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Visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery 被引量:1
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作者 Wei-Qi Chen Vishal Jhanji +2 位作者 Hao-Yu Chen Gui-Hua Zhang Ping Hou 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第5期860-863,共4页
AIM:To investigate the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery.METHODS:In this prospective case series, consecutive patients who underwent combined phacoemulsif... AIM:To investigate the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery.METHODS:In this prospective case series, consecutive patients who underwent combined phacoemulsification and pars plana vitrectomy(PPV) under sub-Tenon anesthesia between October 2008 and September 2009 were enrolled. The patients were asked whether they could see the light of the operating microscope or not between various surgical steps with their contralateral eye being covered.RESULTS:A total of 163 eyes of 163 patients were enrolled in this study. After their contralateral eyes were covered, 152(93.3%) patients said that they could not see any light at least during one of the surgical steps. All eyes recovered to at least light perception on the first postoperative day. The incidence of no light perception during the surgery was not related to demographic factors, including age, gender, or type of ocular diseases.CONCLUSION:The incidence of no light perception during combined phacoemulsification and vitrectomy under sub-Tenon anesthesia was high in our study.Patients should be duly informed about this temporary but potential intraoperative event. 展开更多
关键词 visual impact sub-tenon anesthesia PHACOEMULsIFICATION VITRECTOMY
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Comment on visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery
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作者 Kelvin Z.Li Colin S.Tan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第2期323-324,共2页
Dear Editor,We read with interest the article by Chen etaitlj on the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery. The authors reported that 93.3% of patients in the... Dear Editor,We read with interest the article by Chen etaitlj on the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery. The authors reported that 93.3% of patients in the study experienced loss of perception of light at least during one of the surgical steps after the contralateral eye was covered intraoperatively. Most of the patients (81%) reported losing light perception between 6min and 30min from the commencement of the surgery. 展开更多
关键词 LAsIK Comment on visual impact of sub-tenon anesthesia during combined phacoemulsification and vitrectomy surgery
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Anesthesia and perioperative management for giant adrenal Ewing’s sarcoma with inferior vena cava and right atrium tumor thrombus:A case report
