Background: This study evaluated the tolerability and efficacy of intermittent oxaliplatin treatment based on mFOLFOX6 using oral uracil-tegafur(UFT) and leucovorin(LV) maintenance therapy in the treatment of elderly ...Background: This study evaluated the tolerability and efficacy of intermittent oxaliplatin treatment based on mFOLFOX6 using oral uracil-tegafur(UFT) and leucovorin(LV) maintenance therapy in the treatment of elderly patients with advanced colorectal cancer. Methods: Ten non-elderly patients (70 years) with advanced/recurrent colorectal cancer were enrolled in this prospective, multicenter cooperative group clinical trial. The mFOLFOX6 regimen was administered for eight cycles with maintenance therapy with oral UFT/LV treatment until progression. In cases with disease progression, mFOLFOX6 was reintroduced. Results: Grade 2 peripheral neuropathy was noted in 30.0% and 25.0% of the elderly and non-elderly patients, respectively. The observed time to treatment failure (TTF) was 6.3 months in the elderly patients and 6.4 months in the non-elderly patients. The disease control rate was 83.3% in each group. Conclusion: Our new stop-and-go strategy using oral UFT/LV is well-tolerated and effective even in elderly patients.展开更多
Stop-and-go waves are commonly observed in traffic and pedestrian flows.In most microscopic traffic models,they occur through a phase transition and instability of the homogeneous solution after fine tuning of paramet...Stop-and-go waves are commonly observed in traffic and pedestrian flows.In most microscopic traffic models,they occur through a phase transition and instability of the homogeneous solution after fine tuning of parameters.Inertia effects are believed to play an important role in this mechanism.In this article,we present a novel explanation for stop-and-go waves based on stochastic effects in the absence of inertia.The model used is a first order optimal velocity(OV)model including an additive stochastic noise.A power spectral analysis for single-file pedestrian trajectories highlights the existence of Brownian speed residuals.We use the Ornstein-Uhlenbeck process to describe such a correlated noise.The introduction of this specific colored noise in the first order OV model allows describing realistic stop-and-go behavior without requiring instabilities or phase transitions,the homogeneous configurations being systematically stochastically stable.We compare the stochastic model to deterministic unstable OV models and analyze individual speed autocorrelation to describe the nature of the waves in stationary states.We apply the approach to pedestrian single-file motion and compare simulation results to real pedestrian trajectories.The simulation results are quantitatively very similar to the real trajectories.We discuss plausible values for the model parameters and their meaning.展开更多
In this paper, we present a new macro model for traffic flow on a highway with ramps based on the existing models. We use the new model to study the effects of on-off-ramp on the main road traffic during the morning r...In this paper, we present a new macro model for traffic flow on a highway with ramps based on the existing models. We use the new model to study the effects of on-off-ramp on the main road traffic during the morning rush period and the evening rush period. Numerical tests show that, during the two rush periods, these effects are often different and related to the status of the main road traffic. If the main road traffic flow is uniform, then ramps always produce stop-and-go traffic when the main road density is between two critical values, and ramps have little effect on the main road traffic when the main road density is less than the smaller critical value or greater than the larger critical value. If a small perturbation appears on the main road, ramp may lead to stop-and-go traffic, or relieve or even eliminate the stop-and-go traffic, under different circumstances. These results are consistent with real traffic, which shows that the new model is reasonable.展开更多
This paper deals with the effects of traffic bottlenecks using an extended Lighthill-Whitham-Richards (LWR) model. The solution structure is analytically indicated by the study of the Riemann problem characterized b...This paper deals with the effects of traffic bottlenecks using an extended Lighthill-Whitham-Richards (LWR) model. The solution structure is analytically indicated by the study of the Riemann problem characterized by a discontinuous flux. This leads to a typical solution describing a queue upstream of the bottleneck and its width and height, and informs the design of a δ-mapping algorithm. More significantly, it is found that the kinetic model is able to reproduce stop-and-go waves for a triangular fun-damental diagram. Some simulation examples, which are in agreement with the analytical solutions, are given to support these conclusions.展开更多
