CLINICAL STUDY ON SERUM COPPER AND ZINC LEVELS AND COPPER/ZINC RATIO IN MALIGNANT LYMPHOMA

173 simultaneous determinations of serum copper levels (SCL), serum zinc levels (SZL) and copper/zinc ratio (CZR) were made by atomic absorption spectrophotometry in 51 previously untreated lymphoma patients. SCL and CZR were significantly higher in patients before treatment (mean value 22.97 μmol/L, 1.55, respectively) and in those who did not reach complete remission (mean 21.21 μmol/L, 1.36) as compared with the patients in complete remission (mean 16.36 μmol/L, 1.06) or normal controls (mean 15.67 μmol/L, 0.98). The mean value of SCL and CZR of patients in complete remission did not differ significantly from those of normal controls. Patients in stages HI and IV had higher SCL and CZR (mean 25.15 μmol/L, 1.79) than those in stage Ⅰ and Ⅱ (mean 19.30 μmol/L, 1.16). No significant difference in SZL was observed between the patient groups and normal controls. Thus, SCL and CZR may be used as prognostic indicators for monitoring disease activity and response to therapy in malignant lymphoma.

A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN MURINE IgE LEVEL AND 3-METHYL-CHOLANTHRENE INDUCED FIBROSARCOMA

The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.

A Study on the Dose-Response Relationship between Asbestos Exposure Level and Asbestosis among Workers in a Chinese Chrysotile Product Factory

The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentration values according to conversion factors that were worked out by simultaneous sampling in this study. The conversions were made so that exposure could be expressed in fiber-years (f-yr). Asbestosis was diagnosed on the basis of chest radiographs and occupational histories. Cumulative dust exposure (f-yr) was calculated up to the date of diagnosis for asbestosis patients, and up to September 1982 for the remaining workers. A dose-response relationship expressed as fiber-years exposed vs cumulative prevalence of asbestosis was established by the life table method on the basis of these data. Predicted 3 and 1% prevalence of asbestosis corresponded to 43 and 22 f-yr exposure, respectively. Considering that a worker can work for 35 years, these doses are commensurate with dust concentrations of 1.22 and 0.63 f/ml, respectively. It is recommended that 1 f/ml be taken as the maximum allowable concentration of airborne asbestos dust for the workplace with an anticipated prevalence of about 2% asbestosis after 35 years of exposure. 1990 Academic Press, Inc.

Study on three level system population transfer

Stimulated-Raman-adiabatic-passage (STIRAP) process provides an effective technique to transfer electron population from an initial state (e.g. ground state) to excited final state for both atoms and molecules. In this paper, we present the results of the study on electron population transfer in three level system. We have analyzed the effects of various conditions on the transfer process, such as the time delay of the two laser beams, two-photon off-resonance, one-photon off-resonance and the change of relative laser intensity. The numerical result is compared with experiment, and the reasons for the effects are also given.

A STUDY ON THE SERUM PREGNANCY ZONE PROTEIN LEVELS IN PREGNANT WOMEN AND PATIENTS WITH GYNECOLOGICAL TUMORS

In this study, the serum levels of the pregnancy zone protein (PZP) were determined by PZP-single radial immunodiffusion in 708 cases of normal pregnancy, 207 with abormal pregnancy and 188 with gynecological tumors. The results indicated that serum PZP levels in the normal pregnancy was detectable 5 weeks after gestation. It increased with the advance of gestational weeks, and reached a peak level in week 40. The serum PZP levels in 81.7% of patients with threatened abortion but not aborted were within the normal range, and also mostly in those with pregnancy-nduced hypertension, intrauterine growth retardation (IUGR), anencepbalus and ectopic pregnancy; the serum PZP levels in 51.6% of patients with invasive moles and 80.0% with choriocarcinoma, respectively, were lower than in normal controls. In gynaecological tumors, the serum PZP levels were significantly higher in patients with ovarian carcinomas than in those with other ovarian tumors (P<0.01), and in those with endometrial or cervical carcinoma than in those with uterine myomas (P<0.01). These results suggest that measuring the serum PZP levels may be used as an important reference index to observe threatened abortion and to identify trophoblastic diseases and gynecological tumors.