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作者 Ji-Lian Wang Chuan-Ya Xu +8 位作者 Chun-Jing Geng Lei Liu Ming-Zhu Zhang Hua Wang Ruo-Tao Xiao Lu Liu Geng Zhang Cheng Ni Xiang-Yang Guo 《World Journal of Clinical Cases》 SCIE 2022年第2期643-655,共13页
BACKGROUND Ewing’s sarcoma of the adrenal gland with inferior vena cava(IVC)and right atrium thrombus is extremely rare.Here,we report a case of giant adrenal Ewing’s sarcoma with IVC and right atrium tumor thrombus... BACKGROUND Ewing’s sarcoma of the adrenal gland with inferior vena cava(IVC)and right atrium thrombus is extremely rare.Here,we report a case of giant adrenal Ewing’s sarcoma with IVC and right atrium tumor thrombus and summarize the anesthesia and perioperative management.CASE SUMMARY A young female was admitted to the Department of Urology with intermittent pain under the right costal arch for four months.Enhanced abdominal computed tomography revealed a large retroperitoneal mass(22 cm in diameter),which may have originated from the right adrenal gland and was closely related to the liver.Transthoracic echocardiography showed a strong echogenic filling measuring 70 mm extended from the IVC into the right atrium and ventricle.After preoperative preparation with cardiopulmonary bypass,sufficient blood products,transesophageal echocardiography and multiple monitoring,tumor and thrombus resection by IVC exploration and right atriotomy were successfully performed by a multidisciplinary team.Intraoperative hemodynamic stability was the major concern of anesthesiologists and the status of tumor thrombus and pulmonary embolism were monitored continuously.During transfer of the patient to the intensive care unit(ICU),cardiac arrest occurred without external stimulus.Cardiopulmonary resuscitation was performed immediately and cardiac function was restored after 1 min.In the ICU,extracorporeal membrane oxygenation(ECMO)and continuous renal replacement therapy(CRRT)were provided to maintain cardiac,liver and kidney function.Histopathologic examination confirmed the diagnosis of Ewing’s sarcoma.After postoperative treatments and rehabilitation,the patient was discharged from the urology ward.CONCLUSION An adrenal Ewing’s sarcoma with IVC and right atrium thrombus is extremely rare,and its anesthesia and perioperative management have not been reported.Thus,this report provides significant insights in the perioperative management of patients with adrenal Ewing’s sarcoma and IVC tumor thrombus.Intraoperative circulation fluctuations and sudden cardiovascular events are the major challenges during surgery.In addition,postoperative treatments including ECMO and CRRT provide essential support in critically ill patients.Moreover,this case report also highlights the importance of multidisciplinary cooperation during treatment of the disease. 展开更多
关键词 Ewing’s sarcoma anesthesia Inferior vena cava Cardiac arrest Tumor thrombus
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New onset atrial fibrillation following sub-Tenon's anaesthesia
