Objective： To explore the effects and mechanisms of poly （ADP-ribose） polymerase （PARP） inhibitor 3-aminobenzamide on nerve lesions in streptozotocin-diabetic rats. Methods： Experimental rats were divided into n...Objective： To explore the effects and mechanisms of poly （ADP-ribose） polymerase （PARP） inhibitor 3-aminobenzamide on nerve lesions in streptozotocin-diabetic rats. Methods： Experimental rats were divided into normal control group（NC group）, diabetic control group （DC group ）and diabetic group treated with 3-aminobenzamide （DT group ）.Nerve conduction velocity （NCV）, serum superoxide dismutase （SOD） activity and serum malondialdehyde （MDA） concentration,phosphocreatine （Pcr） ,creatine （Cr） concentration in sciatic nerves were evaluated after 4 weeks. Results： SOD,Pcr activity,and NCV were higher （P 〈 0.05） and MDA concentration were significantly lower in DT group, compared with DC group （P 〈 0.01 ）. Meanwhile, ATP and Cr in sciatic nerves were similar in DT group, compared with DC group （P 〉 0.05）. Conclusion： 3-aminobenzamide could alleviate the established functional and metabolic abnormalities of early DPN in the streptozotocin-induced diabetic rat models,which pro- vided a novel approach for prevention and treatment of diabetic neuropathy.展开更多
文摘Objective： To explore the effects and mechanisms of poly （ADP-ribose） polymerase （PARP） inhibitor 3-aminobenzamide on nerve lesions in streptozotocin-diabetic rats. Methods： Experimental rats were divided into normal control group（NC group）, diabetic control group （DC group ）and diabetic group treated with 3-aminobenzamide （DT group ）.Nerve conduction velocity （NCV）, serum superoxide dismutase （SOD） activity and serum malondialdehyde （MDA） concentration,phosphocreatine （Pcr） ,creatine （Cr） concentration in sciatic nerves were evaluated after 4 weeks. Results： SOD,Pcr activity,and NCV were higher （P 〈 0.05） and MDA concentration were significantly lower in DT group, compared with DC group （P 〈 0.01 ）. Meanwhile, ATP and Cr in sciatic nerves were similar in DT group, compared with DC group （P 〉 0.05）. Conclusion： 3-aminobenzamide could alleviate the established functional and metabolic abnormalities of early DPN in the streptozotocin-induced diabetic rat models,which pro- vided a novel approach for prevention and treatment of diabetic neuropathy.
