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Stress response characteristics of BFRP anchors on loess mudstone slope under rainfall conditions
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作者 WEI Hong WU Hong-gang +3 位作者 WU Dao-yong TANG Lin PAI Li-fang GUAN Wei 《Journal of Mountain Science》 SCIE CSCD 2023年第5期1469-1482,共14页
To investigate the stress response characteristics and shear stress transfer mechanism of BFRP(basalt fiber reinforced plastics)anchors under rainfall conditions and to explore the reinforcement effect of BFRP anchors... To investigate the stress response characteristics and shear stress transfer mechanism of BFRP(basalt fiber reinforced plastics)anchors under rainfall conditions and to explore the reinforcement effect of BFRP anchors,a comparative indoor physical model test was conducted in this study using loess mudstone slope as a typical case,and multi-attribute response data,such as slope displacement,BFRP anchor strain and axial force,were obtained.Based on the variation law of slope displacement,it can be concluded that the deformation displacement of the slope on the side reinforced by BFRP anchors is smaller than that of slopes reinforced with steel anchors;the bearing capacity of BFRP anchor is given priority in time,and the anchoring effect of BFRP anchor at the top of the slope is given priority,and the axial force value of anchor is characterized by a surface amplification effect in space;the axial force is higher around the anchor head and tends to decay as a negative exponential function as the anchor extends in the direction of the interior of the slope;the shear stress of BFRP anchor and anchorage body are unevenly distributed along the axial direction,with the maximum value occurring in the free section near the slope surface and decreases as the BFRP anchor extends towards the interior of the slope.These results can provide a theoretical basis for the optimal design of BFRP anchors. 展开更多
关键词 BFRP stress response characteristics stress transfer mechanism Load transfer curve
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Effects of adjacent bubble on spatiotemporal evolutions of mechanical stresses surrounding bubbles oscillating in tissues
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作者 邹青钦 雷双 +1 位作者 李章勇 秦对 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第1期354-361,共8页
The cavitation dynamics and mechanical stress in viscoelastic tissues, as the primary mechanisms of some ultrasound therapies, are extremely complex due to the interactions of cavitation bubble with adjacent bubbles a... The cavitation dynamics and mechanical stress in viscoelastic tissues, as the primary mechanisms of some ultrasound therapies, are extremely complex due to the interactions of cavitation bubble with adjacent bubbles and surrounding tissues.Therefore, the cavitation dynamics and resultant mechanical stress of two-interacting bubbles in the viscoelastic tissues are numerically investigated, especially focusing on the effects of the adjacent bubble. The results demonstrate that the mechanical stress is highly dependent on the bubble dynamics. The compressive stress and tensile stress are generated at the stage of bubble expansion and collapse stage, respectively. Furthermore, within the initial parameters examined in this paper, the effects of the adjacent bubble will distinctly suppress the radial expansion of the small bubble and consequently lead its associated stresses to decrease. Owing to the superimposition of two stress fields, the mechanical stresses surrounding the small bubble in the direction of the neighboring bubble are smaller than those in other directions. For two interacting cavitation bubbles, the suppression effects of the nearby bubble on both the cavitation dynamics and the stresses surrounding the small bubble increase as the ultrasound amplitude and the initial radius of the large bubble increase, whereas they decrease with the inter-bubble distance increasing. Moreover, increasing the tissue viscoelasticity will reduce the suppression effects of the nearby bubble, except in instances where the compressive stress and tensile stress first increase and then decrease with the tissue elasticity and viscosity increasing respectively. This study can provide a further understanding of the mechanisms of cavitation-associated mechanical damage to the adjacent tissues or cells. 展开更多
关键词 cavitation dynamics cavitation-induced mechanical stress effects of the nearby bubble viscoelastic tissues
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Research on Stress Drops and the Focal Mechanisms of the Xinyuan- Hejing ML6.8 Earthquake Sequences
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作者 Liu Jianming Wang Qiong +4 位作者 Liu Jie Deng Fei Xiang Yuan Yang Wen Li Jin 《Earthquake Research in China》 CSCD 2017年第1期25-38,共14页
