The function of a protein molecule is greatly influenced by its three-dimensional （3D） structure and therefore structure prediction will help identify its biological function. We have updated Sequence, Motif and Str...The function of a protein molecule is greatly influenced by its three-dimensional （3D） structure and therefore structure prediction will help identify its biological function. We have updated Sequence, Motif and Structure （SMS）, the database of structurally rigid peptide fragments, by combining amino acid sequences and the corre- sponding 3D atomic coordinates of non-redundant （25%） and redundant （90%） protein chains available in the Protein Data Bank （PDB）. SMS 2.0 provides information pertaining to the peptide fragments of length 5-14 resi- dues. The entire dataset is divided into three categories, namely, same sequence motifs having similar, intermedi- ate or dissimilar 3D structures. Further, options are provided to facilitate structural superposition using the pro- gram structural alignment of multiple proteins （STAMP） and the popular JAVA plug-in （Jmol） is deployed for visualization. In addition, functionalities are provided to search for the occurrences of the sequence motifs in other structural and sequence databases like PDB, Genome Database （GDB）, Protein Information Resource （PIR） and Swiss-Prot. The updated database along with the search engine is available over the World Wide Web through the following URL http：//cluster.physics.iisc.ernet.in/sms/.展开更多
We develop a new method for smooth and continuous space-variant alignment of the liquid crystal medium in micro-patterned structures, which is based on a radial micro-structured pattern of polymeric ribbons exhibiting...We develop a new method for smooth and continuous space-variant alignment of the liquid crystal medium in micro-patterned structures, which is based on a radial micro-structured pattern of polymeric ribbons exhibiting out-of-plane orientation with respect to the ITO-coated glass plates. Thanks to the broad range of electrical tunability of the optical retardation for the micro-patterned liquid crystal structures, transformation of the fundamental Gaussian beam into different types of specific beams, including generalized cylindrical vector beams, vortex beams, and vectorial vortex beams, is efficiently demonstrated.展开更多
基金supported by a research grant from the Department of Information Technology (DIT) awarded to KS
文摘The function of a protein molecule is greatly influenced by its three-dimensional （3D） structure and therefore structure prediction will help identify its biological function. We have updated Sequence, Motif and Structure （SMS）, the database of structurally rigid peptide fragments, by combining amino acid sequences and the corre- sponding 3D atomic coordinates of non-redundant （25%） and redundant （90%） protein chains available in the Protein Data Bank （PDB）. SMS 2.0 provides information pertaining to the peptide fragments of length 5-14 resi- dues. The entire dataset is divided into three categories, namely, same sequence motifs having similar, intermedi- ate or dissimilar 3D structures. Further, options are provided to facilitate structural superposition using the pro- gram structural alignment of multiple proteins （STAMP） and the popular JAVA plug-in （Jmol） is deployed for visualization. In addition, functionalities are provided to search for the occurrences of the sequence motifs in other structural and sequence databases like PDB, Genome Database （GDB）, Protein Information Resource （PIR） and Swiss-Prot. The updated database along with the search engine is available over the World Wide Web through the following URL http：//cluster.physics.iisc.ernet.in/sms/.
基金supported by the National Natural Science Foundation of China(No.11674182)the National Basic Research Program of China(No.2013CB328702)+5 种基金the Tianjin Natural Science Foundation(No.17JCYBJC16700)the 111 Project(No.B07013)the PCSIRT(No.IRT_13R29)the National Research Program of Slovenia(No.P1-0192)the Hundred Young Academic Leaders Program of Nankai Universitythe Collaborative Innovation Center of Extreme Optics,Shanxi University
文摘We develop a new method for smooth and continuous space-variant alignment of the liquid crystal medium in micro-patterned structures, which is based on a radial micro-structured pattern of polymeric ribbons exhibiting out-of-plane orientation with respect to the ITO-coated glass plates. Thanks to the broad range of electrical tunability of the optical retardation for the micro-patterned liquid crystal structures, transformation of the fundamental Gaussian beam into different types of specific beams, including generalized cylindrical vector beams, vortex beams, and vectorial vortex beams, is efficiently demonstrated.
