STUDIES ON FLUORESCENCE ENHANCING EFFECT AND ALKALINE DEGRADATION MECHANISM OF DOXYCYCLINE AND METHACYCLINE

Degradation reaction of doxycycline or methacycline was carried out in KOH solution and intense fluorescence was obtained.A degradation mechanism of doxycycline or methacycline was suggested.

A Numerical Study of the Mechanism for the Effect of Northern Winter Arctic Ice Cover on the Global Short-Range Climate Evolution

By using a nine-layer global spectral model involving fuller parameterization of physical processes, with a rhomboidal truncation at wavenumber 15, experiments are performed in terms of two numerical schemes, one with long-term mean coverage of Arctic ice (Exp.1), the other without the ice (Exp.2). Results indicate that the Arctic region is a heat source in Exp.2 relative to the case in Exp.1. Under the influence of the polar heat source simulated, there still exist stationary wavetrains that produce WA-EUP and weak PNA patterns in Northern winter. That either the Arctic or the tropical heat source can cause identical climatic effects is due to the fact that the anomaly of the Arctic ice cover will directly induce a south-propagating wavetrain, and bring about the redistribution of the tropical heat source / sink. The redistribution is responsible for new wavetrains that will exert impact on the global climate. The simulation results bear out further that the polar region in Exp.2 as a heat source, can produce, by local forcing, a pair of positive and negative difference centers, which circle the Arctic moving eastwards. Observed in the Northern Hemisphere extratropics is a 40-50 day oscillation in relation to the moving pair, both having the same period.

Control study of short-term curative effect of minimally invasive total hip arthroplasty using metal-on-metal large-diameter femoral head for the elderly patients with femoral neck fractures

Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the elderly patients

OBSERVATION ON CURATIVE EFFECTS OF BEATING-ACUPUNCTURE ON 100 CASES OF CERVICAL SPONDYLOPATHY

Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases improved, the cure rate was 85 %; Of the 50 cases in the filiform needle acupuncture group, 25 cases were cured and 23 improved, the cure rate was 50 %. There was a statis-tically significant difference(P<0.01 ) between the two grdrips. It is indicated that the curative effect of beating-acupuncture on cervical spondylopathy is obviously superior to that of fili form-needle acupuncture, which provides a new therapy without traumatic pain for clinical treatment of cervical spondylopathy,

Dual metal atom catalysts:Advantages in electrocatalytic reactions

The dual-metal-atom catalysts(DACs)have aroused much attention as they possess the advantages of single-atom and metal alloy catalysts.And the DACs have exhibited enhanced performance in various electrocatalytic reactions,such as hydrogen/oxygen evolution and oxygen/carbon dioxide/nitrogen reduction.In this review,we mainly overview the latest understanding of the advantages of DACs for these reactions.This review will start with the familiar characterization methods for DACs,then the primary synthesis strategies for DACs will be discussed.Emphasis is given to the advantages of DACs in catalytic reactions,including the adsorption and activation,electronic structure regulation,breaking scaling relations,reducing energy barriers,cascading and coupling,synergy effect,and providing mechanism research platforms.Finally,personal perspectives and challenges for the further development of DACs are briefly discussed.

生物制剂疗法在重度哮喘治疗中的研究进展

重度哮喘是需要第4级或第5级哮喘药物治疗才能够维持控制或即使在上述治疗下仍表现为“未控制”的哮喘。目前生物制剂疗法为重度哮喘患者提供了新的治疗方法。本文将对治疗重度哮喘的生物制剂进行综述,阐述现有生物制剂的作用机制、疗效和安全性等,并在此基础上对生物制剂疗法的发展方向进行展望。