Based on the digital waveform data recorded by Xinjiang Digital Seismic Network for the Xinyuan-Hejing M_L6.8 earthquake sequences of June 30,2012,this paper analyzes the stress drops of earthquake sequences and the c... Based on the digital waveform data recorded by Xinjiang Digital Seismic Network for the Xinyuan-Hejing M_L6.8 earthquake sequences of June 30,2012,this paper analyzes the stress drops of earthquake sequences and the correlation coefficients of focal mechanisms significant for strong aftershocks.Firstly,the source parameters of the Xinyuan-Hejing M_L6.8 earthquake sequences are obtained by applying the spectrum analysis and the Brunes source model.Then,the correlation coefficients of spectral amplitudes are calculated using the low-frequency spectral amplitude recorded by the same station for the different events.Finally,based on the results of the correlation coefficients of spectral amplitudes,the events with similar focal mechanisms are grouped using the clustering method.The results show that:(1)The stress drop values show a steady trend in the aftershock sequence calm period and the stress drop values show a rise-fall in strong aftershocks.(2)The moving average correlation coefficient of amplitude spectrum begins to spread after the main shock.It shows that the correlation decreases between the main shock and the aftershocks in mechanisms.(3)The results of focal mechanism groups show that the earthquake sequences are mainly strike slips.The stress distribution of the main pressure axis is nearly NS,which is the same as the structural stress field.(4)The magnitude and mechanism show that there is an agreement before the strong aftershock,which shows that the regional stress field is enhanced. 展开更多
关键词 Xinyuan-Hejing ML6. 8 earthquake sequences stress drop The correlationof the focal mechanism Body-wave spectral amplitude Clustering group
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A Comprehensive Review of Experience with the Application of the Mechanical Threshold Stress Model
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作者 Paul S. Follansbee 《Materials Sciences and Applications》 CAS 2023年第5期299-323,共25页
Accurate prediction of stress-strain behavior of metals as a function of arbitrary temperature and strain rate paths has remained a challenge. The Mechanical Threshold Stress constitutive model is one formalism that h... Accurate prediction of stress-strain behavior of metals as a function of arbitrary temperature and strain rate paths has remained a challenge. The Mechanical Threshold Stress constitutive model is one formalism that has emerged following several decades of research. Vast experience has accumulated with the application of the Mechanical Threshold Stress model over a wide variety of pure metals and alloys. Out of this has arisen common trends across metal systems. The magnitude of activation energies presents one example of this, where these variables consistently increase in magnitude as the obstacle to dislocation motion transitions from short range to long range. Trends in strain hardening are also observed. In Face-Centered Cubic metals the magnitude of strain hardening scales with the stacking fault energy;trends in Body-Centered Cubic metals are less clear. Model parameters derived for over twenty metals and alloys are tabulated. Common trends should guide future application of the MTS model and further model development. 展开更多
关键词 Mechanical Threshold stress Constitutive Behavior Deformation Kinetics Strain Hardening Internal State Variable
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Construction of a cDNA-AFLP reaction system of Populus euphratica for abiotic stress studies 被引量:1
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作者 MA Hong-shuang XIA Xin-li YIN Wei-lun 《Forestry Studies in China》 CAS 2011年第2期104-111,共8页
We established a cDNA-AFLP (amplified fragment length polymorphism) system for Populus euphratica, after optimizing several key factors. The results show that optimized CTAB method is suitable for the extraction of ... We established a cDNA-AFLP (amplified fragment length polymorphism) system for Populus euphratica, after optimizing several key factors. The results show that optimized CTAB method is suitable for the extraction of ideal RNA from P euphratica; the double-stranded cDNA (ds-cDNA) is completely digested by the combination of EcoRI and MseI for 4.5 h; the reducible result can be obtained when the preamplification products were diluted 10-fold for selective amplification templates. The amplification products resulting from this reaction system were determined by silver staining and the fragments were clear and stable. Detected by RT-PCR, the optimized differential display cDNA-AFLP technique can accurately reflect the true differences of gene expressions among plants. In addition, 42 pairs of primer arrays, producing repeatable and prolific bands, were successfully selected by this improved method. This investigation establishes a cDNA-AFLP system for P. euphratica, which forms a basis for further study on stress-response genes in P. euphratica. 展开更多