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作者 Elliott Y.Ah-kee James F.Li Yim 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第6期900-901,共2页
Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s block.Cataract surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local anaesth... Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s block.Cataract surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local anaesthesia.This can be done with sub-Tenon’s,retrobulbar,peribulbar,intracameral or topical anaesthesia[1].Sub-Tenon’s anaesthesia involves opening the conjunctiva and tenon’s 展开更多
关键词 Figure New onset atrial fibrillation following sub-tenons anaesthesia
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Necrotizing Scleritis Associated with 5-Fluorouracil and Sub-Tenon’s Block in Patient with Previous Trabeculectomy: A Case Report
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作者 Tuan A. Tran Jeremy O’Connor +2 位作者 Xavier Fagan Tu Tran Dan Nguyen 《Open Journal of Ophthalmology》 2013年第3期73-75,共3页
Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associat... Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associated. We report a case of necrotizing scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of necrotizing scleritis associated with 5-FU. This may implicate alternative approaches to local anaesthetic techniques when using adjunctive 5-FU. 展开更多
关键词 NECROTIZING sCLERITIs 5-FLUOROURACIL sub-tenons Block Glaucoma
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老年全身麻醉患者血清ADP、S-100β蛋白及HIF-1α水平与术后认知功能障碍的相关性分析
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作者 宁栩 陈欢 +1 位作者 司海超 司小萌 《中国医学工程》 2023年第1期96-100,共5页
目的探讨老年全身麻醉患者血清脂联素(ADP)、S-100β蛋白及缺氧诱导因子-1α(HIF-1α)水平与术后认知功能障碍(POCD)的相关性。方法选取南阳市中心医院2017年1月至2019年1月收治的159例接受手术治疗的老年患者,根据术后简易精神状态检查... 目的探讨老年全身麻醉患者血清脂联素(ADP)、S-100β蛋白及缺氧诱导因子-1α(HIF-1α)水平与术后认知功能障碍(POCD)的相关性。方法选取南阳市中心医院2017年1月至2019年1月收治的159例接受手术治疗的老年患者,根据术后简易精神状态检查表(MMSE)评分分为POCD组(MMSE<27分,n=53)和非POCD组(MMSE≥27分,n=106),比较两组患者手术前后ADP、S-100β蛋白、HIF-1α水平变化,Pearson相关性分析MMSE评分与血清ADP、S-100β蛋白、HIF-1α水平的相关性,受试者操作特征(ROC)曲线分析血清ADP、S-100β蛋白、HIF-1α水平对老年全身麻醉POCD的预测价值。结果术后两组血清ADP水平和MMSE评分均明显降低,S-100β蛋白、HIF-1α水平明显提升,POCD组较非POCD组改变更明显(P<0.05);Pearson相关性分析显示,POCD组术后MMSE评分与血清ADP水平呈正相关,与S-100β蛋白、HIF-1α水平呈负相关(P<0.05);ROC曲线显示,ADP+S-100β蛋白+HIF-1α预测老年全身麻醉患者POCD的曲线下面积(AUC)、敏感度、特异度高于各指标单独预测。结论老年全身麻醉POCD患者血清ADP水平明显降低,S-100β蛋白和HIF-1α水平明显提升,与POCD发生密切相关,联合检测能提升POCD预测价值。 展开更多
关键词 老年 全身麻醉 术后认知功能障碍 脂联素 s-100Β蛋白 缺氧诱导因子-1Α
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Rare complication:Tapia's syndrome following shoulder surgery under endotracheal general anesthesia
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作者 Eda Simsek ilker Eren 《World Journal of Otorhinolaryngology》 2015年第2期71-73,共3页