EXPERIMENT STUDY ON THE EFFECT OF SHENG-MAI INJECTION ON THE CONTRACTIVITY OF DIAPHRAGM AND ITS MECHANISM

In this study the effect of Sheng-ai Injection i.e. Red Ginseng-Ophiopogon Root Injection (one kind of traditional Chinese medicines) on the contractivity of diaphragm was observed. The results confirmed that Sheng-ai Injection increased Pdi of the fatigued diaphragm in rabbits and reduced the time needed for the recovery of Pdi of fatigued diaphragm to the normal value. These results suggest that Sheng-Mai Injection can increase the contractive force and promote the recovery of the fatigued diaphragm. The effect of Sheng-ai Injection on the contractivity of the isolated diaphragmatic bundle of rats was also observed and the results confirmed that Sheng-ai Injection increased the diaphragmatic contractive force directly. This effect of increasing the contractive force of diaphragm was attenuated by adding calcium channel blocker isoptin and disappeared when there was no calcium in the extracellular fluid. It is deduced, therefore, that the mechanism of the effect of Sheng-mai Injection is related to the increased influx of calcium from extracellular fluid into the cells.

指套牵引联合手法复位外固定治疗老年桡骨远端骨折的临床效果

目的:对比指套牵引联合手法复位外固定与单纯手法复位外固定治疗老年桡骨远端骨折的临床疗效。方法:选取2022年3月—2023年3月于天津大学天津医院就诊的老年桡骨远端骨折患者1000例,以随机数字表法均分为指套牵引联合手法复位组和单纯手法复位组。在手法复位后2 d、1周、2周、4周、8周、12周及20周对两组患者的腕关节活动度、疼痛评分、Gartland-Werley腕关节功能评分进行比较。结果:排除脱落病例后,指套牵引联合手法复位组纳入487例,手法复位组491例。相比于单纯手法复位,指套牵引联合手法复位显著提升了背伸(P=0.024)、尺偏(P<0.001)、掌屈(P=0.003)活动度,降低了复位8周(P<0.001)、12周(P=0.022)、20周(P=0.002)时患者的Gartland-Werley腕关节功能评分,但没有显著抑制随访期中患者的主观疼痛。结论:指套牵引联合手法复位外固定可部分地提高老年桡骨远端骨折患者复位后腕关节的活动度及功能。

少腹逐瘀汤治疗子宫内膜异位症性不孕的研究进展

子宫内膜异位症(EMT)是近年来育龄期妇女高发疾病。其常表现为进行性加重的痛经、性交痛、月经紊乱、不孕症等。其中EMT女性患者中生育力下降,患者比例逐年升高。少腹逐瘀汤出自《医林改错》,其功效为散寒温经,活血化瘀,有调经种子第一方之称,可治疗瘀血阻滞,久不受孕。通过收集、分析和梳理了近年来少腹逐瘀汤治疗子宫内膜异位症性不孕的相关文献,总结了其可能的治疗机制及临床疗效,为少腹逐瘀汤治疗子宫内膜异位症性不孕提供有力依据。

Acupuncture for ischemic stroke:where are we now?

Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.

氧化苦参碱对人卵巢癌CAOV3细胞的生长抑制作用及机制研究

目的:探讨氧化苦参碱对人卵巢癌CAOV3细胞的生长抑制作用及机制。方法:体外培养人卵巢上皮浆液性癌细胞系CAOV3细胞,氧化苦参碱给药剂量按照0 mg/ml,2 mg/ml,4 mg/ml,8 mg/ml作用于CAOV3细胞24 h,48 h,采用噻唑蓝(MTT)法检测细胞增殖能力,筛选药物最佳作用浓度与药物作用时间;选用4 mg/ml的氧化苦参碱溶液作用于CAOV3细胞,采用划痕实验,检测细胞迁移率;采用Western blotting法检测Caspase3、Bax以及Bcl-2蛋白表达水平;采用流式细胞术检测细胞凋亡率。结果:与空白组相比,氧化苦参碱可以明显降低CAOV3细胞的细胞活力,且抑制作用具有时间依赖性及剂量依赖性,差异具有统计学意义(P<0.05);同时筛选出4 mg/ml氧化苦参碱作用于CAOV3细胞48 h为最佳有效条件。与空白组相比,氧化苦参碱可以抑制CAOV3细胞的迁移,且作用具有时间依赖性,差异具有统计学意义(P<0.05);氧化苦参碱作用于CAOV3细胞后明显升高Caspase3以及Bax蛋白的表达,明显降低Bcl-2蛋白的表达,差异具有统计学意义(P<0.05);氧化苦参碱可以促进CAOV3细胞的早期凋亡。结论:氧化苦参碱可能通过促进细胞的早期凋亡来抑制CAOV3细胞的生长以及迁移,其作用可能与促进Caspase3、Bax蛋白表达、抑制Bcl-2蛋白表达有关。

