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In situ atomic-scale observation of size-dependent (de) potassiation and reversible phase transformation in tetragonal FeSe anodes 被引量:1
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作者 Ran Cai Lixia Bao +12 位作者 Wenqi Zhang Weiwei Xia Chunhao Sun Weikang Dong Xiaoxue Chang Ze Hua Ruiwen Shao Toshio Fukuda Zhefei Sun Haodong Liu Qiaobao Zhang Feng Xu Lixin Dong 《InfoMat》 SCIE CAS CSCD 2023年第1期161-171,共11页
Potassium-ion batteries(PIBs)are considered promising alternatives to lithium-ion batteries owing to cost-effective potassium resources and a suitable redox potential of-2.93 V(vs.-3.04 V for Li+/Li).However,the explo... Potassium-ion batteries(PIBs)are considered promising alternatives to lithium-ion batteries owing to cost-effective potassium resources and a suitable redox potential of-2.93 V(vs.-3.04 V for Li+/Li).However,the exploration of appro-priate electrode materials with the correct size for reversibly accommodating large K+ions presents a significant challenge.In addition,the reaction mecha-nisms and origins of enhanced performance remain elusive.Here,tetragonal FeSe nanoflakes of different sizes are designed to serve as an anode for PIBs,and their live and atomic-scale potassiation/depotassiation mechanisms are revealed for the first time through in situ high-resolution transmission electron micros-copy.We found that FeSe undergoes two distinct structural evolutions,sequen-tially characterized by intercalation and conversion reactions,and the initial intercalation behavior is size-dependent.Apparent expansion induced by the intercalation of K+ions is observed in small-sized FeSe nanoflakes,whereas unexpected cracks are formed along the direction of ionic diffusion in large-sized nanoflakes.The significant stress generation and crack extension originating from the combined effect of mechanical and electrochemical interactions are elucidated by geometric phase analysis and finite-element analysis.Despite the different intercalation behaviors,the formed products of Fe and K_(2)Se after full potassiation can be converted back into the original FeSe phase upon depotassiation.In particular,small-sized nanoflakes exhibit better cycling perfor-mance with well-maintained structural integrity.This article presents the first successful demonstration of atomic-scale visualization that can reveal size-dependent potassiation dynamics.Moreover,it provides valuable guidelines for optimizing the dimensions of electrode materials for advanced PIBs. 展开更多
关键词 elucidated by geometric phase analysis and finite-element analysis. Despite the different intercalation behaviors the formed products of Fe and K 2 Se after full potassiation can be converted back into the original FESE phase upon depotassiation. In particular small-sized nanoflakes exhibit better cycling perfor- mance with well-maintained structural integrity. This article presents the first successful demonstration of ATOMIC-SCALE visualization that can reveal size- dependent potassiation dynamics. Moreover it provides valuable guidelines for optimizing the dimensions of electrode materials for advanced PIBs. KEYWOR DS in situ transmission electron microscopy potassium-ion batteries potassium-ion storage mechanism SIZE-DEPENDENT effects TETRAGONAL FESE
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The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole
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作者 Jean-Claude Perez 《Applied Mathematics》 2013年第10期37-53,共17页
This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the... This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossil genome with multiple symmetries persists. This recalls the “intermingling” of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, which characterize it and its 64 codon populations with correlations greater than 99%. The number “1” is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then “imagine” a kind of hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome: we will show that—simultaneously with the duality between genes and junk DNA—there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information/redundancy involving golden ratio proportions. 展开更多
关键词 Genetic Code CODON Populations Junk DNA Cancer Genomics Chromosomal Translocations Genomes Diversity Chromosomes Diversity WHOLE Human GENOME DNA SEQUENCE Phi the Golden Ratio Fibonacci NUMBERS Information Theory SYMMETRY Cellular Automata Chargaffs CODON Level SYMMETRY Principle Fractal Self-Similarity e Eulers Number Pi form and Substance Redundancy Encryption
