Strain-rate sensitivities of 55vol%-65vol% aluminum 2024-T6/TiB2 composites and the corresponding aluminum 2024-T6 matrix were investigated using split Hopkinson pressure bar method. The experimental results showed th...Strain-rate sensitivities of 55vol%-65vol% aluminum 2024-T6/TiB2 composites and the corresponding aluminum 2024-T6 matrix were investigated using split Hopkinson pressure bar method. The experimental results showed that 55vol%-65vol% aluminum 2024-T6/TiB2 composites exhibited significant strain-rate sensitivities, which were three times higher than the strain-rate sensitivity of the aluminum 2024-T6 matrix. The strain-rate sensitivity of the aluminum 2024-T6 matrix composites rose obviously with increasing reinforcement content(up to 60%), which agreed with that from the previous researches. But it decreased as the ceramic reinforcement content reached 65%. After high strain rates compression, a large number of dislocations and micro-cracks were found inside the matrix and the Ti B2 particles, respectively. These micro-cracks can accelerate the brittle fracture of the composites. The aluminum 2024-T6/Ti B2 composites showed various fracture characteristics and shear instability was the predominant failure mechanism under dynamic loading.展开更多
The activation volume(V∗)and strain-rate sensitivity exponent(m)of CoCrFeMnNi and Al_(0.5)CoCrFeMnNi high entropy alloys(HEAs)with various grain sizes(ranging between 2.4 and 356μm)were measured at different strain r...The activation volume(V∗)and strain-rate sensitivity exponent(m)of CoCrFeMnNi and Al_(0.5)CoCrFeMnNi high entropy alloys(HEAs)with various grain sizes(ranging between 2.4 and 356μm)were measured at different strain rates and strain levels at room temperature.As the strain rate decreased,the plastic strain decreased,and the grain size increased,V∗increased.The enhanced solid-solution strengthening by addition of aluminum decreased V∗.The Hassen plot was modified to capture the grain-size depen-dence of V∗by considering the grain-size dependence of the dislocation density.As the plastic strain increased,the strain rate decreased,and the grain size decreased,m decreased.The behavior of m could be quantitatively predicted by using equations derived for the grain-size-dependent V∗and flow stress.The difference in the grain-size dependence of m between conventional face centered cubic(FCC)metals and FCC HEAs over the nanograin size range could not be explained in terms of a relatively large Hall-Petch slope of the FCC HEAs compared with that of the FCC conventional metals,but was explainable in terms of a substantially higher probability of activation of grain-boundary diffusion-controlled grain-boundary-sliding mechanism at nanograin sizes in the FCC conventional metals than in the FCC HEAs.展开更多
Fluopyram is an succinate dehydrogenase inhibitors(SDHI)fungicide that has been registered in China to control gummy stem blight(GSB)in watermelons for many years.However,whether the field pathogens of GSB are still s...Fluopyram is an succinate dehydrogenase inhibitors(SDHI)fungicide that has been registered in China to control gummy stem blight(GSB)in watermelons for many years.However,whether the field pathogens of GSB are still sensitive to fluopyram or not is unknown.Therefore,we collected 69 Didymella bryoniae isolates from the fields that usually use fluopyram to control GSB to determine the sensitivity change.The EC50(50%inhibition effect)values of fluopyram against D.bryoniae ranged from 0.0691 to 0.3503μg mL–1 and the variation factor was 5.07.The mean EC50 value was(0.1579±0.0669)μg mL–1 and the curve of sensitivity was unimodal.No resistant strains were found in the isolates,which means that the pathogens were still sensitive to fluopyram.The minimal inhibition concentration(MIC)of fluopyram against D.bryoniae was 3μg mL–1.Four low-resistant mutants and two mediumresistant mutants were obtained using fungicide taming and the resistance of mutants could be inherited stably.The growth rate of mutants decreased significantly compared with that of wild-type strains while the biomass of most mutants was similar to that of wild-type strains.The sensitivity of most resistant mutants to various stresses was increased compared with that of wild-type strains.The virulence of mutants receded except for low-resistant mutant XN51FR-1,which had the same lesion area as XN51 on the watermelon leaves.The results indicated that the fitness of resistant mutants was decreased compared with that of wild-type strains.The cross-resistance assay indicated that fluopyram-resistant mutants were positive cross-resistant to all six SDHI fungicides in this test but were still sensitive to fluazinam and tebuconazole.So the resistance risk of D.bryoniae to fluopyram was moderate.In addition,we found that the SdhB gene of low-resistant mutant XN30FR-1 had three new point mutations at positions K258N,A259P,and H277N.Medium-resistant mutant XN52FR-1 showed a mutation at position H277N and other mutants did not have any point mutation.展开更多
Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and s...Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight.展开更多
The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft...The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft.An impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational efficiency.This method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the spacecraft.The Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh quality.The influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and spacecraft.The results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the method.The PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size vs.flux relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.展开更多
We focus on the Mach–Zehnder interferometer(MZI) with the input of a coherent beam and one of the bright entangled twin beams with an external power reference beam employed for measurement. The results show that the ...We focus on the Mach–Zehnder interferometer(MZI) with the input of a coherent beam and one of the bright entangled twin beams with an external power reference beam employed for measurement. The results show that the phase sensitivity can reach sub-Heisenberg limit and approach quantum Cramer–Rao bound by changing the squeezing parameters and the photon number of the coherent beam, under the phase-matching condition. The absence of the external power reference beam will degrade the performance of the phase sensitivity. Meanwhile, this scheme shows good robustness against the losses of the photon detectors. We present a detailed discussion about the phase sensitivities when the inputs are two coherent beams, or a coherent beam plus a single-mode squeezed vacuum beam based on the MZI. This scenario can be applied in the field of phase precision measurements and other optical sensors.展开更多
AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collecte...AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.RESULTS:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were fungi.Gram-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at 0.Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at 0.Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(P<0.05)in the resistance of both to cefoxitin,cotrimoxazole,levofloxacin,cefuroxime,ceftriaxone and ceftazidime,and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria.The distribution of bacterial infection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye parts.Besides,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections.CONCLUSION:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and fungi.Considering the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.展开更多
BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skelet...BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal muscle.However,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to stimulation.Further exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is warranted.AIM To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal muscle.METHODS We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical staining.Then,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG milieus.The effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent assay.The mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG assay.RESULTS The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P<0.01,g=6.26).Compared to Mc group,F4/80+CD86+CD206-cells,tumor necrosis factor-α(TNFα),inerleukin-1β(IL-1β)and IL-6 decreased,and IL-10 increased in McM group(P<0.01,g>0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P<0.01,g>0.8).Compered to M group,myotube area,myotube number and E-MHC were increased in MMc group(P<0.01,g>0.8).In MMc+HG group,myotube area,myotube number,E-MHC,GLUT4 and glucose uptake were decreased compared with M+HG group and MMc group(P<0.01,g>0.8).CONCLUSION Interactions between myoblasts and macrophages under HG milieus results in inflammation and IR,which support that the macrophage may serve as a promising therapeutic target for skeletal muscle atrophy and IR.展开更多
This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared spectroscopy.The three tempo...This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared spectroscopy.The three temporal domains,continuous wave,frequency domain,and time domain,each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption coefficient.Sensitivity is the relationship between a localized perturbation and the recovered effective homogeneous absorption change.Therefore,spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal domains.The review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse media.These works are experimental and theoretical,presenting one-,two-,and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods,domains,and data types.Following this history,we present a compendium of sensitivity maps organized by temporal domain and then data type.This compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one document.Methods for one to generate these maps are provided in Appendix A,including the code.This historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize,investigate,compare,and generate sensitivity to localized absorption change maps.展开更多
The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce...The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable uncertainty.Therefore,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and improvement.This study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation strategies.Through an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant accidents.Seventeen uncertainty parameters of the ISAA program were meticulously screened.Using Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch calculations.Statistical analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure vessel.Uncertainty calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,respectively.The ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.展开更多
This work presents the “n<sup>th</sup>-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (abbreviated as “n<sup>th</sup>-FASAM-N”), which will be shown to be the...This work presents the “n<sup>th</sup>-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (abbreviated as “n<sup>th</sup>-FASAM-N”), which will be shown to be the most efficient methodology for computing exact expressions of sensitivities, of any order, of model responses with respect to features of model parameters and, subsequently, with respect to the model’s uncertain parameters, boundaries, and internal interfaces. The unparalleled efficiency and accuracy of the n<sup>th</sup>-FASAM-N methodology stems from the maximal reduction of the number of adjoint computations (which are considered to be “large-scale” computations) for computing high-order sensitivities. When applying the n<sup>th</sup>-FASAM-N methodology to compute the second- and higher-order sensitivities, the number of large-scale computations is proportional to the number of “model features” as opposed to being proportional to the number of model parameters (which are considerably more than the number of features).When a model has no “feature” functions of parameters, but only comprises primary parameters, the n<sup>th</sup>-FASAM-N methodology becomes identical to the extant n<sup>th</sup> CASAM-N (“n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems”) methodology. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are formulated in linearly increasing higher-dimensional Hilbert spaces as opposed to exponentially increasing parameter-dimensional spaces thus overcoming the curse of dimensionality in sensitivity analysis of nonlinear systems. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N are incomparably more efficient and more accurate than any other methods (statistical, finite differences, etc.) for computing exact expressions of response sensitivities of any order with respect to the model’s features and/or primary uncertain parameters, boundaries, and internal interfaces.展开更多
[Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural pro...[Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural products.[Methods]The sensitivity of 28 kinds of pesticides was determined by using the commercially available enzyme inhibition colorimetric rapid detection kit with Hendu brand.[Results]There was a significant difference in the sensitivity of the kit to each pesticide,and the kit was more sensitive to dichlorvos among the 28 pesticides tested.The sensitivity to methyl isosalifos,dimethoate,isocarbophos,fenthion and phorate was poor,and the sensitivity to quinalphos was different between 3.0 and 2.5 mL.[Conclusions]The large difference of the sensitivity of the enzyme inhibition-colorimetric rapid detection kit for pesticide residues to different kits is a reason for the false positive and false negative test results of the kit,which needs to be considered by relevant personnel.展开更多
Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating du...Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating due to the small size of datasets while mapping the relative importance of properties to the model response.This paper proposes an augmented Bayesian multi-model inference(BMMI)coupled with GSA methodology(BMMI-GSA)to address this issue by estimating the imprecision in the momentindependent sensitivity indices of rock structures arising from the small size of input data.The methodology employs BMMI to quantify the epistemic uncertainties associated with model type and parameters of input properties.The estimated uncertainties are propagated in estimating imprecision in moment-independent Borgonovo’s indices by employing a reweighting approach on candidate probabilistic models.The proposed methodology is showcased for a rock slope prone to stress-controlled failure in the Himalayan region of India.The proposed methodology was superior to the conventional GSA(neglects all epistemic uncertainties)and Bayesian coupled GSA(B-GSA)(neglects model uncertainty)due to its capability to incorporate the uncertainties in both model type and parameters of properties.Imprecise Borgonovo’s indices estimated via proposed methodology provide the confidence intervals of the sensitivity indices instead of their fixed-point estimates,which makes the user more informed in the data collection efforts.Analyses performed with the varying sample sizes suggested that the uncertainties in sensitivity indices reduce significantly with the increasing sample sizes.The accurate importance ranking of properties was only possible via samples of large sizes.Further,the impact of the prior knowledge in terms of prior ranges and distributions was significant;hence,any related assumption should be made carefully.展开更多
This work highlights the unparalleled efficiency of the “n<sup>th</sup>-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-FASAM-N) by con...This work highlights the unparalleled efficiency of the “n<sup>th</sup>-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-FASAM-N) by considering the well-known Nordheim-Fuchs reactor dynamics/safety model. This model describes a short-time self-limiting power excursion in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted, either intentionally or by accident. This nonlinear paradigm model is sufficiently complex to model realistically self-limiting power excursions for short times yet admits closed-form exact expressions for the time-dependent neutron flux, temperature distribution and energy released during the transient power burst. The n<sup>th</sup>-FASAM-N methodology is compared to the extant “n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-CASAM-N) showing that: (i) the 1<sup>st</sup>-FASAM-N and the 1<sup>st</sup>-CASAM-N methodologies are equally efficient for computing the first-order sensitivities;each methodology requires a single large-scale computation for solving the “First-Level Adjoint Sensitivity System” (1<sup>st</sup>-LASS);(ii) the 2<sup>nd</sup>-FASAM-N methodology is considerably more efficient than the 2<sup>nd</sup>-CASAM-N methodology for computing the second-order sensitivities since the number of feature-functions is much smaller than the number of primary parameters;specifically for the Nordheim-Fuchs model, the 2<sup>nd</sup>-FASAM-N methodology requires 2 large-scale computations to obtain all of the exact expressions of the 28 distinct second-order response sensitivities with respect to the model parameters while the 2<sup>nd</sup>-CASAM-N methodology requires 7 large-scale computations for obtaining these 28 second-order sensitivities;(iii) the 3<sup>rd</sup>-FASAM-N methodology is even more efficient than the 3<sup>rd</sup>-CASAM-N methodology: only 2 large-scale computations are needed to obtain the exact expressions of the 84 distinct third-order response sensitivities with respect to the Nordheim-Fuchs model’s parameters when applying the 3<sup>rd</sup>-FASAM-N methodology, while the application of the 3<sup>rd</sup>-CASAM-N methodology requires at least 22 large-scale computations for computing the same 84 distinct third-order sensitivities. Together, the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are the most practical methodologies for computing response sensitivities of any order comprehensively and accurately, overcoming the curse of dimensionality in sensitivity analysis.展开更多
Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenge...Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenges in making sound ethical decisions during clinical practice. These challenges may stem from conflicts between personal values and professional responsibilities. Methodology: Articles downloaded from Pub Med, CNKI, and Google Scholar were reviewed. Results: After rigorous screening, a meticulous analysis was conducted, encompassing 10 articles and involving a substantial cohort of 2863 participants. Existing literature revealed variations in the ethical dilemmas faced by nurses across different departments. The ethical sensitivity of nurses also varies, with higher ethical sensitivity correlating with stronger empathetic abilities. Zhen et al. classified the causes of ethical dilemmas into four main categories: (1) Ethical dilemmas arising from personal reasons of nursing students;(2) Ethical dilemmas stemming from the actions of teachers;(3) Ethical dilemmas triggered by patients;(4) Ethical dilemmas resulting from miscellaneous reasons. Conclusion: According to literature findings, nursing ethical sensitivity was positively linked to the nurse’s ethical decision-making ability. A case study-oriented teaching program has proven effective in enhancing ethical sensitivity among nursing students.展开更多
