Objective: To observe the effect and mechanism of Garlicin in treating coronary heart disease (CHD) with angina pectoris. Methods: Clinical study: 55 patients were selected and randomized into the Garlicin group and t...Objective: To observe the effect and mechanism of Garlicin in treating coronary heart disease (CHD) with angina pectoris. Methods: Clinical study: 55 patients were selected and randomized into the Garlicin group and the nitroglycerin group. To Garlicin group, 60 mg of Garlicin was given by adding in 5% glucose solution for intravenous dripping once per day, the therapeutic course展开更多
Objective: To observe the therapeutic effect of Shenmai Injection (SI) in treating congestive heart failure (CHF). Methods: The changes in cAMP, cGMP, serum cardiac troponin T (cTnT, a specific marker reflecting myoca...Objective: To observe the therapeutic effect of Shenmai Injection (SI) in treating congestive heart failure (CHF). Methods: The changes in cAMP, cGMP, serum cardiac troponin T (cTnT, a specific marker reflecting myocardial injury), creatine kinase (CK) and creatine kinase isoenzyme (CK-展开更多
Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially ce...Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis ( LAT) could reach 25% - 30%(1) , the incidence of embol-展开更多
Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly a...Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly anti-inflammatory and immunosuppres-sive effects of tripterygium glycosides (TG, product of Huangshi Pharmaceutical Factory, 10 mg/展开更多
Objective: To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD). Methods: Eighty-three patients of VD were randomized on ratio of 2 : 1 into two groups, the 54 patients in the tr...Objective: To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD). Methods: Eighty-three patients of VD were randomized on ratio of 2 : 1 into two groups, the 54 patients in the treated group were treated with YTC orally administered, 3 times a展开更多
Objective To investigate the role of endothelin(ET) in the proliferation and collagen synthesis of human scar-derived fibroblasts and the moduktion of its antagonists such as nitric oxide(NO), tetrandrine ( Tet). Meth...Objective To investigate the role of endothelin(ET) in the proliferation and collagen synthesis of human scar-derived fibroblasts and the moduktion of its antagonists such as nitric oxide(NO), tetrandrine ( Tet). Methods With the cultured fibroblasts from the scarring tissue, the cell pdiferation was determined by[3H]-TdR incorporation, while the collagen synthesis was evaluated by[3H]-proline incorporation. Results The ET-1 was significantly increasing the proliferation and collagen synthesis of human scar-derived fibroblasts. The values of [3H]-TdR absorption in the 2.5 ng/ml,25 ng/ml and 100 ng/ml of ET-1 groups were 1.8 times,4 times and 4.9 times more than in the control group, respectively(P【0. 01),while the values of the [3H]-proline incorporation were 1.1 times,3.1 times and 3.8 times respectively(P【0.01). The fibroblasts, treated with 50 μg/ml of S-nitroso-N-acetyl penicillamine(SNAP), were no detectable effect on the basal level of DNA synthesis,but produced decreasing effect on the展开更多
The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultan...The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultaneous after resistance to a single contacted drug has been produced. Tumor cells with MDR would now show a low sensitivity to anti-tumor agents, making chemotherapy ineffective or of little effect. Moreover, MDR is one of the pathogenetic factors for inducing refractory leukemia.展开更多
Starting from the linear shallow-water wave equations including in themselves the effect of a large-scale orograpny, two types of gravity wave solutions are derived on the assumption that the Qinghai-Xizang Plateau se...Starting from the linear shallow-water wave equations including in themselves the effect of a large-scale orograpny, two types of gravity wave solutions are derived on the assumption that the Qinghai-Xizang Plateau serves as an orography in question inclined from west to east at the same slope. One type contains two solutions of high-frequency inertia-gravitational waves and the other solution of low-frequency topography-excited gravity waves, bearing some similarity to Kelvin mode. Both types are similar, respectively, to the gravity waves of the front of the cold surge during the rapid southward advance, and to the strong velocity center of the surge when it propagates southward slowly along the east brim of the Plateau, as shown by the numerical study. Results indicate that the low-frequency wave vanishes whereas its counterpart remains especially in the absence of the orography. In addition, we find that the propagation of the gravity-wave rays is in the form of a trochoid equation, a result in good agreement with the curved path of the strong velocity center going down the east fringe of the Plateau as shown by the numerical study. And probably a waveguide tube of topographic gravity mode is present in the coastwise area downstream of the orography.展开更多