关键词 Populus euphratica CDNA-AFLP abiotic stress mechanism
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Theoretical Investigation of Influence of Mechanical Stress on Magnetic Properties of Ferromagnetic/Antiferromagnetic Bilayers Deposited on Flexible Substrates 被引量:1
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作者 白宇浩 王霞 +1 位作者 穆林平 许小红 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第8期118-122,共5页
Effect of mechanical stress on magnetic properties of an exchange-biased ferromagnetic/antiferromagnetic bilayer deposited on a flexible substrate is investigated. The hysteresis loops with different magnitudes and or... Effect of mechanical stress on magnetic properties of an exchange-biased ferromagnetic/antiferromagnetic bilayer deposited on a flexible substrate is investigated. The hysteresis loops with different magnitudes and orientations of the stress can be classified into three types. The corresponding physical conditions for each type of the loop are deduced based on the principle of minimal energy. The equation of the critical stress is derived, which can judge whether the loops show hysteresis or not. Numerical calculations suggest that except for the magnitude of the mechanical stress, the relative orientation of the stress is also an important factor to tune the exchange bias effect. 展开更多
关键词 of for Theoretical Investigation of Influence of Mechanical stress on Magnetic Properties of Ferromagnetic/Antiferromagnetic Bilayers Deposited on Flexible Substrates is been on from that into
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Influence of intermediate principal stress on failure mechanism of hard rock with a pre-existing circular opening 被引量:5
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作者 张社荣 孙博 +1 位作者 王超 严磊 《Journal of Central South University》 SCIE EI CAS 2014年第4期1571-1582,共12页
Based on particle flow theory, the influences of the magnitude and direction of the intermediate principal stress on failure mechanism of hard rock with a pre-existing circular opening were studied by carrying out tru... Based on particle flow theory, the influences of the magnitude and direction of the intermediate principal stress on failure mechanism of hard rock with a pre-existing circular opening were studied by carrying out true triaxial tests on siltstone specimen. It is shown that peak strength of siltstone specimen increases firstly and subsequently decreases with the increase of the intermediate principal stress. And its turning point is related to the minimum principal stress and the direction of the intermediate principal stress. Failure characteristic(brittleness or ductility) of siltstone is determined by the minimum principal stress and the difference between the intermediate and minimum principal stress. The intermediate principal stress has a significant effect on the types and distributions of microcracks. The failure modes of the specimen are determined by the magnitude and direction of the intermediate principal stress, and related to weakening effect of the opening and inhibition effect of confining pressure in essence: when weakening effect of the opening is greater than inhibition effect of confining pressure, the failure surface is parallel to the x axis(such as σ2=σ3=0 MPa); conversely, the failure surface is parallel to the z axis(such as σ2=20 MPa, σ3=0 MPa). 展开更多
关键词 rock mechanics intermediate principal stress hard rock with pre-existing circular opening failure mechanism discrete element
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Failure mechanism and control technology of water-immersed roadway in high-stress and soft rock in a deep mine 被引量:11
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作者 Yang Renshu Li Yongliang +3 位作者 Guo Dongming Yao Lan Yang Tongmao Li Taotao 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第2期245-252,共8页
Aiming at soft rock ground support issues under conditions of high stress and long-term water immersion, the ground failure mechanism is revealed by taking the deep-water sumps of Jiulong Mine as the engineering backg... Aiming at soft rock ground support issues under conditions of high stress and long-term water immersion, the ground failure mechanism is revealed by taking the deep-water sumps of Jiulong Mine as the engineering background and employing field investigation, tests of rock structure, mechanical properties and mineral composition. The main factors leading to the surrounding rock failure include the high and complex stress state of the water sumps, high-clay content and water-weakened rock, and the unreasonable support design. In this paper, the broken and fractured rock mass near roadway opening is considered as ground small-structure, and deep stable rock mass as ground large-structure. A support technology focusing on cutting off the water, strengthening the small structure of the rock and transferring the large structure of the rock is proposed. The proposed support technology of interconnecting the large and small structures, based on high-strength bolts, high-stiffness shotcrete layer plugging water,strengthening the small structure with deep-hole grouting and shallow-hole grouting, highpretensioned cables tensioned twice to make the large and small structures bearing the pressure evenly,channel-steel and high-pretensioned cables are used to control floor heave. The numerical simulation and field test show that this support system can control the rock deformation of the water sumps and provide technical support to similar roadway support designs. 展开更多
