Effects of Salt Stress on Anatomical Structure of Leaves of Malus sieversii and Malus robusta

[Objective] This study was conducted to compare leaf anatomical structure of Malus sieversii and M. robusta under different salt concentration levels to determine their tolerance to salt and thus to provide rootstock materials for apple production in salinized soil in Southern Xinjiang. [Method] The experiment was conducted with M. sieversii and M. robusta as test materials. Salt stress was simulated using 8 g/L of NaCI solution, and Hoagland nutrient solution was used instead of NaCI solution as control group （CK）. Samples were collected on the 20^th d of treatment, sliced through paraffin processing. The prepared paraffin sections of M. sieversii and M. robusta were then observed under a light microscope for anatomical structures of leaf, upper epidermis, lower epidermis, palisade tissue and spongy tissue. [Result] Compared with the control, the leaf, upper epidermis, lower epidermis and spongy tissue of M. sieversii and M. robusta under salt stress were thickened at different degrees, while the thickness of the palisade tissue was decreased. Moreover, high salt concentration caused severer damage to the cell structure of M. sieversii than to that of M. robusta, as M. robusta cells maintained better structural integrity. [Conclusion] M. robusta has higher adaptability to salt stress than M. sieversii.

Oxidative stress in humans following the Pringle manoeuvre

BACKGROUND: Oxidative stress is induced in the liver by application of the Pringle manoeuvre. Malondialdehyde is a carbonyl compound formed during lipid peroxidation and prostaglandin biosynthesis, which combines with DNA to form a number of adducts. Among them is the DNA ad-duct; 3-(2-deoxybeta-dierythropentafuranosyl) pyr [1,2-alpha]-purin-10(3H) one or M1G. This study was undertaken to determine the suitability of M1G as a novel marker of ischemia-reperfusion injury in the liver and its correlation with both the length of Pringle clamp application and the overall length of the operation. METHODS: Normal and colorectal liver metastatic tissues were obtained in 12 patients before and after application of the Pringle manoeuvre. All samples were snap-frozen in liquid nitrogen at -80 ℃. DNA was extracted and M1G quantification was performed by immunoslotblot analysis. RESULTS: M1G levels in normal liver tissue were 4.0 + 1.0 per 107 nucleotides before the Pringle manoeuvre and 7.4 ± 1.0 per 10 nucleotides after the Pringle manoeuvre (mean ± standard deviation) (P<0.05 by ANOVA). M1G levels in malignant liver tissue were 2.5 ±1.4 per 107 nucleotides before the Pringle manoeuvre and 6. 5 ±1.9 adducts per 10 nucleotides after the Pringle manoeuvre (P <0. 05). Ad-duct levels in normal liver tissue showed a significant correlation with cumulative period of Pringle application. CONCLUSIONS: This is the first time that the tissue levels of M1G before and after application of the Pringle manoeuvre have been studied. The results show that the Pringle manoeuvre exerts significant oxidative stress in human hepa-tocytes, which is Pringle-time dependent. The results highlight the potential for oxidative DNA adducts levels as a tool for measuring the severity of ischemia-reperfusion injury.

Antioxidative stress-induced damage in cochlear explants

The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However,little is known about fighting oxidative stress. In the current study, we evaluated antioxidant-induced cochlear damage by applying several different additional antioxidants. To determine whether excessive antioxidants can cause damage to cochlear cells, we treated cochlear explants with 50 m M M40403, a superoxide dismutase mimetic, 50 m M coenzyme Q-10, a vitamin-like antioxidant, or 50 m M d-methionine, an essential amino acid and the important antioxidant glutathione for 48 h. Control cochlear explants without the antioxidant treatment maintained their normal structures after incubation in the standard serum-free medium for 48 h, indicating the maintenance of the inherent oxidative and antioxidant balance in these cochlear explants. In contrast, M40403 and coenzyme Q-10-treated cochlear explants displayed significant hair cell damage together with slight damage to the auditory nerve fibers.Moreover, d-methiodine-treated explants exhibited severe damage to the surface structure of hair cells and the complete loss of the spiral ganglion neurons and their peripheral fibers. These results indicate that excessive antioxidants are detrimental to cochlear cells, suggesting that inappropriate dosages of antioxidant treatments can interrupt the balance of the inherent oxidative and antioxidant capacity in the cell.