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Polymerase-tautomeric Model for Untargeted Delayed Base Substitution Mutations Formation during Error-prone and SOS Replication of Double-stranded DNA Containing Thymine and Adenine in Some Rare Tautomeric Forms
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作者 Helen A.Grebneva 《Journal of Oncology Research》 2019年第2期24-37,共14页
Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed.Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymi... Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed.Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymine T3*,adenines A2*and A4*so that between them hydrogen bonds are formed.Canonical adenine and cytosine can be incorporated opposite canonical thymine only.Canonical thymine and guanine can be incorporated opposite canonical adenine only.If in the synthesis of DNA containing rare tautomeric forms of thymine T3*,adenines A2*and A4*,involved DNA polymerases with relatively high fidelity of synthesis,mutations not appear.However,if further DNA synthesis will involve DNA polymerases having a low fidelity of synthesis,there may be base substitution mutations.It was shown that the conclusion made in the Tomasetti and Vogelstein cancer risk model that the formation of about 67%of all mutations was not caused by exposure to any mutagens is erroneous. 展开更多
关键词 Radiation-induced genomic instability Untargeted delayed base substitution MUTATIONS UV-mutagenesis Rare tautomeric forms of DNA bases Thymine adenine ERROR-PRONE REPLICATION SOS REPLICATION
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Relationship between Natural Fracture and Structural Style and its Implication for Tight Gas Enrichment:A Case Study of Deep Ahe Formation in the Dibei–Tuzi Area,Kuqa Depression 被引量:1
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作者 XIA Lu XI Kelai +6 位作者 YANG Xianzhang HAN Zhanghua XU Zhenping ZHOU Lu YU Guoding WANG Daoshen WANG Weiyu 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第4期1086-1110,共25页
The deep Lower Jurassic Ahe Formation(J_(1a))in the Dibei–Tuzi area of the Kuqa Depression has not been extensively explored because of the complex distribution of fractures.A study was conducted to investigate the r... The deep Lower Jurassic Ahe Formation(J_(1a))in the Dibei–Tuzi area of the Kuqa Depression has not been extensively explored because of the complex distribution of fractures.A study was conducted to investigate the relationship between the natural fracture distribution and structural style.The J_(1a)fractures in this area were mainly high-angle shear fractures.A backward thrust structure(BTS)is favorable for gas migration and accumulation,probably because natural fractures are more developed in the middle and upper parts of a thick competent layer.The opposing thrust structure(OTS)was strongly compressed,and the natural fractures in the middle and lower parts of the thick competent layer around the fault were more intense.The vertical fracture distribution in the thick competent layers of an imbricate-thrust structure(ITS)differs from that of BTS and OTS.The intensity of the fractures in the ITS anticline is similar to that in the BTS.Fracture density in monoclinic strata in a ITS is controlled by faulting.Overall,the structural style controls the configuration of faults and anticlines,and the stress on the competent layers,which significantly affects deep gas reservoir fractures.The enrichment of deep tight sandstone gas is likely controlled by two closely spaced faults and a fault-related anticline. 展开更多
关键词 fracture distribution structural style deep tight sandstone electrical image logging Kuqa Depression Tarim Basin
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Discussion on the Source of Ore-forming Materials of the Yinan Gold Deposit,Shandong 被引量:1
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作者 S.Y.Dong~(1,2),X.X.Gu~1,K.Li~3,Y.M.Zhang~1,L.Liu~1,W.B.Cheng~1 1.School of Earth Sciences and Resources,China University of Geosciences(Beijing),Beijing 100083,China. 2.School of Earth Sciences,Chengdu University of Technology,Chengdu 610059,China 3.Sichuan Institute of Metallurgical Geology and Exploration,Chengdu 610051,China 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期217-217,共1页
Based on the main characteristics of the tectonic -magmatic evolution of region and Tanlu fault zone,we have discussed ore-bearing magmatic rocks petrochemistry,strontium and lead isotope,and the source of ore-forming... Based on the main characteristics of the tectonic -magmatic evolution of region and Tanlu fault zone,we have discussed ore-bearing magmatic rocks petrochemistry,strontium and lead isotope,and the source of ore-forming materials in Yinan skarn deposit in this paper.The petrochemical features show that the ore-bearing magmatic rocks are calc-alkaline rocks of sub-alkaline series formed during 展开更多
