BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased s...BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations.展开更多
目的评价天王补心汤结合睡眠卫生宣教以及天王补心汤单独干预阴虚火旺型亚健康失眠的临床疗效、安全性、依从性。方法采用多中心、单盲、随机对照研究设计,研究对象为101例阴虚火旺型亚健康失眠受试者,随机分为天王补心汤结合睡眠卫生...目的评价天王补心汤结合睡眠卫生宣教以及天王补心汤单独干预阴虚火旺型亚健康失眠的临床疗效、安全性、依从性。方法采用多中心、单盲、随机对照研究设计,研究对象为101例阴虚火旺型亚健康失眠受试者,随机分为天王补心汤结合睡眠卫生宣教组(治疗组)50例和单纯天王补心汤治疗组(对照组)51例,比较两组有效率、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、临床医生总体印象(clinical global impression-improvement,CGI)评分、WHO生活质量测定量表(quality of life made by WHO,WHOQOL-BREF)评分以及安全性。结果治疗组有效率(68.08%)低于对照组(75.00%),但差异无统计学意义;治疗组治疗前后PSQI评分分别为(12.00±2.25)、(7.55±2.91)分,对照组治疗前后PSQI评分分别为(11.68±2.21)、(7.16±3.13)分,两组治疗后均有明显改善(P<0.01);两组治疗后CGI评分、WHO-QOL-BREF评分也有改善(P<0.01),治疗后各指标两组间比较差异无统计学意义。两组停药2周后与疗程结束时CGI比较,差异无统计学意义(P>0.05),两组间比较差异无统计学意义(P>0.05)。结论天王补心汤联合睡眠卫生宣教与单纯天王补心汤对阴虚火旺型亚健康失眠的干预均有显著效果,疗效相当,且依从性及安全性高。展开更多
Soil properties of healthy,sub-healthy and unhealthy Pinus yunnanensis secondary forest were measured and their correlation with the health conditions of Pinus yunnanensis forest were analyzed.The results revealed tha...Soil properties of healthy,sub-healthy and unhealthy Pinus yunnanensis secondary forest were measured and their correlation with the health conditions of Pinus yunnanensis forest were analyzed.The results revealed that,the soil water content,bulk density,porosity,sand content,cosmid content,CEC and radily available K content changed regularly with the health condition changes of Pinus yunnanensis forest.Correlation analysis revealed that,there were positive correlation between soil water content,porosity,cosmid content,CEC,radily available K content and health conditions of Pinus yunnanensis forest;and negative correlation between bulk density,sand content,meal content and health conditions of Pinus yunnanensis forest.By stepwise regression analysis,the regression models about health conditions of Pinus yunnanensis forest and soil properties were established.展开更多
基金Fundationde AmparoàPesquisa do Estado de Minas Gerais,No.APQ-02320-18.
文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations.
文摘目的评价天王补心汤结合睡眠卫生宣教以及天王补心汤单独干预阴虚火旺型亚健康失眠的临床疗效、安全性、依从性。方法采用多中心、单盲、随机对照研究设计,研究对象为101例阴虚火旺型亚健康失眠受试者,随机分为天王补心汤结合睡眠卫生宣教组(治疗组)50例和单纯天王补心汤治疗组(对照组)51例,比较两组有效率、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、临床医生总体印象(clinical global impression-improvement,CGI)评分、WHO生活质量测定量表(quality of life made by WHO,WHOQOL-BREF)评分以及安全性。结果治疗组有效率(68.08%)低于对照组(75.00%),但差异无统计学意义;治疗组治疗前后PSQI评分分别为(12.00±2.25)、(7.55±2.91)分,对照组治疗前后PSQI评分分别为(11.68±2.21)、(7.16±3.13)分,两组治疗后均有明显改善(P<0.01);两组治疗后CGI评分、WHO-QOL-BREF评分也有改善(P<0.01),治疗后各指标两组间比较差异无统计学意义。两组停药2周后与疗程结束时CGI比较,差异无统计学意义(P>0.05),两组间比较差异无统计学意义(P>0.05)。结论天王补心汤联合睡眠卫生宣教与单纯天王补心汤对阴虚火旺型亚健康失眠的干预均有显著效果,疗效相当,且依从性及安全性高。
文摘Soil properties of healthy,sub-healthy and unhealthy Pinus yunnanensis secondary forest were measured and their correlation with the health conditions of Pinus yunnanensis forest were analyzed.The results revealed that,the soil water content,bulk density,porosity,sand content,cosmid content,CEC and radily available K content changed regularly with the health condition changes of Pinus yunnanensis forest.Correlation analysis revealed that,there were positive correlation between soil water content,porosity,cosmid content,CEC,radily available K content and health conditions of Pinus yunnanensis forest;and negative correlation between bulk density,sand content,meal content and health conditions of Pinus yunnanensis forest.By stepwise regression analysis,the regression models about health conditions of Pinus yunnanensis forest and soil properties were established.
