Conotoxins are short peptide-toxins with specific targets and large diversity. They are usetul in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. in order to explor...Conotoxins are short peptide-toxins with specific targets and large diversity. They are usetul in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. in order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3’ cDNA ends (RACE) method was utilized to systemically analyze the O-superfamily conotoxin content of Conus striatus inhabited near Chinese Hainan Island. Six new O-superfamily conopeptides were identified, one of which is highly homologous to MVIlA, an N-type calcium channel antagonist.展开更多
Introduction: Lichen striatus (LS) is a benign, self-limiting, linear inflammatory skin disease that was rarely reported. Here we report two cases of nail involvement in children with LS.Case presentation: Two childre...Introduction: Lichen striatus (LS) is a benign, self-limiting, linear inflammatory skin disease that was rarely reported. Here we report two cases of nail involvement in children with LS.Case presentation: Two children was referred to our hospital with asymptomatic linear eruption and nail dystrophy. Histopathological examination revealed epidermal hyperkeratosis, infiltration of inflammatory cells 9around the adnexal region, hyperpigmentation in the rete ridges, and focal liquefactive degeneration of the basal layer.Discussion: There is no specific treatment for nail LS. Without treatment, LS can resolve spontaneously over a period of time. Topical steroid treatment can improve symptoms and shorten the duration of the disease. It is important for clinicians to distinguish LS from other linear diseases, which may lead to unnecessary treatment and surgical intervention.Conclusion: The appearance of nail and skin lesions is importance of clinical features in making the diagnosis of nail LS,and also distinguish to other linear and nail diseases.展开更多
文摘Conotoxins are short peptide-toxins with specific targets and large diversity. They are usetul in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. in order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3’ cDNA ends (RACE) method was utilized to systemically analyze the O-superfamily conotoxin content of Conus striatus inhabited near Chinese Hainan Island. Six new O-superfamily conopeptides were identified, one of which is highly homologous to MVIlA, an N-type calcium channel antagonist.
文摘Introduction: Lichen striatus (LS) is a benign, self-limiting, linear inflammatory skin disease that was rarely reported. Here we report two cases of nail involvement in children with LS.Case presentation: Two children was referred to our hospital with asymptomatic linear eruption and nail dystrophy. Histopathological examination revealed epidermal hyperkeratosis, infiltration of inflammatory cells 9around the adnexal region, hyperpigmentation in the rete ridges, and focal liquefactive degeneration of the basal layer.Discussion: There is no specific treatment for nail LS. Without treatment, LS can resolve spontaneously over a period of time. Topical steroid treatment can improve symptoms and shorten the duration of the disease. It is important for clinicians to distinguish LS from other linear diseases, which may lead to unnecessary treatment and surgical intervention.Conclusion: The appearance of nail and skin lesions is importance of clinical features in making the diagnosis of nail LS,and also distinguish to other linear and nail diseases.