关键词 PETROCHEMISTRY strontium ISOTOPE lead ISOTOPE source of ORE-formING materials Yinan gold deposit granite-greenstone belt Tanlu fault zone tectonic-magmatic evolution
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Pastoral Investigation on the Form and Usage of Local-Style Dwelling Houses in Jiarong Tibetan Traditional Village of Danba County
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作者 Bin Cheng Libin Duan Yangliu Fu 《Journal of Building Construction and Planning Research》 2018年第2期52-70,共19页
Under the dual background of rapid development and urbanization, the research is of practical significance for the construction and development of new rural harmonious society on the traditional villages, residential ... Under the dual background of rapid development and urbanization, the research is of practical significance for the construction and development of new rural harmonious society on the traditional villages, residential forms and ways of using. The purpose of this study is to learn the characteristics of the local residential forms and their usage, reveal the relationship between these characteristics and villagers’ lifestyles, and grasp the villagers’ evaluation of the satisfaction on living space, by the investigation of 168 questionnaires, 16 families in-depth interviews and survey mapping in the W, Y and Z villages of Suopo Township, Danba County, Sichuan Province. The resulted showed that: 1) Residents have obvious uniform features, mostly 3 - 5 layers of single-family residences, mostly in the area of 400 - 500 m2. The height of the house and the rooms has a relatively fixed modulus. 2) In the survey of the usage of local dwelling houses, it was found that farmers have a fixed model for the use of residential buildings. Most of the living activities are gathered in their own courtyards, and the utilization of the living room is usually limited. The floors above the second floor often have the terrace formed by the retreat to dry the food. There are often more bedrooms for spare, more than 90% of the family of four or more have two or more living rooms. 3) The residential area is embodied in both horizontal and vertical directions: the first floor of the indoor room from the courtyard to the dining room has the property of semi-open and semi-private space, and it is the main place for neighborhood interaction;and the rooms of the second and above are more private. 4) In the long process of life, the form and usage of houses will change with the changes of external factors. The traditional dwelling houses will be built or renovated, accounting for about 36% of the total amount surveyed. 展开更多
关键词 Suopo Township in Danba JIARONG TIBETAN PASTORAL INVESTIGATION Residential form USAGE
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Bell’s Ternary Quadratic Forms and Tunnel’s Congruent Number Criterion Revisited
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作者 Werner Hürlimann 《Advances in Pure Mathematics》 2015年第5期267-277,共11页
Bell’s theorem determines the number of representations of a positive integer in terms of the ternary quadratic forms x2+by2+cz2 with b,c {1,2,4,8}. This number depends only on the number of representations of an int... Bell’s theorem determines the number of representations of a positive integer in terms of the ternary quadratic forms x2+by2+cz2 with b,c {1,2,4,8}. This number depends only on the number of representations of an integer as a sum of three squares. We present a modern elementary proof of Bell’s theorem that is based on three standard Ramanujan theta function identities and a set of five so-called three-square identities by Hurwitz. We use Bell’s theorem and a slight extension of it to find explicit and finite computable expressions for Tunnel’s congruent number criterion. It is known that this criterion settles the congruent number problem under the weak Birch-Swinnerton-Dyer conjecture. Moreover, we present for the first time an unconditional proof that a square-free number n 3(mod 8) is not congruent. 展开更多
关键词 Sum of SQUARES TERNARY Quadratic form THETA Function HURWITZ Three-Squares formula CONGRUENT Number Weak Birch-Swinnerton-Dyer CONJECTURE
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The effect of traditional Chinese medicine“Tian Gui Recipe (TGR)”on obesity and anovulation in androgen-sterilized rats(ASR) 被引量:1
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作者 Yu Jin(俞瑾) +1 位作者 Sun Fei(孙斐) 《生殖医学杂志》 CAS 2002年第z1期13-21,共9页