In order to investigate the influence of bottleneck on single-file pedestrian flow,we conduct two different bottleneck experiments.The first one is on ring road,while the second one is on straight route.For the first ...In order to investigate the influence of bottleneck on single-file pedestrian flow,we conduct two different bottleneck experiments.The first one is on ring road,while the second one is on straight route.For the first one,the global density is always set to be 1.5 ped/m.The corresponding critical flow rate for the bottleneck activation is about 0.57 ped/s.The data of the detectors set at different locations,including the velocities and time-headways,show that the amplitude of the oscillation of the stop-and-go waves gradually increases during the upstream propagation.Besides,when the measured flow rates are the same,the different situations in the single-file experiments with and without bottleneck are compared and discussed.For the second one,lower flow rates are used and the bottleneck is always activated.In all the runs,the system can reach one stable state,and the time needed is nearly the same.Inside the stable area,the statistics of pedestrians'velocities keeps nearly constant in both time and space.Outside this area,when the waiting time is not long(X=10 s),the phenomenon observed is similar to that found on ring road,e.g.,the statistics of pedestrians'velocities also gradually increases during the upstream propagation.This phenomenon is similar to that found in vehicular traffic flow,which shows the universality of different traffic flows.But when the waiting time becomes longer(X=20 s),this situation will be broken since the actions of many pedestrians become much slower.All these results can facilitate understanding more about the influence of bottleneck on single-file pedestrian flow.展开更多
A standard conservation form is derived in this paper.The hyperbolicity of Helbing's fluid dynamic traffic flow model is proved,which is essential to the general analytical and numerical study of this model.On the ba...A standard conservation form is derived in this paper.The hyperbolicity of Helbing's fluid dynamic traffic flow model is proved,which is essential to the general analytical and numerical study of this model.On the basis of this conservation form,a local discontinuous Galerkin scheme is designed to solve the resulting system efficiently.The evolution of an unstable equilibrium traffic state leading to a stable stop-and-go traveling wave is simulated.This simulation also verifies that the model is truly improved by the introduction of the modified diffusion coefficients,and thus helps to protect vehicles from collisions and avoide the appearance of the extremely large density.展开更多
This paper constructs the probability model of Gunther generator at first, and the finite dimension union distribution of the output sequence is presented. The result shows that the output sequence is an independent a...This paper constructs the probability model of Gunther generator at first, and the finite dimension union distribution of the output sequence is presented. The result shows that the output sequence is an independent and uniformly distributed 0,1 random variable sequence. It gives the theoretical foundation about why Gunther generator can avoid the statistic weakness of the output sequence of stop-and-go generator, and analyzes the coincidence between output sequence and input sequences of Gunther generator. The conclusions of this paper would offer theoretical references for designers and analyzers of clock-controlled generators.展开更多
This paper presents a model matching control (MMC) method based on the sliding mode control (SMC) method for longitudinal acceleration tracking control in a vehicular stop-and-go cruise control system. The nonline...This paper presents a model matching control (MMC) method based on the sliding mode control (SMC) method for longitudinal acceleration tracking control in a vehicular stop-and-go cruise control system. The nonlinearity of the vehicle acceleration response at low speeds was analyzed to develop a transfer function model of the vehicle longitudinal dynamics using the least-mean-square system identification technique. This transfer function was then used to design the MMC controller, including an SMC feedback compensator. The system combines the advantages of the two control methods with robust control and rapid response. Simulations show that the controller enhances the rapid trackability to the vehicle acceleration and improves the system's robustness at low speeds compared with conventional PID MMC controllers.展开更多
