the new China was founded. Due to the closing of the country to international discourse for several decades, international counterparts know very little about dentistry or stomatology, including the sub-discipline oral and maxillofacial surgery. This paper is aimed to introduce the scope, give a brief history, update clinical and basic research, and discuss the future of oral and maxillofacial surgery in China. It will hopefully help international colleagues to have an insight into the developmental history, education system, clinical and basic research achievements, as well as the prospective future of oral and maxillofacial surgery in展开更多
Treatment of head and neck cancer with radiotherapy and/or chemotherapy can cause oral damage.Longterm treatment can damage the salivary glands,the oral mucosa,and the maxilla,leading to altered production of saliva a...Treatment of head and neck cancer with radiotherapy and/or chemotherapy can cause oral damage.Longterm treatment can damage the salivary glands,the oral mucosa,and the maxilla,leading to altered production of saliva and to multiple infections.These lesions can be prevented,limited or avoided by thorough evaluation prior to treatment and by therapeutic followup and preventive measures.The dentist must have strong medical knowledge of the possible short-,medium-,and long-term oral complications of the cancer treatment,and must have knowledge of the protocols for oral management of cancer patients.The availability of a multidisciplinary medical team together with a dentist to attend to the patient prior to the cancer treatment,as well as close communication between team members during and after treatment,is crucial.The aim of the present study was review the stomatological management of head and neck cancer patients treated with chemotherapy and radiotherapy and summarizing current treatments,therapeutic innovation and tissue regeneration perspectives.展开更多
Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to tra...Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional therapies.Faced with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired efficacy.Oral and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders healing.In the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber films.These fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects treatments.Despite their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological aspects.Here,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common classifications.Recent demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are presented.To conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.展开更多
文摘The 19th National Congress of the Communist Party of China has proposed a national strategy for a healthy China,which includes the formulation of a new plan to promote high-quality development.Oral diseases have been included in the national“Medium-and Long-term Plan for the Prevention and Treatment of Chronic Diseases”.Chinas national oral health strategy provides great opportunities for advancements in stomatology and for the improvement of the people s oral health.This article discusses these opportunities for advancement in the field of stomatology in China from six aspects:societal needs of oral health;advances in science and technology;changed diagnosis and treatment modes;application of big data;multidistiplinary integration;and talent training.
文摘Introduction: Epulis is a pseudotumor very common in women. If neglected, it can reach a considerable volume. The marginal gingiva is very involved in the tumor either in isolation or with periodontal and alveolar bone. The epulis sits classically on the vestibular gum, rarely on the palatal side. We report a case of palatal giant epulis which posed a diagnostic problem. Case report: This was a 50-year-old patient with a large tumor occupying the entire oral cavity and pushing all nearby organs. This lesion had been evolving for ten years, with a tendency to gradually increase of its volume. The orthopantomogram revealed the destruction of the underlying alveolar bone without signs of tumor invasion. Surgical excision was performed, removing all the tumor in the vicinity of the nasopalatine vascular pedicle. The pathological examination concludes with an inflammatory epulis. Conclusion: The epulis is a benign tumor of the gum, circumscribed, localized preferentially at the neck of one or two contiguous teeth. It occurs more in women, with a predilection for the vestibular side, rarely the palatal side. In the absence of appropriate treatment it can lead to a large tumor, posing a diagnostic problem and causing functional or aesthetic discomfort. Complete surgical excision with histological examination remains the solution. Healing without sequelae is the rule.
文摘Objective: To understand the status and characteristics of hepatitis B, hepatitis C, syphilis and HIV antibody screening in one dental hospital, and to provide scientific basis for the prevention and treatment of common infectious diseases in dental medical institutions. Methods: Collect all samples of patients screened for hepatitis B, hepatitis C, syphilis and HIV from one stomatological hospital in 2018-2019, and make statistics on the distribution of common infectious diseases among patients in stomatology, such as age, gender, type of treatment, department of treatment, etc. Results: The positive rate of hepatitis B was 2.27%, 39.42% in males and 60.58% in females. It was mainly detected by outpatient department, accounting for 87.5%. The age was concentrated in 30 - 60 years old, accounting for 77.88%. It was mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 82.69%. The positive rate of hepatitis C was 0.1%, 33.33% in men and 66.67% in women. It was mainly detected by outpatient department, accounting for 83.33%. The age is concentrated in 20 - 50 years old, accounting for 100%. It is mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 100%. The positive rate of syphilis was 0.18%, 33.33% for men and 66.67% for women. It was mainly detected by outpatient department, accounting for 83.33%. The age is concentrated in 30 - 50 years old, accounting for 100%. It was mainly distributed in oral and maxillofacial surgery, orthodontics and implant, accounting for 83.33%. HIV was not detected. Conclusion: The positive detection rate of common infectious diseases in the stomatological hospitals is generally lower than the average level. It is mainly distributed in the department of implant, oral and maxillofacial surgery and orthodontics. The highest positive detection rate of common infectious diseases is hepatitis B which is 2.27%, and the lowest is HIV which is 0.