Objectives: A traditional Chinese medicine “Tian Gui Recipe (TGR)” has been used to effectively treat clomiphene resistant anovulatory disease and obesity, especially in polycystic ovary syndrome (PCOS) cases with h... Objectives: A traditional Chinese medicine “Tian Gui Recipe (TGR)” has been used to effectively treat clomiphene resistant anovulatory disease and obesity, especially in polycystic ovary syndrome (PCOS) cases with hyperinsulinemia. The effect of TGR on obesity and anovulation was investigated in androgen-sterilized rats (ASR).Methods: Female SD rats at the age of 9 days were divided into 3 groups. Group ASR (n=15): anovulation was demonstrated at the age of 70 days by vaginal smear in rats while 1.25 mg of testosterone propionate was injected subcutaneously on its 9th neonatal day. Group A+H (n=25): TGR were administered to ASR at the age of 80 days for 3 weeks. Rats with regular estrous cycle and ovulation after herbal treatment were included in this group. Group C (n=15): normal ovulated rats were recruited. Around the age of 112 days or on proestrous day, all rats were sacrificed under anesthesia. Serum leptin, testosterone (T), estrogen (E2), follicular stimulating hormone (FSH), luteinizing hormone (LH) levels were measured with radioimmunoassay (RIA). Double immunofluorescent staining combined with confocal laser scanning microscope and dual in situ hybridization were carried out on sections through areas of arcuate nucleus (ARC) to determine whether estrogen receptor (ER) immunoreactivity (IR) or long form of leptin receptor (OB-Rb) mRNA were expressed in neuropeptide Y (NPY) immuno- and mRNA-containing neurons, and their relationship to proopiomelanocortin (POMC) mRNA-containing neurons. Immunohistochemistry and in situ hybridization were used to observe the levels of ER-, NPY-,gonadotrophin releasing hormone (GnRH)-IR and gene expression levels of NPY, OB-Rb, and POMC in ARC. Meanwhile, the criteria of energy state,including daily food intake, retroperitoneal fat depot pad and body weight,were measured and evaluated. Values of immunohistochemistry and in situ hybridization were expressed in mean optic density (MOD).Results:Seventeen out of the 25 rats (68%) in Group A+H were ovulated after herbal treatment. ASR characterized with significantly high metabolic rate, energy imbalance and obesity (P<0.01,P<0.01,P<0.01).The mean serum leptin, T, E2 levels of ASR were significantly higher than that of Group C and Group A+H (P<0.01,P<0.01), while being contraryto that of FSH, LH levels (P<0.01,P<0.01). ERs were proved distributing in NPY-containing neurons, OB-Rb coexpressed in NPY-synthesizing neurons, and both NPY- and POMC- mRNA expressing neurons overlapped in ARC. Compared to Group C, levels of NPY mRNA and NPY, POMC mRNA expressions increased (P<0.01,P<0.01,P<0.01),OB-Rb mRNA, ER and GnRH immunoreactive expression decreased significantly in the hypothalamus of ASR (P<0.01,P<0.01,P<0.01).These dramatic neuroendocrine changes became normal in ovulated ASR after the herbal treatment (all P>0.05).Conclusion: The elevated peripheral estrogen caused by high testosterone and leptin levels in ASR may down-regulate their corresponding receptors oriented on hypothalamic NPY-containing neurons respectively, therefore challenge the NPY mRNA and NPY,POMC mRNA overexpression. The overexpression of NPY, POMC gene transcription and translation stimulate food intake, promote the deposit of adipocyte tissue, and inhibit GnRH expression and GnRH/FSH, LH release, which contribute to the occurrence of obesity and anovulation in ASR. “TGR” may reverse these abnormal neuroendocrine cascades by lowering levels of testosterone, estrogen and leptin. 展开更多
关键词 androgen-sterilized rat Traditional chinese medicine Neuropeptide Y LEPTIN Long form of LEPTIN RECEPTOR PROOPIOMELANOCORTIN ESTROGEN ESTROGEN RECEPTOR GONADOTROPHIN releasing hormone Double immunohistochemistry Dual in situ hybridization mRNA
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Analysis of Waste-Rock Transportation Process Performance in an Open-Pit Mine Based on Statistical Analysis of Cycle Times Data 被引量:1
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作者 Samwel Victor Manyele 《Engineering(科研)》 2017年第7期649-679,共31页
In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The p... In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes). 展开更多
关键词 Potentially Acid-forming (PAF) ROCK Non-Acid formING (NAF) ROCK TRUCK Utilization TRUCK Fill-Factor QUEUING TIME Loading CYCLE TIME Full and Empty Haul Total CYCLE TIME Theoretical CYCLE TIME Non-Productive CYCLE TIME CYCLE TIME Performance Ratio
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Traditional Architectural Construction Style in the Contemporary Application and Transformation——A Case Study in the Eastern Area of Zhejiang Province 被引量:2
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作者 张友军 刘岚 《Journal of Landscape Research》 2010年第9期12-16,共5页