Edge Structure of Reynolds Stress and Poloidal Flow on the HL-1M Tokamak

The measurement on radial profile of electrostatic Reynolds stress, plasma poloidal rotations, radial and poloidal electric field have been performed in the plasma boundary region of the HL-IM Tokamak using a multi-array of Mach/Langmuir probes. In the experiments of Lower Hybrid Current Drive (LHCD), Supersonic Molecular Beam injection (SMBI), Multi-shot Pellet Injection (MPI) and Neutral Beam injection (NBI), the correlation between the Reynolds stress and poloidal flow in the edge plasma is presented. The results indicate that a sheared poloidal flow can be generated in Tokamak plasma due to radially varying Reynolds stress.

The ROCK pathway inhibitor Y-27632 mitigates hypoxia and oxidative stress-induced injury to retinal Müller cells

Rho kinase （ROCK） was the first downstream Rho effector found to mediate RhoA-induced actin cytoskeletal changes through effects on myosin light chain phosphorylation. There is abundant evidence that the ROCK pathway participates in the pathogenesis of retinal endothelial injury and proliferative epiretinal membrane traction. In this study, we investigated the effect of the ROCK pathway inhibitor Y-27632 on retinal Müller cells subjected to hypoxia or oxidative stress. Müller cells were subjected to hypoxia or oxidative stress by exposure to CoCl2 or H2O2. After a 24-hour treatment with Y-27632, the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay was used to assess the survival of Müller cells. Hoechst 33258 was used to detect apoptosis, while 2′,7′-dichlorodihydrofluorescein diacetate was used to measure reactive oxygen species generation. A transwell chamber system was used to examine the migration ability of Müller cells. Western blot assay was used to detect the expression levels of α-smooth muscle actin, glutamine synthetase and vimentin. After treatment with Y-27632, Müller cells subjected to hypoxia or oxidative stress exhibited a morphology similar to control cells. Y-27632 reduced apoptosis, α-smooth muscle actin expression and reactive oxygen species generation under oxidative stress, and it reduced cell migration under hypoxia. Y-27632 also upregulated glutamine synthetase expression under hypoxia but did not impact vimentin expression. These findings suggest that Y-27632 protects Müller cells against cellular injury caused by oxidative stress and hypoxia by inhibiting the ROCK pathway.

Comparative genomic analysis of N6-methyladenosine regulators in nine rosaceae species and functional characterization in response to drought stress in pear

N 6-methylated adenine(m6 A)is an emerging epigenetic marker in eukaryotic organisms that plays an important role in biological functions and in enriching genetic information.m6 A exerts these functions via the dynamic interplay among m6 A writers,erasers,and readers.However,little is known about the underlying mechanisms of m6 A in plant growth and stress responses.Here,we identified 276 masked m6 A regulators from nine Rosaceae species(Pyrus bretschneideri,Pyrus betulifolia,Pyrus communis,Malus domestica,Fragaria vesca,Prunus avium,Prunus mume,Prunus persica,and Rubus occidentalis).We classified and named these genes in more detail based on phylogenetic and synteny analysis.The expansion of m6 A regulators in Maloideae was dated back to the recent whole-genome duplication(WGD)in Rosaceae.Based on the expression pattern analysis and gene structure analysis of m6 A regulators,m6 A was shown to be a significant factor in regulating plant development and resistance.In addition,PbrMTA1-silenced pear plants displayed significantly reduced drought tolerance and chlorophyll content,as well as increased electrolyte leakage and concentrations of malondialdehyde and H2 O2.

Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid. Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly in- creased, which was associated with retinal ganglion cell death in diabetic retinas. The C/ERB ho- mologous protein pathway directly contributed to glial reactivity, and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy. Our experimental findings in- dicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neu- ronal loss and vascular abnormalities, and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy.

Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress

This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat model.The rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine groups.On day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were sacrificed.Scopolamine-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine treatments.Scopolamine reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be increased.On the other hand,PC and galantamine treatments reversed these changes.In conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE activity.Thus,it was concluded that PC could prevent AD-like conditions and can be used as a functional food.However,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

Focal mechanism of Luding M 6.8 earthquake, September 2022 and analysis of the loading role of the tectonic stress on the seismogenic fault