During emergency response to oil spills incident accurate information is required in order to reduce the risk associated with oil spill disasters. This study focuses on Environmental Sensitivity mapping for sustainabl...During emergency response to oil spills incident accurate information is required in order to reduce the risk associated with oil spill disasters. This study focuses on Environmental Sensitivity mapping for sustainable environmental clean-up and contingency planning along the 3.0 km of AGIP pipeline at Asemoku in Delta State, Nigeria. Geographic information systems (GIS) techniques were used to create an Environmental Sensitivity Index (ESI) map in the study area. A 2018 Google Earth Satellite imagery of the study area was downloaded, and landuse/cover classification scheme comprising of Vegetation, Farmland, Water Body, Wetland, built up area and Bare Surface was adopted. Existing categorization, ranking and classification of the inland habitat were adopted and used to create a Landuse/cover Environmental Sensitivity Index (ESI) map, while the buffer zones of 100 m, 200 m, 300 m and 400 m were adopted. In the ArcGIS 10.8 environment, the landuse/cover map was generated and buffer distances of 100 m, 200 m, 300 m and 400 m were created on the landuse/cover map to ascertain the features that are vulnerable and could be at risk in the event of oil spill. This study established that the Natural Vegetation areas are the most vulnerable and sensitive feature as a result of their size along the created buffer zones. Findings from this study thus provide insight into the most sensitive land-use/land-cover, in the event of a spill or emergency oil spill clean-up response.展开更多
To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the spacecraft.Spacecraft survivability assessment is the key technology in the optimal desi...To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the spacecraft.Spacecraft survivability assessment is the key technology in the optimal design of spacecraft.Spacecraft survivability assessment includes spacecraft impact sensitivity analysis and spacecraft component vulnerability analysis under MM/OD environment.The impact sensitivity refers to the probability of a spacecraft encountering an MM/OD impact while in orbit.Vulnerability refers to the probability that each component of a spacecraft may fail or malfunction when impacted by space debris.Yet this paper mainly analyzes the impact sensitivity and proposes a spacecraft sensitivity assessment method under the MM/OD environment based on a panel method.Under this panel method,a spacecraft geometric model is discretized into small panels,and whether they are impacted by MM/OD or not is determined through the analysis of the shielding or shadowing relationships between panels.The number of impacts on each panel is obtained through calculation,and accordingly the probability of each spacecraft component encountering MM/OD impact can be acquired,thus generating the impact sensibility.This paper extracts data from the NASA’s ORDEM2000,the ESA’s MASTER8 as well as the SDEEM2015(Space Debris Environmental Engineering Model developed by HIT),and uses the PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)method to interpolate and fit the size-flux relationship of space debris.Compared with linear interpolation and cubic spline interpolation,the fitting results through the method are relatively more accurate.The feasibility of this method is also demonstrated through two actual examples shown in this paper,whose results are close to those from ESABASE,although there are some minor errors mainly due to different debris data input.Through the cross-check by three risk assessment software-BUMPER,MDPANTO and MODAOST-under standard operating conditions,the feasibility of this method is again verified.展开更多
Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in l...Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil.展开更多
Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipita...Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipitation in north-west China is unclear.The dendrochronological method was used to study climate response sensitivity of radial growth of Picea schrenkiana from 158 trees at six sites during 1990-2020.The results show that climate warming and increased precipitation significantly promoted the growth of trees.The response to temperature first increased,then decreased.However,the response to increased precipitation and the self-calibrating Palmer Drought Severity Index(scPDSI)increased significantly.In most areas of the Tianshan Mountains,the proportion of trees under increased precipitation and scPDSI positive response was relatively high.Over time,small-diameter trees were strongly affected by drought stress.It is predicted that under continuous warming and increased precipitation,trees in most areas of the Tianshan Mountains,especially those with small diameters,will be more affected by precipitation.展开更多
基金Funded in part by the Fundamental Research Funds for the Central Universities,SCUT(2013ZZ014)the Natural Science Foundation of Guangdong Province(No.S2013010013269)+1 种基金the Doctoral Program Foundation of Institutions of Higher Education of China(No.20130172120027)the National Engineering Research Center Open Fund of SCUT(2011007B)
文摘Strain-rate sensitivities of 55vol%-65vol% aluminum 2024-T6/TiB2 composites and the corresponding aluminum 2024-T6 matrix were investigated using split Hopkinson pressure bar method. The experimental results showed that 55vol%-65vol% aluminum 2024-T6/TiB2 composites exhibited significant strain-rate sensitivities, which were three times higher than the strain-rate sensitivity of the aluminum 2024-T6 matrix. The strain-rate sensitivity of the aluminum 2024-T6 matrix composites rose obviously with increasing reinforcement content(up to 60%), which agreed with that from the previous researches. But it decreased as the ceramic reinforcement content reached 65%. After high strain rates compression, a large number of dislocations and micro-cracks were found inside the matrix and the Ti B2 particles, respectively. These micro-cracks can accelerate the brittle fracture of the composites. The aluminum 2024-T6/Ti B2 composites showed various fracture characteristics and shear instability was the predominant failure mechanism under dynamic loading.