关键词 High stress and soft rock Water immersion Failure mechanism Large and small structures Rework control
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Healing Wounds under Mechanical Stress: A Case Example 被引量:1
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作者 Jennifer D. Hastings Sara Shapiro 《International Journal of Clinical Medicine》 2016年第2期120-126,共7页
This paper challenges the concept that the essential element in wound healing is to offload pressure. We suggest a change in approach that recognizes the integumentary system as one which, like all other body systems,... This paper challenges the concept that the essential element in wound healing is to offload pressure. We suggest a change in approach that recognizes the integumentary system as one which, like all other body systems, adapts to the stresses put upon it. We use a clinical case example to illustrate the use of intentional mechanical stress to promote wound healing and include a review of the relevant literature. The intent of this publication is to call for a new look at clinical practice regarding wound healing and to call for future research directed at investigation of this theory. 展开更多
关键词 WOUNDS Pressure Ulcer Mechanical stress Electric Stimulation WEIGHT-BEARING
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Detection of mechanical stress in the steel structure of a bridge crane
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作者 Leopold Hrabovsky Daniel Cepica Karel Frydrysek 《Theoretical & Applied Mechanics Letters》 CSCD 2021年第6期320-329,共10页
A significant negative aspect in the operation of bridge-type cranes are the technical problems associated with wear of the wheels and the crane track,which causes crane skewing.The main causes of crane skewing includ... A significant negative aspect in the operation of bridge-type cranes are the technical problems associated with wear of the wheels and the crane track,which causes crane skewing.The main causes of crane skewing include unevenness of the crane track,unequal loading of the traction drives depending on the position of the crane trolley,slips and different sizes of travel wheels and combinations of these causes.Firstly,this paper presents a design solution that can be used to detect the magnitude of mechanical stress and deformation of the steel structure of the crane,caused by the effects of skewing.The mechanical stress generated by the transverse forces of the deformed geometric shape of the crane bridge structure is recorded by mechanical stress detectors installed in the inner corners of the crane bridge.The resulting electrical signal from element mechanical voltage detectors,loaded by axial forces,can be used for feedback control of separate crane travel drives controlled by frequency converters.Secondly,this paper presents the calculation of the lateral transverse forces according to CSN 270103 and the determination of the values of mechanical stresses of the deformed steel structure of the crane bridge of a two-girder bridge crane using the finite element method in the program MSC.MARC 2019.Finally,this paper presents the structural and strength design of mechanical stress detectors and the conclusions of laboratory tests of axial force loading of mechanical stress detectors on the test equipment.At the same time,it presents records of the measured axial forces acting in the mechanical stress detectors,arising from the deformation and warping of the crane bridge by the known magnitude of the axial force acting on the crossbeam and from the deformation of the crane bridge caused by the crane operating modes. 展开更多
关键词 Crane skewing Mechanical stress detector Mechanical stress FEM Overhead crane
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Mechanical Stress Induces Neuroendocrine and Immune Responses of Sea Cucumber(Apostichopus japonicus)
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作者 TAN Jie LI Fenghui +5 位作者 SUN Huiling GAO Fei YAN Jingping Gai Chunlei Chen Aihua WANG Qingyin 《Journal of Ocean University of China》 SCIE CAS 2015年第2期350-356,共7页