To reveal the seismogenic mechanism of the Luding earthquake, we employed the 118 China Seismic Network stations to collect the P-wave polarity data from each station, which was then used in the P-wave first motion approach to calculate the focal mechanism solution of the M6.8 Luding earthquake that occurred on September 5,2022. We have also studied the loading effect of tectonic stress on the Luding earthquake fault based on the stress field data for the research area. The results indicate that this earthquake was a strike-slip type, the nodal plane I:strike 167°, dip angle 78°, slip angle 2°;Nodal plane II: strike 77°, dip angle 88°, slip angle 168°. The two fault planes’ instability coefficients of the Luding earthquake are examined considering the region’s background stress field’s condition. The nodal plane I in the Moho circle is discovered to practically coincide with the Coulomb failure line and the tangent point of the Moho circle, indicating that this nodal plane has a high instability coefficient compared to the nodal plane II. The conclusion is that the nodal plane I has a higher likelihood of being the seismogenic fault plane, which is congruent with the seismogenic fault plane suggested by the aftershock distribution, the earthquake radiation energy distribution of a single station, and seismic intensity distribution.The Luding earthquake’s focal mechanism is highly like the theoretical focal mechanism of the fault situated at the location where the Coulomb failure line intersects the Mohr circle, demonstrating that background stress is what caused the earthquake. The substantial fault instability and similarity between the solved and theoretical focal mechanisms make it easier to comprehend the loading effect of tectonic stress on the Luding earthquake fault.

Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination

The anti-oxidative characteristic and immunosuppressive microenvironment contribute to a high resistance of tumor to many treatments.In this work,a glutathione(GSH)-responsive metal-coordinated oxidative stress amplifier(designated as Cu PA)is fabricated to suppress tumor growth through elevating the cellular level of reactive oxygen species(ROS)and eliminating M2 macrophages.Among which,cooper ion(Cu^(2+))is capable of coordinating with thioredoxin(Trx)inhibitor of PX-12 and signal transducer and activator of transcription 6(STAT6)inhibitor of AS1517499 with the assistance of distearoyl phosphoethanolamine-PEG2000(DSPE-PEG2000),which can extensively increase the stability to enhance drug delivery in vitro and in vivo.Furthermore,CuPA can upregulate intracellular ROS to cause tumor cell death through restraining Trx and degrading GSH.Also,Cu PA-mediated STAT6 inhibition results in the elimination of M2 macrophage to reverse the immunosuppressive tumor microenvironment.Finally,the elevated oxidative stress and increased immune activation amplify the synergistic antitumor effect without causing obvious side effect.This work provides a new sight for synergistic tumor suppression through chemo-immunotherapy in consideration of the complex resistant tumor microenvironment.

Simultaneously Improving Mechanical Properties and Stress Corrosion Cracking Resistance of High-Strength Low-Alloy Steel via Finish Rolling within Non-recrystallization Temperature

The effect of hot rolling process on microstructure evolution,mechanical properties and stress corrosion cracking(SCC)resistance of high-strength low-alloy(HSLA)steels was investigated by varying the finish rolling temperature(FRT)and total rolling reduction.The results revealed granular bainite with large equiaxed grains was obtained by a total rolling reduction of60%with the FRT of 950℃(within recrystallization temperature T_(r)).The larger grain size and much less grain boundaries should account for the relatively lower strength and SCC resistance.A larger rolling reduction of 80% under the same FRT resulted in the formation of massive martensite-austenite(M/A)constituents and resultant low ductility and SCC resistance.In contrast,a good combination of strength,ductility and SCC resistance was obtained via 80% rolling reduction with the FRT of 860℃(within non-recrystallization temperature T_(nr)),probably because of the fine grain size and M/A constituents,as well as a high density of grain boundary network.