We propose pro-social control strategies for connected automated vehicles(CAVs)to mitigate jamming waves in mixed-autonomy multi-lane traffic,resulting from car-following dynamics of human-driven vehicles(HDVs).Differ...We propose pro-social control strategies for connected automated vehicles(CAVs)to mitigate jamming waves in mixed-autonomy multi-lane traffic,resulting from car-following dynamics of human-driven vehicles(HDVs).Different from existing studies,which focus mostly on ego vehicle objectives to control CAVs in an individualistic manner,we devise a pro-social control algorithm.The latter takes into account the objectives(i.e.,driving comfort and traffic efficiency)of both the ego vehicle and surrounding HDVs to improve smoothness of the entire observable traffic.Under a model predictive control(MPC)framework that uses acceleration and lane change sequences of CAVs as optimization variables,the problem of individualistic,altruistic,and pro-social control is formulated as a non-convex mixed-integer nonlinear program(MINLP)and relaxed to a convex quadratic program through converting the piece-wise-linear constraints due to the optimal velocity with relative velocity(OVRV)car-following model into linear constraints by introducing slack variables.Low-fidelity simulations using the OVRV model and high-fidelity simulations using PTV VISSIM simulator show that pro-social and altruistic control can provide significant performance gains over individualistic driving in terms of efficiency and comfort on both single-and multi-lane roads.展开更多
Bicycle traffic operations become increasingly important and yet are largely ignored in the traffic flow community,until recently.We hypothesize that there is no qualitative difference between vehicular and bicycle tr...Bicycle traffic operations become increasingly important and yet are largely ignored in the traffic flow community,until recently.We hypothesize that there is no qualitative difference between vehicular and bicycle traffic flow dynamics in single-file case,so the latter can be described by reparameterized car-following models.To test this proposition,we reproduce German(Andresen et al.,2014)and Chinese(Jiang et al.,2016)bicycle experiments on a ring with the intelligent-driver model(IDM)and compare its fit quality(calibration)and predictive power(validation)with that of the necessary-deceleration-model(NDM),which is specifically designed for bike traffic.We find similar quality metrics for both models,so the above hypothesis of a qualitative equivalence cannot be rejected.Moreover,calibration errors of the IDM turn up to be slightly smaller compared to the NDM ones.The NDM represents significant calibration errors for high flow densities,which correspond to flow states,when stop-and-go wave emerge.According to validation tests,the IDM outperforms the NDM as well.Performing two types of validation techniques we discover that inter-driver variation is much higher than the intra-driver variation for bicycle traffic.It coincides with the results obtained from vehicular traffic experiments(NGSIM trajectory data).In addition,we suggest the measure for quantitative comparison of two microscopic fundamental diagrams,which are derived from experimental data and simulated trajectories.The analysis of speed-density relations provides more or less the same results for both models.展开更多
文摘Background: This study evaluated the tolerability and efficacy of intermittent oxaliplatin treatment based on mFOLFOX6 using oral uracil-tegafur(UFT) and leucovorin(LV) maintenance therapy in the treatment of elderly patients with advanced colorectal cancer. Methods: Ten non-elderly patients (70 years) with advanced/recurrent colorectal cancer were enrolled in this prospective, multicenter cooperative group clinical trial. The mFOLFOX6 regimen was administered for eight cycles with maintenance therapy with oral UFT/LV treatment until progression. In cases with disease progression, mFOLFOX6 was reintroduced. Results: Grade 2 peripheral neuropathy was noted in 30.0% and 25.0% of the elderly and non-elderly patients, respectively. The observed time to treatment failure (TTF) was 6.3 months in the elderly patients and 6.4 months in the non-elderly patients. The disease control rate was 83.3% in each group. Conclusion: Our new stop-and-go strategy using oral UFT/LV is well-tolerated and effective even in elderly patients.
基金Financial support by the German Science Foundation under grant SCHA 636/9-1 is gratefully acknowledged.
文摘Stop-and-go waves are commonly observed in traffic and pedestrian flows.In most microscopic traffic models,they occur through a phase transition and instability of the homogeneous solution after fine tuning of parameters.Inertia effects are believed to play an important role in this mechanism.In this article,we present a novel explanation for stop-and-go waves based on stochastic effects in the absence of inertia.The model used is a first order optimal velocity(OV)model including an additive stochastic noise.A power spectral analysis for single-file pedestrian trajectories highlights the existence of Brownian speed residuals.We use the Ornstein-Uhlenbeck process to describe such a correlated noise.The introduction of this specific colored noise in the first order OV model allows describing realistic stop-and-go behavior without requiring instabilities or phase transitions,the homogeneous configurations being systematically stochastically stable.We compare the stochastic model to deterministic unstable OV models and analyze individual speed autocorrelation to describe the nature of the waves in stationary states.We apply the approach to pedestrian single-file motion and compare simulation results to real pedestrian trajectories.The simulation results are quantitatively very similar to the real trajectories.We discuss plausible values for the model parameters and their meaning.