文摘As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior doctors, teachers and scientific researchers in the field. This journal has been included in CA and MEDLINE and is published as a bimonthly periodical, 6 issues a year. To ensure the quality of articles and standardization of editing, please read these instructions carefully and abide by them strictly before writing and submitting manuscripts. All manuscripts that do not adhere to the requirements detailed in these instructions will be returned to the corresponding author(s) for revision. The instructions can be downloaded from : http://www.omschina.org.cn/sjs/baseinfo.asp?ClassID=newsroomcontribute2.
文摘Congratulations to the publisher,members of the editorial board of the journal,all the authors and readers for launching the World Journal of Stomatology(WJS)as a new member of the World series journal family!Significant scientific advances and important breakthroughs need to be published to impact dental care and reach an audience of researchers and clinicians who can create more effective dental treatments for their patients.There is a need to share scientific information,methodologies,therapies,and hypotheses related to stomatology,through an open-access format,to reach the widest possible audience.The WJS was created to fulfill the role of disseminating the most significant,innovative and transformational cutting edge research in dentistry.The WJS is a peer-reviewed open-access periodical centered in stomatology,with a multidisciplinary coverage that will publish high-impact articles in all areas of the dental clinical specialties,applied science,epidemiology,trauma and dental care,dental materials,oral biology and microbiology.The WJS is not scared of controversy or challenges to existing doctrine,since they are supported by high-quality science or unequivocal clinical outcomes.The WJS will avoid publishing confirmatory and low-impact articles.The WJS will only publish articles directly relevant to stomatology and dentistry because this is what our readers expect.If you need to share any exciting dental research discoveries and reach the widest possible audience,you will find in the WJS the most helpful resource to publish your papers!
文摘Stomatology English as an international language in the academic field, it is the basic skill that oral medicine students uses to understand the academic from, master new technologies in clinical, and expand professional horizons. The study targets for the training the ability of applying stomatology English, exploring and practicing in the teaching materials, teacher training, teaching methods and the language application environment, thus forming a "three-step" stomatology English teaching mode and gaining effective results.
文摘The Journal of Stomatology is an academic joural in the field of oral medicine, mainly covering the latest achievements and trends in both basic and clinical researches, aiming at providing the up-to-date information for the clinicians, teachers,
基金supported by the National Natural Science Foundation of China(Nos.81991500 and 81991502).
文摘Research in stomatology(dental medicine)continues to expand globally and is oriented towards solving clinical issues,focusing on clarifying the clinical relevance and potential mechanisms of oral–systemic connections via clinical epidemiology,oral microecological characterization,and the establishment of animal models.Interdisciplinary integration of materials science and tissue engineering with stomatology is expected to lead to the creation of innovative materials and technologies to better resolve the most prevalent and challenging clinical issues such as peri-implantitis,soft and hard tissue defects,and dentin hypersensitivity.With the rapid development of artificial intelligence(AI),5th generation mobile communication technology(5G),and big data applications,“intelligent stomatology”is emerging to build models for better clinical diagnosis and management,accelerate the reform of education,and support the growth and advancement of scientific research.Here,we summarized the current research status,and listed the future prospects and limitations of these three aspects,aiming to provide a basis for more accurate etiological exploration,novel treatment methods,and abundant big data analysis in stomatology to promote the translation of research achievements into practical applications for both clinicians and the public.