2023-08-23辽宁普兰店M 4.6地震震源参数测定及发震构造初判

2023-08-2318:19辽宁省大连市普兰店区发生M 4.6地震,为准确描述本次地震的震源特征,探讨其孕育和发震机理,本文通过测定地震的震源深度,反演震源机制、矩张量及质心深度,给出震源机制中心解;同时分析震源机制与构造应力场的关系,根据小震重定位结果对发震断层面进行拟合,初步确定了本次地震的发震断层。结果表明,普兰店M 4.6地震初始破裂深度为12.0 km,震源机制解参数为节面Ⅰ走向50°,倾伏角75°,滑动角-169°;节面Ⅱ走向317°,倾伏角80°,滑动角-15°,矩震级M W4.8,最优质心深度12 km;地震矩M_(0)为1.796×10^(16)Nm,矩张量解M_(rr)、M_(tt)、M_(pp)、M_(rt)、M_(rp)、M_(tp)分别为-0.004、0.946、-0.942、0.017、-0.305、-0.125;中心解参数为节面Ⅰ走向47.03°,倾伏角79.04°,滑动角-168.15°;节面Ⅱ走向314.75°,倾伏角78.37°,滑动角-11.19°。构造应力场作用在中心解节面Ⅰ上的相对剪应力为0.877,相对正应力为-0.544;投影于节面Ⅱ上的相对剪应力为0.911,相对正应力为0.161。拟合的断层面走向148.91°,倾伏角89.85°,其在构造应力体系下的滑动角为26.47°。综合分析认为,普兰店M 4.6地震发生在NW向普兰店-长海构造带,是沿应力场最优节面以左旋走滑为错动方式的天然地震。

Flow Stress Behaviors and Microstructure Evolution of 300M High Strength Steel under Isothermal Compression

The compressive deformation behaviors of 300M high strength steel were investigated over a wide range of temperatures （850- 1200 C） and strain rates （0. 001- 10 s^- 1 ） on a Gleeble-3800 thermo-mechanical simulator. The measured flow stress was modified by the corrections of the friction and the temperature compensations, which nicely reflect negative effects of the friction and temperature on the flow stress. The corrected stress-strain curves were the dynamic recrystallization type on the conditions of higher deformation temperature and lower strain rate. Flow stress increases with the increase of strain rate at the same deformation temperature and strain. By contrast, flow stress decreases with the increase of temperature at the same strain rate and strain. Dependence of the peak stress on temperature and strain rate for 300M steel is described by means of the conventional hyperbolic sine equation. By re gression analysis, the activation energy （Q） in the whole range of deformation temperature is determined to be 367. 562 kJ/mol. The effects of the temperature and the strain rate on mierostructural evolution are obvious. With the increase of the deformation temperature and the decrease of the strain rate, the original austenite grain sizes of 300M steel increase. At the same time, the corrected flow stress curves more accurately determine the evolution of the microstrueture.

Influence of thickness and initial groove angle in M–K model on limit strain of 7B04 by considering through-thickness stress

Marciniack–Kuczinski(M–K)model is widely used to predict material's forming limit curve(FLC).The prediction of FLC traditionally neglected through-thickness normal stress.However,it cannot be neglected in some forming processes.Much work has been done to study the effect of through-thickness normal stress on FLC with constant through-thickness normal stress or constant ratio of through-thickness normal stress and maximum principal stress.In addition,based on Nakazima test process,the ratio of through-thickness normal stress and maximum principal stress has been derived,which was a function of instantaneous thickness and loading path.Here,initial groove angle in M–K model was not considered.In this paper,uniaxial tension tests and Nakazima tests were performed on 7B04 aluminum alloy.Based on Hill 48 yield criterion and M–K model,the prediction model of FLC was established.The increase of thickness can enhance FLC.Meanwhile,it is necessary to consider through-thickness normal stress and initial groove angle in prediction model.On the left side of FLC,the effect of initial groove angle on FLC is weakened by increasing sheet thickness.On the right side of FLC,the effect of initial groove angle on FLC is strengthened by increasing sheet thickness.On the right side of FLC,the relation between limit strain points with different thicknesses is linear under one certain loading path.Thickness has decisive effect on through-thickness normal stress level and the changing trendy of through-thickness normal stress during calculation is different under different stress condition.

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

Interplay between microglia and environmental risk factors in Alzheimer's disease

Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.

非线性M-C强度准则下预应力锚索加固边坡时效稳定性分析M-P法

拓展传统极限平衡方法在复杂条件下边坡稳定性分析中的适用性一直是岩土工程界的研究热点。众所周知,边坡岩土体剪切失效一般服从于非线性强度准则,而传统极限平衡方法仅适用于线性强度准则下边坡稳定性分析。此外,预应力锚索作为一种主动防护措施,可极大地即时提高边坡稳定性而被广泛应用于中、大型边坡工程加固。然而,在应力松弛、蠕变效应以及腐蚀环境影响下预应力锚索加固边坡稳定性时效特征往往被忽视。由此,基于Morgenstern-Price(M-P)法,嵌入非线性Mohr-Coulomb(M-C)强度准则,并融入应力松弛与蠕变效应下锚索预应力损失模型以及腐蚀环境下锚索性能劣化模型,从而,建立非线性强度准则下预应力锚索加固边坡安全系数时程表达式。进一步,为了解决非线性强度准则下隐式嵌套公式难以求解的问题,归零化条间法向力初始值,并应用迭代循环求解策略,在引入循环终止允许误差判别条件后,可实现边坡稳定性理论真实结果的逼近求解。经过后续算例对比分析,验证了所提方法的可行性和合理性,与此同时,还研究了不同预应力损失速率和不同锈蚀环境下预应力锚索加固边坡稳定性的时效变化规律。

