Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes melli...Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1 A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1 A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1 A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.展开更多
The method to calculate the coupling loss factors for non-conservatively coupled structures by using the mobilities of substructures is studied. By using the form of the energy balance equations of conservatively coup...The method to calculate the coupling loss factors for non-conservatively coupled structures by using the mobilities of substructures is studied. By using the form of the energy balance equations of conservatively coupled systems, the relationship between the coupling loss factors and the energy ratios in non-conservatively coupled systems is derived. The method to calculate the energy ratios by using the mobilities of substructures is introduced, and experiment verification is carried out. The test data agree well with the predicted results.展开更多
A flat-topped etched diffraction grating (EDG) demultiplexer with a low polarization-dependent loss (PDL) is designed. A design and simulation method based on the method of moment (MoM) is proposed. A 65-channcl EDG d...A flat-topped etched diffraction grating (EDG) demultiplexer with a low polarization-dependent loss (PDL) is designed. A design and simulation method based on the method of moment (MoM) is proposed. A 65-channcl EDG demultiplexer with channel spacing of 100 GHz is considered as a design example. A tapered multi-mode interferometer (MMI) is used to flatten the passband of the EDG demultiplexer. The numerical results show that the exit width of the tapered waveguide impacts the loss of the TE case more than that of the TM case. Based on this fact, the exit width of the taper is optimized to obtain the lowest PDL. The tapering angle is also optimized where the minimal ripple is obtained. The designed EDG demultiplexer has an excellent flat-topped spectral response and a very low PDL.展开更多
A novel S-bend with tapered curved waveguides is proposed. The normalized transmitted power is greater than the conventional bend with weakly guided waveguides. Small size and low loss can be reached by the proposed S...A novel S-bend with tapered curved waveguides is proposed. The normalized transmitted power is greater than the conventional bend with weakly guided waveguides. Small size and low loss can be reached by the proposed S-bend.展开更多
A novel coupled quantum well structure - quasi-symmetric coupled quantum well （QSCQW） is proposed. In the case of low applied electric field （F = 25 kV/cm） and low absorption loss （a ≈ 100 cm^-1）, a large field...A novel coupled quantum well structure - quasi-symmetric coupled quantum well （QSCQW） is proposed. In the case of low applied electric field （F = 25 kV/cm） and low absorption loss （a ≈ 100 cm^-1）, a large field-induced refractive index change （for TE mode, △n = 0.0106; for TM mode, △n = 0.0115） is obtained in QSCQW structure at operating wavelength λ = 1550 nm. The value is larger by over one to two order of magnitude compared to that in a rectangular quantum well （RQW） and about 50% larger than that of five-step asymmetric coupled quantum well （FACQW） structure under the above work conditions.展开更多
文摘Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1 A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1 A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1 A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.
文摘The method to calculate the coupling loss factors for non-conservatively coupled structures by using the mobilities of substructures is studied. By using the form of the energy balance equations of conservatively coupled systems, the relationship between the coupling loss factors and the energy ratios in non-conservatively coupled systems is derived. The method to calculate the energy ratios by using the mobilities of substructures is introduced, and experiment verification is carried out. The test data agree well with the predicted results.
基金This work was supported by the National Nat- ural Science Foundation of China under Grant No. 90101024 and 60377022.
文摘A flat-topped etched diffraction grating (EDG) demultiplexer with a low polarization-dependent loss (PDL) is designed. A design and simulation method based on the method of moment (MoM) is proposed. A 65-channcl EDG demultiplexer with channel spacing of 100 GHz is considered as a design example. A tapered multi-mode interferometer (MMI) is used to flatten the passband of the EDG demultiplexer. The numerical results show that the exit width of the tapered waveguide impacts the loss of the TE case more than that of the TM case. Based on this fact, the exit width of the taper is optimized to obtain the lowest PDL. The tapering angle is also optimized where the minimal ripple is obtained. The designed EDG demultiplexer has an excellent flat-topped spectral response and a very low PDL.
文摘A novel S-bend with tapered curved waveguides is proposed. The normalized transmitted power is greater than the conventional bend with weakly guided waveguides. Small size and low loss can be reached by the proposed S-bend.
基金This work was supported by the National NaturalScience Foundation of China under Grant No. 60277034,60436020.
文摘A novel coupled quantum well structure - quasi-symmetric coupled quantum well （QSCQW） is proposed. In the case of low applied electric field （F = 25 kV/cm） and low absorption loss （a ≈ 100 cm^-1）, a large field-induced refractive index change （for TE mode, △n = 0.0106; for TM mode, △n = 0.0115） is obtained in QSCQW structure at operating wavelength λ = 1550 nm. The value is larger by over one to two order of magnitude compared to that in a rectangular quantum well （RQW） and about 50% larger than that of five-step asymmetric coupled quantum well （FACQW） structure under the above work conditions.
