Several studies have shown that fibroblast growth factor-2 （FGF2） can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the...Several studies have shown that fibroblast growth factor-2 （FGF2） can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 （rhFGF2） treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 μg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 μg/mL rhFGF2. Interestingly, treatment with 10 μg/mL rhFGF had a more obviously positive effect on the gap score than treatment with 50 μg/mL rhFGF2. In addition, retrograde neuronal tracing with Dil revealed a significant increase in nerve regeneration in the trigeminal ganglion at 2 and 4 weeks in the rhFGF2 groups （10 μg/mL and 50 μg/mL） than in the PBS group. The 10 μg/mL rhFGF2 group also showed an obviously robust regeneration in axon density in the mental nerve at 4 weeks. Our results demonstrate that 10 μg/mL rhFGF induces mental nerve regeneration and sensory recovery after mental nerve crush injury.展开更多
This thesis makes an analysis of the heroine's mental growth from the initial phase of the heroine's mental trauma to the struggling phase and to the mature phase. It analyzes the reasons and manifestations fo...This thesis makes an analysis of the heroine's mental growth from the initial phase of the heroine's mental trauma to the struggling phase and to the mature phase. It analyzes the reasons and manifestations for her mental solitariness,expounds her confusion and struggling during her growth from the perspective of psychoanalysis and reveals her mental maturity in the end after a series of setbacks and conflicts during pursuit of affection,friendship and kinship. In some senses,the heroine's mental growth displayed in this thesis is the psychological portrayal of some contemporary college students,which has certain educational significance to the student readers especially those who possess the similar life experience and accesses them to have an incisive understanding of real life.展开更多
Little information exists with regard to the relationship between leisure and coping mechanisms among people with physical disabilities.The purpose of this study is to investigate the relationships among leisure,copin...Little information exists with regard to the relationship between leisure and coping mechanisms among people with physical disabilities.The purpose of this study is to investigate the relationships among leisure,coping,and personal growth among people with physical disabilities living in the U.S.Using a purposive sampling strategy,121 participants completed all 3 instruments:assessment of leisure and recreation involvement,coping strategy indicator,and personal growth.Frequency,descriptive analysis,Pearson correlations,and path analysis were utilized to test the relationship between leisure involvement,coping strategies,and personal growth.There were statistically significant direct effects of leisure involvement and avoidance-withdrawal coping strategies on personal growth.The effects of social support seeking coping strategies and problem-solving coping strategies on personal growth were not statistically significant.Results also indicated that leisure involvement had significant direct effects on social support seeking,avoidance-withdrawal,and problem-solving coping strategies.The results demonstrated that leisure engagement was associated with coping strategies and personal growth.In particular,leisure engagement had direct effects on problem-solving coping,social seeking coping,and avoidance/withdrawal coping as well as a direct effect on personal growth.展开更多
Background Recombinant human growth hormone(rhGH)therapy has shown to improve height and body composition in children with Prader–Willi syndrome(PWS),the evidence of early rhGH treatment on motor and mental developme...Background Recombinant human growth hormone(rhGH)therapy has shown to improve height and body composition in children with Prader–Willi syndrome(PWS),the evidence of early rhGH treatment on motor and mental development is still accumulating.This study explored the time effect on psychomotor development,anthropometric indexes,and safety for infants and young children with PWS.Methods A phase 3,single-arm,multicenter,self-controlled study was conducted in six sites.Patients received rhGH at 0.5 mg/m2/day for first four weeks,and 1 mg/m2/day thereafter for up to 52 weeks.Motor development was measured using Peabody Developmental Motor Scales-second edition,mental development using Griffiths Development Scales-Chinese(GDS-C).Height standard deviation score(SDS),body weight SDS,and body mass index(BMI)SDS were also assessed.Results Thirty-five patients were enrolled totally.Significant improvements were observed in height,body weight,and BMI SDS at week 52;GDS-C score showed significant improvement in general quotient(GQ)and sub-quotients.In a linear regression analysis,total motor quotient(TMQ),gross motor quotient(GMQ),and fine motor quotient were negatively correlated with age;however,treatment may attenuate deterioration of TMQ and GMQ.Changes in GQ and locomotor sub-quotient in<9-month group were significantly higher than≥9-month group.Mild to moderate severity adverse drug reactions were reported in six patients.Conclusion Fifty-two-week treatment with rhGH improved growth,BMI,mental development,and lessened the deterioration of motor function in infants and young children with PWS.Improved mental development was more pronounced when instituted in patients<9 months old.展开更多
基金supported by a grant from the Korea Healthcare Technology R&D Project,Ministry for Health,Welfare&Family Affairs,Republic of Korea,No.A101578
文摘Several studies have shown that fibroblast growth factor-2 （FGF2） can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 （rhFGF2） treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 μg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 μg/mL rhFGF2. Interestingly, treatment with 10 μg/mL rhFGF had a more obviously positive effect on the gap score than treatment with 50 μg/mL rhFGF2. In addition, retrograde neuronal tracing with Dil revealed a significant increase in nerve regeneration in the trigeminal ganglion at 2 and 4 weeks in the rhFGF2 groups （10 μg/mL and 50 μg/mL） than in the PBS group. The 10 μg/mL rhFGF2 group also showed an obviously robust regeneration in axon density in the mental nerve at 4 weeks. Our results demonstrate that 10 μg/mL rhFGF induces mental nerve regeneration and sensory recovery after mental nerve crush injury.