Tapia's syndrome is a rare disorder, characterized with paralysis of extracranial part of Nervus Vagus and Nervus Hypoglossus, effecting the ipsilateral vocal cord and the tongue. This complication is usually rela... Tapia's syndrome is a rare disorder, characterized with paralysis of extracranial part of Nervus Vagus and Nervus Hypoglossus, effecting the ipsilateral vocal cord and the tongue. This complication is usually related to intubation and head positioning during surgery. In this study, we report a case with Tapia's syndrome under general anesthesia, following arthroscopic shoulder instability surgery. Patient recovered as short as 3 mo, following complication. 展开更多
关键词 Tapia’s syndrome General anesthesia shoulder arthrocopy COMPLICATION
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Anesthetic management of a pregnant patient with Eisenmenger’s syndrome:A case report
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作者 Ying Zhang Ting-Ting Wei Gang Chen 《World Journal of Clinical Cases》 SCIE 2023年第27期6597-6602,共6页
BACKGROUND Eisenmenger’s syndrome(ES)is a rare complication of congenital heart disease that includes pulmonary artery hypertension and reversed or bidirectional shunts.The mortality rate of pregnant women with ES is... BACKGROUND Eisenmenger’s syndrome(ES)is a rare complication of congenital heart disease that includes pulmonary artery hypertension and reversed or bidirectional shunts.The mortality rate of pregnant women with ES is 30%-70%due to pathophysiological deterioration.Successful perioperative management of a pregnant patient with ES is a challenge for anesthesiologists.CASE SUMMARY A 38-year-old pregnant woman was admitted to the cardiology department of our hospital at 22 wk of gestation with complaints of chest tightness and shortness of breath for 3 wk.Transthoracic echocardiography revealed a bidirectional shunt between the descending aorta and pulmonary artery after interventional closure of the patent ductus arteriosus and severe pulmonary hypertension.ES in pregnancy was our primary suspicion.The patient elected to terminate the pregnancy under adequate preoperative preparation,rigorous intraoperative monitoring,and perfect epidural anesthesia.She was discharged successfully on postoperative day 16.CONCLUSION Our experience in this case suggests that successful outcomes are possible in pregnant patients with ES for termination of pregnancy under epidural anesthesia and intensive monitoring. 展开更多
关键词 Eisenmenger’s syndrome Pulmonary artery hypertension PREGNANCY MONITORING Epidural anesthesia Case report
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不同BIS值对全麻下老年患者腹部手术术后早期认知功能及S100β蛋白的影响 被引量:37
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作者 岳明明 张印龙 +2 位作者 王胜 代志刚 高元丽 《临床麻醉学杂志》 CAS CSCD 北大核心 2016年第2期109-113,共5页
