Objective To explore the influence of styptic fiber on clotting time in rabbits so as to provide experiment data for its development.Methods Onto 0.1 mL aliquots of citrated anti-coagulant rabbit blood placed in a sur...Objective To explore the influence of styptic fiber on clotting time in rabbits so as to provide experiment data for its development.Methods Onto 0.1 mL aliquots of citrated anti-coagulant rabbit blood placed in a surfacial plate 25 ul of 0.2 mol·L-1 CaCl2 solution was dropped,and mixed well with glass stirrer;the resulting mixture was immediately capped with a piece of styptic fiber(test product group)or absorptive gelatin sponge(positive control group)of 2 cm diameter.Then,the surficial plate was rinsed with 30ml of purified water at 5,10,20,30,40 and 50 min after capping;the rinsings were allowed to stand for 1 h and were subjected to OD determination at a wavelength of 541 nm.The above procedure was repeated twice,the average value of the twice experiments was taken for evaluation of the hemostatic effect of test product.For negative control group,all procedures except for capping were same as the test product group.The haemostatic effect was judged by percent OD relative to OD at 0 min in negative control group(OD 0 min)(OD 0 min was considered as 100%);if OD value at a time was less than 80% of OD 0 min,it should be designated as primary clotting time(PCT),less than 20% as complete clotting time(CCT).Results The measured PCT was 20min for both negative and positive control groups;CCT was 50,30 and 5 min for negative control,positive control and test product groups,respectively,showing the test styptic fiber had a CCT 8 times shorter than untreated blood,10 times shorter than negative control and 6 times shorter than positive control.Conclusions The test styptic fiber has powerful hemostatic effect.展开更多
目的分析止血散瘀明目汤与西药联合治疗非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的效果。方法选取2022年8月—2023年7月曹县人民医院收治的NPDR患者98例为研究对象,按照随机数表分为对照组和研究组。对...目的分析止血散瘀明目汤与西药联合治疗非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的效果。方法选取2022年8月—2023年7月曹县人民医院收治的NPDR患者98例为研究对象,按照随机数表分为对照组和研究组。对照组(49例)采用羟苯磺酸钙胶囊治疗,研究组(49例)在其基础上联合止血散瘀明目汤治疗。比较两组的临床疗效、视力指标、糖尿病生存质量特异性量表(Diabetes Specific Quality of Life Scale,DSQL)评分,以及不良反应发生情况。结果研究组总有效率为93.88%高于对照组的75.51%,差异有统计学意义(χ^(2)=6.376,P<0.05)。两组治疗前视力指标对比,差异无统计学意义(P>0.05);研究组治疗3个月后的视力指标为(0.77±0.14)较对照组的(0.67±0.15)高,差异有统计学意义(t=3.412,P<0.05);研究组DSQL评分较对照组低,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义P>0.05)。结论NPDR患者采用止血散瘀明目汤与西药联合治疗能够取得较为理想的效果,进一步提高了视力水平,保障生活质量。展开更多
文摘Objective To explore the influence of styptic fiber on clotting time in rabbits so as to provide experiment data for its development.Methods Onto 0.1 mL aliquots of citrated anti-coagulant rabbit blood placed in a surfacial plate 25 ul of 0.2 mol·L-1 CaCl2 solution was dropped,and mixed well with glass stirrer;the resulting mixture was immediately capped with a piece of styptic fiber(test product group)or absorptive gelatin sponge(positive control group)of 2 cm diameter.Then,the surficial plate was rinsed with 30ml of purified water at 5,10,20,30,40 and 50 min after capping;the rinsings were allowed to stand for 1 h and were subjected to OD determination at a wavelength of 541 nm.The above procedure was repeated twice,the average value of the twice experiments was taken for evaluation of the hemostatic effect of test product.For negative control group,all procedures except for capping were same as the test product group.The haemostatic effect was judged by percent OD relative to OD at 0 min in negative control group(OD 0 min)(OD 0 min was considered as 100%);if OD value at a time was less than 80% of OD 0 min,it should be designated as primary clotting time(PCT),less than 20% as complete clotting time(CCT).Results The measured PCT was 20min for both negative and positive control groups;CCT was 50,30 and 5 min for negative control,positive control and test product groups,respectively,showing the test styptic fiber had a CCT 8 times shorter than untreated blood,10 times shorter than negative control and 6 times shorter than positive control.Conclusions The test styptic fiber has powerful hemostatic effect.
文摘目的分析止血散瘀明目汤与西药联合治疗非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的效果。方法选取2022年8月—2023年7月曹县人民医院收治的NPDR患者98例为研究对象,按照随机数表分为对照组和研究组。对照组(49例)采用羟苯磺酸钙胶囊治疗,研究组(49例)在其基础上联合止血散瘀明目汤治疗。比较两组的临床疗效、视力指标、糖尿病生存质量特异性量表(Diabetes Specific Quality of Life Scale,DSQL)评分,以及不良反应发生情况。结果研究组总有效率为93.88%高于对照组的75.51%,差异有统计学意义(χ^(2)=6.376,P<0.05)。两组治疗前视力指标对比,差异无统计学意义(P>0.05);研究组治疗3个月后的视力指标为(0.77±0.14)较对照组的(0.67±0.15)高,差异有统计学意义(t=3.412,P<0.05);研究组DSQL评分较对照组低,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义P>0.05)。结论NPDR患者采用止血散瘀明目汤与西药联合治疗能够取得较为理想的效果,进一步提高了视力水平,保障生活质量。