基金funded by the Research Foundation of Peking University School and Hospital of Stomatology[grant number PKUSS20200114](J.L.)Scientific Research Project of Clear Aligner of Peking University School and Hospital of Stomatology[grant number B4-WXEA2012359](J.L.)+1 种基金the National Natural Science Foundation of China[grant number 62076011](Y.Z)Beijing Natural Science Foundation[grant number L222116](D.L).
文摘This literature review aims to determine the applications of optimization design in the field of stomatology,to investigate its current usages,methods and benefits.This review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR)guidelines.The electronic literature search was performed through MEDLINE,Scopus,Web of Science databases with a 10-year time restriction:January 2012 till April 2022.Abundant studies focused on optimization design of dental implants,maxillofacial surgery fixation plates or implants,prosthodontics were published.Shape optimization has been commonly used in implant prostheses,and various studies have proved it to be an effective method to improve initial stability and reduce maximum stress.Shape optimization and topology optimization have been widely used in maxillofacial surgery to reduce strain,volume,and weight of internal fixation plates or bone block implants.The lack of further in vivo and in invitro tests is one of the main limitations of current published studies.
文摘The multi-piece post-crown technique is more effective in restoring residual root than other restoration techniques.Various types of adhesives have different material properties that affect restoration.Therefore,the choice of adhesive is particularly important for patients.However,the effect of different kinds of adhesives was not too precise by experimental methods when concerning about individual differences of teeth.One tooth root can only be restored with one type of adhesive in experiment.After the mechanical test,this tooth root cannot be restored with other adhesives.With the help of medical imaging technology,reverse engineering and finite element analysis,a molar model can be reconstructed precisely and restored using different types of adhesives.The same occlusal and chewing loads were exerted on the same restored residual root models with different types of adhesives separately.Results of von Mises stress analysis showed that the adhesives with low Young’s modulus can protect the root canal effectively.However,a root canal concentration is apparently produced around the root canal orifice when chewing.Adhesives with large Young’s modulus can buffer the stress concentration of the root canal orifice.However,the root canal tissue may be destroyed because the adhesive is too hard to buffer the load.
文摘The burden of dental diseases is increasing in the Chinese population.However,the development of the dental industry falls behind the average development level of medical industry in China.The emergence of digital dental technologies has created significant opportunities for the development of the dental industry in China.This article explores the innovative development background of the Chinese dental industry,describes the current innovation status in Chinese medical colleges and enterprises,highlights key problems faced by the nation,enterprises,and hospitals,proposes solutions to these issues,and puts forwards a new concept of building an open and collaborative service system,a transformation path,and a whole-chain support system for innovations in dentistry.
文摘China is the most highly populated developing country. As with other scientific disciplines, dentistry (stomatology) is progressively growing since 1949 when the new China was founded. Due to the closing of the country to international discourse for several decades, international counterparts know very little about dentistry or stomatology, including the sub-discipline oral and maxillofacial surgery. This paper is aimed to introduce the scope, give a brief history, update clinical and basic research, and discuss the future of oral and maxillofacial surgery in China. It will hopefully help international colleagues to have an insight into the developmental history, education system, clinical and basic research achievements, as well as the prospective future of oral and maxillofacial surgery in
文摘Treatment of head and neck cancer with radiotherapy and/or chemotherapy can cause oral damage.Longterm treatment can damage the salivary glands,the oral mucosa,and the maxilla,leading to altered production of saliva and to multiple infections.These lesions can be prevented,limited or avoided by thorough evaluation prior to treatment and by therapeutic followup and preventive measures.The dentist must have strong medical knowledge of the possible short-,medium-,and long-term oral complications of the cancer treatment,and must have knowledge of the protocols for oral management of cancer patients.The availability of a multidisciplinary medical team together with a dentist to attend to the patient prior to the cancer treatment,as well as close communication between team members during and after treatment,is crucial.The aim of the present study was review the stomatological management of head and neck cancer patients treated with chemotherapy and radiotherapy and summarizing current treatments,therapeutic innovation and tissue regeneration perspectives.
基金supported by the National Natural Science Foundation of China(Nos.82101076,81771122,81970985)Key Research Program of Sichuan Science and Technology Department(No.2019YJ0147)Postdoctoral Research Foundation of China(No.2020M683334)。
文摘Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional therapies.Faced with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired efficacy.Oral and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders healing.In the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber films.These fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects treatments.Despite their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological aspects.Here,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common classifications.Recent demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are presented.To conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.