目的研究不同BIS值对全麻下老年患者腹部手术术后早期认知功能及S100β蛋白的影响。方法选择全麻下择期行腹部手术的患者50例,男34例,女16例,年龄65-75岁,ASAⅠ或Ⅱ级,按照随机数字表法分为浅麻醉组(L组)和深麻醉组(D组),每组25例。... 目的研究不同BIS值对全麻下老年患者腹部手术术后早期认知功能及S100β蛋白的影响。方法选择全麻下择期行腹部手术的患者50例,男34例,女16例,年龄65-75岁,ASAⅠ或Ⅱ级,按照随机数字表法分为浅麻醉组(L组)和深麻醉组(D组),每组25例。L组BIS值维持在50-59,D组BIS值维持在30-39。记录入室后静卧5min(T0)、插管前即刻(T1)、手术切皮即刻(T2)、手术进行2h时(T3)、手术进行3h时(T4)、术毕(T5)时的BP、HR、SpO2、ECG、PETCO2、吸入麻醉药浓度、BIS值;记录两组的麻醉时间、手术时间、术后1d的VAS评分、丙泊酚用量、芬太尼用量、咪达唑仑用量。于麻醉前10min、术毕及术后24、48h时采集血液标本,测定S100β蛋白浓度;于术前1d及术后1、3、7d随访记录患者MMSE评分及TMT完成时间。结果 D组T2、T3、T4时BIS值明显低于L组(P〈0.05);D组丙泊酚用量明显多于L组(P〈0.05)。与麻醉前10min比较,术毕和术后48h两组血清S100β蛋白含量明显升高,术后24h两组血清S100β蛋白含量有增高趋势,但差异无统计学意义;与术毕比较,术后24h两组血清S100β蛋白含量明显降低(P〈0.05),L组术毕、术后24h血清S100β蛋白含量明显高于D组(P〈0.05)。与术前1d比较,术后1d两组MMSE评分明显降低,术后3dL组MMSE评分明显降低(P〈0.01);与术后3d比较,术后7dL组MMSE评分明显升高(P〈0.01);L组术后1、3d的MMSE评分明显低于D组(P〈0.05)。与术前1d比较,术后1d两组TMT完成时间明显延长(P〈0.01);与术后1d比较,术后3d两组TMT完成时间明显缩短(P〈0.01);与术后3d比较,术后7dL组的TMT完成时间明显缩短(P〈0.01);术后1、3dL组TMT完成时间明显长于D组(P〈0.05)。术后1dL组POCD发生率明显高于D组(P〈0.05)。结论不同麻醉深度均可保证老年患者术中和术后血流动力学平衡,且术后均发生不同程度的认知功能障碍,但术中将BIS值维持在30-39的深麻醉组血清S100β蛋白水平及早期POCD的发生率较低,术后认知功能损伤程度较轻。 展开更多
关键词 老年 术后认知功能障碍 麻醉深度 s100Β蛋白
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外源性H_2S对氯胺酮全麻大鼠主要生理指标的影响 被引量:4
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作者 李妍 唐琦超 +6 位作者 时静 刘海玉 姜胜 白春杨 白鸽 赵越 范宏刚 《中国畜牧兽医》 CAS 北大核心 2014年第9期150-154,共5页
外源性H2S在诸多方面对中枢神经系统具有保护性作用,本研究通过预试验确定了外源性H2S的给药时间和剂量,将48只SD大鼠随机均分为4组,分别为对照组(CP组)、低剂量组(LP组,7μmol/kg NaHS)、中剂量组(MP组,14μmol/kg NaHS)、高剂量组(GP... 外源性H2S在诸多方面对中枢神经系统具有保护性作用,本研究通过预试验确定了外源性H2S的给药时间和剂量,将48只SD大鼠随机均分为4组,分别为对照组(CP组)、低剂量组(LP组,7μmol/kg NaHS)、中剂量组(MP组,14μmol/kg NaHS)、高剂量组(GP组,28μmol/kg NaHS)。在盐酸氯胺酮麻醉前20min,3个剂量组分别腹腔注射7、14、28μmol/kg NaHS,观察外源性H2S对大鼠体温、心率、呼吸频率、血氧饱和度及血压等生理指标的干预效果。试验结果表明,与对照组相比,3个剂量组体温和血氧饱和度浓度均显著升高(P<0.05),心率和血压均显著降低(P<0.05),但呼吸频率呈先减慢后加快趋势,且这些变化呈显著的剂量依赖性。 展开更多
关键词 外源性H2s 氯胺酮 麻醉 生理指标
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老年全身麻醉患者血清S-100β蛋白、神经元特异性烯醇化酶及脑氧饱和度与认知功能障碍的相关性 被引量:25
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作者 汪辉德 钟庆 翁艳 《检验医学与临床》 CAS 2018年第9期1252-1254,1258,共4页
目的探讨老年全身麻醉患者血清S-100β蛋白、神经元特异性烯醇化酶(NSE)及脑氧饱和度(rSO_2)与术后认知功能障碍(POCD)的相关性。方法选取该院127例选择全身麻醉进行手术的老年患者为研究对象,分为POCD组63例和对照组64例,分别检测2组... 目的探讨老年全身麻醉患者血清S-100β蛋白、神经元特异性烯醇化酶(NSE)及脑氧饱和度(rSO_2)与术后认知功能障碍(POCD)的相关性。方法选取该院127例选择全身麻醉进行手术的老年患者为研究对象,分为POCD组63例和对照组64例,分别检测2组患者术前、术中及术后血清S-100β蛋白、NES及rSO_2水平,并进行比对,分析3项检测指标与老年全身麻醉患者POCD的相关性。结果与对照组相比,POCD组患者血清S-100β和NES在手术开始时刻(T1)、手术进行1h(T2)、术毕(T3)和术后24h(T4)均明显升高,且明显高于麻醉诱导前(T0)(P<0.05);2组患者rSO_2水平在术中明显升高,并在术后降低,且POCD组术后rSO_2水平明显低于对照组及其T0时水平(P<0.05);血清S-100β蛋白和NES水平与老年全身麻醉患者MMSE评分呈负相关(r=-0.684、-0.729),而rSO_2则与患者简易智力精神状态量表评分呈正相关(r=0.891)。结论老年全身麻醉患者血清S-100β蛋白、NES和rSO_2均与POCD明显相关,可作为早期诊断POCD的参考依据。 展开更多
关键词 麻醉 s-100Β蛋白 神经元特异性烯醇化酶 脑氧饱和度 认知功能障碍
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右美托咪定联合瑞芬太尼对髋关节置换术老年患者S-100β和高迁移率族蛋白B1的影响 被引量:9
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作者 支燕 赵满意 顾羊林 《西北药学杂志》 CAS 2019年第6期806-810,共5页
目的研究右美托咪定联合瑞芬太尼治疗全身麻醉下髋关节置换术老年患者的疗效及其对患者血清S-100β和高迁移率族蛋白B1(HMGB1)水平的影响。方法选取拟行髋关节置换术老年患者80例,按照随机数字表法分为对照组和观察组,每组40例。对照组... 目的研究右美托咪定联合瑞芬太尼治疗全身麻醉下髋关节置换术老年患者的疗效及其对患者血清S-100β和高迁移率族蛋白B1(HMGB1)水平的影响。方法选取拟行髋关节置换术老年患者80例,按照随机数字表法分为对照组和观察组,每组40例。对照组给予瑞芬太尼进行全身麻醉诱导及维持,观察组给予瑞芬太尼及右美托咪定进行全身麻醉维持及诱导。观察比较2组患者的简易精神状态评价量表(MMSE)评分、术后睁眼时间、拔管时间、呼吸恢复时间、S-100β水平、HMGB1水平及不良反应。结果术后1 d,2组患者的MMSE评分比较差异无统计学意义(P>0.05),观察组的术后认知功能障碍(POCD)发生率低于对照组(P<0.05)。术后3 d及术后7 d,观察组的MMSE评分高于对照组,POCD发生率低于对照组(P<0.05)。2组患者的拔管时间、睁眼时间及恢复呼吸时间差异无统计学意义。术前2组患者的S-100β及HMGB1水平相当,但术毕及术后1 d,观察组的S-100β及HMGB1水平均低于对照组(P<0.05)。2组患者的不良反应发生率差异无统计学意义。结论右美托咪定联合瑞芬太尼用于全身麻醉下髋关节置换术老年患者具有良好的效果,可有效减轻患者的POCD和术后炎症反应,且安全性高。 展开更多