文摘This thesis makes an analysis of the heroine's mental growth from the initial phase of the heroine's mental trauma to the struggling phase and to the mature phase. It analyzes the reasons and manifestations for her mental solitariness,expounds her confusion and struggling during her growth from the perspective of psychoanalysis and reveals her mental maturity in the end after a series of setbacks and conflicts during pursuit of affection,friendship and kinship. In some senses,the heroine's mental growth displayed in this thesis is the psychological portrayal of some contemporary college students,which has certain educational significance to the student readers especially those who possess the similar life experience and accesses them to have an incisive understanding of real life.
基金supported by Leisure Research Institute at Indiana University.
文摘Little information exists with regard to the relationship between leisure and coping mechanisms among people with physical disabilities.The purpose of this study is to investigate the relationships among leisure,coping,and personal growth among people with physical disabilities living in the U.S.Using a purposive sampling strategy,121 participants completed all 3 instruments:assessment of leisure and recreation involvement,coping strategy indicator,and personal growth.Frequency,descriptive analysis,Pearson correlations,and path analysis were utilized to test the relationship between leisure involvement,coping strategies,and personal growth.There were statistically significant direct effects of leisure involvement and avoidance-withdrawal coping strategies on personal growth.The effects of social support seeking coping strategies and problem-solving coping strategies on personal growth were not statistically significant.Results also indicated that leisure involvement had significant direct effects on social support seeking,avoidance-withdrawal,and problem-solving coping strategies.The results demonstrated that leisure engagement was associated with coping strategies and personal growth.In particular,leisure engagement had direct effects on problem-solving coping,social seeking coping,and avoidance/withdrawal coping as well as a direct effect on personal growth.
文摘Background Recombinant human growth hormone(rhGH)therapy has shown to improve height and body composition in children with Prader–Willi syndrome(PWS),the evidence of early rhGH treatment on motor and mental development is still accumulating.This study explored the time effect on psychomotor development,anthropometric indexes,and safety for infants and young children with PWS.Methods A phase 3,single-arm,multicenter,self-controlled study was conducted in six sites.Patients received rhGH at 0.5 mg/m2/day for first four weeks,and 1 mg/m2/day thereafter for up to 52 weeks.Motor development was measured using Peabody Developmental Motor Scales-second edition,mental development using Griffiths Development Scales-Chinese(GDS-C).Height standard deviation score(SDS),body weight SDS,and body mass index(BMI)SDS were also assessed.Results Thirty-five patients were enrolled totally.Significant improvements were observed in height,body weight,and BMI SDS at week 52;GDS-C score showed significant improvement in general quotient(GQ)and sub-quotients.In a linear regression analysis,total motor quotient(TMQ),gross motor quotient(GMQ),and fine motor quotient were negatively correlated with age;however,treatment may attenuate deterioration of TMQ and GMQ.Changes in GQ and locomotor sub-quotient in<9-month group were significantly higher than≥9-month group.Mild to moderate severity adverse drug reactions were reported in six patients.Conclusion Fifty-two-week treatment with rhGH improved growth,BMI,mental development,and lessened the deterioration of motor function in infants and young children with PWS.Improved mental development was more pronounced when instituted in patients<9 months old.
