We study the effect of electrodes with varying thickness on thickness-twist vibration of a piezoelectric plate resonator of crystals of 6 mm symmetry. An exact theoretical analysis is performed. Results show that non-...We study the effect of electrodes with varying thickness on thickness-twist vibration of a piezoelectric plate resonator of crystals of 6 mm symmetry. An exact theoretical analysis is performed. Results show that non-uniform electrodes have a strong effect on mode shapes, and suggest the possibility of using nonuniform electrodes for strong energy trapping.展开更多
The electric admittance of a compound system composed of a thickness-shear mode (TSM) quartz crystal resonator (QCR) and an array of surface viscoelastic micro-beams (MBs) is studied. The governing equations of ...The electric admittance of a compound system composed of a thickness-shear mode (TSM) quartz crystal resonator (QCR) and an array of surface viscoelastic micro-beams (MBs) is studied. The governing equations of the MBs are derived from the Timoshenko-beam theory in consideration of shear deformation. The electrical admittance is described directly in terms of the physical properties of the surface epoxy resin (SU-8) MBs from an electrically forced vibration analysis. It is found that both the inertia effect and the constraint effect of the MBs produce competitive influence on the resonant frequency and admittance of the compound QCR system. By further comparing the numerical results calculated from the Timoshenko-beam model with those from the Euler-beam model, the shear deformation is found to lead to some deviation of an admittance spectrum. The deviations are revealed to be evident around the admittance peak(s) and reach the maximum when a natural frequency of the MBs is identical to the fundamental frequency of the QCR. Besides, a higher order vibration mode of the MBs corresponds to a larger deviation at the resonance.展开更多
The modelling and determination of the geometric parameters of a solar cell are important data, which influence the evaluation of its performance under specific operating conditions, as well as its industrial developm...The modelling and determination of the geometric parameters of a solar cell are important data, which influence the evaluation of its performance under specific operating conditions, as well as its industrial development for a low cost. In this work, an n+/p/p+ crystalline silicon solar cell is studied under monochromatic illumination in modulation and placed in a constant magnetic field. The minority carriers’ diffusion coefficient (<em>D</em>(<em>ω</em>, <em>B</em>), in the (<em>p</em>) base leads to maximum values (Dmax) at resonance frequencies (<em>ωr</em>). These values are used in expressions of AC minority carriers recombination velocity (Sb(Dmax, H)) in the rear of the base, to extract the optimum thickness while solar cell is subjected to these specific conditions. Optimum thickness modelling relationships, depending respectively on Dmax, <em>ωr</em> and <em>B</em>, are then established, and will be data for industrial development of low-cost solar cells for specific use.展开更多
BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel motility.The hypothesis was that assessment of the motility index(MI)should reflect diffe...BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel motility.The hypothesis was that assessment of the motility index(MI)should reflect differences in motility between clinical conditions.AIM To aim of the present observational,cross-sectional study was to evaluate the use of the MI in daily clinical practice.METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate.Healthy volunteers were included as controls.MRE was prepared and conducted in accordance with clinical routines.On the day of examination,all the participants had to complete the visual analog scale for irritable bowel syndrome(IBS)and IBS-symptom severity scale.Maps of MI were calculated from dynamic MR images.ANOVA was used to evaluate differences in MI between groups,classified as healthy,Crohn’s disease,ulcerative colitis,IBS,other assorted disorders and dysmotility.Logistic and linear regression were applied to the MI values.All medical records were scrutinized for medical history.RESULTS In all,224 examinations were included(inclusion prevalence 76.3%),with 22 controls and 202 patients.There was a significant difference in the MI of the jejunum(P=0.021)and terminal ileum(P=0.007)between the different groups.The MI was inversely associated with the mural thickness of the terminal ileum in men(P<0.001)and women(P=0.063)after adjustments,and tended to be lower in men than in women(P=0.056).Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men(P<0.001)and women(P=0.030).In women,diarrhea was inversely associated with the MI of the jejunum(P=0.029),and constipation was positively associated with the MI of the terminal ileum(P=0.039).CONCLUSION Although MIs differ across diseases,a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness.Symptoms are weakly associated with the MI.展开更多
Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance i...Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI). Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness. Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM (left: 2.52±0.07 mm; right: 2.51±0.08 mm) were significant thinner than those in the normal controls (left: 2.56±0.09 mm; right: 2.56±0.09 mm) (both P〈0.05). Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course. Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.展开更多