关键词 右美托咪定 瑞芬太尼 全身麻醉 髋关节置换术 s-100Β 高迁移率族蛋白B1
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48例Ebstein畸形患者手术的麻醉处理研究 被引量:1
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作者 陈芳 于钦军 +1 位作者 常勇男 李立环 《中国循环杂志》 CSCD 北大核心 2009年第5期383-386,共4页
目的:探讨埃博斯坦(Ebstein)畸形患者手术治疗的麻醉处理方法。方法:对1999-01至2008-05在我院手术治疗的Ebstein畸形患者共48例进行了总结。全部病例采用静吸复合全身麻醉。术中除常规监测外,经食管超声心动图是围术期必要的监测手段... 目的:探讨埃博斯坦(Ebstein)畸形患者手术治疗的麻醉处理方法。方法:对1999-01至2008-05在我院手术治疗的Ebstein畸形患者共48例进行了总结。全部病例采用静吸复合全身麻醉。术中除常规监测外,经食管超声心动图是围术期必要的监测手段。麻醉维持以中、大剂量芬太尼为主,辅以静脉泵入异丙酚和吸入低浓度的异氟醚或七氟醚。术中控制适当容量,使用血管活性药物,调整内环境至稳定,避免肺血管阻力增加,避免心律失常。结果:全组患者35例治愈,9例好转,4例死亡。出院患者症状均有明显改善,围术期血流动力学基本平稳。结论:术前正确评估患者病情,选择正确麻醉方式,术中维护心血管功能稳定和维持低状态肺血管阻力,避免心律失常是患者安全渡过围术期的关键。 展开更多
关键词 Ebstein’s畸形 麻醉
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右美托咪定对Wilson病继发脾功能亢进患者全身麻醉下脾切除术后躁动的影响 被引量:2
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作者 张永志 张野 +1 位作者 张丁 季淼 《中国药房》 CAS 北大核心 2017年第32期4513-4516,共4页
目的:观察右美托咪定对Wilson病继发脾功能亢进患者全身麻醉下脾切除术后躁动的影响。方法:选取某院2016年1-12月的全身麻醉下行脾切除术Wilson病继发脾功能亢进患者60例,按随机数字表法分为对照组和观察组,各30例。观察组患者麻醉诱导... 目的:观察右美托咪定对Wilson病继发脾功能亢进患者全身麻醉下脾切除术后躁动的影响。方法:选取某院2016年1-12月的全身麻醉下行脾切除术Wilson病继发脾功能亢进患者60例,按随机数字表法分为对照组和观察组,各30例。观察组患者麻醉诱导前15 min静脉恒速泵注右美托咪定0.4μg/kg,之后为0.4μg/(kg·h)维持至脾切除后;对照组患者给予等量的生理盐水,其余麻醉方案两组相同。观察两组患者开始泵注前(T_0)、插管前(T_1)、插管后1 min(T_2)、拔管前(T_3)及拔管后3 min(T_4)的平均动脉压(MAP)、心率(HR)和血氧饱和度(SpO_2),记录两组患者T_3和T_4时间点Riker镇静-躁动评分(SAS),比较两组患者麻醉后监测治疗室(PACU)停留时间及心动过缓发生情况。结果:T_0时,两组患者MAP、HR、SpO_2水平比较,差异无统计学意义(P>0.05);T1、T_2、T_3、T_4时,两组患者MAP、HR水平均显著降低,且观察组显著低于对照组,差异均有统计学意义(P<0.05);但SpO_2所有时间点均为100%,组间比较,差异无统计学意义(P>0.05)。观察组患者T_3、T_4时Riker SAS评分均显著低于对照组,差异均有统计学意义(P<0.05)。观察组患者心动过缓发生率为26.67%,显著高于对照组的3.33%,差异有统计学意义(P<0.05),但静脉注射阿托品后均得以纠正。观察组PACU停留时间显著短于对照组,差异有统计学意义(P<0.05)。结论:右美托咪定能稳定Wilson病继发脾功能亢进患者术后血流动力学,降低躁动情况,并缩短PACU转出时间。 展开更多
关键词 右美托咪定 术后躁动 WILsON病 脾切除 全身麻醉
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右美托咪定对颅脑损伤患者血清S100β蛋白及神经元特异烯醇化酶的影响 被引量:7
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作者 马骋 沈晶 +4 位作者 陈益君 陈春茹 何建国 邵景汉 黄长顺 《现代实用医学》 2015年第6期708-710,共3页
目的探讨在全身麻醉下使用右美托咪定对颅脑损伤患者血清S100β蛋白及神经元特异性烯醇化酶(NSE)水平的影响。方法 80例在全身麻醉下行开颅血肿清除去骨瓣减压术患者,随机分为右美托咪定组(观察组,=40)和0.9%氯化钠注射液组(对照组,=40... 目的探讨在全身麻醉下使用右美托咪定对颅脑损伤患者血清S100β蛋白及神经元特异性烯醇化酶(NSE)水平的影响。方法 80例在全身麻醉下行开颅血肿清除去骨瓣减压术患者,随机分为右美托咪定组(观察组,=40)和0.9%氯化钠注射液组(对照组,=40)分别于麻醉诱导即刻(T1)、术毕即刻(T2)、术毕6h(T3)、术毕12 h(T4)、术毕24 h(T5)抽取患者静脉血,用酶联免疫吸附(ELISA)测定S100β蛋白及NSE值。结果两组血清S100β蛋白、NSE浓度T2、T3、T4及T5较T1均显著升高(均<0.05);与对照组比较,观察组T2、T3、T4及T5时点的S100蛋白、NSE浓度均明显降低,差异均有统计学意义(均<0.05)。结论使用右美托咪定可使颅脑损伤患者血清S100蛋白及NSE浓度下降,具有脑保护作用。 展开更多
关键词 颅脑损伤 全身麻醉 右美托咪定 神经元特异性烯醇化酶 s100蛋白
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针刺麻醉与气体麻醉对老年患者术后认知功能障碍及NSE、S-100β蛋白水平变化的影响 被引量:33
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作者 刘智 滕永杰 何慧鑫 《世界中医药》 CAS 2018年第11期2858-2861,共4页