Traditional architectural construction style had rich connotation for application and transformation in contemporary architectural space design.With buildings in the eastern areas of Zhejiang Province as the research ... Traditional architectural construction style had rich connotation for application and transformation in contemporary architectural space design.With buildings in the eastern areas of Zhejiang Province as the research subjects,the paper explored forms of application and transformation and specific design techniques from microcosmic point. 展开更多
关键词 TRADITIONAL architecture Construction style APPLICATION and transformation
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Comparative Study on Spatial Forms of Ancient Waterside Towns Based on Google Earth Pro-Taking the Example of Qingmuchuan,Fenghuang and Houliu in Southern Shaanxi,China 被引量:5
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作者 Mei Yang Zhaoyang Feng 《Journal of Environmental Science and Engineering(B)》 2020年第1期12-22,共11页
The purpose of this study is to address the problem of ancient towns dying out in developing countries,particularly China.Intensifying conflicts between human settlements and the natural environment are described,and ... The purpose of this study is to address the problem of ancient towns dying out in developing countries,particularly China.Intensifying conflicts between human settlements and the natural environment are described,and guidelines are proposed for the development of waterside ancient towns in China’s southern Shaanxi Province in the interest of conserving cultural and natural heritage.The towns of Qingmuchuan,Fenghuang and Houliu were selected as representative examples due to their strong reputation among tourists.They have the characteristics of traditional southern Shaanxi towns,but each has a completely different layout,space and structure.The comparative findings of this research provide a point of reference for establishing guidelines to preserve the integrity of ancient towns worldwide.In this paper,we compare the geographical conditions with the layout and texture of the streets by Google Earth Pro.And we analyze the details of spaces along the river zones,architectural styles and building decorations in order to research the relationship between the natural environment and the human settlement conditions.We note the unfortunate common trend of commercial development steadily taking over the natural environment,particularly the rivers and unique elements of the old towns.Finally,we summarize the similarities and differences of the spatial forms among these towns and put forward proposals for the further development of ancient towns.This research is important for all regions which stand to lose their national treasures.Consequently,measures should be to taken to curtail hyper development before we lose our historicscenery. 展开更多
关键词 Google Earth PRO waterside ANCIENT TOWNS comparative study on spatial forms Qingmuchuan Fenghuang Houliu
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The Forming Conditions of and Ore-searching Direction for B, Mg,Pb, Zn and Au Deposits in the Liaoji Proterozoic Rift
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作者 Zhu Yongzheng and Yao Fengliang (College of Earth Sciences,Jilin University, Changchun 130026 P. R. China) 《Global Geology》 2001年第1期20-25,共6页
The Liaoji Proterozoic rift is an inter-intracontinenatl rift developed from Archean granite-greenstone tectonic regime and contains many important mineral deposits of U, B, magnesite, Pb-Zn, Au, Ag, Co and P. These d... The Liaoji Proterozoic rift is an inter-intracontinenatl rift developed from Archean granite-greenstone tectonic regime and contains many important mineral deposits of U, B, magnesite, Pb-Zn, Au, Ag, Co and P. These deposits were formed as the result of late mobilization, transportation and concentfation of the previously enriched ore-forming mate- rials in several ore-bearing formations formed during the rift stage. So the metallogeny of these deposits in the rift shows both inheritance and new generation of the ore-forming materials. In future ore-searching practice, attentions should be paid on the studies of the ore-bearing formations in the rift, on the multiple stages of metallogeny and and on multiple derivations of the ore-forming materials. 展开更多
关键词 Liaoji PROTEROZOIC rift B Mg Pb - Zn AU deposits ORE - forming conditions ORE - SEARCHING direction
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Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines
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作者 Yoshiko Yasuda Yasuhiro Maeda +9 位作者 Satoshi Hara Motoyoshi Tanaka Eiji Koike Yoh Watanabe Seiji Masuda Harufumi Yamasaki Katsumi Okumoto Hiroyoshi Konishi Yoshitaka Horiuchi Hiroshi Hoshiai 《Journal of Cancer Therapy》 2011年第1期40-53,共14页
We examined the effect of blocking the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against x... We examined the effect of blocking the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against xenografts of female reproductive organ malignancies and of cancer cell lines in nude mice. We transfected seven cancer cell lines of various origins to express constitutively active sEpoR, and examined their tumorigenesis in nude mice. Suppression of the tumor growth, decrease in viable and proliferating cells and reduction of vascular density were seen individually in all xenografts of transfected cell lines compared with the controls. Quantitative RT-PCR analyses showed that expression levels of Epo, EpoR, ?1A-adrenaline receptor (?1A-ADR) and muscalinic acetylcholine receptor subunit 3 mRNAs (m3-AchR) were higher in the majority of the wild-type xenografts than in the corresponding cell lines except for A549. In some of the transfected xenografts, EpoR, ?1A-ADR and m3-AchR mRNAs were down-regulated. Western blot analyses revealed that the constitutively activated ERK1/2MAPK was discernible in the majority of non-transfected cell lines and was reduced in the transfected cell lines. However, it was regained after exposure to acetylcholine and/or noradrenaline. These findings suggest that constitutively active sEpoR can effectively destroy the xenografts but signals from the autonomic neurotransmitters of the host produced under stress may interfere with this antitumor activity. 展开更多
关键词 ERYTHROPOIETIN ERYTHROPOIETIN RECEPTOR Soluble form of ERYTHROPOIETIN RECEPTOR ERK1/2/MAPK Adrenoreceptor ACETYLCHOLINE RECEPTOR Immunohistochemistry Western BLOT Real-Time RT-PCR NUDE Mice
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Mykert-Sanzheevka Field of Polycomponent Ores (Pb, Zn, Ag, Au, PGE): Geologic-Substance Characteristics and Formation Features of Ore-Forming System 被引量:2
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作者 Alexander Vasilyevich Tatarinov Lyubov Ilyinichna Yalovik +1 位作者 Anatoly Georgievich Mironov Victor Fedorovich Posokhov 《Geomaterials》 2020年第1期1-23,共23页
The new results of geologic-structural, petrographic and mineralogic-geochemical researches of Mykert-Sanzheevka ore field—the Uda-Vitim mineragenic zone South-West ending of West Transbaikalia are given. Its main or... The new results of geologic-structural, petrographic and mineralogic-geochemical researches of Mykert-Sanzheevka ore field—the Uda-Vitim mineragenic zone South-West ending of West Transbaikalia are given. Its main ore-controlling structure, represented by losange, consisting of rhombohedral and tetrahedral blocks-duplexes mosaic clusters, which are separated by narrow tectonic sutures, is specified. It is clarified that polycomponent ores clusters are confined with these small-block sutures, made by subvolcanic dykes of shoshonite-latite volcano-plutonic association (233 - 188 million years), apodyke dynamometamorphites (breccias, cataclasite, mylonites) and also mechanometasomatites. Four stages of the dynamometamorphites formation characterized by different species compositions of ore minerals appeared as a result of mechanochemical reactions are determined. A carbonyl model of mineral microaggregates formation with films containing noble metal nanoparticles is proposed. Ore-forming system features of Mykert-Sanzheevka field are considered. 展开更多
关键词 Polycomponent ORES Dynamometamorphism Mechanometasomatites Noble Metals MICROAGGREGATES NANOPHASES Trace Minerals ORE-formING SYSTEM CARBONYL Compounds Geochemical Microanomalies
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Attachment Styles and Traumatic Responses: Exploring the Impact of Parental Interaction on Child Development and Coping Mechanisms
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作者 Kelvin N. Christie Adalgiza Sandoval 《Open Journal of Psychiatry》 2024年第S1期467-489,共23页