路基高边坡自适应锚索支护效果及稳定性研究

该研究以贵州毕威高速公路乌木铺高边坡支护为工程背景,采用大型有限差分软件FLAC^(3D)进行数值模拟,分析支护结构在各阶段的受力机理和工作性能,研究表明,在安装锚索之前,安全系数为1.06;在安装1 400 kN和1 500 kN锚索之后,安全系数增加到1.11;安装所有锚索后,安全系数增加到1.29,在锚索的锚固作用下,边坡的滑动趋势变小,边坡水平和竖向位移明显减小,边坡分级支护后的自适应锚索的锚固效果较好,边坡基本稳定。验证自适应锚索分级支护方法在乌木铺高边坡的适用性和可行性,为准确确定边坡的真实应力状态提供理论依据和数值参考。

有创-无创序贯机械通气治疗慢性阻塞性肺疾病合并呼吸衰竭患者的效果

目的:探讨有创-无创序贯机械通气治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的效果。方法:回顾性分析2022年6月至2023年6月该院收治的66例COPD合并呼吸衰竭患者的临床资料,按照机械通气方法的不同将其分为观察组和对照组各33例。对照组采取有创机械通气治疗,观察组采取有创-无创序贯机械通气治疗。比较两组总机械通气时间、有创机械通气时间、住院时间,治疗前后动脉血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH值]、心功能损伤指标[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)]水平,治疗2周内脱机成功率及并发症发生率。结果:治疗后,观察组总机械通气时间、有创机械通气时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组PaO_(2)水平、pH值均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05);观察组脱机成功率为96.97%(32/33),高于对照组的75.76%(25/33),并发症发生率为6.06%(2/33),低于对照组的24.24%(8/33),差异均有统计学意义(P<0.05)。结论:有创-无创序贯机械通气用于COPD合并呼吸衰竭患者中能够缩短机械通气时间和住院时间,改善患者血气指标和心功能,提高脱机成功率,并降低并发症发生率,效果优于常规有创机械通气治疗。

纳米聚合物微球调驱全过程探索研究

为了研究纳米聚合物微球深部调驱机理、生产现场应用效果以及对后期原油破乳脱水的影响,应用光学显微镜、扫描电镜对纳米聚合物微球粒径变化规律进行观察,并分析内在原因,采用热沉降化学法等手段研究微球乳液是否对原油破乳脱水产生影响,同时,结合生产现场试验应用效果,对纳米聚合物微球调驱进行了全过程探索研究。结果表明:小粒径微球更易进入油层深部滞留,微球本身膨胀变大进行封堵,增大油层比表面积,降低油层渗透率,其调驱适应性小粒径聚合物微球更占优势,现场应用效果明显,有效缓解了含水率上升的矛盾,取得了良好的控水效果。经室内实验证明,采出液中的微球乳液对原油破乳脱水基本不产生影响,甚至有一定的正向作用。