目的:探究针刺麻醉与气体麻醉联合对老年患者术后认知功能障碍及对NSE、S-100β蛋白水平的影响。方法:选取2015年1月至2016年9月湖南省中医药大学第一附属医院收治与标准相符的手术老年患者99例。随机盲法将患者分为观察组(n=50)和对照... 目的:探究针刺麻醉与气体麻醉联合对老年患者术后认知功能障碍及对NSE、S-100β蛋白水平的影响。方法:选取2015年1月至2016年9月湖南省中医药大学第一附属医院收治与标准相符的手术老年患者99例。随机盲法将患者分为观察组(n=50)和对照组(n=49)。观察组术前对百会穴、内关穴、足三里穴、三阴交穴等进行预先行电针,并实施全麻和吸入七氯烷维持麻醉,过程一直保持电针不变。对照组在全麻基础上仅吸入七氯烷维持麻醉。比较2组手术前24 h及术后1 h、24 h的简易智能量表(MMSE)所评定的认知功能改变;检测2组患者手术开始前24 h、手术结束时、手术24 h的血清NSE、S-100β蛋白变化。结果:与对照组比较,观察组术后1 h MMSE评分显著升高(P <0. 05),认知功能障碍(POCD)和躁动症发生率显著减少(P <0. 05)。与对照组比较,在手术1 h和手术24 h后,观察组的颈内静脉血清NSE、S-100β蛋白浓度显著降低(P <0. 05)。结论:针刺麻醉联合气体麻醉优于单纯气体麻醉,由于老年人神经系统的脆弱性,联合麻醉能够减轻麻醉对神经系统的损伤,进一步加快认知功能的修复,降低术后认知功能发生率,具有较好的临床应用价值。 展开更多
关键词 针刺麻醉 气体麻醉 老年患者 认知功能 NEs s-100Β
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Plasma-Lyte 148: A clinical review 被引量:5
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作者 Laurence Weinberg Neil Collins +2 位作者 Kiara Van Mourik Chong Tan Rinaldo Bellomo 《World Journal of Critical Care Medicine》 2016年第4期235-250,共16页
AIM To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine.METHODS We performed an e... AIM To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine.METHODS We performed an electronic literature search from Medline and Pub Med(via Ovid), anesthesia and pharmacology textbooks, and online sources including studies that compared Plasma-Lyte 148 to other crystalloid solutions. The following keywords were used: "surgery", "anaesthesia", "anesthesia", "anesthesiology", "anaesthesiology", "fluids", "fluid therapy", "crystalloid", "saline", "plasma-Lyte", "plasmalyte", "hartmann's", "ringers" "acetate", "gluconate", "malate", "lactate". All relevant articles were accessed in full. We summarized the data and reported the data in tables and text. RESULTS We retrieved 104 articles relevant to the choice of Plasma-Lyte 148 for fluid intervention in critical illness, surgery and perioperative medicine. We analyzed the data and reported the results in tables and text.CONCLUSION Plasma-Lyte 148 is an isotonic, buffered intravenous crystalloid solution with a physiochemical composition that closely reflects human plasma. Emerging data supports the use of buffered crystalloid solutions in preference to saline in improving physicochemical outcomes. Further large randomized controlled trials assessing the comparative effectiveness of PlasmaLyte 148 and other crystalloid solutions in measuring clinically important outcomes such as morbidity and mortality are needed. 展开更多
关键词 surgery anesthesia Fluid therapy CRYsTALLOIDs sALINE Plasma-Lyte Hartmann’s Ringers ACETATE GLUCONATE LACTATE
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硬膜外阻滞麻醉和全身麻醉对术后老年患者血清S-100β蛋白水平及认知功能的影响 被引量:6
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作者 蒋敢 吕苗苗 +1 位作者 曹艳 王军 《贵州医科大学学报》 CAS 2020年第6期722-726,共5页