This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical... This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical framework of attachment theory and incorporating contemporary research, the paper discusses how parental interactions shape the neural circuitry of infants and children, influencing their ability to form secure or insecure attachments. These attachment styles, in turn, play a critical role in determining the child’s coping mechanisms when faced with trauma. This paper focuses on trying to understand how attachment theory is connected to the reaction to trauma with a highlight on the four major styles of attachments which are secure, anxious, avoidant, and disorganized to mention but a few, and how they influence stress and adversity in children. Attachment theory holds that human beings’ ability to form affectional bonds in infancy determines their patterns of relatedness across the life cycle. The type of attachment that is secure usually supports healthy adaptation and good coping mechanisms regardless of the trauma in the childhood of the child. While secure attachment mostly facilitates favorable trauma-related outcomes, anxious or avoidant attachment can exacerbate or alter the responses. The caregiving system that is avoidant attachment has implications of autonomous self-functioning which has features of suppression of the emotional response and poor search for emotional support during stress. From the principles of developmental psychology and trauma theory, the paper also focuses on the major significance of the child’s early caregivers’ interactions that define the resilience and vulnerability factor. This knowledge is therefore critical in designing specific interventions based on the improvement of coping behaviors and emotional regulatory systems of children who have been exposed to trauma. Finally, we have the synthesis of new knowledge about the role of secure attachment relationships as its fundamental element in shaping adaptive traumatization and psychological development. The article also delves into the physiological processes involved in emotional regulation and the role of cortisol in disrupting attachment. Finally, the implications of these findings for therapeutic interventions and the challenges of addressing prolonged grief and traumatic responses in clinical settings are considered. 展开更多
关键词 Attachment styles Traumatic Response Parental Interaction Child Development Emotional Regulation CORTISOL Grief Coping NEUROBIOLOGY Therapeutic Interventions
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Investigation of Excavator Performance Factors in an Open-Pit Mine Using Loading Cycle Time
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作者 Samwel Victor Manyele 《Engineering(科研)》 2017年第7期599-624,共26页
This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was use... This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine. 展开更多
关键词 Potentially Acid-forming (PAF) ROCK Non-Acid formING (NAF) ROCK TRUCK Utilization TRUCK Fill-Factor Queuing TIME LOADING CYCLE TIME Full and Empty Haul Total CYCLE TIME Theoretical CYCLE TIME Non-Productive CYCLE TIME CYCLE TIME Performance Ratio
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HISTORICAL-DYNAMIC INTEGRATIVE CLASSIFICATION OF BASINOGENESIS AND ORE-FORMING BASINS
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作者 CHEN Guoda (Chang sha Institnte of Geutectunics, A cad emia Sinica, Chang sha 410013) 《Geotectonica et Metallogenia》 1994年第Z1期1-26,共26页
Interesting classifications of basinogenesis and basins were proposed by many seientists. They classified basinogenesis and basins mainly from a single angle, either from a historical angle or from a dynamie angle. In... Interesting classifications of basinogenesis and basins were proposed by many seientists. They classified basinogenesis and basins mainly from a single angle, either from a historical angle or from a dynamie angle. In order to more comprehensively understand them for moore effectively guidlilg prospeeting and exploration, the author integrates the two methods of analysis wilh cach other and proposes an integrative classification. According to the historieal-dynamic integrative classification, basinogenesis and basins can be divided into three types: occanic erust type. embryo-continental (transitional ) erust iype and continental crust type. Oceanie erust type call be subdivided into mobile region type (mainly tensional) and stable region type. Embryo-continental type includes pre-geosynclinal type (divisible into several mobile region types and stable region types with tensional type predoiminating among mobile region trpes) and early-geosynelinal type (mainly tensional). Continental erust type ineludes late-gcosynelinal (fold belt) type (compressional or tensional), platform type (mainly sinking and rarely tensional subsidence-aulacogen) and gcodepression (diwa) type (compressional, tensional or compressional-tensional ). 展开更多
关键词 basinogenesis and ORE-formING basin historical-dynamic INTEGRATIVE classification oceanic CRUST TYPE embryo-continental (transitional) CRUST TYPE CONTINENTAL CRUST TYPE pre-geosynelinal TYPE geosynclinal TYPE platform TYPE geodepression (di
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THE CHANGE OF THE GENERAL FORM AND THE TRANSPORT OF THE WATER, LOAD AND SALT ABOUT THE NORTH-BRANCH OF THE CHANGJIANG RIVER MOUTH 被引量:1