理想M-C材料强度评估判据与等效塑性应变

基于理想Mohr-Coulomb(M-C)屈服准则,该文提出了拉伸、压缩和剪切等效应力的概念及其公式,并给出了三个相应的强度评估条件.根据塑性功等效原则,分别导出了与上述等效应力共轭的拉伸、压缩等效塑性应变和等效塑性剪应变,探论了不同的摩擦因数下等效应变的变化特征.与Mises等效应变不同,所得到的M-C等效应变能够反映静水压力的影响,也可退化为简单应力状态.这些等效应力和等效应变概念都具有明确的物理意义,将能够应用于更准确、有效地评估拉、压性能不同材料的强度,对于用简单拉伸、压缩或剪切试验标定复杂应力状态下本构模型参数也具有直接应用价值.

Effects of Ning Shen Ling Granule (宁神灵冲剂) and Dehydroepiandrosterone on Cognitive Function in Mice Undergoing Chronic Mild Stress

Objective： To investigate the changes of spontaneous and cognitive behavior, and cholinergic M receptors in the brain of mice subjected to chronic mild stress （CMS）, and to determine the effect of Ning Shen Ling Granule （宁神灵冲剂, NSL） and dehydroepiandrosterone （DHEA） on them. Methods：CMS model mice were established by applying stress every day for 3 consecutive weeks with 7 kinds of unforeseeable stress sources, and they were medicated for 1 week beginning at the 3rd week of modeling. The changes in behavior were determined by Morris Water Maze and spontaneous movement test, and M-receptor binding activity in cerebral cortex, hippocampus and hypothalamus were measured by radioactive ligand assay with 3H-QNB. Results： （1） The spontaneous movement in CMS model mice was significantly reduced, with the latency for searching platform in Morris Water Maze obviously prolonged （P〈0.01）, and these abnormal changes in behavior were improved in those treated with NSL and DHEA. （2） The binding ability of M-receptor in cerebral cortex and hippocampus of CMS mice was significantly decreased as compared with those in the control group （P〈0.05）, but could be restored to the normal level after intervention with NSL or DHEA. Conclusion： The decline of spontaneous movement and spatial learning and memory ability could be induced in animals by chronic mild stress, and that may be related to the low activity of central cholinergic M-receptors. Both NSL and DHEA could effectively alleviate the above-mentioned changes.

基于MAPK信号通路的中药治疗急性胰腺炎作用机制研究进展

随着对急性胰腺炎(acute pancreatitis,AP)的深入研究,具有成分丰富、靶点众多特点的中药,被发现在调节机体免疫炎症反应中发挥着重要的作用,并为治疗AP提供关键方向。本文通过对近年相关文献的搜集梳理发现,由细胞外调节蛋白激酶(extracellular regulated protein kinases,ERK)1/2、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)三条主要子通路构成的MAPK信号通路在抑制炎症反应、抗氧化应激、促进细胞凋亡等方面具有显著的作用。近年来,中医药领域以MAPK信号通路为起点,发挥辨病辨证特色优势对中药方剂、中药单体、中药提取物及中药活性成分等干预AP中MAPK信号通路进行了大量的研究,并将中药治疗AP的机制归纳为调控炎症因子、介导信号因子表达以抑制炎症级联反应;通过减少活性氧产生和释放、调控氧化酶的活性达到抑制氧化应激反应;增加线粒体膜通透性调节半胱氨酸天冬氨酸蛋白酶3(Caspase-3)、B淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)和Bcl-2相关X蛋白(Bcl-2 associated X,Bax)等蛋白与基因的表达、诱导内质网应激,进而平衡细胞凋亡,达到减轻胰腺损伤的作用。因此,本文针对目前基于MAPK信号通路中药治疗AP的相关文献进行总结分析,旨在为今后治疗AP的研究提供一定的参考。