基金supported by the Mid-Career Re-searcher Program through the National Research Foundation of Ko-rea funded by the Ministry of Education,Scienceand Technology (No.NRF-2020R1A2C1008105).
文摘The activation volume(V∗)and strain-rate sensitivity exponent(m)of CoCrFeMnNi and Al_(0.5)CoCrFeMnNi high entropy alloys(HEAs)with various grain sizes(ranging between 2.4 and 356μm)were measured at different strain rates and strain levels at room temperature.As the strain rate decreased,the plastic strain decreased,and the grain size increased,V∗increased.The enhanced solid-solution strengthening by addition of aluminum decreased V∗.The Hassen plot was modified to capture the grain-size depen-dence of V∗by considering the grain-size dependence of the dislocation density.As the plastic strain increased,the strain rate decreased,and the grain size decreased,m decreased.The behavior of m could be quantitatively predicted by using equations derived for the grain-size-dependent V∗and flow stress.The difference in the grain-size dependence of m between conventional face centered cubic(FCC)metals and FCC HEAs over the nanograin size range could not be explained in terms of a relatively large Hall-Petch slope of the FCC HEAs compared with that of the FCC conventional metals,but was explainable in terms of a substantially higher probability of activation of grain-boundary diffusion-controlled grain-boundary-sliding mechanism at nanograin sizes in the FCC conventional metals than in the FCC HEAs.
基金sponsored by the National Key R&D Program of China(2022YFD1400900)the National Natural Science Foundation of China(32272585)the Fundamental Research Funds for the Central Universities,China(KYCXJC2023003)。
文摘Fluopyram is an succinate dehydrogenase inhibitors(SDHI)fungicide that has been registered in China to control gummy stem blight(GSB)in watermelons for many years.However,whether the field pathogens of GSB are still sensitive to fluopyram or not is unknown.Therefore,we collected 69 Didymella bryoniae isolates from the fields that usually use fluopyram to control GSB to determine the sensitivity change.The EC50(50%inhibition effect)values of fluopyram against D.bryoniae ranged from 0.0691 to 0.3503μg mL–1 and the variation factor was 5.07.The mean EC50 value was(0.1579±0.0669)μg mL–1 and the curve of sensitivity was unimodal.No resistant strains were found in the isolates,which means that the pathogens were still sensitive to fluopyram.The minimal inhibition concentration(MIC)of fluopyram against D.bryoniae was 3μg mL–1.Four low-resistant mutants and two mediumresistant mutants were obtained using fungicide taming and the resistance of mutants could be inherited stably.The growth rate of mutants decreased significantly compared with that of wild-type strains while the biomass of most mutants was similar to that of wild-type strains.The sensitivity of most resistant mutants to various stresses was increased compared with that of wild-type strains.The virulence of mutants receded except for low-resistant mutant XN51FR-1,which had the same lesion area as XN51 on the watermelon leaves.The results indicated that the fitness of resistant mutants was decreased compared with that of wild-type strains.The cross-resistance assay indicated that fluopyram-resistant mutants were positive cross-resistant to all six SDHI fungicides in this test but were still sensitive to fluazinam and tebuconazole.So the resistance risk of D.bryoniae to fluopyram was moderate.In addition,we found that the SdhB gene of low-resistant mutant XN30FR-1 had three new point mutations at positions K258N,A259P,and H277N.Medium-resistant mutant XN52FR-1 showed a mutation at position H277N and other mutants did not have any point mutation.
基金supported by the Doctor Foundation of Gansu Academy of Agricultural Sciences,China(2020GAAS33)the Young Science and Technology Lifting Engineering Talents in Gansu Province,China(2020-18)the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2017-ICS)。
文摘Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight.