参附注射液对肺保护通气策略实施下急性呼吸窘迫综合征患者临床疗效观察及呼吸力学影响研究

目的针对参附注射液对肺保护通气策略实施急性呼吸窘迫综合征(ARDS)患者临床疗效观察及呼吸力学影响进行分析。方法选取2022年9月至11月赣南医学院第一附属医院综合重症加强护理病房(ICU)、急诊ICU、呼吸ICU收治的40例脓毒症诱发ARDS患者作为研究对象。采用随机数字表分为对照组和观察组,每组各20例。对照组采用ARDS保护性肺保护通气策略治疗基础上加以5%葡萄糖注射液100 ml静脉滴注,观察组采用常规ARDS肺保护通气策略治疗及常规基础治疗上加用参附注射液40 ml加入5%葡萄糖注射液100 ml静脉滴注。比较两组临床疗效、ICU住院时间、机械通气时间、动脉血气血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(PaO_(2)/FiO_(2))、肺静态顺应性(Cstat)、气道平台压(Pplat)、吸气峰压(PIP)、血管外肺水指数(EVLW)及治疗满意度。结果治疗后观察组在ICU住院时间以及机械通气时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组PaO_(2)、PaCO_(2)、PaO_(2)/FiO_(2)的比较,差异无统计学意义(P>0.05)。治疗后观察组PaO_(2)、PaCO_(2)、PaO_(2)/FiO_(2)高于对照组,差异有统计学意义(P<0.05)。治疗前,两组吸力学参数的比较,差异无统计学意义(P>0.05)。治疗后观察组Pplat、PIP低于对照组,Cstat高于对照组,差异有统计学意义(P<0.05)。两组治疗前血管外肺水指数EVLW的比较,差异无统计学意义(P>0.05)。治疗后观察组血管外肺水指数EVLW低于对照组,差异有统计学意义(P<0.05)。治疗后观察组总满意度高于对照组,差异有统计学意义(P<0.05)。结论ARDS患者进行临床治疗时,开展常规肺保护通气策略,结合参附注射液,可获得明显的临床疗效,对于呼吸力学产生的影响比较积极。

机械取栓治疗超时间窗急性前循环脑梗死患者近、远期疗效评估

目的:探究机械取栓治疗超时间窗急性前循环脑梗死近、远期疗效。方法:回顾性收集自2020年5月至2023年10月期间本院收治的98例超时间急性前循环脑梗死患者的临床资料。98例超时间急性前循环脑梗死患者根据取栓方式的差异将其分为对照组(静脉溶栓,n=47例)与观察组(机械取栓,n=51例)。分析对比两组的血管再通率、近期疗效、远期疗效以及并发症发生情况。结果:观察组血管再通率、近期疗效有效率显著高于对照组(P<0.05)。术后3m,观察组的预后良好率显著高于对照组,并发症发生率显著低于对照组(P<0.05)。结论:相较于静脉溶栓,机械取栓对超时间窗急性前循环脑梗死患者的临床效果更佳,能提高血管再通率,提升患者的近期、远期疗效,减少并发症。

Clinical efficacy of mask continuous positive airway pressure mechanical ventilation in children with severe pneumonia

Objective: To investigate the clinical effects of the mask continuous positive airway pressure (CPAP) mechanical ventilation in children with severe pneumonia. Methods: A total of 100 cases of children with severe pneumonia were randomly divided into two groups, study group with 50 children and control group with 50 children. These 100 children were given comprehensive treatment measures: treatment of anti-infection, anti-respiratory failure, anti-heart failure (if necessary), relieving cough and reducing sputum, aerosol inhalation, limited fluid volume, nutrition support etc. Children in the study group were added mask continuous positive airway pressure mechanical ventilation (CPAP). Children in the control group were added ordinary mask oxygen inhalation. Investigated and checked the treatment effect in these two groups. Results: After treatment, SaO2, PaO2 in both two groups were showed significantly higher than before the treatment. PaO2 of the study group is obviously higher than the control group. The oxygen inhalation time of the study group was obviously lesser than the control group. The total effective rate of the study group was significantly higher than the control group which was 96.0% vs 66.0%. Conclusion: The mask continuous positive airway pressure (CPAP) mechanical ventilation can significantly improve the related symptoms and blood gas status of the children with severe pneumonia, shorten the oxygen inhalation time and had remarkable effect.