Grading procedure in routine sea cucumber hatchery production is thought to affect juvenile sea cucumber immunologi- cal response. The present study investigated the impact of a 3-min mechanical perturbation mimicking... Grading procedure in routine sea cucumber hatchery production is thought to affect juvenile sea cucumber immunologi- cal response. The present study investigated the impact of a 3-min mechanical perturbation mimicking the grading procedure on neuroendocrine and immune parameters of the sea cucumber Apostichopusjaponicus. During the application of stress, concentrations of noradrenaline and dopamine in coelomic fluid increased significantly, indicating that the mechanical perturbation resulted in a transient state of stress in sea cucumbers. Coelomocytes concentration in coelomic fluid increased transiently after the beginning of stressing, and reached the maximum in 1 h. Whereas, coelomocytes phagocytosis at 3 min, superoxide anion production from 3 min to 0.5 h, acid phosphatase activity at 0.5 h, and phenoloxidase activity from 3 min to 0.5 h were all significantly down-regulated. All of the immune parameters recovered to baseline levels after the experiment was conducted for 8 h, and an immunostimulation occurred after the stress considering the phagocytosis and acid phosphatase activity. The results suggested that, as in other marine invertebrates, neuroendocrine/immnne connections exist in sea cucumber A. japonicus. Mechanical stress can elicit a profound influence on sea cucumber neuroendocrine system. Neuroendocrine messengers act in turn to modulate the immunity fimctions. Therefore, these ef- fects should be considered for developing better husbandry procedures. 展开更多
关键词 Apostichopusjaponicus mechanical stress NEUROENDOCRINE immune response
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An analytical model of thermal mechanical stress induced by through silicon via
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作者 董刚 石涛 +1 位作者 赵颖博 杨银堂 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第5期444-450,共7页
We present an accurate through silicon via (TSV) thermal mechanical stress analytical model which is verified by using finite element method (FEM). The results show only a very small error. By using the proposed a... We present an accurate through silicon via (TSV) thermal mechanical stress analytical model which is verified by using finite element method (FEM). The results show only a very small error. By using the proposed analytical model, we also study the impacts of the TSV radius size, the thickness, the material of Cu diffusion barrier, and liner on the stress. It is found that the liner can absorb the stress effectively induced by coefficient of thermal expansion mismatch. The stress decreases with the increase of liner thickness. Benzocyclobutene (BCB) as a liner material is better than SiO2. However, the Cu diffusion barrier has little effect on the stress. The stress with a smaller TSV has a smaller value. Based on the analytical model, we explore and validate the linear superposition principle of stress tensors and demonstrate the accuracy of this method against detailed FEM simulations. The analytic solutions of stress of two TSVs and three TSVs have high precision against the finite element result. 展开更多
关键词 through silicon via finite element method (FEM) thermal mechanical stress
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Apparent Stress Changes of the 2010 Luanxian Earthquake Sequence
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作者 Li He Liu Wenbing +4 位作者 Wang Yixi Zhang Jieqing Gao Ye Kang Jian Zhang Changxuan 《Earthquake Research in China》 CSCD 2015年第3期293-302,共10页
On March 6,2010,an earthquake of M L4. 5 took place in Luanxian,Hebei Province,with plenty of foreshocks and aftershocks. From December 2009 to March 2010,a series of M L≥ 2. 5 earthquakes were recorded by the digita... On March 6,2010,an earthquake of M L4. 5 took place in Luanxian,Hebei Province,with plenty of foreshocks and aftershocks. From December 2009 to March 2010,a series of M L≥ 2. 5 earthquakes were recorded by the digital seismic network of the capital region,which were selected to calculate the apparent stress in this region. The results show that,firstly,a high value anomaly of apparent stress appeared before the M L4. 5 and peak value appeared on the main shock, which then decreased after the ML4. 5 earthquake. The apparent stress of the main shock is much greater than that of most aftershocks,the sequence type is considered as a main shock-aftershock. Secondly,the size of apparent stress perfectly reflects the state of the stress field in the hypocenter region,and we can discuss seismic sequence properties through the changing process of apparent stress,in combination with the traditional methods to identify a sequence more accurately. Finally,in the case of magnitude less than or equal to M L3. 3,correlation between magnitude and apparent stress is positive. 展开更多
关键词 Apparent stress Focal mechanism solution Luanxian earthquake sequence
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Research on the Source Parameters and Correlation Coefficients of Focal Mechanisms for the Yingjiang Earthquake Sequences in 2008
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作者 Deng Fei Liu Jie 《Earthquake Research in China》 CSCD 2015年第1期68-83,共16页