文摘The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft.An impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational efficiency.This method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the spacecraft.The Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh quality.The influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and spacecraft.The results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the method.The PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size vs.flux relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12104190,12104189,and 12204312)the Natural Science Foundation of Jiangsu Province (Grant No.BK20210874)+2 种基金the Jiangsu Provincial Key Research and Development Program (Grant No.BE2022143)the Jiangxi Provincial Natural Science Foundation (Grant Nos.20224BAB211014 and 20232BAB201042)the General Project of Natural Science Research in Colleges and Universities of Jiangsu Province (Grant No.20KJB140008)。
文摘We focus on the Mach–Zehnder interferometer(MZI) with the input of a coherent beam and one of the bright entangled twin beams with an external power reference beam employed for measurement. The results show that the phase sensitivity can reach sub-Heisenberg limit and approach quantum Cramer–Rao bound by changing the squeezing parameters and the photon number of the coherent beam, under the phase-matching condition. The absence of the external power reference beam will degrade the performance of the phase sensitivity. Meanwhile, this scheme shows good robustness against the losses of the photon detectors. We present a detailed discussion about the phase sensitivities when the inputs are two coherent beams, or a coherent beam plus a single-mode squeezed vacuum beam based on the MZI. This scenario can be applied in the field of phase precision measurements and other optical sensors.
文摘AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.RESULTS:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were fungi.Gram-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at 0.Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at 0.Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(P<0.05)in the resistance of both to cefoxitin,cotrimoxazole,levofloxacin,cefuroxime,ceftriaxone and ceftazidime,and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria.The distribution of bacterial infection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye parts.Besides,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections.CONCLUSION:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and fungi.Considering the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.
基金Supported by National Natural Science Foundation of China,No.32200944“Qing Lan”Project of Jiangsu Provincethe Jiangsu Research Institute of Sports Science Foundation,No.BM-2023-03.
文摘BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal muscle.However,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to stimulation.Further exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is warranted.AIM To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal muscle.METHODS We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical staining.Then,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG milieus.The effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent assay.The mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG assay.RESULTS The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P<0.01,g=6.26).Compared to Mc group,F4/80+CD86+CD206-cells,tumor necrosis factor-α(TNFα),inerleukin-1β(IL-1β)and IL-6 decreased,and IL-10 increased in McM group(P<0.01,g>0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P<0.01,g>0.8).Compered to M group,myotube area,myotube number and E-MHC were increased in MMc group(P<0.01,g>0.8).In MMc+HG group,myotube area,myotube number,E-MHC,GLUT4 and glucose uptake were decreased compared with M+HG group and MMc group(P<0.01,g>0.8).CONCLUSION Interactions between myoblasts and macrophages under HG milieus results in inflammation and IR,which support that the macrophage may serve as a promising therapeutic target for skeletal muscle atrophy and IR.
文摘This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared spectroscopy.The three temporal domains,continuous wave,frequency domain,and time domain,each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption coefficient.Sensitivity is the relationship between a localized perturbation and the recovered effective homogeneous absorption change.Therefore,spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal domains.The review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse media.These works are experimental and theoretical,presenting one-,two-,and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods,domains,and data types.Following this history,we present a compendium of sensitivity maps organized by temporal domain and then data type.This compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one document.Methods for one to generate these maps are provided in Appendix A,including the code.This historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize,investigate,compare,and generate sensitivity to localized absorption change maps.
基金This work was supported financially by the National Natural Science Foundation of China(No.12375176).
文摘The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable uncertainty.Therefore,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and improvement.This study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation strategies.Through an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant accidents.Seventeen uncertainty parameters of the ISAA program were meticulously screened.Using Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch calculations.Statistical analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure vessel.Uncertainty calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,respectively.The ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.
文摘This work presents the “n<sup>th</sup>-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (abbreviated as “n<sup>th</sup>-FASAM-N”), which will be shown to be the most efficient methodology for computing exact expressions of sensitivities, of any order, of model responses with respect to features of model parameters and, subsequently, with respect to the model’s uncertain parameters, boundaries, and internal interfaces. The unparalleled efficiency and accuracy of the n<sup>th</sup>-FASAM-N methodology stems from the maximal reduction of the number of adjoint computations (which are considered to be “large-scale” computations) for computing high-order sensitivities. When applying the n<sup>th</sup>-FASAM-N methodology to compute the second- and higher-order sensitivities, the number of large-scale computations is proportional to the number of “model features” as opposed to being proportional to the number of model parameters (which are considerably more than the number of features).When a model has no “feature” functions of parameters, but only comprises primary parameters, the n<sup>th</sup>-FASAM-N methodology becomes identical to the extant n<sup>th</sup> CASAM-N (“n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems”) methodology. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are formulated in linearly increasing higher-dimensional Hilbert spaces as opposed to exponentially increasing parameter-dimensional spaces thus overcoming the curse of dimensionality in sensitivity analysis of nonlinear systems. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N are incomparably more efficient and more accurate than any other methods (statistical, finite differences, etc.) for computing exact expressions of response sensitivities of any order with respect to the model’s features and/or primary uncertain parameters, boundaries, and internal interfaces.