超高龄急性缺血性脑卒中病人行可回收支架机械取栓的效果及安全性

目的 观察超高龄急性缺血性脑卒中病人行可回收支架机械取栓的效果及安全性。方法 选择2018年6月至2020年12月本院收治的133例老年急性缺血性脑卒中病人为研究对象,根据年龄将≥90岁的病人作为超高龄组(47例),年龄<90岁的病人作为老年组(86例)。所有病人均接受静脉溶栓和可回收支架机械取栓治疗。比较2组临床疗效、治疗不同时点中国脑卒中临床神经功能缺损量表(CSS)评分、取栓时间、取栓次数、是否植入支架、血管再通率、改良脑梗死溶栓(mTICI)分级、术后并发症发生情况及术后3个月内死亡率。结果 2组总有效率差异无统计学意义(74.47%比84.88%,P>0.05)。治疗后3 d至4周,2组CSS评分均呈下降趋势(P<0.05),但2组间差异均无统计学意义(P>0.05)。2组血管再通率、mTICI分级差异无统计学意义(P>0.05)。与老年组相比,超高龄组取栓时间较长、取栓次数较少、植入支架率较高(P<0.05)。2组术后并发症总发生率差异无统计学意义(17.02%比11.63%,P>0.05)。术后3个月内超高龄组死亡7例(14.89%),老年组死亡10例(11.63%),差异无统计学意义(P>0.05)。结论 超高龄急性缺血性脑卒中病人发病时也可接受可回收支架机械取栓治疗,不应只因年龄因素放弃治疗。

改进型简支组合箱梁破坏机理及设计问题研究

改进型组合箱梁是以平钢板置换传统波纹钢腹板组合箱梁下翼板(RC板)而建造的新型钢混结构。为完善该类结构设计理论,其更为精准的力学分析尤为必要。对改进型组合箱梁悬臂板和上下翼板设置了2个不同的剪滞纵向位移差函数,同时引入剪滞翘曲应力和弯矩自平衡条件,进而建立该类组合箱梁的弹性控制微分方程,基于此实现改进型组合箱梁力学性能弹性阶段的精细化分析,其破坏模式则主要以试验研究为主。研究表明:简支改进型组合箱梁,其钢底板正应力约为顶板的20倍,而钢底板与顶板的设计强度之比为13.6,因此,竖向弯曲状态该类结构钢底板将会发生屈服破坏;由于剪力滞效应影响,钢底板与腹板相交处,钢底板首先发生屈服,继而随着竖向荷载增加,其屈服点逐渐向钢底板横向中心延伸;改进型组合箱梁破坏形式,钢底板首先屈服,且其挠度快速增加,继而上翼板(RC板)压溃;基于改进型组合箱梁破坏特点,通过施加预应力筋,并合理调整箱梁材料和断面几何参数,进而实现顶板和钢底板的协调破坏。因而,本文方法是对改进型组合箱梁力学性能演化规律的探索,其分析成果将对该类结构设计具有指导作用。

500例旋提手法治疗颈椎病的影像学特点与疗效研究

目的:回顾性总结旋提手法治疗颈椎病的影像学特点及疗效。方法:选取2016年4月至2021年4月就诊于中国中医科学院望京医院脊柱二科,诊断为颈椎病(除外脊髓型颈椎病)且经旋提手法治疗的500例患者作为研究对象,对其一般情况、影像学特点(X线平片、CT及MRI)及手法治疗的疗效、疗程、安全性进行回顾性分析。结果:500例患者中男171例,女329例;年龄17~82岁,平均年龄(52.17±12.84)岁;颈型、神经根型、椎动脉型、混合型颈椎病比例分别为5.60%、62.60%、10.40%、21.40%;X线诊断生理曲度异常及颈椎失稳比例分别为96.00%和47.00%;CT诊断颈椎间盘突出、颈椎管狭窄及后纵韧带骨化比例分别为86.12%、48.98%、22.86%;MRI诊断颈椎间盘突出、颈椎管狭窄比例分别为96.18%、54.60%;旋提手法治疗颈型、神经根型、椎动脉型、混合型颈椎病的有效率分别为96.43%、96.17%、98.08%、96.26%,治愈率分别为17.86%、15.65%、17.31%、14.95%;疗程7~23 d,平均疗程(13.553.06)d;500例患者接受旋提手法治疗均无不良反应发生。结论:颈椎曲度异常和颈椎间盘突出是颈椎病的主要影像学表现;旋提手法治疗颈椎病疗效确切,安全性高,其中颈型与椎动脉型颈椎病患者见效较快;该手法可应用于无脊髓型颈椎病症状体征但存在颈椎间盘突出、颈椎管狭窄及后纵韧带骨化患者,但应重视询问病史与体格检查,排除手法禁忌。