目的:分析硬膜外阻滞麻醉和全身麻醉对术后老年患者血清S-100β蛋白水平及认知功能的影响。方法:老年患者100例随机均分为对照组(实施全身麻醉)和研究组(实施硬膜外阻滞麻醉),收集2组患者年龄、性别、手术类型及ASA分级等基础资料;抽取... 目的:分析硬膜外阻滞麻醉和全身麻醉对术后老年患者血清S-100β蛋白水平及认知功能的影响。方法:老年患者100例随机均分为对照组(实施全身麻醉)和研究组(实施硬膜外阻滞麻醉),收集2组患者年龄、性别、手术类型及ASA分级等基础资料;抽取2组患者术前和术后6、12、24及72 h的静脉血,采用酶联免疫吸附(ELIAS)方法检测血清S-100β蛋白;采用简易精神状态量表(MMSE)评估2组患者术前和术后6、12、24及72 h的认知功能,同时比较2组患者手术时长、手术出血量、麻醉时间、补液量及疼痛程度(VAS评分)等手术治疗相关指标。结果:2组老年患者的年龄、性别、手术类型及ASA分级等基础资料比较差异无统计学意义(P>0. 05);研究组术后6 h、12 h、24 h血清S-100β蛋白水平高于对照组,但认知功能评分低于对照组,差异均有统计学意义(P <0. 05);2组患者手术时长、手术出血量、VAS评分、麻醉时间及补液量等手术相关指标均值差异无统计学意义(P>0. 05)。结论:与全身麻醉相比,硬膜外阻滞麻醉能够减轻术后老年患者的认知功能障碍程度,可能与降低血清S-100β蛋白水平有关。 展开更多
关键词 麻醉 全身 老年人 外科手术 硬膜外阻滞麻醉 s-100Β蛋白 认知功能
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硬膜外阻滞麻醉与全麻对老年患者术后血清S-100β蛋白水平及认知功能的影响比较 被引量:3
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作者 江跃东 胡汉宇 《中外医学研究》 2019年第18期1-3,共3页
目的:比较硬膜外阻滞麻醉与全麻对老年患者术后血清S-100β蛋白水平及认知功能的影响。方法:90例拟行手术治疗的老年患者根据数字表法随机分为两组,全麻组(n=45)采用全身麻醉,硬膜外阻滞麻醉组(n=45)采用硬膜外阻滞麻醉。检测两组患者... 目的:比较硬膜外阻滞麻醉与全麻对老年患者术后血清S-100β蛋白水平及认知功能的影响。方法:90例拟行手术治疗的老年患者根据数字表法随机分为两组,全麻组(n=45)采用全身麻醉,硬膜外阻滞麻醉组(n=45)采用硬膜外阻滞麻醉。检测两组患者在麻醉诱导前后简易精神状态检查量表(mini-mental state examination,MMSE)评分及血清S-100β蛋白水平,比较两组手术时间、麻醉时间、VAS评分、失血量、输液量等指标及睁眼时间、拔管时间、应答时间等麻醉清醒指标,观察两组患者术后认知功能障碍(postoperative cognitive dysfunction,POCD)发生率。结果:两组手术时间、麻醉时间、VAS评分、失血量、输液量比较差异均无统计学意义(P>0.05)。两组麻醉诱导前及麻醉后72 h的MMSE评分比较差异无统计学意义(P>0.05),而麻醉后6、12、24 h的MMSE评分明显低于麻醉诱导前(P<0.05),且硬膜外阻滞麻醉组MMSE评分均高于全麻组(P<0.05)。两组麻醉诱导前及麻醉后72 h的血清S-100β蛋白水平比较差异无统计学意义(P>0.05),而麻醉后6、12、24 h的血清S-100β蛋白水平明显高于麻醉诱导前(P<0.05),且硬膜外阻滞麻醉组血清S-100β蛋白水平均低于全麻组(P<0.05)。两组睁眼时间、拔管时间及应答时间等麻醉清醒指标及术后72 h的POCD发生率比较差异无统计学意义(P>0.05),硬膜外阻滞麻醉组术后24 h的POCD发生率明显低于全麻组(P<0.05)。结论:与全麻比较,硬膜外阻滞麻醉可明显降低老年患者术后24 h的POCD发生率,可能与其减少血清S-100β蛋白等炎症因子释放有关。 展开更多
关键词 硬膜外阻滞麻醉 全身麻醉 术后认知功能障碍 s-100Β蛋白
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老年全麻术患者血清HIF-1α,S-100β蛋白,BDNF水平及rSO_(2)的动态检测与围术期神经认知紊乱的相关性分析 被引量:5
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作者 马磊 蔡亲东 陈基胜 《现代检验医学杂志》 CAS 2021年第5期153-158,共6页
目的探讨老年全身麻醉患者血清低氧诱导因子-1α(HIF-1α)、S-100β蛋白、脑源性神经营养因子(BDNF)、脑氧饱和度(rSO_(2))变化与围术期神经认知紊乱(PND)的相关性。方法选择2019年3月~2020年9月海口市第三人民医院手术室接诊的141例接... 目的探讨老年全身麻醉患者血清低氧诱导因子-1α(HIF-1α)、S-100β蛋白、脑源性神经营养因子(BDNF)、脑氧饱和度(rSO_(2))变化与围术期神经认知紊乱(PND)的相关性。方法选择2019年3月~2020年9月海口市第三人民医院手术室接诊的141例接受全身麻醉手术的老年患者,将术后7天MMSE评分<26分和(或)MoCA评分<26分患者归为PND组(33例),其余为认知功能正常组(108例)。分别于术前、术后1天、3天、7天检测血清HIF-1α,S-100β蛋白、BDNF水平以及rSO_(2)。分析HIF-1α,S-100β蛋白、BDNF,rSO_(2)与MMSE评分、MoCA评分相关性。结果PND组年龄大于认知功能正常组(t=3.106,P<0.05),初中文化程度比例高于认知功能正常组(χ^(2)=10.517,P<0.05),差异均有统计学意义。PND组和认知功能正常组围术期间MMSE评分、MoCA评分、BDNF水平呈先降低后升高变化趋势(F=8.005~13.054,均P<0.001),血清HIF-1α,S-100β蛋白水平、rSO_(2)呈先升高后降低趋势(F=7.882~17.154,P<0.001)。PND组术后1天、3天、7天MMSE评分、MoCA评分、BDNF水平低于认知功能正常组(F=12.54~18.094,均P<0.05),血清HIF-1α,S-100β蛋白水平、rSO_(2)高于认知功能正常组(F=15.346~25.134,均P<0.05)。Pearson相关分析结果显示认知障碍组患者血清HIF-1α,S-100β蛋白水平、rSO_(2)与MoCA评分、MMSE评分均呈负相关(MoCA:r=-0.506~-0.563,MMSE:r=-0.532~-0.601,均P<0.001),BDNF水平与MoCA评分、MMSE评分均呈正相关(r=0.597,0.534,均P<0.001)。联合HIF-1α,S-100β蛋白、BDNF,rSO_(2)诊断老年全身麻醉患者围术期PND的曲线下面积(AUC)为0.901,高于单独诊断的0.709,0.717,0.718和0.705(P<0.05)。结论老年全身麻醉手术围术期血清HIF-1α,S-100β蛋白水平、rSO_(2)升高,BDNF水平降低与认知功能损伤密切相关,可作为老年全身麻醉术后PND早期识别和病情评估的参考指标。 展开更多
关键词 全身麻醉 认识功能障碍 低氧诱导因子-1Α s-100Β蛋白 脑源性神经营养因子 脑氧饱和度
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