文摘[Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural products.[Methods]The sensitivity of 28 kinds of pesticides was determined by using the commercially available enzyme inhibition colorimetric rapid detection kit with Hendu brand.[Results]There was a significant difference in the sensitivity of the kit to each pesticide,and the kit was more sensitive to dichlorvos among the 28 pesticides tested.The sensitivity to methyl isosalifos,dimethoate,isocarbophos,fenthion and phorate was poor,and the sensitivity to quinalphos was different between 3.0 and 2.5 mL.[Conclusions]The large difference of the sensitivity of the enzyme inhibition-colorimetric rapid detection kit for pesticide residues to different kits is a reason for the false positive and false negative test results of the kit,which needs to be considered by relevant personnel.
文摘Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating due to the small size of datasets while mapping the relative importance of properties to the model response.This paper proposes an augmented Bayesian multi-model inference(BMMI)coupled with GSA methodology(BMMI-GSA)to address this issue by estimating the imprecision in the momentindependent sensitivity indices of rock structures arising from the small size of input data.The methodology employs BMMI to quantify the epistemic uncertainties associated with model type and parameters of input properties.The estimated uncertainties are propagated in estimating imprecision in moment-independent Borgonovo’s indices by employing a reweighting approach on candidate probabilistic models.The proposed methodology is showcased for a rock slope prone to stress-controlled failure in the Himalayan region of India.The proposed methodology was superior to the conventional GSA(neglects all epistemic uncertainties)and Bayesian coupled GSA(B-GSA)(neglects model uncertainty)due to its capability to incorporate the uncertainties in both model type and parameters of properties.Imprecise Borgonovo’s indices estimated via proposed methodology provide the confidence intervals of the sensitivity indices instead of their fixed-point estimates,which makes the user more informed in the data collection efforts.Analyses performed with the varying sample sizes suggested that the uncertainties in sensitivity indices reduce significantly with the increasing sample sizes.The accurate importance ranking of properties was only possible via samples of large sizes.Further,the impact of the prior knowledge in terms of prior ranges and distributions was significant;hence,any related assumption should be made carefully.
文摘This work highlights the unparalleled efficiency of the “n<sup>th</sup>-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-FASAM-N) by considering the well-known Nordheim-Fuchs reactor dynamics/safety model. This model describes a short-time self-limiting power excursion in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted, either intentionally or by accident. This nonlinear paradigm model is sufficiently complex to model realistically self-limiting power excursions for short times yet admits closed-form exact expressions for the time-dependent neutron flux, temperature distribution and energy released during the transient power burst. The n<sup>th</sup>-FASAM-N methodology is compared to the extant “n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-CASAM-N) showing that: (i) the 1<sup>st</sup>-FASAM-N and the 1<sup>st</sup>-CASAM-N methodologies are equally efficient for computing the first-order sensitivities;each methodology requires a single large-scale computation for solving the “First-Level Adjoint Sensitivity System” (1<sup>st</sup>-LASS);(ii) the 2<sup>nd</sup>-FASAM-N methodology is considerably more efficient than the 2<sup>nd</sup>-CASAM-N methodology for computing the second-order sensitivities since the number of feature-functions is much smaller than the number of primary parameters;specifically for the Nordheim-Fuchs model, the 2<sup>nd</sup>-FASAM-N methodology requires 2 large-scale computations to obtain all of the exact expressions of the 28 distinct second-order response sensitivities with respect to the model parameters while the 2<sup>nd</sup>-CASAM-N methodology requires 7 large-scale computations for obtaining these 28 second-order sensitivities;(iii) the 3<sup>rd</sup>-FASAM-N methodology is even more efficient than the 3<sup>rd</sup>-CASAM-N methodology: only 2 large-scale computations are needed to obtain the exact expressions of the 84 distinct third-order response sensitivities with respect to the Nordheim-Fuchs model’s parameters when applying the 3<sup>rd</sup>-FASAM-N methodology, while the application of the 3<sup>rd</sup>-CASAM-N methodology requires at least 22 large-scale computations for computing the same 84 distinct third-order sensitivities. Together, the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are the most practical methodologies for computing response sensitivities of any order comprehensively and accurately, overcoming the curse of dimensionality in sensitivity analysis.