High energy γ-rays can be used in many fields, such as nuclear waste transmutation, flash photographics, and astrophysics. The13 C(p, γ)14 N resonance reaction was used to generate high energy and mono-energetic γ-...High energy γ-rays can be used in many fields, such as nuclear waste transmutation, flash photographics, and astrophysics. The13 C(p, γ)14 N resonance reaction was used to generate high energy and mono-energetic γ-rays in this work. The thick-target yield of the 9.17-MeV γ-ray from the resonance in this reaction was determined to be(4.7±0.4)×10-9γ/proton,which was measured by a HPGe detector. Meanwhile, the angular distribution of 9.17-MeV γ-ray was also determined.The absolute efficiency of HPGe detector was calibrated using56 Co and152 Eu sources with known radioactive activities and calculated by GEANT4 simulation.展开更多
In this paper, the coupled extension and thickness- twist vibrations are studied for AT-cut quartz plates under Lateral Field Excitation (LFE) with variations along the x1- direction. Mindlin's two-dimensional equa...In this paper, the coupled extension and thickness- twist vibrations are studied for AT-cut quartz plates under Lateral Field Excitation (LFE) with variations along the x1- direction. Mindlin's two-dimensional equations are used for anisotropic crystal plates. Both free and electrically forced vibrations are considered. Important vibration characteristics are obtained, including dispersion relations, frequency spectra, and motional capacitances. It is shown that, to avoid the effects of the couplings between extension and thickness-twist vibrations, a series of discrete values of the length/thickness ratio of the crystal plate need to be excluded. The results are of fundamental significance for the design of LFE resonators and sensors.展开更多
The thickness-dependent magnetic anisotropy of obliquely deposited Fe(001)/Pd thin films on Mg(001) is investigated by fitting the field-dependent resonant field curve using the Kittel equation.In this study, three Fe...The thickness-dependent magnetic anisotropy of obliquely deposited Fe(001)/Pd thin films on Mg(001) is investigated by fitting the field-dependent resonant field curve using the Kittel equation.In this study, three Fe film samples with thicknesses of 50 monolayers(ML), 45 ML, and 32 ML deposited at 0°, 45°, and 55°, respectively, are used.The magnetic anisotropy constant obtained from ferromagnetic resonance(FMR) spectra exhibits a dominant fourfold magnetocrystalline anisotropy(MCA) at the normal deposition angle with larger Fe thickness.However, the in-plane uniaxial magnetic anisotropy(UMA) is induced by a higher oblique deposition angle and a smaller thickness.Its hard axis lies between the [100] and [010] directions.The FMR data-fitting analysis yields a precise measurement of smaller contributions to the magnetic anisotropy, such as in-plane UMA.Due to MCA, when the magnetic field is weaker than the saturated field,the magnetization direction does not always align with the external field.The squared frequency-dependent resonant field measurement gives an isotropic Landé g-factor of 2.07.Our results are consistent with previous experiments conducted on the magneto-optical Kerr effect(MOKE) and anisotropic magnetoresistance(AMR) systems.Thus, a vector network analyzer ferromagnetic resonance(VNA-FMR) test-method for finding UMA in obliquely deposited Fe(001)/Pd bilayer ferromagnetic thin films, and determining the magnetic anisotropy constants with respect to the film normal deposition, is proposed.展开更多
In this proceeding,some highlight results on the constraints of the nuclear matter equation of state(EOS)from the data of nucleus resonance and neutron-skin thickness using the Bayesian approach based on the Skyrme-Ha...In this proceeding,some highlight results on the constraints of the nuclear matter equation of state(EOS)from the data of nucleus resonance and neutron-skin thickness using the Bayesian approach based on the Skyrme-Hartree-Fock model and its extension have been presented.Typically,the anti-correlation and positive correlations between the slope parameter and the value of the symmetry energy at the saturation density under the constraint of the neutron-skin thickness and the isovector giant dipole resonance have been discussed respectively.It’s shown that the Bayesian analysis can help to find a compromise for the“PREXII puzzle”and the“soft Tin puzzle”.The possible modifications on the constraints of lower-order EOS parameters as well as the relevant correlation when higher-order EOS parameters are incorporated as independent variables have been further illustrated.For a given model and parameter space,the Bayesian approach serves as a good analysis tool suitable for multi-messengers versus multi-variables,and is helpful for constraining quantitatively the model parameters as well as their correlations.展开更多
Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal b...Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.展开更多
文摘We study the effect of electrodes with varying thickness on thickness-twist vibration of a piezoelectric plate resonator of crystals of 6 mm symmetry. An exact theoretical analysis is performed. Results show that non-uniform electrodes have a strong effect on mode shapes, and suggest the possibility of using nonuniform electrodes for strong energy trapping.