基金supported by National Natural Science Foundation of China under Grant Nos. 70701002 and 70521001the State Key Basic Research Program of China under Grant No. 2006CB705503the Research Grants Council of the Hong Kong Special Administrative Region under Grant No. HKU7187/05E
文摘In this paper, we present a new macro model for traffic flow on a highway with ramps based on the existing models. We use the new model to study the effects of on-off-ramp on the main road traffic during the morning rush period and the evening rush period. Numerical tests show that, during the two rush periods, these effects are often different and related to the status of the main road traffic. If the main road traffic flow is uniform, then ramps always produce stop-and-go traffic when the main road density is between two critical values, and ramps have little effect on the main road traffic when the main road density is less than the smaller critical value or greater than the larger critical value. If a small perturbation appears on the main road, ramp may lead to stop-and-go traffic, or relieve or even eliminate the stop-and-go traffic, under different circumstances. These results are consistent with real traffic, which shows that the new model is reasonable.
基金supported by the National Natural Science Foundation of China (Nos. 70629001 and10771134)the National Basic Research Program of China (973 Program) (No. 2006CB705500)+1 种基金the Research Grants Council of the Hong Kong Special Administrative Region of China(No. HKU7183/08E)the Research Committee of The University of Hong Kong (No. 10207394)
文摘This paper deals with the effects of traffic bottlenecks using an extended Lighthill-Whitham-Richards (LWR) model. The solution structure is analytically indicated by the study of the Riemann problem characterized by a discontinuous flux. This leads to a typical solution describing a queue upstream of the bottleneck and its width and height, and informs the design of a δ-mapping algorithm. More significantly, it is found that the kinetic model is able to reproduce stop-and-go waves for a triangular fun-damental diagram. Some simulation examples, which are in agreement with the analytical solutions, are given to support these conclusions.
基金the National Natural Science Foundation of China(Grant Nos.71801036,71971056,71621001,and 11302022)the Fundamental Research Funds for the Central Universities,China.
文摘In order to investigate the influence of bottleneck on single-file pedestrian flow,we conduct two different bottleneck experiments.The first one is on ring road,while the second one is on straight route.For the first one,the global density is always set to be 1.5 ped/m.The corresponding critical flow rate for the bottleneck activation is about 0.57 ped/s.The data of the detectors set at different locations,including the velocities and time-headways,show that the amplitude of the oscillation of the stop-and-go waves gradually increases during the upstream propagation.Besides,when the measured flow rates are the same,the different situations in the single-file experiments with and without bottleneck are compared and discussed.For the second one,lower flow rates are used and the bottleneck is always activated.In all the runs,the system can reach one stable state,and the time needed is nearly the same.Inside the stable area,the statistics of pedestrians'velocities keeps nearly constant in both time and space.Outside this area,when the waiting time is not long(X=10 s),the phenomenon observed is similar to that found on ring road,e.g.,the statistics of pedestrians'velocities also gradually increases during the upstream propagation.This phenomenon is similar to that found in vehicular traffic flow,which shows the universality of different traffic flows.But when the waiting time becomes longer(X=20 s),this situation will be broken since the actions of many pedestrians become much slower.All these results can facilitate understanding more about the influence of bottleneck on single-file pedestrian flow.
基金supported by the National Natural Science Foundation of China (No. 11072141)the Shanghai Program for Innovative Research Team in Universities+1 种基金the University Research Committee of the University of Hong Kong (No. 201007176059)the Outstanding Researcher Award from the University of Hong Kong
文摘A standard conservation form is derived in this paper.The hyperbolicity of Helbing's fluid dynamic traffic flow model is proved,which is essential to the general analytical and numerical study of this model.On the basis of this conservation form,a local discontinuous Galerkin scheme is designed to solve the resulting system efficiently.The evolution of an unstable equilibrium traffic state leading to a stable stop-and-go traveling wave is simulated.This simulation also verifies that the model is truly improved by the introduction of the modified diffusion coefficients,and thus helps to protect vehicles from collisions and avoide the appearance of the extremely large density.