Study of broadband THz time-domain spectroscopy at different relative humidity levels

Two detection techniques of broadband terahertz（THz）time-domain spectroscopy-THz air-biased coherent detection（THz-ABCD;from 0.3 to 14 THz）and electro-optical（EO）detection（from 0.3 to 7 THz）-are both performed at several different relative humidity levels.The THz power exponentially decays with the increase in relative humidity.The dynamic range of the main pulse in the time domain linearly decreases as the relative humidity increases from 0%to 40%,and linear fittings show that the slopes are-0.017 and-0.019 for THz-ABCD and EO detection,respectively.Because of the multiple reflections caused by the crystal in the common EO detection,THz-ABCD has better spectral resolution（17 GHz）than that of EO detection（170 GHz）.The spectrum of water vapor absorption measured by THz-ABCD is also compared with that measured by the Fourier transform infrared spectroscopy（FTIR）.

A prospective comparison cohort study between baseline serum uric acid level and coronary artery disease in first-degree relatives and non-first-degree relatives of type 2 diabetes males

Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease(CAD)in the first-degree relatives or nonfirst-degree relatives of men with type 2 diabetes.Methods Three hundred and eighty-one men with negative coronary angiography for the first time were divided into diabetes and non-diabetes groups and followed-up for

A cohort study on the association between fasting plasma glucose level over 5. 3 mmol / L and risks of abnormal glucose metabolism and cardiovascular diseases in the elderly

Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort study with 1 064 non-diabetic subjects(980males;84 females)aged 60 or over,who carried out annual health check-up in Chinese PLA General

Impact of preozonation on the bioactivity and biodiversity of subsequent biofilters under low temperature conditions-- A pilot study

The combination of preozonation and subsequent biological granular activated carbon （O3/BAC） filtration is well known as a promising method for the removal of many pollutants. Temperature and nutrients are the dominant factors in external conditions to influence the biological communities. To explore the influence of preozonation under low temperature, the factors such as dissolved oxygen （DO）, dissolved organic carbon （DOC） and NH4^＋-N were analyzed from the sampling ports every week; triphenyl tetrazolium ehloride-dehydrogenase activity （TTC-DHA） and the nitrifying activity were detected along the bed height ofbiofilter at four levels （10. 40. 70 and i 10 cm） on the 90th, 110th, and 130th day; ~nicrobial community, based on 16S rRNA gene-denaturing gradient gel electrophoresis （DGGE）, was monitored on the 130th day of the operation. The observed microbial property showed that preozonation had a positive influence on bioactivity, biomass and nitrifying activity. Community analysis showed no significant difference on the biodiversity of nitrifying bacteria between the parallel filters in the inlet end based on the method employed. This result showed that biofilters＇ performance is not correlated well with microbial biodiversity. The elevated functionality in O3/BAC filters can be a result of increased microbial activity, which was promoted by preozonation.

CURRENT STUDIES ON BIOLOGICAL EFFECTS OF LOW LEVEL INTERNAL IRRADIATION

The biological effects of relative low level internal irradiation were introduced. 1. Life span studies on carcinogenesis. Pacific Northwest Laboratory observed 3782 rats given a single inhalation of 239Pu O2 at initial lung burden ranging from 0.25 to 180 nCi. Significant life span shortening was found at lung dose > 8 Gy and it was indicated that the presence of a 'possible' threshold of about 1 Gy for lung tumor formation. 2. Health effects of radon and its progeny. Both experimental and epidemiological survey were studied. The nominal probability coefficient (fatality) for the public and workers are 7.90×105 per mJhm-3 (2.77 ×10~4 per working level month, WLM). 3. Health effects of 3H on postnatal brain development and neurobehavior, genetic effects, carcinogenic effects and adaptive effects of 3H were investigated. 4. Study on the effects of neuroendocrine system under low level irradiation of 75Se (Auger electron emitter) and 35S (β-particles emitter). The results showed that the neuroendocrine system is very sensitive to small dose of internal irradiation.