基金Project supported by the National Natural Science Foundation of China(Nos.11272127 and51435006)the Research Fund for the Doctoral Program of Higher Education of China(No.20130142110022)
文摘The electric admittance of a compound system composed of a thickness-shear mode (TSM) quartz crystal resonator (QCR) and an array of surface viscoelastic micro-beams (MBs) is studied. The governing equations of the MBs are derived from the Timoshenko-beam theory in consideration of shear deformation. The electrical admittance is described directly in terms of the physical properties of the surface epoxy resin (SU-8) MBs from an electrically forced vibration analysis. It is found that both the inertia effect and the constraint effect of the MBs produce competitive influence on the resonant frequency and admittance of the compound QCR system. By further comparing the numerical results calculated from the Timoshenko-beam model with those from the Euler-beam model, the shear deformation is found to lead to some deviation of an admittance spectrum. The deviations are revealed to be evident around the admittance peak(s) and reach the maximum when a natural frequency of the MBs is identical to the fundamental frequency of the QCR. Besides, a higher order vibration mode of the MBs corresponds to a larger deviation at the resonance.
文摘The modelling and determination of the geometric parameters of a solar cell are important data, which influence the evaluation of its performance under specific operating conditions, as well as its industrial development for a low cost. In this work, an n+/p/p+ crystalline silicon solar cell is studied under monochromatic illumination in modulation and placed in a constant magnetic field. The minority carriers’ diffusion coefficient (<em>D</em>(<em>ω</em>, <em>B</em>), in the (<em>p</em>) base leads to maximum values (Dmax) at resonance frequencies (<em>ωr</em>). These values are used in expressions of AC minority carriers recombination velocity (Sb(Dmax, H)) in the rear of the base, to extract the optimum thickness while solar cell is subjected to these specific conditions. Optimum thickness modelling relationships, depending respectively on Dmax, <em>ωr</em> and <em>B</em>, are then established, and will be data for industrial development of low-cost solar cells for specific use.
基金the Development Foundation of Region Skåne,No.REGSKANE-619091the Foundation of Skåne University Hospital,No.2017-008and the Dir Albert Påhlsson’s Foundation,No.2019.
文摘BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel motility.The hypothesis was that assessment of the motility index(MI)should reflect differences in motility between clinical conditions.AIM To aim of the present observational,cross-sectional study was to evaluate the use of the MI in daily clinical practice.METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate.Healthy volunteers were included as controls.MRE was prepared and conducted in accordance with clinical routines.On the day of examination,all the participants had to complete the visual analog scale for irritable bowel syndrome(IBS)and IBS-symptom severity scale.Maps of MI were calculated from dynamic MR images.ANOVA was used to evaluate differences in MI between groups,classified as healthy,Crohn’s disease,ulcerative colitis,IBS,other assorted disorders and dysmotility.Logistic and linear regression were applied to the MI values.All medical records were scrutinized for medical history.RESULTS In all,224 examinations were included(inclusion prevalence 76.3%),with 22 controls and 202 patients.There was a significant difference in the MI of the jejunum(P=0.021)and terminal ileum(P=0.007)between the different groups.The MI was inversely associated with the mural thickness of the terminal ileum in men(P<0.001)and women(P=0.063)after adjustments,and tended to be lower in men than in women(P=0.056).Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men(P<0.001)and women(P=0.030).In women,diarrhea was inversely associated with the MI of the jejunum(P=0.029),and constipation was positively associated with the MI of the terminal ileum(P=0.039).CONCLUSION Although MIs differ across diseases,a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness.Symptoms are weakly associated with the MI.
基金Supported by the Foundation for Medical and Health Sci&Tech innovation Project of Sanya(2016YW37)the Special Financial Grant from China Postdoctoral Science Foundation(2014T70960)
文摘Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI). Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness. Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM (left: 2.52±0.07 mm; right: 2.51±0.08 mm) were significant thinner than those in the normal controls (left: 2.56±0.09 mm; right: 2.56±0.09 mm) (both P〈0.05). Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course. Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.
基金Project supported by the National Natural Science Foundation of China(Grant No.11655003)
文摘High energy γ-rays can be used in many fields, such as nuclear waste transmutation, flash photographics, and astrophysics. The13 C(p, γ)14 N resonance reaction was used to generate high energy and mono-energetic γ-rays in this work. The thick-target yield of the 9.17-MeV γ-ray from the resonance in this reaction was determined to be(4.7±0.4)×10-9γ/proton,which was measured by a HPGe detector. Meanwhile, the angular distribution of 9.17-MeV γ-ray was also determined.The absolute efficiency of HPGe detector was calibrated using56 Co and152 Eu sources with known radioactive activities and calculated by GEANT4 simulation.