基金Supported by the Open Subject for Computer Network and Information Security Key Laboratory of Ministry of Education of China(20040108)
文摘This paper constructs the probability model of Gunther generator at first, and the finite dimension union distribution of the output sequence is presented. The result shows that the output sequence is an independent and uniformly distributed 0,1 random variable sequence. It gives the theoretical foundation about why Gunther generator can avoid the statistic weakness of the output sequence of stop-and-go generator, and analyzes the coincidence between output sequence and input sequences of Gunther generator. The conclusions of this paper would offer theoretical references for designers and analyzers of clock-controlled generators.
文摘This paper presents a model matching control (MMC) method based on the sliding mode control (SMC) method for longitudinal acceleration tracking control in a vehicular stop-and-go cruise control system. The nonlinearity of the vehicle acceleration response at low speeds was analyzed to develop a transfer function model of the vehicle longitudinal dynamics using the least-mean-square system identification technique. This transfer function was then used to design the MMC controller, including an SMC feedback compensator. The system combines the advantages of the two control methods with robust control and rapid response. Simulations show that the controller enhances the rapid trackability to the vehicle acceleration and improves the system's robustness at low speeds compared with conventional PID MMC controllers.
基金supported and funded by the Transport Area of Advance.The project IRIS is acknowledged for financial support.
文摘We propose pro-social control strategies for connected automated vehicles(CAVs)to mitigate jamming waves in mixed-autonomy multi-lane traffic,resulting from car-following dynamics of human-driven vehicles(HDVs).Different from existing studies,which focus mostly on ego vehicle objectives to control CAVs in an individualistic manner,we devise a pro-social control algorithm.The latter takes into account the objectives(i.e.,driving comfort and traffic efficiency)of both the ego vehicle and surrounding HDVs to improve smoothness of the entire observable traffic.Under a model predictive control(MPC)framework that uses acceleration and lane change sequences of CAVs as optimization variables,the problem of individualistic,altruistic,and pro-social control is formulated as a non-convex mixed-integer nonlinear program(MINLP)and relaxed to a convex quadratic program through converting the piece-wise-linear constraints due to the optimal velocity with relative velocity(OVRV)car-following model into linear constraints by introducing slack variables.Low-fidelity simulations using the OVRV model and high-fidelity simulations using PTV VISSIM simulator show that pro-social and altruistic control can provide significant performance gains over individualistic driving in terms of efficiency and comfort on both single-and multi-lane roads.
文摘Bicycle traffic operations become increasingly important and yet are largely ignored in the traffic flow community,until recently.We hypothesize that there is no qualitative difference between vehicular and bicycle traffic flow dynamics in single-file case,so the latter can be described by reparameterized car-following models.To test this proposition,we reproduce German(Andresen et al.,2014)and Chinese(Jiang et al.,2016)bicycle experiments on a ring with the intelligent-driver model(IDM)and compare its fit quality(calibration)and predictive power(validation)with that of the necessary-deceleration-model(NDM),which is specifically designed for bike traffic.We find similar quality metrics for both models,so the above hypothesis of a qualitative equivalence cannot be rejected.Moreover,calibration errors of the IDM turn up to be slightly smaller compared to the NDM ones.The NDM represents significant calibration errors for high flow densities,which correspond to flow states,when stop-and-go wave emerge.According to validation tests,the IDM outperforms the NDM as well.Performing two types of validation techniques we discover that inter-driver variation is much higher than the intra-driver variation for bicycle traffic.It coincides with the results obtained from vehicular traffic experiments(NGSIM trajectory data).In addition,we suggest the measure for quantitative comparison of two microscopic fundamental diagrams,which are derived from experimental data and simulated trajectories.The analysis of speed-density relations provides more or less the same results for both models.