文摘Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenges in making sound ethical decisions during clinical practice. These challenges may stem from conflicts between personal values and professional responsibilities. Methodology: Articles downloaded from Pub Med, CNKI, and Google Scholar were reviewed. Results: After rigorous screening, a meticulous analysis was conducted, encompassing 10 articles and involving a substantial cohort of 2863 participants. Existing literature revealed variations in the ethical dilemmas faced by nurses across different departments. The ethical sensitivity of nurses also varies, with higher ethical sensitivity correlating with stronger empathetic abilities. Zhen et al. classified the causes of ethical dilemmas into four main categories: (1) Ethical dilemmas arising from personal reasons of nursing students;(2) Ethical dilemmas stemming from the actions of teachers;(3) Ethical dilemmas triggered by patients;(4) Ethical dilemmas resulting from miscellaneous reasons. Conclusion: According to literature findings, nursing ethical sensitivity was positively linked to the nurse’s ethical decision-making ability. A case study-oriented teaching program has proven effective in enhancing ethical sensitivity among nursing students.
文摘During emergency response to oil spills incident accurate information is required in order to reduce the risk associated with oil spill disasters. This study focuses on Environmental Sensitivity mapping for sustainable environmental clean-up and contingency planning along the 3.0 km of AGIP pipeline at Asemoku in Delta State, Nigeria. Geographic information systems (GIS) techniques were used to create an Environmental Sensitivity Index (ESI) map in the study area. A 2018 Google Earth Satellite imagery of the study area was downloaded, and landuse/cover classification scheme comprising of Vegetation, Farmland, Water Body, Wetland, built up area and Bare Surface was adopted. Existing categorization, ranking and classification of the inland habitat were adopted and used to create a Landuse/cover Environmental Sensitivity Index (ESI) map, while the buffer zones of 100 m, 200 m, 300 m and 400 m were adopted. In the ArcGIS 10.8 environment, the landuse/cover map was generated and buffer distances of 100 m, 200 m, 300 m and 400 m were created on the landuse/cover map to ascertain the features that are vulnerable and could be at risk in the event of oil spill. This study established that the Natural Vegetation areas are the most vulnerable and sensitive feature as a result of their size along the created buffer zones. Findings from this study thus provide insight into the most sensitive land-use/land-cover, in the event of a spill or emergency oil spill clean-up response.
基金supported by the National Natural Science Foundation of China(Grant No.11772113)。
文摘To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the spacecraft.Spacecraft survivability assessment is the key technology in the optimal design of spacecraft.Spacecraft survivability assessment includes spacecraft impact sensitivity analysis and spacecraft component vulnerability analysis under MM/OD environment.The impact sensitivity refers to the probability of a spacecraft encountering an MM/OD impact while in orbit.Vulnerability refers to the probability that each component of a spacecraft may fail or malfunction when impacted by space debris.Yet this paper mainly analyzes the impact sensitivity and proposes a spacecraft sensitivity assessment method under the MM/OD environment based on a panel method.Under this panel method,a spacecraft geometric model is discretized into small panels,and whether they are impacted by MM/OD or not is determined through the analysis of the shielding or shadowing relationships between panels.The number of impacts on each panel is obtained through calculation,and accordingly the probability of each spacecraft component encountering MM/OD impact can be acquired,thus generating the impact sensibility.This paper extracts data from the NASA’s ORDEM2000,the ESA’s MASTER8 as well as the SDEEM2015(Space Debris Environmental Engineering Model developed by HIT),and uses the PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)method to interpolate and fit the size-flux relationship of space debris.Compared with linear interpolation and cubic spline interpolation,the fitting results through the method are relatively more accurate.The feasibility of this method is also demonstrated through two actual examples shown in this paper,whose results are close to those from ESABASE,although there are some minor errors mainly due to different debris data input.Through the cross-check by three risk assessment software-BUMPER,MDPANTO and MODAOST-under standard operating conditions,the feasibility of this method is again verified.
基金National Science Foundation for Excellent Young Scholars of China under Grant No.51722801National Natural Science Foundation of China under Grant Nos.51808006 and 52078016。
文摘Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil.
基金funded by the National Natural Science Foundation of China(No.31971460 and 32271646)the National Key Research and Development Program of China(2021YFD2200401)。
文摘Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipitation in north-west China is unclear.The dendrochronological method was used to study climate response sensitivity of radial growth of Picea schrenkiana from 158 trees at six sites during 1990-2020.The results show that climate warming and increased precipitation significantly promoted the growth of trees.The response to temperature first increased,then decreased.However,the response to increased precipitation and the self-calibrating Palmer Drought Severity Index(scPDSI)increased significantly.In most areas of the Tianshan Mountains,the proportion of trees under increased precipitation and scPDSI positive response was relatively high.Over time,small-diameter trees were strongly affected by drought stress.It is predicted that under continuous warming and increased precipitation,trees in most areas of the Tianshan Mountains,especially those with small diameters,will be more affected by precipitation.