基金supported by the National Natural Science Foundation of China(11372146)Research Fund for the Doctoral Program of Higher Education of China(20123305120007)+2 种基金Impact and Safety of Coastal Engineering Initiative,a COE Program of Zhejiang Provincial Government at Ningbo University(zj1110,zj1201,zj1229,and zj1203)Research Project Foundation of Zhejiang Educational Department(201327293)Young Doctoral Innovation Fund by Ningbo Polythchnic
文摘In this paper, the coupled extension and thickness- twist vibrations are studied for AT-cut quartz plates under Lateral Field Excitation (LFE) with variations along the x1- direction. Mindlin's two-dimensional equations are used for anisotropic crystal plates. Both free and electrically forced vibrations are considered. Important vibration characteristics are obtained, including dispersion relations, frequency spectra, and motional capacitances. It is shown that, to avoid the effects of the couplings between extension and thickness-twist vibrations, a series of discrete values of the length/thickness ratio of the crystal plate need to be excluded. The results are of fundamental significance for the design of LFE resonators and sensors.
基金Project supported by the National Basic Research Program of China(Grant Nos.2015CB921403 and 2016YFA0300701)the National Natural Science Foundation of China(Grant Nos.51427801,11374350,and 51671212)the Chinese Government Scholarship(Grant No.2015GXYG37)
文摘The thickness-dependent magnetic anisotropy of obliquely deposited Fe(001)/Pd thin films on Mg(001) is investigated by fitting the field-dependent resonant field curve using the Kittel equation.In this study, three Fe film samples with thicknesses of 50 monolayers(ML), 45 ML, and 32 ML deposited at 0°, 45°, and 55°, respectively, are used.The magnetic anisotropy constant obtained from ferromagnetic resonance(FMR) spectra exhibits a dominant fourfold magnetocrystalline anisotropy(MCA) at the normal deposition angle with larger Fe thickness.However, the in-plane uniaxial magnetic anisotropy(UMA) is induced by a higher oblique deposition angle and a smaller thickness.Its hard axis lies between the [100] and [010] directions.The FMR data-fitting analysis yields a precise measurement of smaller contributions to the magnetic anisotropy, such as in-plane UMA.Due to MCA, when the magnetic field is weaker than the saturated field,the magnetization direction does not always align with the external field.The squared frequency-dependent resonant field measurement gives an isotropic Landé g-factor of 2.07.Our results are consistent with previous experiments conducted on the magneto-optical Kerr effect(MOKE) and anisotropic magnetoresistance(AMR) systems.Thus, a vector network analyzer ferromagnetic resonance(VNA-FMR) test-method for finding UMA in obliquely deposited Fe(001)/Pd bilayer ferromagnetic thin films, and determining the magnetic anisotropy constants with respect to the film normal deposition, is proposed.
基金Supported by National Natural Science Foundation of China (11922514)。
文摘In this proceeding,some highlight results on the constraints of the nuclear matter equation of state(EOS)from the data of nucleus resonance and neutron-skin thickness using the Bayesian approach based on the Skyrme-Hartree-Fock model and its extension have been presented.Typically,the anti-correlation and positive correlations between the slope parameter and the value of the symmetry energy at the saturation density under the constraint of the neutron-skin thickness and the isovector giant dipole resonance have been discussed respectively.It’s shown that the Bayesian analysis can help to find a compromise for the“PREXII puzzle”and the“soft Tin puzzle”.The possible modifications on the constraints of lower-order EOS parameters as well as the relevant correlation when higher-order EOS parameters are incorporated as independent variables have been further illustrated.For a given model and parameter space,the Bayesian approach serves as a good analysis tool suitable for multi-messengers versus multi-variables,and is helpful for constraining quantitatively the model parameters as well as their correlations.
基金supported by grants from Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA22096018(to JY)Guangxi Key Research and Development Program,No.AB22080053(to DD)+6 种基金Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA23023004(to MZ)the National Natural Science Foundation of China,Nos.82260021(to MZ),82060315(to DD)the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2021GXNSFBA220007(to GD)Clinical Research Center For Medical Imaging in Hunan Province,No.2020SK4001(to JL)Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection in Hunan Province,No.2020SK3006(to JL)Science and Technology Innovation Program of Hunan Province,No.2021RC4016(to JL)Key Project of the Natural Science Foundation of Hunan Province,No.2024JJ3041(to JL).
文摘Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.