文摘Objective: To observe the effect and mechanism of Garlicin in treating coronary heart disease (CHD) with angina pectoris. Methods: Clinical study: 55 patients were selected and randomized into the Garlicin group and the nitroglycerin group. To Garlicin group, 60 mg of Garlicin was given by adding in 5% glucose solution for intravenous dripping once per day, the therapeutic course
文摘Objective: To observe the therapeutic effect of Shenmai Injection (SI) in treating congestive heart failure (CHF). Methods: The changes in cAMP, cGMP, serum cardiac troponin T (cTnT, a specific marker reflecting myocardial injury), creatine kinase (CK) and creatine kinase isoenzyme (CK-
基金This project is supported by Guangdong Provincial Ad-ministration of TCM(No.99592)
文摘Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis ( LAT) could reach 25% - 30%(1) , the incidence of embol-
文摘Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly anti-inflammatory and immunosuppres-sive effects of tripterygium glycosides (TG, product of Huangshi Pharmaceutical Factory, 10 mg/
文摘Objective: To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD). Methods: Eighty-three patients of VD were randomized on ratio of 2 : 1 into two groups, the 54 patients in the treated group were treated with YTC orally administered, 3 times a
文摘Objective To investigate the role of endothelin(ET) in the proliferation and collagen synthesis of human scar-derived fibroblasts and the moduktion of its antagonists such as nitric oxide(NO), tetrandrine ( Tet). Methods With the cultured fibroblasts from the scarring tissue, the cell pdiferation was determined by[3H]-TdR incorporation, while the collagen synthesis was evaluated by[3H]-proline incorporation. Results The ET-1 was significantly increasing the proliferation and collagen synthesis of human scar-derived fibroblasts. The values of [3H]-TdR absorption in the 2.5 ng/ml,25 ng/ml and 100 ng/ml of ET-1 groups were 1.8 times,4 times and 4.9 times more than in the control group, respectively(P【0. 01),while the values of the [3H]-proline incorporation were 1.1 times,3.1 times and 3.8 times respectively(P【0.01). The fibroblasts, treated with 50 μg/ml of S-nitroso-N-acetyl penicillamine(SNAP), were no detectable effect on the basal level of DNA synthesis,but produced decreasing effect on the
文摘The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultaneous after resistance to a single contacted drug has been produced. Tumor cells with MDR would now show a low sensitivity to anti-tumor agents, making chemotherapy ineffective or of little effect. Moreover, MDR is one of the pathogenetic factors for inducing refractory leukemia.
基金The study is supported by National Natural Science Foundation of ChinaMonsoon Research Funds, State Meteorological Administration of PRC.
文摘Starting from the linear shallow-water wave equations including in themselves the effect of a large-scale orograpny, two types of gravity wave solutions are derived on the assumption that the Qinghai-Xizang Plateau serves as an orography in question inclined from west to east at the same slope. One type contains two solutions of high-frequency inertia-gravitational waves and the other solution of low-frequency topography-excited gravity waves, bearing some similarity to Kelvin mode. Both types are similar, respectively, to the gravity waves of the front of the cold surge during the rapid southward advance, and to the strong velocity center of the surge when it propagates southward slowly along the east brim of the Plateau, as shown by the numerical study. Results indicate that the low-frequency wave vanishes whereas its counterpart remains especially in the absence of the orography. In addition, we find that the propagation of the gravity-wave rays is in the form of a trochoid equation, a result in good agreement with the curved path of the strong velocity center going down the east fringe of the Plateau as shown by the numerical study. And probably a waveguide tube of topographic gravity mode is present in the coastwise area downstream of the orography.