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作者 陈宝冲 《Chinese Geographical Science》 SCIE CSCD 1994年第3期242-251,共10页
The general form of the north-branch of the Changjiang River mouth has changed much as a result of the change of the main stream lines of the Nantong reach of the Changjiang River and the influence of human activities... The general form of the north-branch of the Changjiang River mouth has changed much as a result of the change of the main stream lines of the Nantong reach of the Changjiang River and the influence of human activities since 1915. By the 1930s, the main stream lines of the Nantong reach of the Changjiang River has shifted to the Tongzhou Bar west channel. The north-branch at the Changjiang River mouth has become atrophic because of Tongzhou Bar east channel's deposition. After 1958, Toughal Bar and Jiangxin Bar were exploited. And in 1970, the north channel of Jiangxin Bar was blocked up. All these things make the water of the north-branch more difficult to pass through. It leads to the decline of the total discharge percentage of the north-branch. And it causes the rising tide to go back to the south-branch. However, since 1978, with the development of Tongzhou Bar east channel and its left bank being scoured, the water amount of the north-branch has been increasing. And the water,load and salt of going back to the south-branch has been becoming less. 展开更多
关键词 north-branch of the CHANGJIANG RIVER MOUTH change of RIVER form transport of water load and SALT
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Effects of the Form Factor and the Force of the Gravity on the Thermal Exchanges by Natural Convection in a Rectangular Cavity Filled with Nanofluid
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作者 L. Eljamali A. Wakif +2 位作者 Z. Boulahia M. Zaydan R. Sehaqui 《Engineering(科研)》 2019年第1期59-73,共15页
Effects of the form factor on natural convection heat transfer and fluid flow in a two-dimensional cavity filled with Al2O3-nanofluid has been analyzed numerically. A model was developed to explain the behavior of nan... Effects of the form factor on natural convection heat transfer and fluid flow in a two-dimensional cavity filled with Al2O3-nanofluid has been analyzed numerically. A model was developed to explain the behavior of nanofluids taking account of the volume fraction φ. The Navier-Stokes equations are solved numerically by alternating an implicit method (Method ADI) for various Rayleigh numbers varies as 103, 104 and 105. The nanofluid used is aluminum oxide with water Pr = 6.2;solid volume fraction φ is varied as 0%, 5% and 10%. Inclination angle Φ varies from 0° to 90° with a step the 15° and the form report varies as R = 0.25, 0.5, 1 and 4. The problem considered is a two-dimensional heat transfer enclosure. The vertical walls are differentially heated;the right is cold when the left is hot. The horizontal walls are assumed to be insulated. The nanofluid in the cavity is considered as incompressible, Newtonian and laminar flow. The nanoparticles are assumed to have a shape and a uniform size. However, it is supposed that the two fluid phases and nanoparticles are in a state of thermal equilibrium and they sink at the same speed. The thermophysical properties of nanofluids are assumed to be constant at the exception of the variation of density in the force of buoyancy, which is based on the approximation of Boussinesq values. 展开更多
关键词 NANOFLUID Heat Transfer THERMAL EXCHANGES Natural Convection The FORCE of the GRAVITY form Factor
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LRS Bianchi Type-I Cosmological Model with Anisotropic Dark Energy and Special Form of Deceleration Parameter
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作者 Kishor Shankarrao Adhav Rajesh Purushottam Wankhade Abhijit Shankarrao Bansod 《Journal of Modern Physics》 2013年第8期1037-1040,共4页
We have studied Locally Rotationally Symmetric (LRS) Bianchi type-I cosmological model filled with anisotropic fluid in general theory of relativity. The solutions of the field equations are obtained by using special ... We have studied Locally Rotationally Symmetric (LRS) Bianchi type-I cosmological model filled with anisotropic fluid in general theory of relativity. The solutions of the field equations are obtained by using special form of deceleration parameter which gives early deceleration and late time accelerating cosmological model. The geometrical and physical aspect of the model is also studied. 展开更多
关键词 LRS Bianchi Type-I Space-Time SPECIAL form of Deceleration Parameter ANISOTROPIC Fluid Dark Energy ISOTROPIZATION
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