The source parameters of the Yingjiang earthquake sequences in 2008 are obtained by applying spectral analysis and Brunes source model,based on the digital waveform data recorded by the Yunnan Digital Seismic Network.... The source parameters of the Yingjiang earthquake sequences in 2008 are obtained by applying spectral analysis and Brunes source model,based on the digital waveform data recorded by the Yunnan Digital Seismic Network.The correlation coefficients are calculated using the low-frequency spectral amplitudes of 2 events recorded by a same station,then,events with similar focal mechanism are grouped using the clustering analysis method.Compared to the obtained focal mechanisms,it is found that there are good correlations with the azimuth of P axes in each clustering group,and the larger the correlation coefficient,the closer the azimuths of P axes.We divide the Yingjiang area into 3 regions to analyze the stress level and stress direction by combining the source parameters and the mean focal mechanism of each group.The results show:The change and transformation of the focal mechanism types at different stages can represent the temporal characteristics of the regional stress field.If the earthquake focal mechanism types are concentrated in a time period and switch to the direction of regional stress field,it may be a sign of strong earthquake.There is some relationship between the stress drop and the type of focal mechanism.Those earthquakes with stress fields revealed by focal mechanism types closer to the regional tectonic stress field will have higher stress drop,while those with the focal mechanism-revealed stress fields differing a lot from the regional tectonic stress field will generally have a lower stress drop. 展开更多
关键词 stress drop Correlation of focal mechanisms Clustering group Yingjiangearthquake sequences in 2008
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Analysis of Stress Strain State of X-60 Pipe Weld Joints Employing Magnetic-Anisotropy Indicator of Mechanical Stress
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作者 Hamid Suliman Hamid Elhag Nikulin Vasili +1 位作者 Isaac Einav Yagoub Kamal Eldin 《Engineering(科研)》 2016年第7期499-508,共11页
This research presents an experimental study of analysis of stress strain state SSS of X-60 pipe weld joints employing magnetic anisotropy indicator of mechanical stresses Stress Vision (IMS) using of “before and af... This research presents an experimental study of analysis of stress strain state SSS of X-60 pipe weld joints employing magnetic anisotropy indicator of mechanical stresses Stress Vision (IMS) using of “before and after” comparison approach taking readings on pipe base metal, weld area and heat affected zone (HAZ) before and after hydrotest. Test results were compared with X-ray testing results for welded joints and with metallographic testing. Test results demonstrate the relevance of applied test conditions and redistribution of residual stresses. A new equation was established for estimating the residual (technological) and operating stresses in other pipelines with a tolerance of 15% in the field of elastic deformation (up to the yield point), according to Hooke law. 展开更多
关键词 stress Strain State (SSS) Residual stresses stress Concentration Indicator of Mechanical stress
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Application of the Mechanical Threshold Stress Model to Large Strain Processing
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作者 Paul S. Follansbee 《Materials Sciences and Applications》 2022年第5期300-316,共17页
Large-strain deformations introduce several confounding factors that affect the application of the Mechanical Threshold Stress model. These include the decrease with the increasing stress of the normalized activation ... Large-strain deformations introduce several confounding factors that affect the application of the Mechanical Threshold Stress model. These include the decrease with the increasing stress of the normalized activation energy characterizing deformation kinetics, the tendency toward Stage IV hardening at high strains, and the influence of crystallographic texture. Minor additions to the Mechanical Threshold Stress model are introduced to account for variations of the activation energy and the addition of Stage IV hardening. Crystallographic texture cannot be modeled using an isotropic formulation, but some common trends when analyzing predominantly shear deformation followed by uniaxial deformation are described. Comparisons of model predictions with measurements in copper processed using Equal Channel Angular Pressing are described. 展开更多
关键词 Mechanical Threshold stress Model Large-Strain Deformations ECAP stress-Strain Curves Shear Deformations Activation Energy STRAIN-HARDENING
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A THEORETICAL APPROACH TO NONLINEAR MECHANICAL PROPERTIES OF THE ARTERIAL WALL WITH INITIAL STRESS
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《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第4期77-78,共2页
关键词 SG A THEORETICAL APPROACH TO NONLINEAR MECHANICAL PROPERTIES OF THE ARTERIAL WALL WITH INITIAL stress LI
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Mechanical stimulation devices formechanobiology studies:a market,literature,and patents review 被引量:1
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作者 F.Melo-Fonseca O.Carvalho +2 位作者 M.Gasik G.Miranda F.S.Silva 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2023年第3期340-371,共32页
Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body.Tomore closely mimic the complex physiological environment,... Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body.Tomore closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic cultures.Unlike bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or compressive.This review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to improvement.These are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies. 展开更多
关键词 BIOMATERIALS POLYMERS Actuators Mechanical stress MECHANOTRANSDUCTION
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Characterization of Electrical Tree Degradation of Epoxy Resin under Thermal and Temperature Stresses by Photoelastic Effect
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作者 Hein Htet Aung Yuhuai Wang +2 位作者 Jin Li Ying Zhang Tatsuo Takada 《Chinese Journal of Electrical Engineering》 EI CSCD 2024年第1期12-20,共9页
Epoxy resin is widely used in the support,insulation,and packaging components of electrical equipment owing to their excellent insulation,thermal,and mechanical properties.However,epoxy-resin insulation often suffers ... Epoxy resin is widely used in the support,insulation,and packaging components of electrical equipment owing to their excellent insulation,thermal,and mechanical properties.However,epoxy-resin insulation often suffers from thermal and mechanical stresses under extreme environmental conditions and a compact design,which can induce electrical tree degradation and insulation failure in electrical equipment.In this study,the photoelastic method is employed to investigate the thermal-mechanical coupling stress dependence of the electrical treeing behavior of epoxy resin.Typical electrical tree growth morphology and stress distribution were observed using the photoelastic method.The correlation between the tree length and overall accumulated damage with an increase in mechanical stress is determined.The results show that compressive stress retards the growth of electrical trees along the electric field,while tensile stress has accelerating effects.This proves that the presence of thermal stress can induce more severe accumulated damage. 展开更多
关键词 Epoxy resin electrical tree degradation thermal stress mechanical stress photoelastic effects
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The role of mechanical stretch and TGF-β2 in epithelial-mesenchymal transition of retinal pigment epithelial cells 被引量:9
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作者 Qian Cao Qu-Zhen Deji +4 位作者 Ya-Jun Liu Wei Ye Wang-Dui Zhaba Qin Jiang Feng Yan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第12期1832-1838,共7页
AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RPE) cells. METHODS:... AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RPE) cells. METHODS: Human RPE cells were inoculated on BioF ex 6-well plates and RPE cells received 0, 1, 2, 3, or 4 mild stretch injuries delivered 3h apart after 24h of culture. The device of mechanical stress parameters were set to sine wave, frequency 1 Hz, stretch strength 20%. For treatment with TGF-β2, when the inoculated RPE cells in 6-well plates were around 60% confluent, serum was reduced to 0 for 12h and recombinant human TGF-β2(0, 1, 5, 10 ng/mL)was added for 48h. α-SMA, Vimentin and N-Cadherin, fibronectin proteins expressions were detected by Western blotting, confocal cell immunofluorescence and quantitative real-time polymerase chain reaction(q RT-PCR). Then we detected the change of mi RNA-29b and ascertained the changes of phosphatidylinositol 3-kinase-serine threonine protein kinase(PI3K/Akt) pathway after RPE cells were stretched by the device of mechanical stress and induced by TGF-β2 by Western blotting, confocal cell immunofluorescence and qR T-PCR. RESULTS: Mechanical stress induce EMT and activate the PI3K/Akt pathway in ways that lead to the EMT process. TGF-β2 induce RPE cells EMT and in a certain range and TGF-β2 decrease the miR NA-29b expression in RPE cells, and the inhibitory effect is more obvious with the increase of TGF-β2 concentration. CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and mi RNA-29b in pathogenesis of proliferative vitreoretinopathy(PVR) which may be a potential target for preventing or treating PVR. 展开更多
关键词 mechanical stress transforming growth factor-beta2 microRNA 29b epithelial-mesenchymal transition phosphatidylinositol 3-kinase-serine threonine protein kinase pathway proliferative vitreoretinopathy
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